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6VAC

Mouse retromer (VPS26/VPS35/VPS29) heterotrimer

Functional Information from GO Data
ChainGOidnamespacecontents
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005764cellular_componentlysosome
A0005768cellular_componentendosome
A0005769cellular_componentearly endosome
A0005770cellular_componentlate endosome
A0005829cellular_componentcytosol
A0006624biological_processvacuolar protein processing
A0007040biological_processlysosome organization
A0010008cellular_componentendosome membrane
A0010628biological_processpositive regulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0010821biological_processregulation of mitochondrion organization
A0014069cellular_componentpostsynaptic density
A0015031biological_processprotein transport
A0016020cellular_componentmembrane
A0030904cellular_componentretromer complex
A0030906cellular_componentretromer, cargo-selective complex
A0031647biological_processregulation of protein stability
A0031648biological_processprotein destabilization
A0031748molecular_functionD1 dopamine receptor binding
A0032456biological_processendocytic recycling
A0032463biological_processnegative regulation of protein homooligomerization
A0033365biological_processprotein localization to organelle
A0036010biological_processprotein localization to endosome
A0042147biological_processretrograde transport, endosome to Golgi
A0043005cellular_componentneuron projection
A0043025cellular_componentneuronal cell body
A0043653biological_processmitochondrial fragmentation involved in apoptotic process
A0045056biological_processtranscytosis
A0045202cellular_componentsynapse
A0045732biological_processpositive regulation of protein catabolic process
A0048471cellular_componentperinuclear region of cytoplasm
A0050728biological_processnegative regulation of inflammatory response
A0050804biological_processmodulation of chemical synaptic transmission
A0050882biological_processvoluntary musculoskeletal movement
A0051246biological_processregulation of protein metabolic process
A0060161biological_processpositive regulation of dopamine receptor signaling pathway
A0061357biological_processpositive regulation of Wnt protein secretion
A0090128biological_processregulation of synapse maturation
A0090141biological_processpositive regulation of mitochondrial fission
A0090263biological_processpositive regulation of canonical Wnt signaling pathway
A0090326biological_processpositive regulation of locomotion involved in locomotory behavior
A0097422cellular_componenttubular endosome
A0098691cellular_componentdopaminergic synapse
A0098793cellular_componentpresynapse
A0098794cellular_componentpostsynapse
A0098887biological_processneurotransmitter receptor transport, endosome to postsynaptic membrane
A0098978cellular_componentglutamatergic synapse
A0099003biological_processvesicle-mediated transport in synapse
A0099073cellular_componentmitochondrion-derived vesicle
A0099074biological_processmitochondrion to lysosome vesicle-mediated transport
A0099639biological_processneurotransmitter receptor transport, endosome to plasma membrane
A0150052biological_processregulation of postsynapse assembly
A1902823biological_processnegative regulation of late endosome to lysosome transport
A1902950biological_processregulation of dendritic spine maintenance
A1903181biological_processpositive regulation of dopamine biosynthetic process
A1903828biological_processnegative regulation of protein localization
A1904377biological_processpositive regulation of protein localization to cell periphery
A1905166biological_processnegative regulation of lysosomal protein catabolic process
A2000331biological_processregulation of terminal button organization
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005764cellular_componentlysosome
B0005768cellular_componentendosome
B0005769cellular_componentearly endosome
B0005829cellular_componentcytosol
B0006886biological_processintracellular protein transport
B0010008cellular_componentendosome membrane
B0015031biological_processprotein transport
B0016020cellular_componentmembrane
B0030904cellular_componentretromer complex
B0030906cellular_componentretromer, cargo-selective complex
B0031982cellular_componentvesicle
B0032456biological_processendocytic recycling
B0042147biological_processretrograde transport, endosome to Golgi
B0097422cellular_componenttubular endosome
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005768cellular_componentendosome
C0005829cellular_componentcytosol
C0006896biological_processGolgi to vacuole transport
C0010008cellular_componentendosome membrane
C0015031biological_processprotein transport
C0016020cellular_componentmembrane
C0030904cellular_componentretromer complex
C0030906cellular_componentretromer, cargo-selective complex
C0032456biological_processendocytic recycling
C0042147biological_processretrograde transport, endosome to Golgi
C0043231cellular_componentintracellular membrane-bounded organelle
C0046872molecular_functionmetal ion binding
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues7
DetailsBINDING:
ChainResidueDetails
CASP8
CHIS10
CASN39
CASP62
CHIS86
CHIS115
CHIS117

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9UBQ0
ChainResidueDetails
CLYS50

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:17947660, ECO:0007744|PubMed:19131326
ChainResidueDetails
ATYR791

224004

PDB entries from 2024-08-21

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