6VA9
Crystal structure of glucose-6-phosphate dehydrogenase R393H mutant in complex with catalytic NADP+
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004345 | molecular_function | glucose-6-phosphate dehydrogenase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005536 | molecular_function | D-glucose binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006006 | biological_process | glucose metabolic process |
A | 0006098 | biological_process | pentose-phosphate shunt |
A | 0006629 | biological_process | lipid metabolic process |
A | 0006695 | biological_process | cholesterol biosynthetic process |
A | 0006739 | biological_process | NADP metabolic process |
A | 0006740 | biological_process | NADPH regeneration |
A | 0006749 | biological_process | glutathione metabolic process |
A | 0009051 | biological_process | pentose-phosphate shunt, oxidative branch |
A | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
A | 0010041 | biological_process | response to iron(III) ion |
A | 0010734 | biological_process | negative regulation of protein glutathionylation |
A | 0014070 | biological_process | response to organic cyclic compound |
A | 0016020 | cellular_component | membrane |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016614 | molecular_function | oxidoreductase activity, acting on CH-OH group of donors |
A | 0019322 | biological_process | pentose biosynthetic process |
A | 0021762 | biological_process | substantia nigra development |
A | 0030246 | molecular_function | carbohydrate binding |
A | 0032094 | biological_process | response to food |
A | 0034451 | cellular_component | centriolar satellite |
A | 0034599 | biological_process | cellular response to oxidative stress |
A | 0042802 | molecular_function | identical protein binding |
A | 0042803 | molecular_function | protein homodimerization activity |
A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
A | 0043249 | biological_process | erythrocyte maturation |
A | 0043523 | biological_process | regulation of neuron apoptotic process |
A | 0045471 | biological_process | response to ethanol |
A | 0046390 | biological_process | ribose phosphate biosynthetic process |
A | 0050661 | molecular_function | NADP binding |
A | 0051156 | biological_process | glucose 6-phosphate metabolic process |
A | 0061052 | biological_process | negative regulation of cell growth involved in cardiac muscle cell development |
A | 0070062 | cellular_component | extracellular exosome |
A | 1904879 | biological_process | positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel |
A | 2000378 | biological_process | negative regulation of reactive oxygen species metabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 19 |
Details | binding site for residue NAP A 601 |
Chain | Residue |
A | SER40 |
A | ALA127 |
A | LEU142 |
A | PRO143 |
A | PRO144 |
A | TYR147 |
A | GLU170 |
A | LYS171 |
A | PRO172 |
A | TYR202 |
A | TYR249 |
A | GLY41 |
A | ASP42 |
A | LEU43 |
A | ALA71 |
A | ARG72 |
A | SER73 |
A | TYR112 |
A | ASN126 |
Functional Information from PROSITE/UniProt
site_id | PS00069 |
Number of Residues | 7 |
Details | G6P_DEHYDROGENASE Glucose-6-phosphate dehydrogenase active site. DHYLGKE |
Chain | Residue | Details |
A | ASP200-GLU206 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:P11411 |
Chain | Residue | Details |
A | HIS263 |
site_id | SWS_FT_FI2 |
Number of Residues | 13 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10745013, ECO:0000269|PubMed:15858258, ECO:0007744|PDB:1QKI, ECO:0007744|PDB:2BH9 |
Chain | Residue | Details |
A | GLY38 | |
A | ASP421 | |
A | ARG487 | |
A | TYR503 | |
A | TRP509 | |
A | ARG72 | |
A | TYR147 | |
A | LYS171 | |
A | ARG357 | |
A | LYS366 | |
A | ARG370 | |
A | HIS393 | |
A | TYR401 |
site_id | SWS_FT_FI3 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15858258, ECO:0007744|PDB:2BH9 |
Chain | Residue | Details |
A | HIS201 | |
A | GLU239 | |
A | ASP258 |
site_id | SWS_FT_FI4 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15858258, ECO:0007744|PDB:2BHL |
Chain | Residue | Details |
A | LYS360 | |
A | ARG365 | |
A | GLN395 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | MOD_RES: N-acetylalanine => ECO:0000269|PubMed:7857286, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378 |
Chain | Residue | Details |
A | ALA2 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER8 |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | THR10 |
site_id | SWS_FT_FI8 |
Number of Residues | 3 |
Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
A | LYS89 | |
A | LYS432 | |
A | LYS497 |
site_id | SWS_FT_FI9 |
Number of Residues | 1 |
Details | MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
A | LYS171 |
site_id | SWS_FT_FI10 |
Number of Residues | 1 |
Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:24769394, ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
A | LYS403 |
site_id | SWS_FT_FI11 |
Number of Residues | 1 |
Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | TYR503 |