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6V79

Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 (CD2) complexed with NF2376

Functional Information from GO Data
ChainGOidnamespacecontents
A0000118cellular_componenthistone deacetylase complex
A0004407molecular_functionhistone deacetylase activity
A0006325biological_processchromatin organization
A0016575biological_processhistone deacetylation
B0000118cellular_componenthistone deacetylase complex
B0004407molecular_functionhistone deacetylase activity
B0006325biological_processchromatin organization
B0016575biological_processhistone deacetylation
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue ZN A 801
ChainResidue
AASP612
AHIS614
AASP705
AQQD804
AHOH915

site_idAC2
Number of Residues5
Detailsbinding site for residue K A 802
ChainResidue
ALEU634
AASP610
AASP612
AHIS614
ASER633

site_idAC3
Number of Residues5
Detailsbinding site for residue K A 803
ChainResidue
APHE623
AASP626
AVAL629
ATYR662
AHOH931

site_idAC4
Number of Residues17
Detailsbinding site for residue QQD A 804
ChainResidue
ASER531
AHIS574
AGLY582
APHE583
AASP612
AHIS614
APHE643
AASN645
AASP705
ALEU712
AGLY743
ATYR745
AZN801
AHOH915
BTHR777
BVAL781
BASN784

site_idAC5
Number of Residues5
Detailsbinding site for residue EDO A 805
ChainResidue
ASER484
ACYS486
BLEU557
BTHR600
BHOH916

site_idAC6
Number of Residues5
Detailsbinding site for residue ZN B 801
ChainResidue
BASP612
BHIS614
BASP705
BQQD804
BHOH909

site_idAC7
Number of Residues5
Detailsbinding site for residue K B 802
ChainResidue
BASP610
BASP612
BHIS614
BSER633
BLEU634

site_idAC8
Number of Residues6
Detailsbinding site for residue K B 803
ChainResidue
BPHE623
BASP626
BVAL629
BTYR662
BHOH912
BHOH975

site_idAC9
Number of Residues18
Detailsbinding site for residue QQD B 804
ChainResidue
ATHR777
ATHR780
AVAL781
AASN784
BSER531
BHIS574
BGLY582
BPHE583
BASP612
BHIS614
BPHE643
BASN645
BASP705
BLEU712
BGLY743
BTYR745
BZN801
BHOH909

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PDB entries from 2024-11-06

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