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6VIX

BRD4_Bromodomain2 complex with pyrrolopyridone compound 18

Functional Information from PDB Data
site_idAC1
Number of Residues14
Detailsbinding site for residue QYV A 501
ChainResidue
ATRP374
AMET442
AHOH613
AHOH623
CALA371
CTRP374
APRO375
AVAL380
AASP381
ALEU385
AASN433
AHIS437
AGLU438
AVAL439

site_idAC2
Number of Residues16
Detailsbinding site for residue QYV B 501
ChainResidue
BTRP374
BPRO375
BPHE376
BPRO379
BVAL380
BASP381
BLEU385
BLEU387
BASN433
BGLU438
BVAL439
BMET442
BHOH613
BHOH638
DTRP374
DQYV501

site_idAC3
Number of Residues15
Detailsbinding site for residue QYV C 501
ChainResidue
ATRP374
ATYR377
ALYS378
CTRP374
CPRO375
CPHE376
CVAL380
CASP381
CLEU385
CLEU387
CASN433
CGLU438
CVAL439
CHOH608
CHOH635

site_idAC4
Number of Residues17
Detailsbinding site for residue QYV D 501
ChainResidue
BTRP374
BGLU438
BQYV501
DTRP374
DPRO375
DPHE376
DVAL380
DASP381
DLEU385
DLEU387
DASN433
DPRO434
DVAL439
DMET442
DHOH605
DHOH621
DHOH630

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsSITE: Acetylated histone binding => ECO:0000269|PubMed:22464331
ChainResidueDetails
AASN433
BASN433
CASN433
DASN433

227344

PDB entries from 2024-11-13

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