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6VAB

Mouse retromer sub-structure: VPS35/VPS35 flat dimer

Functional Information from GO Data
ChainGOidnamespacecontents
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005768cellular_componentendosome
A0005829cellular_componentcytosol
A0006886biological_processintracellular protein transport
A0006896biological_processGolgi to vacuole transport
A0010008cellular_componentendosome membrane
A0015031biological_processprotein transport
A0016020cellular_componentmembrane
A0030904cellular_componentretromer complex
A0030906cellular_componentretromer, cargo-selective complex
A0032456biological_processendocytic recycling
A0032991cellular_componentprotein-containing complex
A0042147biological_processretrograde transport, endosome to Golgi
A0046872molecular_functionmetal ion binding
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005764cellular_componentlysosome
B0005768cellular_componentendosome
B0005769cellular_componentearly endosome
B0005770cellular_componentlate endosome
B0005829cellular_componentcytosol
B0006624biological_processvacuolar protein processing
B0006886biological_processintracellular protein transport
B0007040biological_processlysosome organization
B0009967biological_processpositive regulation of signal transduction
B0010008cellular_componentendosome membrane
B0010628biological_processpositive regulation of gene expression
B0010629biological_processnegative regulation of gene expression
B0010821biological_processregulation of mitochondrion organization
B0014069cellular_componentpostsynaptic density
B0015031biological_processprotein transport
B0016020cellular_componentmembrane
B0030904cellular_componentretromer complex
B0030906cellular_componentretromer, cargo-selective complex
B0031647biological_processregulation of protein stability
B0031648biological_processprotein destabilization
B0031748molecular_functionD1 dopamine receptor binding
B0032456biological_processendocytic recycling
B0032463biological_processnegative regulation of protein homooligomerization
B0036010biological_processprotein localization to endosome
B0042147biological_processretrograde transport, endosome to Golgi
B0042176biological_processregulation of protein catabolic process
B0043005cellular_componentneuron projection
B0043025cellular_componentneuronal cell body
B0043653biological_processmitochondrial fragmentation involved in apoptotic process
B0045056biological_processtranscytosis
B0045202cellular_componentsynapse
B0045732biological_processpositive regulation of protein catabolic process
B0048471cellular_componentperinuclear region of cytoplasm
B0050728biological_processnegative regulation of inflammatory response
B0050793biological_processregulation of developmental process
B0050804biological_processmodulation of chemical synaptic transmission
B0050882biological_processvoluntary musculoskeletal movement
B0051049biological_processregulation of transport
B0051246biological_processregulation of protein metabolic process
B0060161biological_processpositive regulation of dopamine receptor signaling pathway
B0061357biological_processpositive regulation of Wnt protein secretion
B0090128biological_processregulation of synapse maturation
B0090141biological_processpositive regulation of mitochondrial fission
B0090263biological_processpositive regulation of canonical Wnt signaling pathway
B0090326biological_processpositive regulation of locomotion involved in locomotory behavior
B0097422cellular_componenttubular endosome
B0098691cellular_componentdopaminergic synapse
B0098793cellular_componentpresynapse
B0098794cellular_componentpostsynapse
B0098887biological_processneurotransmitter receptor transport, endosome to postsynaptic membrane
B0098978cellular_componentglutamatergic synapse
B0099073cellular_componentmitochondrion-derived vesicle
B0099074biological_processmitochondrion to lysosome vesicle-mediated transport
B0099175biological_processregulation of postsynapse organization
B0099639biological_processneurotransmitter receptor transport, endosome to plasma membrane
B0150052biological_processregulation of postsynapse assembly
B1902823biological_processnegative regulation of late endosome to lysosome transport
B1902950biological_processregulation of dendritic spine maintenance
B1903181biological_processpositive regulation of dopamine biosynthetic process
B1903828biological_processnegative regulation of protein localization
B1903829biological_processpositive regulation of protein localization
B1904377biological_processpositive regulation of protein localization to cell periphery
B1905166biological_processnegative regulation of lysosomal protein catabolic process
B2000331biological_processregulation of terminal button organization
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005768cellular_componentendosome
C0005829cellular_componentcytosol
C0006886biological_processintracellular protein transport
C0006896biological_processGolgi to vacuole transport
C0010008cellular_componentendosome membrane
C0015031biological_processprotein transport
C0016020cellular_componentmembrane
C0030904cellular_componentretromer complex
C0030906cellular_componentretromer, cargo-selective complex
C0032456biological_processendocytic recycling
C0032991cellular_componentprotein-containing complex
C0042147biological_processretrograde transport, endosome to Golgi
C0046872molecular_functionmetal ion binding
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005764cellular_componentlysosome
D0005768cellular_componentendosome
D0005769cellular_componentearly endosome
D0005770cellular_componentlate endosome
D0005829cellular_componentcytosol
D0006624biological_processvacuolar protein processing
D0006886biological_processintracellular protein transport
D0007040biological_processlysosome organization
D0009967biological_processpositive regulation of signal transduction
D0010008cellular_componentendosome membrane
D0010628biological_processpositive regulation of gene expression
D0010629biological_processnegative regulation of gene expression
D0010821biological_processregulation of mitochondrion organization
D0014069cellular_componentpostsynaptic density
D0015031biological_processprotein transport
D0016020cellular_componentmembrane
D0030904cellular_componentretromer complex
D0030906cellular_componentretromer, cargo-selective complex
D0031647biological_processregulation of protein stability
D0031648biological_processprotein destabilization
D0031748molecular_functionD1 dopamine receptor binding
D0032456biological_processendocytic recycling
D0032463biological_processnegative regulation of protein homooligomerization
D0036010biological_processprotein localization to endosome
D0042147biological_processretrograde transport, endosome to Golgi
D0042176biological_processregulation of protein catabolic process
D0043005cellular_componentneuron projection
D0043025cellular_componentneuronal cell body
D0043653biological_processmitochondrial fragmentation involved in apoptotic process
D0045056biological_processtranscytosis
D0045202cellular_componentsynapse
D0045732biological_processpositive regulation of protein catabolic process
D0048471cellular_componentperinuclear region of cytoplasm
D0050728biological_processnegative regulation of inflammatory response
D0050793biological_processregulation of developmental process
D0050804biological_processmodulation of chemical synaptic transmission
D0050882biological_processvoluntary musculoskeletal movement
D0051049biological_processregulation of transport
D0051246biological_processregulation of protein metabolic process
D0060161biological_processpositive regulation of dopamine receptor signaling pathway
D0061357biological_processpositive regulation of Wnt protein secretion
D0090128biological_processregulation of synapse maturation
D0090141biological_processpositive regulation of mitochondrial fission
D0090263biological_processpositive regulation of canonical Wnt signaling pathway
D0090326biological_processpositive regulation of locomotion involved in locomotory behavior
D0097422cellular_componenttubular endosome
D0098691cellular_componentdopaminergic synapse
D0098793cellular_componentpresynapse
D0098794cellular_componentpostsynapse
D0098887biological_processneurotransmitter receptor transport, endosome to postsynaptic membrane
D0098978cellular_componentglutamatergic synapse
D0099073cellular_componentmitochondrion-derived vesicle
D0099074biological_processmitochondrion to lysosome vesicle-mediated transport
D0099175biological_processregulation of postsynapse organization
D0099639biological_processneurotransmitter receptor transport, endosome to plasma membrane
D0150052biological_processregulation of postsynapse assembly
D1902823biological_processnegative regulation of late endosome to lysosome transport
D1902950biological_processregulation of dendritic spine maintenance
D1903181biological_processpositive regulation of dopamine biosynthetic process
D1903828biological_processnegative regulation of protein localization
D1903829biological_processpositive regulation of protein localization
D1904377biological_processpositive regulation of protein localization to cell periphery
D1905166biological_processnegative regulation of lysosomal protein catabolic process
D2000331biological_processregulation of terminal button organization
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9UBQ0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues193
DetailsRegion: {"description":"Interaction with IGF2R cytoplasmic domain","evidences":[{"source":"UniProtKB","id":"Q96QK1","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

247947

PDB entries from 2026-01-21

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