6V90
Crystal structure of the p300 acetyltransferase domain with AcCoA competitive inhibitor 12
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue QSD A 1701 |
| Chain | Residue |
| A | LEU1398 |
| A | PRO1458 |
| A | ARG1462 |
| A | LEU1463 |
| A | TRP1466 |
| A | HOH1825 |
| A | ASP1399 |
| A | SER1400 |
| A | PRO1440 |
| A | GLY1443 |
| A | ASP1444 |
| A | HIS1451 |
| A | GLN1455 |
| A | ILE1457 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 1702 |
| Chain | Residue |
| A | ALA1350 |
| A | GLU1351 |
| A | SER1352 |
| A | ARG1462 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 1703 |
| Chain | Residue |
| A | ARG1478 |
| A | ARG1478 |
| A | HIS1481 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue CL A 1704 |
| Chain | Residue |
| A | LEU1398 |
| A | TYR1446 |
| A | LYS1558 |
| A | HOH1849 |
| A | HOH1853 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24819397 |
| Chain | Residue | Details |
| A | LEU1398 | |
| A | ARG1410 | |
| A | ILE1457 | |
| A | ARG1462 | |
| A | TRP1466 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:17065153 |
| Chain | Residue | Details |
| A | LYS1336 | |
| A | LYS1473 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000269|PubMed:15004546 |
| Chain | Residue | Details |
| A | LYS1499 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:18995842, ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | PRO1574 | |
| A | ASN1578 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000269|PubMed:15004546, ECO:0000269|PubMed:18995842 |
| Chain | Residue | Details |
| A | SER1581 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000269|PubMed:15004546, ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | ALA1586 | |
| A | LYS1592 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | THR1587 | |
| A | PRO1615 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:15004546, ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS1590 |
