Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005525 | molecular_function | GTP binding |
| A | 0007165 | biological_process | signal transduction |
| A | 0016020 | cellular_component | membrane |
| B | 0005085 | molecular_function | guanyl-nucleotide exchange factor activity |
| B | 0007264 | biological_process | small GTPase-mediated signal transduction |
| C | 0003924 | molecular_function | GTPase activity |
| C | 0005525 | molecular_function | GTP binding |
| C | 0007165 | biological_process | signal transduction |
| C | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 31 |
| Details | binding site for residue GNP A 201 |
| Chain | Residue |
| A | GLY12 |
| A | ASP30 |
| A | GLU31 |
| A | TYR32 |
| A | PRO34 |
| A | THR35 |
| A | GLY60 |
| A | GLN61 |
| A | ASN116 |
| A | LYS117 |
| A | ASP119 |
| A | GLY13 |
| A | LEU120 |
| A | SER145 |
| A | ALA146 |
| A | LYS147 |
| A | MG202 |
| A | HOH321 |
| A | HOH358 |
| A | HOH368 |
| A | HOH371 |
| A | HOH373 |
| A | VAL14 |
| A | HOH410 |
| A | HOH424 |
| A | GLY15 |
| A | LYS16 |
| A | SER17 |
| A | ALA18 |
| A | PHE28 |
| A | VAL29 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 202 |
| Chain | Residue |
| A | SER17 |
| A | THR35 |
| A | GNP201 |
| A | HOH321 |
| A | HOH358 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | binding site for residue QTM B 2001 |
| Chain | Residue |
| B | VAL852 |
| B | MET878 |
| B | ASN879 |
| B | VAL883 |
| B | TYR884 |
| B | LEU886 |
| B | THR889 |
| B | PHE890 |
| B | ILE893 |
| B | GLU902 |
| B | HIS905 |
| B | HOH2176 |
| B | HOH2327 |
| B | HOH2372 |
| B | HOH2517 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue FMT B 2002 |
| Chain | Residue |
| B | GLN566 |
| B | MET567 |
| B | HIS616 |
| B | MET617 |
| B | HOH2169 |
| B | HOH2240 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue FMT B 2003 |
| Chain | Residue |
| A | ARG128 |
| B | ARG767 |
| B | PRO768 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue FMT B 2004 |
| Chain | Residue |
| A | GLU37 |
| A | MET67 |
| A | GLN70 |
| B | ALA619 |
| B | ARG688 |
| B | HOH2145 |
| B | HOH2148 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue FMT B 2005 |
| Chain | Residue |
| B | GLU611 |
| B | TYR615 |
| B | HIS616 |
| B | ARG647 |
| B | TYR681 |
| B | HOH2268 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | binding site for residue FMT B 2006 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 2007 |
| Chain | Residue |
| B | SER793 |
| B | ASP794 |
| B | PRO978 |
| B | TYR979 |
| B | HOH2262 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 2008 |
| Chain | Residue |
| B | ARG786 |
| B | GLU864 |
| B | VAL1040 |
| B | HOH2102 |
| B | HOH2237 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue FMT C 201 |
| Chain | Residue |
| B | LEU938 |
| C | LYS16 |
| C | SER17 |
| C | GLU62 |
| C | HOH302 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue NA C 202 |
| Chain | Residue |
| C | ASN85 |
| C | ASN86 |
| C | THR87 |
| C | THR124 |
| C | HOH463 |
| C | HOH469 |
Functional Information from PROSITE/UniProt
| site_id | PS00720 |
| Number of Residues | 34 |
| Details | RASGEF Ras Guanine-nucleotide exchange factors domain signature. VPFfGiyLtNIlkteegnpevlkrhgkel.................INFsK |
| Chain | Residue | Details |
| B | VAL927-LYS960 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| C | GLY13 | |
| C | VAL29 | |
| C | ALA59 | |
| C | ASN116 | |
| C | SER145 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylmethionine; in GTPase HRas; alternate => ECO:0000269|Ref.12 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylthreonine; in GTPase HRas, N-terminally processed => ECO:0000269|Ref.12 |
| Chain | Residue | Details |
| C | CYS118 | |
| Chain | Residue | Details |
| C | THR35 | |
