Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008134 | molecular_function | transcription factor binding |
| A | 0016567 | biological_process | protein ubiquitination |
| A | 0031463 | cellular_component | Cul3-RING ubiquitin ligase complex |
| B | 0008134 | molecular_function | transcription factor binding |
| B | 0016567 | biological_process | protein ubiquitination |
| B | 0031463 | cellular_component | Cul3-RING ubiquitin ligase complex |
| C | 0008134 | molecular_function | transcription factor binding |
| C | 0016567 | biological_process | protein ubiquitination |
| C | 0031463 | cellular_component | Cul3-RING ubiquitin ligase complex |
| D | 0008134 | molecular_function | transcription factor binding |
| D | 0016567 | biological_process | protein ubiquitination |
| D | 0031463 | cellular_component | Cul3-RING ubiquitin ligase complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue FMT A 701 |
| Chain | Residue |
| A | TYR491 |
| A | PRO492 |
| A | GLU493 |
| A | ARG494 |
| A | HOH889 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue FMT A 702 |
| Chain | Residue |
| A | ARG326 |
| A | HIS562 |
| A | GLN563 |
| A | HOH843 |
| site_id | AC3 |
| Number of Residues | 19 |
| Details | binding site for residue Q5Y A 703 |
| Chain | Residue |
| A | TYR334 |
| A | SER363 |
| A | ASN382 |
| A | ASN414 |
| A | ARG415 |
| A | ARG483 |
| A | SER508 |
| A | GLY509 |
| A | TYR525 |
| A | SER555 |
| A | ALA556 |
| A | TYR572 |
| A | PHE577 |
| A | SER602 |
| A | GLY603 |
| A | FMT711 |
| A | HOH890 |
| A | HOH943 |
| A | HOH1009 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue FMT A 704 |
| Chain | Residue |
| A | VAL411 |
| A | HIS432 |
| A | HIS437 |
| A | FMT707 |
| B | THR501 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 705 |
| Chain | Residue |
| A | HOH874 |
| A | HOH942 |
| A | HOH945 |
| A | HOH968 |
| A | HOH1005 |
| A | HOH1041 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue FMT A 706 |
| Chain | Residue |
| A | CYS513 |
| A | VAL514 |
| A | THR560 |
| A | VAL561 |
| A | HOH832 |
| A | HOH833 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue FMT A 707 |
| Chain | Residue |
| A | HIS437 |
| A | SER439 |
| A | FMT704 |
| A | HOH813 |
| A | HOH853 |
| B | THR501 |
| B | HOH896 |
| B | HOH952 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 708 |
| Chain | Residue |
| A | TRP450 |
| A | HOH935 |
| A | HOH1028 |
| A | HOH1045 |
| A | HOH1051 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 709 |
| Chain | Residue |
| A | THR598 |
| A | HOH834 |
| B | HOH892 |
| B | HOH945 |
| B | HOH1003 |
| B | HOH1012 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue FMT A 710 |
| Chain | Residue |
| A | HOH829 |
| D | GLU446 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue FMT A 711 |
| Chain | Residue |
| A | ARG415 |
| A | GLY462 |
| A | PHE478 |
| A | ARG483 |
| A | SER508 |
| A | Q5Y703 |
| D | HOH813 |
| site_id | AD3 |
| Number of Residues | 8 |
| Details | binding site for residue FMT A 712 |
| Chain | Residue |
| A | ASN504 |
| A | HOH809 |
| A | HOH827 |
| A | HOH864 |
| A | HOH1020 |
| B | SER439 |
| B | FMT705 |
| B | HOH898 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue FMT A 713 |
| Chain | Residue |
| A | ARG494 |
| A | HOH801 |
| A | HOH815 |
| A | HOH816 |
| C | LEU327 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue FMT A 714 |
| Chain | Residue |
| A | ARG494 |
| A | GLU496 |
| C | PRO398 |
| C | MET399 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue FMT A 715 |
| Chain | Residue |
| A | LEU468 |
| A | ASN469 |
| A | LEU471 |
| A | TYR473 |
| A | VAL539 |
| C | THR400 |
| site_id | AD7 |
| Number of Residues | 8 |
| Details | binding site for residue FMT B 701 |
| Chain | Residue |
| B | HIS437 |
| B | FMT705 |
| B | HOH954 |
| B | HOH955 |
| B | HOH963 |
| B | VAL411 |
| B | HIS432 |
| B | ILE435 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue FMT B 702 |
| Chain | Residue |
| B | TYR491 |
| B | PRO492 |
| B | GLU493 |
| B | ARG494 |
| B | HOH861 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue FMT B 703 |
| Chain | Residue |
| B | ARG415 |
| B | GLY462 |
| B | PHE478 |
| B | ARG483 |
| B | SER508 |
| B | Q5Y707 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue FMT B 704 |
| Chain | Residue |
| A | PHE335 |
| A | THR576 |
| A | PHE577 |
| B | THR598 |
| B | HOH991 |
| site_id | AE2 |
| Number of Residues | 8 |
| Details | binding site for residue FMT B 705 |
| Chain | Residue |
| A | THR501 |
| A | FMT712 |
| B | ILE435 |
| B | HIS437 |
| B | FMT701 |
| B | HOH831 |
| B | HOH876 |
| B | HOH898 |
| site_id | AE3 |
| Number of Residues | 4 |
| Details | binding site for residue FMT B 706 |
| Chain | Residue |
| A | HOH826 |
| A | HOH903 |
| B | THR545 |
| B | PHE546 |
| site_id | AE4 |
| Number of Residues | 16 |
| Details | binding site for residue Q5Y B 707 |
| Chain | Residue |
| B | TYR334 |
| B | SER363 |
| B | ASN414 |
| B | ARG415 |
| B | SER508 |
| B | GLY509 |
| B | TYR525 |
| B | SER555 |
| B | ALA556 |
| B | TYR572 |
| B | PHE577 |
| B | SER602 |
| B | GLY603 |
| B | FMT703 |
| B | HOH903 |
| C | ARG447 |
| site_id | AE5 |
| Number of Residues | 3 |
| Details | binding site for residue FMT B 708 |
| Chain | Residue |
| B | THR388 |
| B | ASP389 |
| B | HIS432 |
| site_id | AE6 |
| Number of Residues | 5 |
| Details | binding site for residue FMT B 709 |
| Chain | Residue |
| B | TYR334 |
| B | PHE335 |
| B | ARG336 |
| B | PHE577 |
| B | HOH877 |
| site_id | AE7 |
| Number of Residues | 6 |
| Details | binding site for residue FMT B 710 |
| Chain | Residue |
| B | GLN337 |
| B | SER338 |
| B | LEU339 |
| B | SER340 |
| B | HOH849 |
| B | HOH1021 |
| site_id | AE8 |
| Number of Residues | 7 |
| Details | binding site for residue FMT B 711 |
| Chain | Residue |
| B | CYS513 |
| B | VAL514 |
| B | THR560 |
| B | VAL561 |
| B | HOH822 |
| B | HOH844 |
| B | HOH985 |
| site_id | AE9 |
| Number of Residues | 4 |
| Details | binding site for residue FMT B 712 |
| Chain | Residue |
| A | ARG596 |
| B | LEU578 |
| B | ASP579 |
| B | SER580 |
| site_id | AF1 |
| Number of Residues | 7 |
| Details | binding site for residue FMT B 713 |
| Chain | Residue |
| B | ILE421 |
| B | ASP422 |
| B | HIS424 |
| B | TYR426 |
| B | ARG442 |
| B | ARG470 |
| B | HOH823 |
| site_id | AF2 |
| Number of Residues | 7 |
| Details | binding site for residue FMT B 714 |
| Chain | Residue |
| A | ASN504 |
| A | TRP544 |
| A | HOH827 |
| B | ASN438 |
| B | PRO455 |
| B | ARG459 |
| B | HOH819 |
| site_id | AF3 |
| Number of Residues | 8 |
| Details | binding site for residue FMT B 715 |
| Chain | Residue |
| B | LEU557 |
| B | GLY558 |
| B | ILE559 |
| B | VAL606 |
| B | NA721 |
| B | HOH885 |
| B | HOH917 |
| B | HOH980 |
| site_id | AF4 |
| Number of Residues | 3 |
| Details | binding site for residue FMT B 716 |
| Chain | Residue |
| B | MET456 |
| B | LEU457 |
| B | HOH866 |
| site_id | AF5 |
| Number of Residues | 6 |
| Details | binding site for residue FMT B 717 |
| Chain | Residue |
| B | ALA366 |
| B | ILE416 |
| B | GLY417 |
| B | VAL463 |
| B | HOH835 |
| B | HOH885 |
| site_id | AF6 |
| Number of Residues | 8 |
| Details | binding site for residue FMT B 718 |
| Chain | Residue |
| B | GLY367 |
| B | VAL606 |
| B | NA721 |
| B | HOH807 |
| B | HOH809 |
| B | HOH822 |
| B | HOH887 |
| B | HOH985 |
| site_id | AF7 |
| Number of Residues | 6 |
| Details | binding site for residue FMT B 719 |
| Chain | Residue |
| B | ASN485 |
| B | ALA502 |
| B | HOH810 |
| B | HOH857 |
| B | HOH966 |
| B | HOH997 |
| site_id | AF8 |
| Number of Residues | 6 |
| Details | binding site for residue NA B 720 |
| Chain | Residue |
| B | VAL465 |
| B | VAL512 |
| B | HOH809 |
| B | HOH886 |
| B | HOH946 |
| B | HOH962 |
| site_id | AF9 |
| Number of Residues | 6 |
| Details | binding site for residue NA B 721 |
| Chain | Residue |
| B | ILE559 |
| B | VAL606 |
| B | FMT715 |
| B | FMT718 |
| B | HOH809 |
| B | HOH980 |
| site_id | AG1 |
| Number of Residues | 4 |
| Details | binding site for residue FMT C 701 |
| Chain | Residue |
| C | ARG326 |
| C | HIS562 |
| C | GLN563 |
| C | HOH803 |
| site_id | AG2 |
| Number of Residues | 5 |
| Details | binding site for residue FMT C 702 |
| Chain | Residue |
| C | TYR491 |
| C | PRO492 |
| C | GLU493 |
| C | ARG494 |
| C | HOH888 |
| site_id | AG3 |
| Number of Residues | 5 |
| Details | binding site for residue FMT C 703 |
| Chain | Residue |
| A | MET399 |
| A | THR400 |
| C | TYR473 |
| C | FMT720 |
| C | HOH807 |
| site_id | AG4 |
| Number of Residues | 6 |
| Details | binding site for residue FMT C 704 |
| Chain | Residue |
| C | GLU449 |
| C | TRP450 |
| C | HIS451 |
| C | HOH817 |
| C | HOH819 |
| C | HOH824 |
| site_id | AG5 |
| Number of Residues | 6 |
| Details | binding site for residue NA C 705 |
| Chain | Residue |
| C | VAL465 |
| C | VAL512 |
| C | FMT711 |
| C | HOH802 |
| C | HOH954 |
| C | HOH992 |
| site_id | AG6 |
| Number of Residues | 21 |
| Details | binding site for residue Q5Y C 706 |
| Chain | Residue |
| C | TYR334 |
| C | SER363 |
| C | ASN382 |
| C | ASN414 |
| C | ARG415 |
| C | ARG483 |
| C | SER508 |
| C | GLY509 |
| C | TYR525 |
| C | SER555 |
| C | ALA556 |
| C | TYR572 |
| C | SER602 |
| C | GLY603 |
| C | FMT718 |
| C | HOH813 |
| C | HOH909 |
| C | HOH914 |
| D | ARG336 |
| D | PRO384 |
| D | DTT709 |
| site_id | AG7 |
| Number of Residues | 7 |
| Details | binding site for residue DTD C 707 |
| Chain | Residue |
| C | TYR334 |
| C | ARG336 |
| C | PRO384 |
| C | ASN387 |
| D | ASN382 |
| D | Q5Y704 |
| D | DTT709 |
| site_id | AG8 |
| Number of Residues | 5 |
| Details | binding site for residue FMT C 708 |
| Chain | Residue |
| C | ILE421 |
| C | ASP422 |
| C | FMT715 |
| C | HOH871 |
| C | HOH906 |
| site_id | AG9 |
| Number of Residues | 3 |
| Details | binding site for residue FMT C 709 |
| Chain | Residue |
| C | TYR345 |
| C | PRO347 |
| C | TYR567 |
| site_id | AH1 |
| Number of Residues | 4 |
| Details | binding site for residue FMT C 710 |
| Chain | Residue |
| C | PHE335 |
| C | GLY600 |
| C | HOH866 |
| C | HOH899 |
| site_id | AH2 |
| Number of Residues | 8 |
| Details | binding site for residue FMT C 711 |
| Chain | Residue |
| C | VAL512 |
| C | ILE559 |
| C | VAL606 |
| C | NA705 |
| C | FMT712 |
| C | FMT717 |
| C | HOH809 |
| C | HOH917 |
| site_id | AH3 |
| Number of Residues | 6 |
| Details | binding site for residue FMT C 712 |
| Chain | Residue |
| C | ILE559 |
| C | THR560 |
| C | VAL606 |
| C | FMT711 |
| C | FMT717 |
| C | HOH826 |
| site_id | AH4 |
| Number of Residues | 5 |
| Details | binding site for residue FMT C 713 |
| Chain | Residue |
| C | PHE335 |
| C | ARG336 |
| C | HOH867 |
| D | ARG336 |
| D | FMT712 |
| site_id | AH5 |
| Number of Residues | 5 |
| Details | binding site for residue FMT C 714 |
| Chain | Residue |
| C | CYS434 |
| C | ILE435 |
| C | HIS436 |
| C | ARG459 |
| C | HOH894 |
| site_id | AH6 |
| Number of Residues | 5 |
| Details | binding site for residue FMT C 715 |
| Chain | Residue |
| C | VAL420 |
| C | FMT708 |
| C | HOH801 |
| C | HOH806 |
| C | HOH906 |
| site_id | AH7 |
| Number of Residues | 7 |
| Details | binding site for residue FMT C 716 |
| Chain | Residue |
| C | VAL465 |
| C | VAL467 |
| C | VAL514 |
| C | HOH802 |
| C | HOH806 |
| C | HOH881 |
| C | HOH992 |
| site_id | AH8 |
| Number of Residues | 7 |
| Details | binding site for residue FMT C 717 |
| Chain | Residue |
| C | GLY367 |
| C | VAL606 |
| C | FMT711 |
| C | FMT712 |
| C | HOH802 |
| C | HOH852 |
| C | HOH891 |
| site_id | AH9 |
| Number of Residues | 7 |
| Details | binding site for residue FMT C 718 |
| Chain | Residue |
| C | GLY462 |
| C | VAL463 |
| C | GLY509 |
| C | ALA510 |
| C | Q5Y706 |
| C | HOH808 |
| C | HOH811 |
| site_id | AI1 |
| Number of Residues | 4 |
| Details | binding site for residue FMT C 719 |
| Chain | Residue |
| C | TYR426 |
| C | ARG442 |
| C | TYR490 |
| C | PRO492 |
| site_id | AI2 |
| Number of Residues | 6 |
| Details | binding site for residue FMT C 720 |
| Chain | Residue |
| A | MET399 |
| C | TYR491 |
| C | MET499 |
| C | ILE500 |
| C | FMT703 |
| C | HOH998 |
| site_id | AI3 |
| Number of Residues | 6 |
| Details | binding site for residue FMT D 701 |
| Chain | Residue |
| D | ILE421 |
| D | ASP422 |
| D | HIS424 |
| D | TYR426 |
| D | ARG442 |
| D | ARG470 |
| site_id | AI4 |
| Number of Residues | 3 |
| Details | binding site for residue FMT D 702 |
| Chain | Residue |
| C | HOH865 |
| D | GLY574 |
| D | HIS575 |
| site_id | AI5 |
| Number of Residues | 5 |
| Details | binding site for residue FMT D 703 |
| Chain | Residue |
| D | TYR491 |
| D | PRO492 |
| D | GLU493 |
| D | ARG494 |
| D | HOH901 |
| site_id | AI6 |
| Number of Residues | 20 |
| Details | binding site for residue Q5Y D 704 |
| Chain | Residue |
| C | ARG336 |
| C | PRO384 |
| C | DTD707 |
| D | TYR334 |
| D | SER363 |
| D | ASN382 |
| D | ASN414 |
| D | ARG415 |
| D | SER508 |
| D | GLY509 |
| D | TYR525 |
| D | GLN530 |
| D | SER555 |
| D | ALA556 |
| D | TYR572 |
| D | SER602 |
| D | GLY603 |
| D | FMT717 |
| D | HOH804 |
| D | HOH900 |
| site_id | AI7 |
| Number of Residues | 10 |
| Details | binding site for residue FMT D 705 |
| Chain | Residue |
| D | VAL512 |
| D | ILE559 |
| D | VAL606 |
| D | NA708 |
| D | HOH807 |
| D | HOH816 |
| D | HOH828 |
| D | HOH869 |
| D | HOH890 |
| D | HOH942 |
| site_id | AI8 |
| Number of Residues | 4 |
| Details | binding site for residue FMT D 706 |
| Chain | Residue |
| D | CYS434 |
| D | ILE435 |
| D | HIS436 |
| D | ARG459 |
| site_id | AI9 |
| Number of Residues | 3 |
| Details | binding site for residue FMT D 707 |
| Chain | Residue |
| D | SER439 |
| D | LEU452 |
| D | HOH860 |
| site_id | AJ1 |
| Number of Residues | 6 |
| Details | binding site for residue NA D 708 |
| Chain | Residue |
| D | VAL465 |
| D | VAL512 |
| D | FMT705 |
| D | HOH822 |
| D | HOH913 |
| D | HOH942 |
| site_id | AJ2 |
| Number of Residues | 5 |
| Details | binding site for residue DTT D 709 |
| Chain | Residue |
| C | ASN382 |
| C | Q5Y706 |
| C | DTD707 |
| D | TYR334 |
| D | ARG336 |
| site_id | AJ3 |
| Number of Residues | 5 |
| Details | binding site for residue NA D 710 |
| Chain | Residue |
| D | TRP450 |
| D | HOH951 |
| D | HOH966 |
| D | HOH973 |
| D | HOH996 |
| site_id | AJ4 |
| Number of Residues | 3 |
| Details | binding site for residue FMT D 711 |
| Chain | Residue |
| D | VAL514 |
| D | HIS516 |
| D | ASN517 |
| site_id | AJ5 |
| Number of Residues | 5 |
| Details | binding site for residue FMT D 712 |
| Chain | Residue |
| C | ARG336 |
| C | FMT713 |
| D | PHE335 |
| D | ARG336 |
| D | HOH907 |
| site_id | AJ6 |
| Number of Residues | 4 |
| Details | binding site for residue FMT D 713 |
| Chain | Residue |
| D | VAL411 |
| D | HIS432 |
| D | ILE435 |
| D | HIS437 |
| site_id | AJ7 |
| Number of Residues | 4 |
| Details | binding site for residue FMT D 714 |
| Chain | Residue |
| D | ARG326 |
| D | HIS562 |
| D | GLN563 |
| D | HOH801 |
| site_id | AJ8 |
| Number of Residues | 3 |
| Details | binding site for residue FMT D 715 |
| Chain | Residue |
| D | ILE421 |
| D | ASP422 |
| D | HOH820 |
| site_id | AJ9 |
| Number of Residues | 4 |
| Details | binding site for residue FMT D 716 |
| Chain | Residue |
| B | MET399 |
| B | THR400 |
| D | TYR473 |
| D | TYR537 |
| site_id | AK1 |
| Number of Residues | 9 |
| Details | binding site for residue FMT D 717 |
| Chain | Residue |
| D | GLY462 |
| D | VAL463 |
| D | GLY509 |
| D | ALA510 |
| D | Q5Y704 |
| D | FMT718 |
| D | HOH803 |
| D | HOH810 |
| D | HOH871 |
| site_id | AK2 |
| Number of Residues | 7 |
| Details | binding site for residue FMT D 718 |
| Chain | Residue |
| D | LEU365 |
| D | VAL604 |
| D | FMT717 |
| D | HOH803 |
| D | HOH825 |
| D | HOH867 |
| D | HOH890 |
| site_id | AK3 |
| Number of Residues | 6 |
| Details | binding site for residue FMT D 719 |
| Chain | Residue |
| D | ALA466 |
| D | VAL467 |
| D | VAL514 |
| D | HOH822 |
| D | HOH826 |
| D | HOH942 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 180 |
| Details | Repeat: {"description":"Kelch 1"} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 200 |
| Details | Repeat: {"description":"Kelch 2"} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 184 |
| Details | Repeat: {"description":"Kelch 3"} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 184 |
| Details | Repeat: {"description":"Kelch 4"} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 184 |
| Details | Repeat: {"description":"Kelch 5"} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Site: {"description":"Sensor for electrophilic agents","evidences":[{"source":"UniProtKB","id":"Q9Z2X8","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"S-cGMP-cysteine","evidences":[{"source":"UniProtKB","id":"Q9Z2X8","evidenceCode":"ECO:0000250"}]} |
6V6Z
