Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help
SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6VAK

Cryo-EM structure of human CALHM2

Functional Information from GO Data
ChainGOidnamespacecontents
A0005261molecular_functionmonoatomic cation channel activity
A0005886cellular_componentplasma membrane
A0042802molecular_functionidentical protein binding
A0043065biological_processpositive regulation of apoptotic process
A0048167biological_processregulation of synaptic plasticity
A0070509biological_processcalcium ion import
A0098655biological_processmonoatomic cation transmembrane transport
A1903978biological_processregulation of microglial cell activation
A1904669biological_processATP export
B0005261molecular_functionmonoatomic cation channel activity
B0005886cellular_componentplasma membrane
B0042802molecular_functionidentical protein binding
B0043065biological_processpositive regulation of apoptotic process
B0048167biological_processregulation of synaptic plasticity
B0070509biological_processcalcium ion import
B0098655biological_processmonoatomic cation transmembrane transport
B1903978biological_processregulation of microglial cell activation
B1904669biological_processATP export
C0005261molecular_functionmonoatomic cation channel activity
C0005886cellular_componentplasma membrane
C0042802molecular_functionidentical protein binding
C0043065biological_processpositive regulation of apoptotic process
C0048167biological_processregulation of synaptic plasticity
C0070509biological_processcalcium ion import
C0098655biological_processmonoatomic cation transmembrane transport
C1903978biological_processregulation of microglial cell activation
C1904669biological_processATP export
D0005261molecular_functionmonoatomic cation channel activity
D0005886cellular_componentplasma membrane
D0042802molecular_functionidentical protein binding
D0043065biological_processpositive regulation of apoptotic process
D0048167biological_processregulation of synaptic plasticity
D0070509biological_processcalcium ion import
D0098655biological_processmonoatomic cation transmembrane transport
D1903978biological_processregulation of microglial cell activation
D1904669biological_processATP export
E0005261molecular_functionmonoatomic cation channel activity
E0005886cellular_componentplasma membrane
E0042802molecular_functionidentical protein binding
E0043065biological_processpositive regulation of apoptotic process
E0048167biological_processregulation of synaptic plasticity
E0070509biological_processcalcium ion import
E0098655biological_processmonoatomic cation transmembrane transport
E1903978biological_processregulation of microglial cell activation
E1904669biological_processATP export
F0005261molecular_functionmonoatomic cation channel activity
F0005886cellular_componentplasma membrane
F0042802molecular_functionidentical protein binding
F0043065biological_processpositive regulation of apoptotic process
F0048167biological_processregulation of synaptic plasticity
F0070509biological_processcalcium ion import
F0098655biological_processmonoatomic cation transmembrane transport
F1903978biological_processregulation of microglial cell activation
F1904669biological_processATP export
G0005261molecular_functionmonoatomic cation channel activity
G0005886cellular_componentplasma membrane
G0042802molecular_functionidentical protein binding
G0043065biological_processpositive regulation of apoptotic process
G0048167biological_processregulation of synaptic plasticity
G0070509biological_processcalcium ion import
G0098655biological_processmonoatomic cation transmembrane transport
G1903978biological_processregulation of microglial cell activation
G1904669biological_processATP export
H0005261molecular_functionmonoatomic cation channel activity
H0005886cellular_componentplasma membrane
H0042802molecular_functionidentical protein binding
H0043065biological_processpositive regulation of apoptotic process
H0048167biological_processregulation of synaptic plasticity
H0070509biological_processcalcium ion import
H0098655biological_processmonoatomic cation transmembrane transport
H1903978biological_processregulation of microglial cell activation
H1904669biological_processATP export
I0005261molecular_functionmonoatomic cation channel activity
I0005886cellular_componentplasma membrane
I0042802molecular_functionidentical protein binding
I0043065biological_processpositive regulation of apoptotic process
I0048167biological_processregulation of synaptic plasticity
I0070509biological_processcalcium ion import
I0098655biological_processmonoatomic cation transmembrane transport
I1903978biological_processregulation of microglial cell activation
I1904669biological_processATP export
J0005261molecular_functionmonoatomic cation channel activity
J0005886cellular_componentplasma membrane
J0042802molecular_functionidentical protein binding
J0043065biological_processpositive regulation of apoptotic process
J0048167biological_processregulation of synaptic plasticity
J0070509biological_processcalcium ion import
J0098655biological_processmonoatomic cation transmembrane transport
J1903978biological_processregulation of microglial cell activation
J1904669biological_processATP export
K0005261molecular_functionmonoatomic cation channel activity
K0005886cellular_componentplasma membrane
K0042802molecular_functionidentical protein binding
K0043065biological_processpositive regulation of apoptotic process
K0048167biological_processregulation of synaptic plasticity
K0070509biological_processcalcium ion import
K0098655biological_processmonoatomic cation transmembrane transport
K1903978biological_processregulation of microglial cell activation
K1904669biological_processATP export
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues594
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues253
DetailsTransmembrane: {"description":"Helical; Name=S2","evidences":[{"source":"PubMed","id":"31776515","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6UIV","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues330
DetailsTransmembrane: {"description":"Helical; Name=S3","evidences":[{"source":"PubMed","id":"31776515","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6UIV","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues286
DetailsTransmembrane: {"description":"Helical; Name=S4","evidences":[{"source":"PubMed","id":"31776515","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6UIV","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues77
DetailsRegion: {"description":"Hemichannel docking","evidences":[{"source":"PubMed","id":"31776515","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31988524","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6UIV","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues407
DetailsRegion: {"description":"Intersubunit interaction","evidences":[{"source":"PubMed","id":"31776515","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6UIV","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues11
DetailsSite: {"description":"Not N-glycosylated","evidences":[{"source":"PubMed","id":"31776515","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

252091

PDB entries from 2026-04-15

PDB statisticsPDBj update infoContact PDBjnumon