6V6D

Cryo-EM structure of human pannexin 1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002020	molecular_function	protease binding
A	0002931	biological_process	response to ischemia
A	0003779	molecular_function	actin binding
A	0005102	molecular_function	signaling receptor binding
A	0005198	molecular_function	structural molecule activity
A	0005243	molecular_function	gap junction channel activity
A	0005253	molecular_function	monoatomic anion channel activity
A	0005262	molecular_function	calcium channel activity
A	0005347	molecular_function	ATP transmembrane transporter activity
A	0005515	molecular_function	protein binding
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005886	cellular_component	plasma membrane
A	0005921	cellular_component	gap junction
A	0006811	biological_process	monoatomic ion transport
A	0006812	biological_process	monoatomic cation transport
A	0006816	biological_process	calcium ion transport
A	0007267	biological_process	cell-cell signaling
A	0015267	molecular_function	channel activity
A	0015867	biological_process	ATP transport
A	0016020	cellular_component	membrane
A	0022829	molecular_function	wide pore channel activity
A	0022840	molecular_function	leak channel activity
A	0030154	biological_process	cell differentiation
A	0032059	cellular_component	bleb
A	0032730	biological_process	positive regulation of interleukin-1 alpha production
A	0032731	biological_process	positive regulation of interleukin-1 beta production
A	0032732	biological_process	positive regulation of interleukin-1 production
A	0032991	cellular_component	protein-containing complex
A	0033198	biological_process	response to ATP
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0044325	molecular_function	transmembrane transporter binding
A	0044877	molecular_function	protein-containing complex binding
A	0048477	biological_process	oogenesis
A	0051015	molecular_function	actin filament binding
A	0055077	molecular_function	gap junction hemi-channel activity
A	0060907	biological_process	positive regulation of macrophage cytokine production
A	0070588	biological_process	calcium ion transmembrane transport
A	0097110	molecular_function	scaffold protein binding
A	0098656	biological_process	monoatomic anion transmembrane transport
B	0002020	molecular_function	protease binding
B	0002931	biological_process	response to ischemia
B	0003779	molecular_function	actin binding
B	0005102	molecular_function	signaling receptor binding
B	0005198	molecular_function	structural molecule activity
B	0005243	molecular_function	gap junction channel activity
B	0005253	molecular_function	monoatomic anion channel activity
B	0005262	molecular_function	calcium channel activity
B	0005347	molecular_function	ATP transmembrane transporter activity
B	0005515	molecular_function	protein binding
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005886	cellular_component	plasma membrane
B	0005921	cellular_component	gap junction
B	0006811	biological_process	monoatomic ion transport
B	0006812	biological_process	monoatomic cation transport
B	0006816	biological_process	calcium ion transport
B	0007267	biological_process	cell-cell signaling
B	0015267	molecular_function	channel activity
B	0015867	biological_process	ATP transport
B	0016020	cellular_component	membrane
B	0022829	molecular_function	wide pore channel activity
B	0022840	molecular_function	leak channel activity
B	0030154	biological_process	cell differentiation
B	0032059	cellular_component	bleb
B	0032730	biological_process	positive regulation of interleukin-1 alpha production
B	0032731	biological_process	positive regulation of interleukin-1 beta production
B	0032732	biological_process	positive regulation of interleukin-1 production
B	0032991	cellular_component	protein-containing complex
B	0033198	biological_process	response to ATP
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0044325	molecular_function	transmembrane transporter binding
B	0044877	molecular_function	protein-containing complex binding
B	0048477	biological_process	oogenesis
B	0051015	molecular_function	actin filament binding
B	0055077	molecular_function	gap junction hemi-channel activity
B	0060907	biological_process	positive regulation of macrophage cytokine production
B	0070588	biological_process	calcium ion transmembrane transport
B	0097110	molecular_function	scaffold protein binding
B	0098656	biological_process	monoatomic anion transmembrane transport
C	0002020	molecular_function	protease binding
C	0002931	biological_process	response to ischemia
C	0003779	molecular_function	actin binding
C	0005102	molecular_function	signaling receptor binding
C	0005198	molecular_function	structural molecule activity
C	0005243	molecular_function	gap junction channel activity
C	0005253	molecular_function	monoatomic anion channel activity
C	0005262	molecular_function	calcium channel activity
C	0005347	molecular_function	ATP transmembrane transporter activity
C	0005515	molecular_function	protein binding
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005886	cellular_component	plasma membrane
C	0005921	cellular_component	gap junction
C	0006811	biological_process	monoatomic ion transport
C	0006812	biological_process	monoatomic cation transport
C	0006816	biological_process	calcium ion transport
C	0007267	biological_process	cell-cell signaling
C	0015267	molecular_function	channel activity
C	0015867	biological_process	ATP transport
C	0016020	cellular_component	membrane
C	0022829	molecular_function	wide pore channel activity
C	0022840	molecular_function	leak channel activity
C	0030154	biological_process	cell differentiation
C	0032059	cellular_component	bleb
C	0032730	biological_process	positive regulation of interleukin-1 alpha production
C	0032731	biological_process	positive regulation of interleukin-1 beta production
C	0032732	biological_process	positive regulation of interleukin-1 production
C	0032991	cellular_component	protein-containing complex
C	0033198	biological_process	response to ATP
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0044325	molecular_function	transmembrane transporter binding
C	0044877	molecular_function	protein-containing complex binding
C	0048477	biological_process	oogenesis
C	0051015	molecular_function	actin filament binding
C	0055077	molecular_function	gap junction hemi-channel activity
C	0060907	biological_process	positive regulation of macrophage cytokine production
C	0070588	biological_process	calcium ion transmembrane transport
C	0097110	molecular_function	scaffold protein binding
C	0098656	biological_process	monoatomic anion transmembrane transport
D	0002020	molecular_function	protease binding
D	0002931	biological_process	response to ischemia
D	0003779	molecular_function	actin binding
D	0005102	molecular_function	signaling receptor binding
D	0005198	molecular_function	structural molecule activity
D	0005243	molecular_function	gap junction channel activity
D	0005253	molecular_function	monoatomic anion channel activity
D	0005262	molecular_function	calcium channel activity
D	0005347	molecular_function	ATP transmembrane transporter activity
D	0005515	molecular_function	protein binding
D	0005783	cellular_component	endoplasmic reticulum
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0005886	cellular_component	plasma membrane
D	0005921	cellular_component	gap junction
D	0006811	biological_process	monoatomic ion transport
D	0006812	biological_process	monoatomic cation transport
D	0006816	biological_process	calcium ion transport
D	0007267	biological_process	cell-cell signaling
D	0015267	molecular_function	channel activity
D	0015867	biological_process	ATP transport
D	0016020	cellular_component	membrane
D	0022829	molecular_function	wide pore channel activity
D	0022840	molecular_function	leak channel activity
D	0030154	biological_process	cell differentiation
D	0032059	cellular_component	bleb
D	0032730	biological_process	positive regulation of interleukin-1 alpha production
D	0032731	biological_process	positive regulation of interleukin-1 beta production
D	0032732	biological_process	positive regulation of interleukin-1 production
D	0032991	cellular_component	protein-containing complex
D	0033198	biological_process	response to ATP
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0044325	molecular_function	transmembrane transporter binding
D	0044877	molecular_function	protein-containing complex binding
D	0048477	biological_process	oogenesis
D	0051015	molecular_function	actin filament binding
D	0055077	molecular_function	gap junction hemi-channel activity
D	0060907	biological_process	positive regulation of macrophage cytokine production
D	0070588	biological_process	calcium ion transmembrane transport
D	0097110	molecular_function	scaffold protein binding
D	0098656	biological_process	monoatomic anion transmembrane transport
E	0002020	molecular_function	protease binding
E	0002931	biological_process	response to ischemia
E	0003779	molecular_function	actin binding
E	0005102	molecular_function	signaling receptor binding
E	0005198	molecular_function	structural molecule activity
E	0005243	molecular_function	gap junction channel activity
E	0005253	molecular_function	monoatomic anion channel activity
E	0005262	molecular_function	calcium channel activity
E	0005347	molecular_function	ATP transmembrane transporter activity
E	0005515	molecular_function	protein binding
E	0005783	cellular_component	endoplasmic reticulum
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005886	cellular_component	plasma membrane
E	0005921	cellular_component	gap junction
E	0006811	biological_process	monoatomic ion transport
E	0006812	biological_process	monoatomic cation transport
E	0006816	biological_process	calcium ion transport
E	0007267	biological_process	cell-cell signaling
E	0015267	molecular_function	channel activity
E	0015867	biological_process	ATP transport
E	0016020	cellular_component	membrane
E	0022829	molecular_function	wide pore channel activity
E	0022840	molecular_function	leak channel activity
E	0030154	biological_process	cell differentiation
E	0032059	cellular_component	bleb
E	0032730	biological_process	positive regulation of interleukin-1 alpha production
E	0032731	biological_process	positive regulation of interleukin-1 beta production
E	0032732	biological_process	positive regulation of interleukin-1 production
E	0032991	cellular_component	protein-containing complex
E	0033198	biological_process	response to ATP
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0044325	molecular_function	transmembrane transporter binding
E	0044877	molecular_function	protein-containing complex binding
E	0048477	biological_process	oogenesis
E	0051015	molecular_function	actin filament binding
E	0055077	molecular_function	gap junction hemi-channel activity
E	0060907	biological_process	positive regulation of macrophage cytokine production
E	0070588	biological_process	calcium ion transmembrane transport
E	0097110	molecular_function	scaffold protein binding
E	0098656	biological_process	monoatomic anion transmembrane transport
F	0002020	molecular_function	protease binding
F	0002931	biological_process	response to ischemia
F	0003779	molecular_function	actin binding
F	0005102	molecular_function	signaling receptor binding
F	0005198	molecular_function	structural molecule activity
F	0005243	molecular_function	gap junction channel activity
F	0005253	molecular_function	monoatomic anion channel activity
F	0005262	molecular_function	calcium channel activity
F	0005347	molecular_function	ATP transmembrane transporter activity
F	0005515	molecular_function	protein binding
F	0005783	cellular_component	endoplasmic reticulum
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0005886	cellular_component	plasma membrane
F	0005921	cellular_component	gap junction
F	0006811	biological_process	monoatomic ion transport
F	0006812	biological_process	monoatomic cation transport
F	0006816	biological_process	calcium ion transport
F	0007267	biological_process	cell-cell signaling
F	0015267	molecular_function	channel activity
F	0015867	biological_process	ATP transport
F	0016020	cellular_component	membrane
F	0022829	molecular_function	wide pore channel activity
F	0022840	molecular_function	leak channel activity
F	0030154	biological_process	cell differentiation
F	0032059	cellular_component	bleb
F	0032730	biological_process	positive regulation of interleukin-1 alpha production
F	0032731	biological_process	positive regulation of interleukin-1 beta production
F	0032732	biological_process	positive regulation of interleukin-1 production
F	0032991	cellular_component	protein-containing complex
F	0033198	biological_process	response to ATP
F	0034220	biological_process	monoatomic ion transmembrane transport
F	0044325	molecular_function	transmembrane transporter binding
F	0044877	molecular_function	protein-containing complex binding
F	0048477	biological_process	oogenesis
F	0051015	molecular_function	actin filament binding
F	0055077	molecular_function	gap junction hemi-channel activity
F	0060907	biological_process	positive regulation of macrophage cytokine production
F	0070588	biological_process	calcium ion transmembrane transport
F	0097110	molecular_function	scaffold protein binding
F	0098656	biological_process	monoatomic anion transmembrane transport
G	0002020	molecular_function	protease binding
G	0002931	biological_process	response to ischemia
G	0003779	molecular_function	actin binding
G	0005102	molecular_function	signaling receptor binding
G	0005198	molecular_function	structural molecule activity
G	0005243	molecular_function	gap junction channel activity
G	0005253	molecular_function	monoatomic anion channel activity
G	0005262	molecular_function	calcium channel activity
G	0005347	molecular_function	ATP transmembrane transporter activity
G	0005515	molecular_function	protein binding
G	0005783	cellular_component	endoplasmic reticulum
G	0005789	cellular_component	endoplasmic reticulum membrane
G	0005886	cellular_component	plasma membrane
G	0005921	cellular_component	gap junction
G	0006811	biological_process	monoatomic ion transport
G	0006812	biological_process	monoatomic cation transport
G	0006816	biological_process	calcium ion transport
G	0007267	biological_process	cell-cell signaling
G	0015267	molecular_function	channel activity
G	0015867	biological_process	ATP transport
G	0016020	cellular_component	membrane
G	0022829	molecular_function	wide pore channel activity
G	0022840	molecular_function	leak channel activity
G	0030154	biological_process	cell differentiation
G	0032059	cellular_component	bleb
G	0032730	biological_process	positive regulation of interleukin-1 alpha production
G	0032731	biological_process	positive regulation of interleukin-1 beta production
G	0032732	biological_process	positive regulation of interleukin-1 production
G	0032991	cellular_component	protein-containing complex
G	0033198	biological_process	response to ATP
G	0034220	biological_process	monoatomic ion transmembrane transport
G	0044325	molecular_function	transmembrane transporter binding
G	0044877	molecular_function	protein-containing complex binding
G	0048477	biological_process	oogenesis
G	0051015	molecular_function	actin filament binding
G	0055077	molecular_function	gap junction hemi-channel activity
G	0060907	biological_process	positive regulation of macrophage cytokine production
G	0070588	biological_process	calcium ion transmembrane transport
G	0097110	molecular_function	scaffold protein binding
G	0098656	biological_process	monoatomic anion transmembrane transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	560
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00351","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	189
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	7
Details	Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"UniProtKB","id":"Q9JIP4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	7
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"17715132","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30918116","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32494015","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33947837","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---