6VDL

HCV NS3/4A protease A156T mutant in complex with glecaprevir

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008236	molecular_function	serine-type peptidase activity
A	0019087	biological_process	transformation of host cell by virus

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1201

Chain	Residue
A	CYS1097
A	CYS1099
A	CYS1145
A	HIS1149

---

site_id	AC2
Number of Residues	23
Details	binding site for residue O31 A 1202

Chain	Residue
A	ASP1081
A	ILE1132
A	LEU1135
A	LYS1136
A	GLY1137
A	SER1138
A	SER1139
A	PHE1154
A	ARG1155
A	THR1156
A	ALA1157
A	SO41205
A	HOH1318
A	HOH1377
A	HOH1386
A	HOH1432
A	HOH1433
A	HOH1442
A	HIS982
A	GLN1041
A	THR1042
A	PHE1043
A	HIS1057

---

site_id	AC3
Number of Residues	5
Details	binding site for residue GOL A 1203

Chain	Residue
A	GLY980
A	MET983
A	LEU1000
A	GLU1032
A	GLY1148

---

site_id	AC4
Number of Residues	4
Details	binding site for residue GOL A 1204

Chain	Residue
A	LYS989
A	THR1040
A	ARG1062
A	HOH1368

---

site_id	AC5
Number of Residues	9
Details	binding site for residue SO4 A 1205

Chain	Residue
A	TYR1006
A	GLN1008
A	TYR1056
A	O311202
A	HOH1321
A	HOH1340
A	HOH1353
A	HOH1397
A	HOH1423

---

site_id	AC6
Number of Residues	9
Details	binding site for residue SO4 A 1206

Chain	Residue
A	ARG1109
A	HIS1110
A	HOH1311
A	HOH1330
A	HOH1374
A	HOH1383
A	HOH1426
A	HOH1444
A	HOH1448

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU01166

Chain	Residue	Details
A	HIS1057
A	ASP1081
A	SER1139

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01166

Chain	Residue	Details
A	CYS1097
A	CYS1099
A	CYS1145
A	HIS1149

---