Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6VFS

ClpXP from Neisseria meningitidis - Conformation A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005524	molecular_function	ATP binding
A	0006457	biological_process	protein folding
A	0008270	molecular_function	zinc ion binding
A	0009376	cellular_component	HslUV protease complex
A	0016887	molecular_function	ATP hydrolysis activity
A	0046872	molecular_function	metal ion binding
A	0046983	molecular_function	protein dimerization activity
A	0051082	molecular_function	unfolded protein binding
A	0051301	biological_process	cell division
A	0051603	biological_process	proteolysis involved in protein catabolic process
A	0140662	molecular_function	ATP-dependent protein folding chaperone
B	0000166	molecular_function	nucleotide binding
B	0005524	molecular_function	ATP binding
B	0006457	biological_process	protein folding
B	0008270	molecular_function	zinc ion binding
B	0009376	cellular_component	HslUV protease complex
B	0016887	molecular_function	ATP hydrolysis activity
B	0046872	molecular_function	metal ion binding
B	0046983	molecular_function	protein dimerization activity
B	0051082	molecular_function	unfolded protein binding
B	0051301	biological_process	cell division
B	0051603	biological_process	proteolysis involved in protein catabolic process
B	0140662	molecular_function	ATP-dependent protein folding chaperone
C	0000166	molecular_function	nucleotide binding
C	0005524	molecular_function	ATP binding
C	0006457	biological_process	protein folding
C	0008270	molecular_function	zinc ion binding
C	0009376	cellular_component	HslUV protease complex
C	0016887	molecular_function	ATP hydrolysis activity
C	0046872	molecular_function	metal ion binding
C	0046983	molecular_function	protein dimerization activity
C	0051082	molecular_function	unfolded protein binding
C	0051301	biological_process	cell division
C	0051603	biological_process	proteolysis involved in protein catabolic process
C	0140662	molecular_function	ATP-dependent protein folding chaperone
D	0000166	molecular_function	nucleotide binding
D	0005524	molecular_function	ATP binding
D	0006457	biological_process	protein folding
D	0008270	molecular_function	zinc ion binding
D	0009376	cellular_component	HslUV protease complex
D	0016887	molecular_function	ATP hydrolysis activity
D	0046872	molecular_function	metal ion binding
D	0046983	molecular_function	protein dimerization activity
D	0051082	molecular_function	unfolded protein binding
D	0051301	biological_process	cell division
D	0051603	biological_process	proteolysis involved in protein catabolic process
D	0140662	molecular_function	ATP-dependent protein folding chaperone
E	0000166	molecular_function	nucleotide binding
E	0005524	molecular_function	ATP binding
E	0006457	biological_process	protein folding
E	0008270	molecular_function	zinc ion binding
E	0009376	cellular_component	HslUV protease complex
E	0016887	molecular_function	ATP hydrolysis activity
E	0046872	molecular_function	metal ion binding
E	0046983	molecular_function	protein dimerization activity
E	0051082	molecular_function	unfolded protein binding
E	0051301	biological_process	cell division
E	0051603	biological_process	proteolysis involved in protein catabolic process
E	0140662	molecular_function	ATP-dependent protein folding chaperone
F	0000166	molecular_function	nucleotide binding
F	0005524	molecular_function	ATP binding
F	0006457	biological_process	protein folding
F	0008270	molecular_function	zinc ion binding
F	0009376	cellular_component	HslUV protease complex
F	0016887	molecular_function	ATP hydrolysis activity
F	0046872	molecular_function	metal ion binding
F	0046983	molecular_function	protein dimerization activity
F	0051082	molecular_function	unfolded protein binding
F	0051301	biological_process	cell division
F	0051603	biological_process	proteolysis involved in protein catabolic process
F	0140662	molecular_function	ATP-dependent protein folding chaperone
H	0004176	molecular_function	ATP-dependent peptidase activity
H	0004252	molecular_function	serine-type endopeptidase activity
H	0005737	cellular_component	cytoplasm
H	0006508	biological_process	proteolysis
H	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
H	0008233	molecular_function	peptidase activity
H	0008236	molecular_function	serine-type peptidase activity
H	0009368	cellular_component	endopeptidase Clp complex
H	0016787	molecular_function	hydrolase activity
H	0051117	molecular_function	ATPase binding
I	0004176	molecular_function	ATP-dependent peptidase activity
I	0004252	molecular_function	serine-type endopeptidase activity
I	0005737	cellular_component	cytoplasm
I	0006508	biological_process	proteolysis
I	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
I	0008233	molecular_function	peptidase activity
I	0008236	molecular_function	serine-type peptidase activity
I	0009368	cellular_component	endopeptidase Clp complex
I	0016787	molecular_function	hydrolase activity
I	0051117	molecular_function	ATPase binding
J	0004176	molecular_function	ATP-dependent peptidase activity
J	0004252	molecular_function	serine-type endopeptidase activity
J	0005737	cellular_component	cytoplasm
J	0006508	biological_process	proteolysis
J	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
J	0008233	molecular_function	peptidase activity
J	0008236	molecular_function	serine-type peptidase activity
J	0009368	cellular_component	endopeptidase Clp complex
J	0016787	molecular_function	hydrolase activity
J	0051117	molecular_function	ATPase binding
K	0004176	molecular_function	ATP-dependent peptidase activity
K	0004252	molecular_function	serine-type endopeptidase activity
K	0005737	cellular_component	cytoplasm
K	0006508	biological_process	proteolysis
K	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
K	0008233	molecular_function	peptidase activity
K	0008236	molecular_function	serine-type peptidase activity
K	0009368	cellular_component	endopeptidase Clp complex
K	0016787	molecular_function	hydrolase activity
K	0051117	molecular_function	ATPase binding
L	0004176	molecular_function	ATP-dependent peptidase activity
L	0004252	molecular_function	serine-type endopeptidase activity
L	0005737	cellular_component	cytoplasm
L	0006508	biological_process	proteolysis
L	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
L	0008233	molecular_function	peptidase activity
L	0008236	molecular_function	serine-type peptidase activity
L	0009368	cellular_component	endopeptidase Clp complex
L	0016787	molecular_function	hydrolase activity
L	0051117	molecular_function	ATPase binding
M	0004176	molecular_function	ATP-dependent peptidase activity
M	0004252	molecular_function	serine-type endopeptidase activity
M	0005737	cellular_component	cytoplasm
M	0006508	biological_process	proteolysis
M	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
M	0008233	molecular_function	peptidase activity
M	0008236	molecular_function	serine-type peptidase activity
M	0009368	cellular_component	endopeptidase Clp complex
M	0016787	molecular_function	hydrolase activity
M	0051117	molecular_function	ATPase binding
N	0004176	molecular_function	ATP-dependent peptidase activity
N	0004252	molecular_function	serine-type endopeptidase activity
N	0005737	cellular_component	cytoplasm
N	0006508	biological_process	proteolysis
N	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
N	0008233	molecular_function	peptidase activity
N	0008236	molecular_function	serine-type peptidase activity
N	0009368	cellular_component	endopeptidase Clp complex
N	0016787	molecular_function	hydrolase activity
N	0051117	molecular_function	ATPase binding
O	0004176	molecular_function	ATP-dependent peptidase activity
O	0004252	molecular_function	serine-type endopeptidase activity
O	0005737	cellular_component	cytoplasm
O	0006508	biological_process	proteolysis
O	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
O	0008233	molecular_function	peptidase activity
O	0008236	molecular_function	serine-type peptidase activity
O	0009368	cellular_component	endopeptidase Clp complex
O	0016787	molecular_function	hydrolase activity
O	0051117	molecular_function	ATPase binding
P	0004176	molecular_function	ATP-dependent peptidase activity
P	0004252	molecular_function	serine-type endopeptidase activity
P	0005737	cellular_component	cytoplasm
P	0006508	biological_process	proteolysis
P	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
P	0008233	molecular_function	peptidase activity
P	0008236	molecular_function	serine-type peptidase activity
P	0009368	cellular_component	endopeptidase Clp complex
P	0016787	molecular_function	hydrolase activity
P	0051117	molecular_function	ATPase binding
Q	0004176	molecular_function	ATP-dependent peptidase activity
Q	0004252	molecular_function	serine-type endopeptidase activity
Q	0005737	cellular_component	cytoplasm
Q	0006508	biological_process	proteolysis
Q	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
Q	0008233	molecular_function	peptidase activity
Q	0008236	molecular_function	serine-type peptidase activity
Q	0009368	cellular_component	endopeptidase Clp complex
Q	0016787	molecular_function	hydrolase activity
Q	0051117	molecular_function	ATPase binding
R	0004176	molecular_function	ATP-dependent peptidase activity
R	0004252	molecular_function	serine-type endopeptidase activity
R	0005737	cellular_component	cytoplasm
R	0006508	biological_process	proteolysis
R	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
R	0008233	molecular_function	peptidase activity
R	0008236	molecular_function	serine-type peptidase activity
R	0009368	cellular_component	endopeptidase Clp complex
R	0016787	molecular_function	hydrolase activity
R	0051117	molecular_function	ATPase binding
S	0004176	molecular_function	ATP-dependent peptidase activity
S	0004252	molecular_function	serine-type endopeptidase activity
S	0005737	cellular_component	cytoplasm
S	0006508	biological_process	proteolysis
S	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
S	0008233	molecular_function	peptidase activity
S	0008236	molecular_function	serine-type peptidase activity
S	0009368	cellular_component	endopeptidase Clp complex
S	0016787	molecular_function	hydrolase activity
S	0051117	molecular_function	ATPase binding
T	0004176	molecular_function	ATP-dependent peptidase activity
T	0004252	molecular_function	serine-type endopeptidase activity
T	0005737	cellular_component	cytoplasm
T	0006508	biological_process	proteolysis
T	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
T	0008233	molecular_function	peptidase activity
T	0008236	molecular_function	serine-type peptidase activity
T	0009368	cellular_component	endopeptidase Clp complex
T	0016787	molecular_function	hydrolase activity
T	0051117	molecular_function	ATPase binding
U	0004176	molecular_function	ATP-dependent peptidase activity
U	0004252	molecular_function	serine-type endopeptidase activity
U	0005737	cellular_component	cytoplasm
U	0006508	biological_process	proteolysis
U	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
U	0008233	molecular_function	peptidase activity
U	0008236	molecular_function	serine-type peptidase activity
U	0009368	cellular_component	endopeptidase Clp complex
U	0016787	molecular_function	hydrolase activity
U	0051117	molecular_function	ATPase binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue ATP E 501

Chain	Residue
E	HIS77
E	THR126
E	LEU127
E	ALA368
E	ARG369
E	MG502
F	GLU302
F	ARG306
E	VAL78
E	ILE79
E	GLN81
E	THR121
E	GLY122
E	SER123
E	GLY124
E	LYS125

site_id	AC2
Number of Residues	3
Details	binding site for residue MG E 502

Chain	Residue
E	THR126
E	ASP184
E	ATP501

site_id	AC3
Number of Residues	13
Details	binding site for residue ADP A 501

Chain	Residue
A	HIS77
A	VAL78
A	ILE79
A	GLN81
A	GLY122
A	SER123
A	GLY124
A	LYS125
A	THR126
A	LEU127
A	ILE324
A	ALA368
A	ARG369

site_id	AC4
Number of Residues	12
Details	binding site for residue ADP F 501

Chain	Residue
F	HIS77
F	VAL78
F	ILE79
F	GLN81
F	THR121
F	GLY122
F	SER123
F	GLY124
F	LYS125
F	THR126
F	LEU127
F	ILE324

site_id	AC5
Number of Residues	16
Details	binding site for residue ATP C 501

Chain	Residue
C	HIS77
C	VAL78
C	ILE79
C	GLN81
C	THR121
C	GLY122
C	SER123
C	GLY124
C	LYS125
C	THR126
C	LEU127
C	ALA368
C	ARG369
C	MG502
D	GLU302
D	ARG306

site_id	AC6
Number of Residues	3
Details	binding site for residue MG C 502

Chain	Residue
C	THR126
C	ASP184
C	ATP501

site_id	AC7
Number of Residues	14
Details	binding site for residue ATP B 501

Chain	Residue
B	HIS77
B	VAL78
B	ILE79
B	GLN81
B	GLY122
B	SER123
B	GLY124
B	LYS125
B	THR126
B	LEU127
B	ALA368
B	MG502
C	GLU302
C	ARG306

site_id	AC8
Number of Residues	3
Details	binding site for residue MG B 502

Chain	Residue
B	THR126
B	ASP184
B	ATP501

site_id	AC9
Number of Residues	15
Details	binding site for residue ATP D 501

Chain	Residue
D	HIS77
D	VAL78
D	ILE79
D	THR121
D	GLY122
D	SER123
D	GLY124
D	LYS125
D	THR126
D	LEU127
D	ALA368
D	ARG369
D	MG502
E	GLU302
E	ARG306

site_id	AD1
Number of Residues	3
Details	binding site for residue MG D 502

Chain	Residue
D	THR126
D	ASP184
D	ATP501

Functional Information from PROSITE/UniProt

site_id	PS00381
Number of Residues	12
Details	CLP_PROTEASE_SER Endopeptidase Clp serine active site. TlcLGqAASMGA

Chain	Residue	Details
L	THR94-ALA105

site_id	PS00382
Number of Residues	14
Details	CLP_PROTEASE_HIS Endopeptidase Clp histidine active site. RfalPnsrIMIHQP

Chain	Residue	Details
L	ARG116-PRO129

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	ACT_SITE: Nucleophile => ECO:0000255\|HAMAP-Rule:MF_00444

Chain	Residue	Details
L	SER102
I	SER102
J	SER102
K	SER102
M	SER102
N	SER102
C	CYS30
C	CYS33
B	CYS8
B	CYS11
B	CYS30
O	SER102
B	CYS33
D	CYS8
D	CYS11
D	CYS30
D	CYS33
P	SER102
Q	SER102
R	SER102
S	SER102
T	SER102
U	SER102
H	SER102

site_id	SWS_FT_FI2
Number of Residues	14
Details	ACT_SITE: ACT_SITE => ECO:0000255\|HAMAP-Rule:MF_00444

Chain	Residue	Details
L	HIS127
I	HIS127
J	HIS127
K	HIS127
M	HIS127
N	HIS127
O	HIS127
P	HIS127
Q	HIS127
R	HIS127
S	HIS127
T	HIS127
U	HIS127
H	HIS127

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)