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6VAO

Human cofilin-1 decorated actin filament

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0001725cellular_componentstress fiber
A0003785molecular_functionactin monomer binding
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005523molecular_functiontropomyosin binding
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005856cellular_componentcytoskeleton
A0005865cellular_componentstriated muscle thin filament
A0005884cellular_componentactin filament
A0010628biological_processpositive regulation of gene expression
A0016787molecular_functionhydrolase activity
A0019904molecular_functionprotein domain specific binding
A0030027cellular_componentlamellipodium
A0030041biological_processactin filament polymerization
A0030175cellular_componentfilopodium
A0030240biological_processskeletal muscle thin filament assembly
A0031013molecular_functiontroponin I binding
A0031432molecular_functiontitin binding
A0031941cellular_componentfilamentous actin
A0032036molecular_functionmyosin heavy chain binding
A0032432cellular_componentactin filament bundle
A0042802molecular_functionidentical protein binding
A0044297cellular_componentcell body
A0048306molecular_functioncalcium-dependent protein binding
A0048741biological_processskeletal muscle fiber development
A0051017biological_processactin filament bundle assembly
A0090131biological_processmesenchyme migration
A0098723cellular_componentskeletal muscle myofibril
A0140660molecular_functioncytoskeletal motor activator activity
B0000287molecular_functionmagnesium ion binding
B0001725cellular_componentstress fiber
B0003785molecular_functionactin monomer binding
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005523molecular_functiontropomyosin binding
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005856cellular_componentcytoskeleton
B0005865cellular_componentstriated muscle thin filament
B0005884cellular_componentactin filament
B0010628biological_processpositive regulation of gene expression
B0016787molecular_functionhydrolase activity
B0019904molecular_functionprotein domain specific binding
B0030027cellular_componentlamellipodium
B0030041biological_processactin filament polymerization
B0030175cellular_componentfilopodium
B0030240biological_processskeletal muscle thin filament assembly
B0031013molecular_functiontroponin I binding
B0031432molecular_functiontitin binding
B0031941cellular_componentfilamentous actin
B0032036molecular_functionmyosin heavy chain binding
B0032432cellular_componentactin filament bundle
B0042802molecular_functionidentical protein binding
B0044297cellular_componentcell body
B0048306molecular_functioncalcium-dependent protein binding
B0048741biological_processskeletal muscle fiber development
B0051017biological_processactin filament bundle assembly
B0090131biological_processmesenchyme migration
B0098723cellular_componentskeletal muscle myofibril
B0140660molecular_functioncytoskeletal motor activator activity
C0000287molecular_functionmagnesium ion binding
C0001725cellular_componentstress fiber
C0003785molecular_functionactin monomer binding
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005523molecular_functiontropomyosin binding
C0005524molecular_functionATP binding
C0005737cellular_componentcytoplasm
C0005856cellular_componentcytoskeleton
C0005865cellular_componentstriated muscle thin filament
C0005884cellular_componentactin filament
C0010628biological_processpositive regulation of gene expression
C0016787molecular_functionhydrolase activity
C0019904molecular_functionprotein domain specific binding
C0030027cellular_componentlamellipodium
C0030041biological_processactin filament polymerization
C0030175cellular_componentfilopodium
C0030240biological_processskeletal muscle thin filament assembly
C0031013molecular_functiontroponin I binding
C0031432molecular_functiontitin binding
C0031941cellular_componentfilamentous actin
C0032036molecular_functionmyosin heavy chain binding
C0032432cellular_componentactin filament bundle
C0042802molecular_functionidentical protein binding
C0044297cellular_componentcell body
C0048306molecular_functioncalcium-dependent protein binding
C0048741biological_processskeletal muscle fiber development
C0051017biological_processactin filament bundle assembly
C0090131biological_processmesenchyme migration
C0098723cellular_componentskeletal muscle myofibril
C0140660molecular_functioncytoskeletal motor activator activity
D0000287molecular_functionmagnesium ion binding
D0001725cellular_componentstress fiber
D0003785molecular_functionactin monomer binding
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005523molecular_functiontropomyosin binding
D0005524molecular_functionATP binding
D0005737cellular_componentcytoplasm
D0005856cellular_componentcytoskeleton
D0005865cellular_componentstriated muscle thin filament
D0005884cellular_componentactin filament
D0010628biological_processpositive regulation of gene expression
D0016787molecular_functionhydrolase activity
D0019904molecular_functionprotein domain specific binding
D0030027cellular_componentlamellipodium
D0030041biological_processactin filament polymerization
D0030175cellular_componentfilopodium
D0030240biological_processskeletal muscle thin filament assembly
D0031013molecular_functiontroponin I binding
D0031432molecular_functiontitin binding
D0031941cellular_componentfilamentous actin
D0032036molecular_functionmyosin heavy chain binding
D0032432cellular_componentactin filament bundle
D0042802molecular_functionidentical protein binding
D0044297cellular_componentcell body
D0048306molecular_functioncalcium-dependent protein binding
D0048741biological_processskeletal muscle fiber development
D0051017biological_processactin filament bundle assembly
D0090131biological_processmesenchyme migration
D0098723cellular_componentskeletal muscle myofibril
D0140660molecular_functioncytoskeletal motor activator activity
E0000287molecular_functionmagnesium ion binding
E0001725cellular_componentstress fiber
E0003785molecular_functionactin monomer binding
E0005509molecular_functioncalcium ion binding
E0005515molecular_functionprotein binding
E0005523molecular_functiontropomyosin binding
E0005524molecular_functionATP binding
E0005737cellular_componentcytoplasm
E0005856cellular_componentcytoskeleton
E0005865cellular_componentstriated muscle thin filament
E0005884cellular_componentactin filament
E0010628biological_processpositive regulation of gene expression
E0016787molecular_functionhydrolase activity
E0019904molecular_functionprotein domain specific binding
E0030027cellular_componentlamellipodium
E0030041biological_processactin filament polymerization
E0030175cellular_componentfilopodium
E0030240biological_processskeletal muscle thin filament assembly
E0031013molecular_functiontroponin I binding
E0031432molecular_functiontitin binding
E0031941cellular_componentfilamentous actin
E0032036molecular_functionmyosin heavy chain binding
E0032432cellular_componentactin filament bundle
E0042802molecular_functionidentical protein binding
E0044297cellular_componentcell body
E0048306molecular_functioncalcium-dependent protein binding
E0048741biological_processskeletal muscle fiber development
E0051017biological_processactin filament bundle assembly
E0090131biological_processmesenchyme migration
E0098723cellular_componentskeletal muscle myofibril
E0140660molecular_functioncytoskeletal motor activator activity
F0000281biological_processmitotic cytokinesis
F0003779molecular_functionactin binding
F0005515molecular_functionprotein binding
F0005615cellular_componentextracellular space
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0005856cellular_componentcytoskeleton
F0005886cellular_componentplasma membrane
F0005925cellular_componentfocal adhesion
F0007010biological_processcytoskeleton organization
F0007266biological_processRho protein signal transduction
F0009615biological_processresponse to virus
F0015629cellular_componentactin cytoskeleton
F0016020cellular_componentmembrane
F0016363cellular_componentnuclear matrix
F0022604biological_processregulation of cell morphogenesis
F0030027cellular_componentlamellipodium
F0030036biological_processactin cytoskeleton organization
F0030042biological_processactin filament depolymerization
F0030043biological_processactin filament fragmentation
F0030424cellular_componentaxon
F0030426cellular_componentgrowth cone
F0031258cellular_componentlamellipodium membrane
F0031982cellular_componentvesicle
F0032587cellular_componentruffle membrane
F0040019biological_processpositive regulation of embryonic development
F0042995cellular_componentcell projection
F0043066biological_processnegative regulation of apoptotic process
F0044794biological_processpositive regulation by host of viral process
F0051014biological_processactin filament severing
F0051015molecular_functionactin filament binding
F0051293biological_processestablishment of spindle localization
F0061001biological_processregulation of dendritic spine morphogenesis
F0070062cellular_componentextracellular exosome
G0000281biological_processmitotic cytokinesis
G0003779molecular_functionactin binding
G0005515molecular_functionprotein binding
G0005615cellular_componentextracellular space
G0005634cellular_componentnucleus
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0005856cellular_componentcytoskeleton
G0005886cellular_componentplasma membrane
G0005925cellular_componentfocal adhesion
G0007010biological_processcytoskeleton organization
G0007266biological_processRho protein signal transduction
G0009615biological_processresponse to virus
G0015629cellular_componentactin cytoskeleton
G0016020cellular_componentmembrane
G0016363cellular_componentnuclear matrix
G0022604biological_processregulation of cell morphogenesis
G0030027cellular_componentlamellipodium
G0030036biological_processactin cytoskeleton organization
G0030042biological_processactin filament depolymerization
G0030043biological_processactin filament fragmentation
G0030424cellular_componentaxon
G0030426cellular_componentgrowth cone
G0031258cellular_componentlamellipodium membrane
G0031982cellular_componentvesicle
G0032587cellular_componentruffle membrane
G0040019biological_processpositive regulation of embryonic development
G0042995cellular_componentcell projection
G0043066biological_processnegative regulation of apoptotic process
G0044794biological_processpositive regulation by host of viral process
G0051014biological_processactin filament severing
G0051015molecular_functionactin filament binding
G0051293biological_processestablishment of spindle localization
G0061001biological_processregulation of dendritic spine morphogenesis
G0070062cellular_componentextracellular exosome
H0000281biological_processmitotic cytokinesis
H0003779molecular_functionactin binding
H0005515molecular_functionprotein binding
H0005615cellular_componentextracellular space
H0005634cellular_componentnucleus
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0005856cellular_componentcytoskeleton
H0005886cellular_componentplasma membrane
H0005925cellular_componentfocal adhesion
H0007010biological_processcytoskeleton organization
H0007266biological_processRho protein signal transduction
H0009615biological_processresponse to virus
H0015629cellular_componentactin cytoskeleton
H0016020cellular_componentmembrane
H0016363cellular_componentnuclear matrix
H0022604biological_processregulation of cell morphogenesis
H0030027cellular_componentlamellipodium
H0030036biological_processactin cytoskeleton organization
H0030042biological_processactin filament depolymerization
H0030043biological_processactin filament fragmentation
H0030424cellular_componentaxon
H0030426cellular_componentgrowth cone
H0031258cellular_componentlamellipodium membrane
H0031982cellular_componentvesicle
H0032587cellular_componentruffle membrane
H0040019biological_processpositive regulation of embryonic development
H0042995cellular_componentcell projection
H0043066biological_processnegative regulation of apoptotic process
H0044794biological_processpositive regulation by host of viral process
H0051014biological_processactin filament severing
H0051015molecular_functionactin filament binding
H0051293biological_processestablishment of spindle localization
H0061001biological_processregulation of dendritic spine morphogenesis
H0070062cellular_componentextracellular exosome
I0000281biological_processmitotic cytokinesis
I0003779molecular_functionactin binding
I0005515molecular_functionprotein binding
I0005615cellular_componentextracellular space
I0005634cellular_componentnucleus
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0005856cellular_componentcytoskeleton
I0005886cellular_componentplasma membrane
I0005925cellular_componentfocal adhesion
I0007010biological_processcytoskeleton organization
I0007266biological_processRho protein signal transduction
I0009615biological_processresponse to virus
I0015629cellular_componentactin cytoskeleton
I0016020cellular_componentmembrane
I0016363cellular_componentnuclear matrix
I0022604biological_processregulation of cell morphogenesis
I0030027cellular_componentlamellipodium
I0030036biological_processactin cytoskeleton organization
I0030042biological_processactin filament depolymerization
I0030043biological_processactin filament fragmentation
I0030424cellular_componentaxon
I0030426cellular_componentgrowth cone
I0031258cellular_componentlamellipodium membrane
I0031982cellular_componentvesicle
I0032587cellular_componentruffle membrane
I0040019biological_processpositive regulation of embryonic development
I0042995cellular_componentcell projection
I0043066biological_processnegative regulation of apoptotic process
I0044794biological_processpositive regulation by host of viral process
I0051014biological_processactin filament severing
I0051015molecular_functionactin filament binding
I0051293biological_processestablishment of spindle localization
I0061001biological_processregulation of dendritic spine morphogenesis
I0070062cellular_componentextracellular exosome
J0000281biological_processmitotic cytokinesis
J0003779molecular_functionactin binding
J0005515molecular_functionprotein binding
J0005615cellular_componentextracellular space
J0005634cellular_componentnucleus
J0005737cellular_componentcytoplasm
J0005829cellular_componentcytosol
J0005856cellular_componentcytoskeleton
J0005886cellular_componentplasma membrane
J0005925cellular_componentfocal adhesion
J0007010biological_processcytoskeleton organization
J0007266biological_processRho protein signal transduction
J0009615biological_processresponse to virus
J0015629cellular_componentactin cytoskeleton
J0016020cellular_componentmembrane
J0016363cellular_componentnuclear matrix
J0022604biological_processregulation of cell morphogenesis
J0030027cellular_componentlamellipodium
J0030036biological_processactin cytoskeleton organization
J0030042biological_processactin filament depolymerization
J0030043biological_processactin filament fragmentation
J0030424cellular_componentaxon
J0030426cellular_componentgrowth cone
J0031258cellular_componentlamellipodium membrane
J0031982cellular_componentvesicle
J0032587cellular_componentruffle membrane
J0040019biological_processpositive regulation of embryonic development
J0042995cellular_componentcell projection
J0043066biological_processnegative regulation of apoptotic process
J0044794biological_processpositive regulation by host of viral process
J0051014biological_processactin filament severing
J0051015molecular_functionactin filament binding
J0051293biological_processestablishment of spindle localization
J0061001biological_processregulation of dendritic spine morphogenesis
J0070062cellular_componentextracellular exosome
Functional Information from PDB Data
site_idAC1
Number of Residues3
Detailsbinding site for residue MG D 401
ChainResidue
DGLN137
DASP154
DADP402

site_idAC2
Number of Residues15
Detailsbinding site for residue ADP D 402
ChainResidue
DASP157
DLYS213
DGLU214
DGLY302
DTHR303
DMET305
DTYR306
DLYS336
DMG401
DGLY13
DSER14
DGLY15
DLEU16
DLYS18
DGLY156

site_idAC3
Number of Residues3
Detailsbinding site for residue MG A 401
ChainResidue
AGLN137
AASP154
AADP402

site_idAC4
Number of Residues15
Detailsbinding site for residue ADP A 402
ChainResidue
AGLY13
ASER14
AGLY15
ALEU16
ALYS18
AGLY156
AASP157
ALYS213
AGLU214
AGLY302
ATHR303
AMET305
ATYR306
ALYS336
AMG401

site_idAC5
Number of Residues3
Detailsbinding site for residue MG B 401
ChainResidue
BGLN137
BASP154
BADP402

site_idAC6
Number of Residues15
Detailsbinding site for residue ADP B 402
ChainResidue
BGLY13
BSER14
BGLY15
BLEU16
BLYS18
BGLY156
BASP157
BLYS213
BGLU214
BGLY302
BTHR303
BMET305
BTYR306
BLYS336
BMG401

site_idAC7
Number of Residues3
Detailsbinding site for residue MG C 401
ChainResidue
CGLN137
CASP154
CADP402

site_idAC8
Number of Residues15
Detailsbinding site for residue ADP C 402
ChainResidue
CGLY13
CSER14
CGLY15
CLEU16
CLYS18
CGLY156
CASP157
CLYS213
CGLU214
CGLY302
CTHR303
CMET305
CTYR306
CLYS336
CMG401

site_idAC9
Number of Residues3
Detailsbinding site for residue MG E 401
ChainResidue
EGLN137
EASP154
EADP402

site_idAD1
Number of Residues15
Detailsbinding site for residue ADP E 402
ChainResidue
EGLY13
ESER14
EGLY15
ELEU16
ELYS18
EGLY156
EASP157
ELYS213
EGLU214
EGLY302
ETHR303
EMET305
ETYR306
ELYS336
EMG401

Functional Information from PROSITE/UniProt
site_idPS00406
Number of Residues11
DetailsACTINS_1 Actins signature 1. YVGDEAQs.KRG
ChainResidueDetails
DTYR53-GLY63

site_idPS00432
Number of Residues9
DetailsACTINS_2 Actins signature 2. WITKqEYDE
ChainResidueDetails
DTRP356-GLU364

site_idPS01132
Number of Residues13
DetailsACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR
ChainResidueDetails
DLEU104-ARG116

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues5
DetailsMOD_RES: N-acetylalanine => ECO:0000269|PubMed:30550596, ECO:0000269|Ref.9, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712
ChainResidueDetails
JALA2
FALA2
GALA2
HALA2
IALA2

site_idSWS_FT_FI2
Number of Residues5
DetailsMOD_RES: Phosphoserine; by NRK => ECO:0000269|PubMed:12837278, ECO:0000269|PubMed:30550596, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
JSER3
FSER3
GSER3
HSER3
ISER3

site_idSWS_FT_FI3
Number of Residues5
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P18760
ChainResidueDetails
JSER8
EMET47
FSER8
GSER8
HSER8
ISER8
BMET47
CMET44
CMET47
EMET44

site_idSWS_FT_FI4
Number of Residues15
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
JLYS13
HLYS13
HLYS73
HLYS144
ILYS13
ILYS73
ILYS144
JLYS73
JLYS144
FLYS13
FLYS73
FLYS144
GLYS13
GLYS73
GLYS144

site_idSWS_FT_FI5
Number of Residues5
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231
ChainResidueDetails
JTHR25
FTHR25
GTHR25
HTHR25
ITHR25

site_idSWS_FT_FI6
Number of Residues5
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
JSER41
FSER41
GSER41
HSER41
ISER41

site_idSWS_FT_FI7
Number of Residues5
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:30550596
ChainResidueDetails
JTHR63
FTHR63
GTHR63
HTHR63
ITHR63

site_idSWS_FT_FI8
Number of Residues5
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332
ChainResidueDetails
JTYR68
FTYR68
GTYR68
HTYR68
ITYR68

site_idSWS_FT_FI9
Number of Residues5
DetailsMOD_RES: Phosphotyrosine => ECO:0000269|PubMed:30550596
ChainResidueDetails
JTYR82
FTYR82
GTYR82
HTYR82
ITYR82

site_idSWS_FT_FI10
Number of Residues5
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:30550596
ChainResidueDetails
JSER108
FSER108
GSER108
HSER108
ISER108

site_idSWS_FT_FI11
Number of Residues5
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455
ChainResidueDetails
JTYR140
FTYR140
GTYR140
HTYR140
ITYR140

site_idSWS_FT_FI12
Number of Residues5
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:30550596, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
JSER156
FSER156
GSER156
HSER156
ISER156

site_idSWS_FT_FI13
Number of Residues10
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
JLYS132
FLYS132
GLYS132
HLYS132
ILYS132

222415

PDB entries from 2024-07-10

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