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6VF2

DNA Polymerase Mu, 8-oxorGTP:At Product State Ternary Complex, 50 mM Mg2+ (960 min)

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0003887molecular_functionDNA-directed DNA polymerase activity
A0005634cellular_componentnucleus
A0006281biological_processDNA repair
A0016779molecular_functionnucleotidyltransferase activity
A0034061molecular_functionDNA polymerase activity
Functional Information from PDB Data
site_idAC1
Number of Residues1
Detailsbinding site for residue DTT A 501
ChainResidue
ACYS180

site_idAC2
Number of Residues6
Detailsbinding site for residue NA A 502
ChainResidue
ATHR241
AILE243
AVAL246
AHOH797
PDT3
PHOH209

site_idAC3
Number of Residues6
Detailsbinding site for residue NA A 503
ChainResidue
AMG509
AHOH660
AHOH690
P8GM5
AASP330
AASP332

site_idAC4
Number of Residues5
Detailsbinding site for residue EPE A 504
ChainResidue
ALEU149
ALYS325
ALEU326
AGLN327
AHOH619

site_idAC5
Number of Residues7
Detailsbinding site for residue EDO A 505
ChainResidue
AARG387
AARG445
AASN457
ASER458
PEDO101
TDT6
TDA7

site_idAC6
Number of Residues6
Detailsbinding site for residue EDO A 506
ChainResidue
AHIS152
ATHR314
ATHR336
APHE427
AHOH601
AHOH630

site_idAC7
Number of Residues2
Detailsbinding site for residue EDO A 507
ChainResidue
APHE385
AGLY410

site_idAC8
Number of Residues5
Detailsbinding site for residue EDO A 508
ChainResidue
AASN457
AHIS459
AHOH662
TDA7
TDC8

site_idAC9
Number of Residues6
Detailsbinding site for residue MG A 509
ChainResidue
AASP330
AASP332
AASP418
ANA503
PDA4
P8GM5

site_idAD1
Number of Residues7
Detailsbinding site for residue EDO P 101
ChainResidue
AARG387
AGLY433
ATRP434
AARG445
AEDO505
PDA4
P8GM5

Functional Information from PROSITE/UniProt
site_idPS00522
Number of Residues20
DetailsDNA_POLYMERASE_X DNA polymerase family X signature. GGFrRGklqGhDVDFLIthP
ChainResidueDetails
AGLY319-PRO338

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AASP330
AASP332
AALA430

site_idSWS_FT_FI2
Number of Residues1
DetailsSITE: Responsible for the low discrimination between dNTP and rNTP
ChainResidueDetails
AARG445

226707

PDB entries from 2024-10-30

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