6V8O

RSC core

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0000086	biological_process	G2/M transition of mitotic cell cycle
C	0000785	cellular_component	chromatin
C	0003682	molecular_function	chromatin binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0006337	biological_process	nucleosome disassembly
C	0006338	biological_process	chromatin remodeling
C	0006368	biological_process	transcription elongation by RNA polymerase II
C	0016586	cellular_component	RSC-type complex
D	0000785	cellular_component	chromatin
D	0003674	molecular_function	molecular_function
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0006325	biological_process	chromatin organization
D	0006337	biological_process	nucleosome disassembly
D	0006338	biological_process	chromatin remodeling
D	0006368	biological_process	transcription elongation by RNA polymerase II
D	0016586	cellular_component	RSC-type complex
E	0000785	cellular_component	chromatin
E	0003674	molecular_function	molecular_function
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0006325	biological_process	chromatin organization
E	0006337	biological_process	nucleosome disassembly
E	0006338	biological_process	chromatin remodeling
E	0006368	biological_process	transcription elongation by RNA polymerase II
E	0016586	cellular_component	RSC-type complex
E	0031490	molecular_function	chromatin DNA binding
F	0000724	biological_process	double-strand break repair via homologous recombination
F	0003682	molecular_function	chromatin binding
F	0005634	cellular_component	nucleus
F	0006276	biological_process	plasmid maintenance
F	0006303	biological_process	double-strand break repair via nonhomologous end joining
F	0006325	biological_process	chromatin organization
F	0006337	biological_process	nucleosome disassembly
F	0006338	biological_process	chromatin remodeling
F	0006368	biological_process	transcription elongation by RNA polymerase II
F	0007059	biological_process	chromosome segregation
F	0007062	biological_process	sister chromatid cohesion
F	0016586	cellular_component	RSC-type complex
F	0030435	biological_process	sporulation resulting in formation of a cellular spore
F	0042173	biological_process	regulation of sporulation resulting in formation of a cellular spore
F	0070914	biological_process	UV-damage excision repair
G	0000785	cellular_component	chromatin
G	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
G	0003677	molecular_function	DNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0006325	biological_process	chromatin organization
G	0006337	biological_process	nucleosome disassembly
G	0006338	biological_process	chromatin remodeling
G	0006355	biological_process	regulation of DNA-templated transcription
G	0006368	biological_process	transcription elongation by RNA polymerase II
G	0008270	molecular_function	zinc ion binding
G	0016586	cellular_component	RSC-type complex
G	0033262	biological_process	regulation of nuclear cell cycle DNA replication
G	0043565	molecular_function	sequence-specific DNA binding
G	0045944	biological_process	positive regulation of transcription by RNA polymerase II
G	0046872	molecular_function	metal ion binding
H	0000785	cellular_component	chromatin
H	0003682	molecular_function	chromatin binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0006325	biological_process	chromatin organization
H	0006337	biological_process	nucleosome disassembly
H	0006338	biological_process	chromatin remodeling
H	0006366	biological_process	transcription by RNA polymerase II
H	0006368	biological_process	transcription elongation by RNA polymerase II
H	0016586	cellular_component	RSC-type complex
H	0140006	molecular_function	histone H3 reader activity
H	0140008	molecular_function	histone H4 reader activity
I	0000785	cellular_component	chromatin
I	0003677	molecular_function	DNA binding
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0006303	biological_process	double-strand break repair via nonhomologous end joining
I	0006325	biological_process	chromatin organization
I	0006337	biological_process	nucleosome disassembly
I	0006338	biological_process	chromatin remodeling
I	0006355	biological_process	regulation of DNA-templated transcription
I	0006368	biological_process	transcription elongation by RNA polymerase II
I	0008270	molecular_function	zinc ion binding
I	0016514	cellular_component	SWI/SNF complex
I	0016586	cellular_component	RSC-type complex
I	0042393	molecular_function	histone binding
I	0045893	biological_process	positive regulation of DNA-templated transcription
I	0046872	molecular_function	metal ion binding
J	0000785	cellular_component	chromatin
J	0003677	molecular_function	DNA binding
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0006303	biological_process	double-strand break repair via nonhomologous end joining
J	0006325	biological_process	chromatin organization
J	0006337	biological_process	nucleosome disassembly
J	0006338	biological_process	chromatin remodeling
J	0006355	biological_process	regulation of DNA-templated transcription
J	0006368	biological_process	transcription elongation by RNA polymerase II
J	0008270	molecular_function	zinc ion binding
J	0016514	cellular_component	SWI/SNF complex
J	0016586	cellular_component	RSC-type complex
J	0042393	molecular_function	histone binding
J	0045893	biological_process	positive regulation of DNA-templated transcription
J	0046872	molecular_function	metal ion binding
K	0000785	cellular_component	chromatin
K	0003677	molecular_function	DNA binding
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0006303	biological_process	double-strand break repair via nonhomologous end joining
K	0006325	biological_process	chromatin organization
K	0006337	biological_process	nucleosome disassembly
K	0006338	biological_process	chromatin remodeling
K	0006355	biological_process	regulation of DNA-templated transcription
K	0006368	biological_process	transcription elongation by RNA polymerase II
K	0008270	molecular_function	zinc ion binding
K	0016514	cellular_component	SWI/SNF complex
K	0016586	cellular_component	RSC-type complex
K	0042393	molecular_function	histone binding
K	0045893	biological_process	positive regulation of DNA-templated transcription
K	0046872	molecular_function	metal ion binding
L	0000785	cellular_component	chromatin
L	0003677	molecular_function	DNA binding
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0006303	biological_process	double-strand break repair via nonhomologous end joining
L	0006325	biological_process	chromatin organization
L	0006337	biological_process	nucleosome disassembly
L	0006338	biological_process	chromatin remodeling
L	0006355	biological_process	regulation of DNA-templated transcription
L	0006368	biological_process	transcription elongation by RNA polymerase II
L	0008270	molecular_function	zinc ion binding
L	0016514	cellular_component	SWI/SNF complex
L	0016586	cellular_component	RSC-type complex
L	0042393	molecular_function	histone binding
L	0045893	biological_process	positive regulation of DNA-templated transcription
L	0046872	molecular_function	metal ion binding
M	0000785	cellular_component	chromatin
M	0005198	molecular_function	structural molecule activity
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0006325	biological_process	chromatin organization
M	0006337	biological_process	nucleosome disassembly
M	0006338	biological_process	chromatin remodeling
M	0016586	cellular_component	RSC-type complex
M	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
N	0000785	cellular_component	chromatin
N	0003677	molecular_function	DNA binding
N	0005634	cellular_component	nucleus
N	0006325	biological_process	chromatin organization
N	0006337	biological_process	nucleosome disassembly
N	0006338	biological_process	chromatin remodeling
N	0006355	biological_process	regulation of DNA-templated transcription
N	0006357	biological_process	regulation of transcription by RNA polymerase II
N	0006368	biological_process	transcription elongation by RNA polymerase II
N	0009303	biological_process	rRNA transcription
N	0016586	cellular_component	RSC-type complex
O	0000785	cellular_component	chromatin
O	0003674	molecular_function	molecular_function
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0006325	biological_process	chromatin organization
O	0006337	biological_process	nucleosome disassembly
O	0006338	biological_process	chromatin remodeling
O	0006357	biological_process	regulation of transcription by RNA polymerase II
O	0006368	biological_process	transcription elongation by RNA polymerase II
O	0016586	cellular_component	RSC-type complex
Q	0000086	biological_process	G2/M transition of mitotic cell cycle
Q	0000228	cellular_component	nuclear chromosome
Q	0000785	cellular_component	chromatin
Q	0003712	molecular_function	transcription coregulator activity
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0006302	biological_process	double-strand break repair
Q	0006325	biological_process	chromatin organization
Q	0006337	biological_process	nucleosome disassembly
Q	0006338	biological_process	chromatin remodeling
Q	0006357	biological_process	regulation of transcription by RNA polymerase II
Q	0006368	biological_process	transcription elongation by RNA polymerase II
Q	0007059	biological_process	chromosome segregation
Q	0016586	cellular_component	RSC-type complex
Q	0031491	molecular_function	nucleosome binding
Q	0033262	biological_process	regulation of nuclear cell cycle DNA replication
Q	0034080	biological_process	CENP-A containing chromatin assembly
R	0000166	molecular_function	nucleotide binding
R	0000775	cellular_component	chromosome, centromeric region
R	0000785	cellular_component	chromatin
R	0003677	molecular_function	DNA binding
R	0003678	molecular_function	DNA helicase activity
R	0003682	molecular_function	chromatin binding
R	0003824	molecular_function	catalytic activity
R	0004386	molecular_function	helicase activity
R	0005515	molecular_function	protein binding
R	0005524	molecular_function	ATP binding
R	0005634	cellular_component	nucleus
R	0006284	biological_process	base-excision repair
R	0006302	biological_process	double-strand break repair
R	0006325	biological_process	chromatin organization
R	0006337	biological_process	nucleosome disassembly
R	0006338	biological_process	chromatin remodeling
R	0006355	biological_process	regulation of DNA-templated transcription
R	0006366	biological_process	transcription by RNA polymerase II
R	0006368	biological_process	transcription elongation by RNA polymerase II
R	0007010	biological_process	cytoskeleton organization
R	0007059	biological_process	chromosome segregation
R	0010468	biological_process	regulation of gene expression
R	0015616	molecular_function	DNA translocase activity
R	0016586	cellular_component	RSC-type complex
R	0016787	molecular_function	hydrolase activity
R	0016887	molecular_function	ATP hydrolysis activity
R	0031507	biological_process	heterochromatin formation
R	0034080	biological_process	CENP-A containing chromatin assembly
R	0042393	molecular_function	histone binding
R	0045944	biological_process	positive regulation of transcription by RNA polymerase II
R	0051321	biological_process	meiotic cell cycle
R	0140008	molecular_function	histone H4 reader activity
R	0140015	molecular_function	histone H3K14ac reader activity
R	0140054	molecular_function	histone H2A reader activity
R	0140658	molecular_function	ATP-dependent chromatin remodeler activity
R	0140750	molecular_function	nucleosome array spacer activity
S	0000785	cellular_component	chromatin
S	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
S	0003677	molecular_function	DNA binding
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0006303	biological_process	double-strand break repair via nonhomologous end joining
S	0006325	biological_process	chromatin organization
S	0006337	biological_process	nucleosome disassembly
S	0006338	biological_process	chromatin remodeling
S	0006355	biological_process	regulation of DNA-templated transcription
S	0006368	biological_process	transcription elongation by RNA polymerase II
S	0008270	molecular_function	zinc ion binding
S	0016586	cellular_component	RSC-type complex
S	0043565	molecular_function	sequence-specific DNA binding
S	0045944	biological_process	positive regulation of transcription by RNA polymerase II
S	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN I 601

Chain	Residue
I	CYS260
I	CYS263
I	CYS283
I	CYS286

---

Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	57
Details	BROMODOMAIN_1 Bromodomain signature. FkdFiklpSrkfhp..QYYykIqqpMsineIksrdye....YedgpsnflldvelLtkNCqaY

Chain	Residue	Details
H	PHE77-TYR133
H	SER210-PHE267
F	SER40-TYR95
R	THR1275-TYR1332

---

site_id	PS00463
Number of Residues	30
Details	ZN2_CY6_FUNGAL_1 Zn(2)-C6 fungal-type DNA-binding domain signature. ACvqCRkrKigCdrvkpi......CgnCmkhnkmd.C

Chain	Residue	Details
G	ALA13-CYS42
S	ALA14-CYS43

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	194
Details	Domain: {"description":"SWIRM","evidences":[{"source":"PROSITE-ProRule","id":"PRU00247","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	52
Details	Domain: {"description":"SANT","evidences":[{"source":"PROSITE-ProRule","id":"PRU00624","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	54
Details	Zinc finger: {"description":"ZZ-type; degenerate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00228","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00228","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	64
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	41
Details	Region: {"description":"Interaction with STH1","evidences":[{"source":"PubMed","id":"9154831","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---