6VFE
Gasdermin D pore
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 759 |
| Details | TRANSMEM: Beta stranded => ECO:0000269|PubMed:33883744, ECO:0007744|PDB:6VFE |
| Chain | Residue | Details |
| A | GLN91-ALA97 | |
| C | LYS103-ALA108 | |
| Y | CYS191-GLN197 | |
| Z | GLN91-ALA97 | |
| Z | LYS103-ALA108 | |
| Z | GLY180-LEU186 | |
| Z | CYS191-GLN197 | |
| a | GLN91-ALA97 | |
| a | LYS103-ALA108 | |
| a | GLY180-LEU186 | |
| a | CYS191-GLN197 | |
| b | GLN91-ALA97 | |
| C | GLY180-LEU186 | |
| b | LYS103-ALA108 | |
| b | GLY180-LEU186 | |
| b | CYS191-GLN197 | |
| c | GLN91-ALA97 | |
| c | LYS103-ALA108 | |
| c | GLY180-LEU186 | |
| c | CYS191-GLN197 | |
| d | GLN91-ALA97 | |
| d | LYS103-ALA108 | |
| d | GLY180-LEU186 | |
| C | CYS191-GLN197 | |
| d | CYS191-GLN197 | |
| e | GLN91-ALA97 | |
| e | LYS103-ALA108 | |
| e | GLY180-LEU186 | |
| e | CYS191-GLN197 | |
| f | GLN91-ALA97 | |
| f | LYS103-ALA108 | |
| f | GLY180-LEU186 | |
| f | CYS191-GLN197 | |
| g | GLN91-ALA97 | |
| D | GLN91-ALA97 | |
| g | LYS103-ALA108 | |
| g | GLY180-LEU186 | |
| g | CYS191-GLN197 | |
| D | LYS103-ALA108 | |
| D | GLY180-LEU186 | |
| D | CYS191-GLN197 | |
| E | GLN91-ALA97 | |
| E | LYS103-ALA108 | |
| E | GLY180-LEU186 | |
| A | LYS103-ALA108 | |
| E | CYS191-GLN197 | |
| F | GLN91-ALA97 | |
| F | LYS103-ALA108 | |
| F | GLY180-LEU186 | |
| F | CYS191-GLN197 | |
| G | GLN91-ALA97 | |
| G | LYS103-ALA108 | |
| G | GLY180-LEU186 | |
| G | CYS191-GLN197 | |
| H | GLN91-ALA97 | |
| A | GLY180-LEU186 | |
| H | LYS103-ALA108 | |
| H | GLY180-LEU186 | |
| H | CYS191-GLN197 | |
| I | GLN91-ALA97 | |
| I | LYS103-ALA108 | |
| I | GLY180-LEU186 | |
| I | CYS191-GLN197 | |
| J | GLN91-ALA97 | |
| J | LYS103-ALA108 | |
| J | GLY180-LEU186 | |
| A | CYS191-GLN197 | |
| J | CYS191-GLN197 | |
| K | GLN91-ALA97 | |
| K | LYS103-ALA108 | |
| K | GLY180-LEU186 | |
| K | CYS191-GLN197 | |
| L | GLN91-ALA97 | |
| L | LYS103-ALA108 | |
| L | GLY180-LEU186 | |
| L | CYS191-GLN197 | |
| M | GLN91-ALA97 | |
| B | GLN91-ALA97 | |
| M | LYS103-ALA108 | |
| M | GLY180-LEU186 | |
| M | CYS191-GLN197 | |
| N | GLN91-ALA97 | |
| N | LYS103-ALA108 | |
| N | GLY180-LEU186 | |
| N | CYS191-GLN197 | |
| O | GLN91-ALA97 | |
| O | LYS103-ALA108 | |
| O | GLY180-LEU186 | |
| B | LYS103-ALA108 | |
| O | CYS191-GLN197 | |
| P | GLN91-ALA97 | |
| P | LYS103-ALA108 | |
| P | GLY180-LEU186 | |
| P | CYS191-GLN197 | |
| Q | GLN91-ALA97 | |
| Q | LYS103-ALA108 | |
| Q | GLY180-LEU186 | |
| Q | CYS191-GLN197 | |
| R | GLN91-ALA97 | |
| B | GLY180-LEU186 | |
| R | LYS103-ALA108 | |
| R | GLY180-LEU186 | |
| R | CYS191-GLN197 | |
| S | GLN91-ALA97 | |
| S | LYS103-ALA108 | |
| S | GLY180-LEU186 | |
| S | CYS191-GLN197 | |
| T | GLN91-ALA97 | |
| T | LYS103-ALA108 | |
| T | GLY180-LEU186 | |
| B | CYS191-GLN197 | |
| T | CYS191-GLN197 | |
| U | GLN91-ALA97 | |
| U | LYS103-ALA108 | |
| U | GLY180-LEU186 | |
| U | CYS191-GLN197 | |
| V | GLN91-ALA97 | |
| V | LYS103-ALA108 | |
| V | GLY180-LEU186 | |
| V | CYS191-GLN197 | |
| W | GLN91-ALA97 | |
| C | GLN91-ALA97 | |
| W | LYS103-ALA108 | |
| W | GLY180-LEU186 | |
| W | CYS191-GLN197 | |
| X | GLN91-ALA97 | |
| X | LYS103-ALA108 | |
| X | GLY180-LEU186 | |
| X | CYS191-GLN197 | |
| Y | GLN91-ALA97 | |
| Y | LYS103-ALA108 | |
| Y | GLY180-LEU186 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 33 |
| Details | SITE: Cleavage; by CASP3 or CASP7 => ECO:0000269|PubMed:28045099, ECO:0000269|PubMed:28392147, ECO:0000269|PubMed:37327784 |
| Chain | Residue | Details |
| A | ASP87 | |
| J | ASP87 | |
| K | ASP87 | |
| L | ASP87 | |
| M | ASP87 | |
| N | ASP87 | |
| O | ASP87 | |
| P | ASP87 | |
| Q | ASP87 | |
| R | ASP87 | |
| S | ASP87 | |
| B | ASP87 | |
| T | ASP87 | |
| U | ASP87 | |
| V | ASP87 | |
| W | ASP87 | |
| X | ASP87 | |
| Y | ASP87 | |
| Z | ASP87 | |
| a | ASP87 | |
| b | ASP87 | |
| c | ASP87 | |
| C | ASP87 | |
| d | ASP87 | |
| e | ASP87 | |
| f | ASP87 | |
| g | ASP87 | |
| D | ASP87 | |
| E | ASP87 | |
| F | ASP87 | |
| G | ASP87 | |
| H | ASP87 | |
| I | ASP87 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 33 |
| Details | SITE: Cleavage; by enterovirus 71 (EV71) Protease 3C and coronavirus SARS-CoV-2 proteinase nsp5 => ECO:0000269|PubMed:28679757, ECO:0000269|PubMed:35594856 |
| Chain | Residue | Details |
| A | GLN193 | |
| J | GLN193 | |
| K | GLN193 | |
| L | GLN193 | |
| M | GLN193 | |
| N | GLN193 | |
| O | GLN193 | |
| P | GLN193 | |
| Q | GLN193 | |
| R | GLN193 | |
| S | GLN193 | |
| B | GLN193 | |
| T | GLN193 | |
| U | GLN193 | |
| V | GLN193 | |
| W | GLN193 | |
| X | GLN193 | |
| Y | GLN193 | |
| Z | GLN193 | |
| a | GLN193 | |
| b | GLN193 | |
| c | GLN193 | |
| C | GLN193 | |
| d | GLN193 | |
| e | GLN193 | |
| f | GLN193 | |
| g | GLN193 | |
| D | GLN193 | |
| E | GLN193 | |
| F | GLN193 | |
| G | GLN193 | |
| H | GLN193 | |
| I | GLN193 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 66 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455 |
| Chain | Residue | Details |
| A | TYR37 | |
| E | TYR158 | |
| F | TYR37 | |
| F | TYR158 | |
| G | TYR37 | |
| G | TYR158 | |
| H | TYR37 | |
| H | TYR158 | |
| I | TYR37 | |
| I | TYR158 | |
| J | TYR37 | |
| A | TYR158 | |
| J | TYR158 | |
| K | TYR37 | |
| K | TYR158 | |
| L | TYR37 | |
| L | TYR158 | |
| M | TYR37 | |
| M | TYR158 | |
| N | TYR37 | |
| N | TYR158 | |
| O | TYR37 | |
| B | TYR37 | |
| O | TYR158 | |
| P | TYR37 | |
| P | TYR158 | |
| Q | TYR37 | |
| Q | TYR158 | |
| R | TYR37 | |
| R | TYR158 | |
| S | TYR37 | |
| S | TYR158 | |
| T | TYR37 | |
| B | TYR158 | |
| T | TYR158 | |
| U | TYR37 | |
| U | TYR158 | |
| V | TYR37 | |
| V | TYR158 | |
| W | TYR37 | |
| W | TYR158 | |
| X | TYR37 | |
| X | TYR158 | |
| Y | TYR37 | |
| C | TYR37 | |
| Y | TYR158 | |
| Z | TYR37 | |
| Z | TYR158 | |
| a | TYR37 | |
| a | TYR158 | |
| b | TYR37 | |
| b | TYR158 | |
| c | TYR37 | |
| c | TYR158 | |
| d | TYR37 | |
| C | TYR158 | |
| d | TYR158 | |
| e | TYR37 | |
| e | TYR158 | |
| f | TYR37 | |
| f | TYR158 | |
| g | TYR37 | |
| g | TYR158 | |
| D | TYR37 | |
| D | TYR158 | |
| E | TYR37 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 66 |
| Details | MOD_RES: S-(2-succinyl)cysteine => ECO:0000269|PubMed:32820063 |
| Chain | Residue | Details |
| A | CYS56 | |
| E | CYS191 | |
| F | CYS56 | |
| F | CYS191 | |
| G | CYS56 | |
| G | CYS191 | |
| H | CYS56 | |
| H | CYS191 | |
| I | CYS56 | |
| I | CYS191 | |
| J | CYS56 | |
| A | CYS191 | |
| J | CYS191 | |
| K | CYS56 | |
| K | CYS191 | |
| L | CYS56 | |
| L | CYS191 | |
| M | CYS56 | |
| M | CYS191 | |
| N | CYS56 | |
| N | CYS191 | |
| O | CYS56 | |
| B | CYS56 | |
| O | CYS191 | |
| P | CYS56 | |
| P | CYS191 | |
| Q | CYS56 | |
| Q | CYS191 | |
| R | CYS56 | |
| R | CYS191 | |
| S | CYS56 | |
| S | CYS191 | |
| T | CYS56 | |
| B | CYS191 | |
| T | CYS191 | |
| U | CYS56 | |
| U | CYS191 | |
| V | CYS56 | |
| V | CYS191 | |
| W | CYS56 | |
| W | CYS191 | |
| X | CYS56 | |
| X | CYS191 | |
| Y | CYS56 | |
| C | CYS56 | |
| Y | CYS191 | |
| Z | CYS56 | |
| Z | CYS191 | |
| a | CYS56 | |
| a | CYS191 | |
| b | CYS56 | |
| b | CYS191 | |
| c | CYS56 | |
| c | CYS191 | |
| d | CYS56 | |
| C | CYS191 | |
| d | CYS191 | |
| e | CYS56 | |
| e | CYS191 | |
| f | CYS56 | |
| f | CYS191 | |
| g | CYS56 | |
| g | CYS191 | |
| D | CYS56 | |
| D | CYS191 | |
| E | CYS56 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 33 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER185 | |
| J | SER185 | |
| K | SER185 | |
| L | SER185 | |
| M | SER185 | |
| N | SER185 | |
| O | SER185 | |
| P | SER185 | |
| Q | SER185 | |
| R | SER185 | |
| S | SER185 | |
| B | SER185 | |
| T | SER185 | |
| U | SER185 | |
| V | SER185 | |
| W | SER185 | |
| X | SER185 | |
| Y | SER185 | |
| Z | SER185 | |
| a | SER185 | |
| b | SER185 | |
| c | SER185 | |
| C | SER185 | |
| d | SER185 | |
| e | SER185 | |
| f | SER185 | |
| g | SER185 | |
| D | SER185 | |
| E | SER185 | |
| F | SER185 | |
| G | SER185 | |
| H | SER185 | |
| I | SER185 |
