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6VAI

Cryo-EM structure of a dimer of undecameric human CALHM2

Functional Information from GO Data
ChainGOidnamespacecontents
A0005261molecular_functionmonoatomic cation channel activity
A0005886cellular_componentplasma membrane
A0034220biological_processmonoatomic ion transmembrane transport
A0043065biological_processpositive regulation of apoptotic process
A0048167biological_processregulation of synaptic plasticity
A0070509biological_processcalcium ion import
A0098655biological_processmonoatomic cation transmembrane transport
A1903978biological_processregulation of microglial cell activation
A1904669biological_processATP export
B0005261molecular_functionmonoatomic cation channel activity
B0005886cellular_componentplasma membrane
B0034220biological_processmonoatomic ion transmembrane transport
B0043065biological_processpositive regulation of apoptotic process
B0048167biological_processregulation of synaptic plasticity
B0070509biological_processcalcium ion import
B0098655biological_processmonoatomic cation transmembrane transport
B1903978biological_processregulation of microglial cell activation
B1904669biological_processATP export
C0005261molecular_functionmonoatomic cation channel activity
C0005886cellular_componentplasma membrane
C0034220biological_processmonoatomic ion transmembrane transport
C0043065biological_processpositive regulation of apoptotic process
C0048167biological_processregulation of synaptic plasticity
C0070509biological_processcalcium ion import
C0098655biological_processmonoatomic cation transmembrane transport
C1903978biological_processregulation of microglial cell activation
C1904669biological_processATP export
D0005261molecular_functionmonoatomic cation channel activity
D0005886cellular_componentplasma membrane
D0034220biological_processmonoatomic ion transmembrane transport
D0043065biological_processpositive regulation of apoptotic process
D0048167biological_processregulation of synaptic plasticity
D0070509biological_processcalcium ion import
D0098655biological_processmonoatomic cation transmembrane transport
D1903978biological_processregulation of microglial cell activation
D1904669biological_processATP export
E0005261molecular_functionmonoatomic cation channel activity
E0005886cellular_componentplasma membrane
E0034220biological_processmonoatomic ion transmembrane transport
E0043065biological_processpositive regulation of apoptotic process
E0048167biological_processregulation of synaptic plasticity
E0070509biological_processcalcium ion import
E0098655biological_processmonoatomic cation transmembrane transport
E1903978biological_processregulation of microglial cell activation
E1904669biological_processATP export
F0005261molecular_functionmonoatomic cation channel activity
F0005886cellular_componentplasma membrane
F0034220biological_processmonoatomic ion transmembrane transport
F0043065biological_processpositive regulation of apoptotic process
F0048167biological_processregulation of synaptic plasticity
F0070509biological_processcalcium ion import
F0098655biological_processmonoatomic cation transmembrane transport
F1903978biological_processregulation of microglial cell activation
F1904669biological_processATP export
G0005261molecular_functionmonoatomic cation channel activity
G0005886cellular_componentplasma membrane
G0034220biological_processmonoatomic ion transmembrane transport
G0043065biological_processpositive regulation of apoptotic process
G0048167biological_processregulation of synaptic plasticity
G0070509biological_processcalcium ion import
G0098655biological_processmonoatomic cation transmembrane transport
G1903978biological_processregulation of microglial cell activation
G1904669biological_processATP export
H0005261molecular_functionmonoatomic cation channel activity
H0005886cellular_componentplasma membrane
H0034220biological_processmonoatomic ion transmembrane transport
H0043065biological_processpositive regulation of apoptotic process
H0048167biological_processregulation of synaptic plasticity
H0070509biological_processcalcium ion import
H0098655biological_processmonoatomic cation transmembrane transport
H1903978biological_processregulation of microglial cell activation
H1904669biological_processATP export
I0005261molecular_functionmonoatomic cation channel activity
I0005886cellular_componentplasma membrane
I0034220biological_processmonoatomic ion transmembrane transport
I0043065biological_processpositive regulation of apoptotic process
I0048167biological_processregulation of synaptic plasticity
I0070509biological_processcalcium ion import
I0098655biological_processmonoatomic cation transmembrane transport
I1903978biological_processregulation of microglial cell activation
I1904669biological_processATP export
J0005261molecular_functionmonoatomic cation channel activity
J0005886cellular_componentplasma membrane
J0034220biological_processmonoatomic ion transmembrane transport
J0043065biological_processpositive regulation of apoptotic process
J0048167biological_processregulation of synaptic plasticity
J0070509biological_processcalcium ion import
J0098655biological_processmonoatomic cation transmembrane transport
J1903978biological_processregulation of microglial cell activation
J1904669biological_processATP export
K0005261molecular_functionmonoatomic cation channel activity
K0005886cellular_componentplasma membrane
K0034220biological_processmonoatomic ion transmembrane transport
K0043065biological_processpositive regulation of apoptotic process
K0048167biological_processregulation of synaptic plasticity
K0070509biological_processcalcium ion import
K0098655biological_processmonoatomic cation transmembrane transport
K1903978biological_processregulation of microglial cell activation
K1904669biological_processATP export
L0005261molecular_functionmonoatomic cation channel activity
L0005886cellular_componentplasma membrane
L0034220biological_processmonoatomic ion transmembrane transport
L0043065biological_processpositive regulation of apoptotic process
L0048167biological_processregulation of synaptic plasticity
L0070509biological_processcalcium ion import
L0098655biological_processmonoatomic cation transmembrane transport
L1903978biological_processregulation of microglial cell activation
L1904669biological_processATP export
M0005261molecular_functionmonoatomic cation channel activity
M0005886cellular_componentplasma membrane
M0034220biological_processmonoatomic ion transmembrane transport
M0043065biological_processpositive regulation of apoptotic process
M0048167biological_processregulation of synaptic plasticity
M0070509biological_processcalcium ion import
M0098655biological_processmonoatomic cation transmembrane transport
M1903978biological_processregulation of microglial cell activation
M1904669biological_processATP export
N0005261molecular_functionmonoatomic cation channel activity
N0005886cellular_componentplasma membrane
N0034220biological_processmonoatomic ion transmembrane transport
N0043065biological_processpositive regulation of apoptotic process
N0048167biological_processregulation of synaptic plasticity
N0070509biological_processcalcium ion import
N0098655biological_processmonoatomic cation transmembrane transport
N1903978biological_processregulation of microglial cell activation
N1904669biological_processATP export
O0005261molecular_functionmonoatomic cation channel activity
O0005886cellular_componentplasma membrane
O0034220biological_processmonoatomic ion transmembrane transport
O0043065biological_processpositive regulation of apoptotic process
O0048167biological_processregulation of synaptic plasticity
O0070509biological_processcalcium ion import
O0098655biological_processmonoatomic cation transmembrane transport
O1903978biological_processregulation of microglial cell activation
O1904669biological_processATP export
P0005261molecular_functionmonoatomic cation channel activity
P0005886cellular_componentplasma membrane
P0034220biological_processmonoatomic ion transmembrane transport
P0043065biological_processpositive regulation of apoptotic process
P0048167biological_processregulation of synaptic plasticity
P0070509biological_processcalcium ion import
P0098655biological_processmonoatomic cation transmembrane transport
P1903978biological_processregulation of microglial cell activation
P1904669biological_processATP export
Q0005261molecular_functionmonoatomic cation channel activity
Q0005886cellular_componentplasma membrane
Q0034220biological_processmonoatomic ion transmembrane transport
Q0043065biological_processpositive regulation of apoptotic process
Q0048167biological_processregulation of synaptic plasticity
Q0070509biological_processcalcium ion import
Q0098655biological_processmonoatomic cation transmembrane transport
Q1903978biological_processregulation of microglial cell activation
Q1904669biological_processATP export
R0005261molecular_functionmonoatomic cation channel activity
R0005886cellular_componentplasma membrane
R0034220biological_processmonoatomic ion transmembrane transport
R0043065biological_processpositive regulation of apoptotic process
R0048167biological_processregulation of synaptic plasticity
R0070509biological_processcalcium ion import
R0098655biological_processmonoatomic cation transmembrane transport
R1903978biological_processregulation of microglial cell activation
R1904669biological_processATP export
S0005261molecular_functionmonoatomic cation channel activity
S0005886cellular_componentplasma membrane
S0034220biological_processmonoatomic ion transmembrane transport
S0043065biological_processpositive regulation of apoptotic process
S0048167biological_processregulation of synaptic plasticity
S0070509biological_processcalcium ion import
S0098655biological_processmonoatomic cation transmembrane transport
S1903978biological_processregulation of microglial cell activation
S1904669biological_processATP export
T0005261molecular_functionmonoatomic cation channel activity
T0005886cellular_componentplasma membrane
T0034220biological_processmonoatomic ion transmembrane transport
T0043065biological_processpositive regulation of apoptotic process
T0048167biological_processregulation of synaptic plasticity
T0070509biological_processcalcium ion import
T0098655biological_processmonoatomic cation transmembrane transport
T1903978biological_processregulation of microglial cell activation
T1904669biological_processATP export
U0005261molecular_functionmonoatomic cation channel activity
U0005886cellular_componentplasma membrane
U0034220biological_processmonoatomic ion transmembrane transport
U0043065biological_processpositive regulation of apoptotic process
U0048167biological_processregulation of synaptic plasticity
U0070509biological_processcalcium ion import
U0098655biological_processmonoatomic cation transmembrane transport
U1903978biological_processregulation of microglial cell activation
U1904669biological_processATP export
V0005261molecular_functionmonoatomic cation channel activity
V0005886cellular_componentplasma membrane
V0034220biological_processmonoatomic ion transmembrane transport
V0043065biological_processpositive regulation of apoptotic process
V0048167biological_processregulation of synaptic plasticity
V0070509biological_processcalcium ion import
V0098655biological_processmonoatomic cation transmembrane transport
V1903978biological_processregulation of microglial cell activation
V1904669biological_processATP export
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues462
DetailsTRANSMEM: Helical; Name=S1 => ECO:0000269|PubMed:31776515, ECO:0007744|PDB:6UIV
ChainResidueDetails
AMET22-ALA43
JMET22-ALA43
KMET22-ALA43
LMET22-ALA43
MMET22-ALA43
NMET22-ALA43
OMET22-ALA43
PMET22-ALA43
QMET22-ALA43
RMET22-ALA43
SMET22-ALA43
BMET22-ALA43
TMET22-ALA43
UMET22-ALA43
VMET22-ALA43
CMET22-ALA43
DMET22-ALA43
EMET22-ALA43
FMET22-ALA43
GMET22-ALA43
HMET22-ALA43
IMET22-ALA43

site_idSWS_FT_FI2
Number of Residues1188
DetailsTOPO_DOM: Extracellular => ECO:0000305
ChainResidueDetails
APHE44-ARG52
ESER133-ARG179
FPHE44-ARG52
FSER133-ARG179
GPHE44-ARG52
GSER133-ARG179
HPHE44-ARG52
HSER133-ARG179
IPHE44-ARG52
ISER133-ARG179
JPHE44-ARG52
ASER133-ARG179
JSER133-ARG179
KPHE44-ARG52
KSER133-ARG179
LPHE44-ARG52
LSER133-ARG179
MPHE44-ARG52
MSER133-ARG179
NPHE44-ARG52
NSER133-ARG179
OPHE44-ARG52
BPHE44-ARG52
OSER133-ARG179
PPHE44-ARG52
PSER133-ARG179
QPHE44-ARG52
QSER133-ARG179
RPHE44-ARG52
RSER133-ARG179
SPHE44-ARG52
SSER133-ARG179
TPHE44-ARG52
BSER133-ARG179
TSER133-ARG179
UPHE44-ARG52
USER133-ARG179
VPHE44-ARG52
VSER133-ARG179
CPHE44-ARG52
CSER133-ARG179
DPHE44-ARG52
DSER133-ARG179
EPHE44-ARG52

site_idSWS_FT_FI3
Number of Residues506
DetailsTRANSMEM: Helical; Name=S2 => ECO:0000269|PubMed:31776515, ECO:0007744|PDB:6UIV
ChainResidueDetails
AASN53-ASN76
JASN53-ASN76
KASN53-ASN76
LASN53-ASN76
MASN53-ASN76
NASN53-ASN76
OASN53-ASN76
PASN53-ASN76
QASN53-ASN76
RASN53-ASN76
SASN53-ASN76
BASN53-ASN76
TASN53-ASN76
UASN53-ASN76
VASN53-ASN76
CASN53-ASN76
DASN53-ASN76
EASN53-ASN76
FASN53-ASN76
GASN53-ASN76
HASN53-ASN76
IASN53-ASN76

site_idSWS_FT_FI4
Number of Residues3080
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305
ChainResidueDetails
AASN77-LEU101
EHIS207-SER323
FASN77-LEU101
FHIS207-SER323
GASN77-LEU101
GHIS207-SER323
HASN77-LEU101
HHIS207-SER323
IASN77-LEU101
IHIS207-SER323
JASN77-LEU101
AHIS207-SER323
JHIS207-SER323
KASN77-LEU101
KHIS207-SER323
LASN77-LEU101
LHIS207-SER323
MASN77-LEU101
MHIS207-SER323
NASN77-LEU101
NHIS207-SER323
OASN77-LEU101
BASN77-LEU101
OHIS207-SER323
PASN77-LEU101
PHIS207-SER323
QASN77-LEU101
QHIS207-SER323
RASN77-LEU101
RHIS207-SER323
SASN77-LEU101
SHIS207-SER323
TASN77-LEU101
BHIS207-SER323
THIS207-SER323
UASN77-LEU101
UHIS207-SER323
VASN77-LEU101
VHIS207-SER323
CASN77-LEU101
CHIS207-SER323
DASN77-LEU101
DHIS207-SER323
EASN77-LEU101

site_idSWS_FT_FI5
Number of Residues660
DetailsTRANSMEM: Helical; Name=S3 => ECO:0000269|PubMed:31776515, ECO:0007744|PDB:6UIV
ChainResidueDetails
ALEU102-LEU132
JLEU102-LEU132
KLEU102-LEU132
LLEU102-LEU132
MLEU102-LEU132
NLEU102-LEU132
OLEU102-LEU132
PLEU102-LEU132
QLEU102-LEU132
RLEU102-LEU132
SLEU102-LEU132
BLEU102-LEU132
TLEU102-LEU132
ULEU102-LEU132
VLEU102-LEU132
CLEU102-LEU132
DLEU102-LEU132
ELEU102-LEU132
FLEU102-LEU132
GLEU102-LEU132
HLEU102-LEU132
ILEU102-LEU132

site_idSWS_FT_FI6
Number of Residues572
DetailsTRANSMEM: Helical; Name=S4 => ECO:0000269|PubMed:31776515, ECO:0007744|PDB:6UIV
ChainResidueDetails
ALEU180-LYS206
JLEU180-LYS206
KLEU180-LYS206
LLEU180-LYS206
MLEU180-LYS206
NLEU180-LYS206
OLEU180-LYS206
PLEU180-LYS206
QLEU180-LYS206
RLEU180-LYS206
SLEU180-LYS206
BLEU180-LYS206
TLEU180-LYS206
ULEU180-LYS206
VLEU180-LYS206
CLEU180-LYS206
DLEU180-LYS206
ELEU180-LYS206
FLEU180-LYS206
GLEU180-LYS206
HLEU180-LYS206
ILEU180-LYS206

site_idSWS_FT_FI7
Number of Residues22
DetailsSITE: Not N-glycosylated => ECO:0000269|PubMed:31776515
ChainResidueDetails
AASN168
JASN168
KASN168
LASN168
MASN168
NASN168
OASN168
PASN168
QASN168
RASN168
SASN168
BASN168
TASN168
UASN168
VASN168
CASN168
DASN168
EASN168
FASN168
GASN168
HASN168
IASN168

222926

PDB entries from 2024-07-24

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