Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | binding site for residue HEC A 601 |
| Chain | Residue |
| A | SER187 |
| A | LEU229 |
| A | PHE256 |
| A | SER257 |
| A | ARG260 |
| A | LEU264 |
| A | GLN267 |
| A | LEU268 |
| A | PRO271 |
| A | MET322 |
| A | ARG434 |
| A | CYS188 |
| A | HOH736 |
| A | HOH766 |
| A | HOH931 |
| A | CYS191 |
| A | HIS192 |
| A | GLN214 |
| A | SER222 |
| A | ARG224 |
| A | ASN225 |
| A | ALA226 |
| site_id | AC2 |
| Number of Residues | 24 |
| Details | binding site for residue HEC A 602 |
| Chain | Residue |
| A | GLY365 |
| A | ASN366 |
| A | CYS367 |
| A | SER369 |
| A | CYS370 |
| A | HIS371 |
| A | ASP391 |
| A | ILE393 |
| A | VAL395 |
| A | LEU433 |
| A | THR435 |
| A | PRO436 |
| A | LYS444 |
| A | PHE447 |
| A | MET448 |
| A | HIS449 |
| A | LEU456 |
| A | MET463 |
| A | ASN492 |
| A | HOH783 |
| A | HOH829 |
| A | HOH837 |
| A | HOH879 |
| A | HOH978 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 603 |
| Chain | Residue |
| A | LYS153 |
| A | VAL154 |
| A | HIS239 |
| A | PHE252 |
| A | ASP387 |
| A | PHE388 |
| A | HOH918 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 604 |
| Chain | Residue |
| A | CYS370 |
| A | ASP387 |
| A | TYR390 |
| A | ASP391 |
| A | THR435 |
| A | HOH715 |
| A | HOH774 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 605 |
| Chain | Residue |
| A | GLY294 |
| A | PRO484 |
| A | TYR487 |
| A | HOH710 |
| A | HOH724 |
| A | HOH729 |
| A | HOH763 |
| A | HOH956 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 606 |
| Chain | Residue |
| A | ASP193 |
| A | GLY195 |
| A | ARG196 |
| A | THR201 |
| A | PRO543 |
| A | HOH726 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 607 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 608 |
| Chain | Residue |
| A | ALA377 |
| A | SER378 |
| A | ARG379 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 609 |
| Chain | Residue |
| A | HOH895 |
| A | HOH934 |
| A | HOH1045 |
| A | HOH1066 |
| A | HOH1074 |
| A | HOH1141 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 603 |
| Chain | Residue |
| B | ARG313 |
| B | GLU320 |
| B | LEU356 |
| B | ASP375 |
| B | HOH712 |
| B | HOH734 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 604 |
| Chain | Residue |
| B | TRP423 |
| B | PRO424 |
| B | GLN428 |
| B | TRP429 |
| B | GOL609 |
| B | HOH709 |
| B | HOH742 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 605 |
| Chain | Residue |
| B | TYR390 |
| B | ASP391 |
| B | THR435 |
| B | HOH702 |
| B | HOH735 |
| B | CYS370 |
| B | ASP387 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 606 |
| Chain | Residue |
| B | LYS153 |
| B | VAL154 |
| B | HIS239 |
| B | PHE252 |
| B | ASP387 |
| B | HOH967 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 607 |
| Chain | Residue |
| B | ARG238 |
| B | ARG260 |
| B | GLU266 |
| B | LYS344 |
| B | HOH741 |
| B | HOH971 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 608 |
| Chain | Residue |
| B | PRO396 |
| B | ARG397 |
| B | TRP473 |
| B | HIS475 |
| B | HOH936 |
| B | HOH975 |
| site_id | AD7 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 609 |
| Chain | Residue |
| B | ARG173 |
| B | GLY294 |
| B | ALA297 |
| B | PRO424 |
| B | GOL604 |
| B | HOH710 |
| B | HOH730 |
| B | HOH962 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue CL B 610 |
| Chain | Residue |
| B | ALA377 |
| B | SER378 |
| B | ARG379 |
| B | ARG382 |
| site_id | AD9 |
| Number of Residues | 5 |
| Details | binding site for residue CL B 611 |
| Chain | Residue |
| A | GLY304 |
| A | PRO305 |
| A | SER306 |
| A | ARG313 |
| B | LYS539 |
| site_id | AE1 |
| Number of Residues | 26 |
| Details | binding site for Di-peptide HEC B 601 and CYS B 191 |
| Chain | Residue |
| B | SER187 |
| B | CYS188 |
| B | ALA189 |
| B | SER190 |
| B | HIS192 |
| B | PRO200 |
| B | PRO213 |
| B | GLN214 |
| B | SER222 |
| B | ARG224 |
| B | ASN225 |
| B | ALA226 |
| B | PRO227 |
| B | LEU229 |
| B | PHE256 |
| B | SER257 |
| B | ARG260 |
| B | LEU264 |
| B | GLN267 |
| B | PRO271 |
| B | MET278 |
| B | MET322 |
| B | ARG434 |
| B | HOH743 |
| B | HOH782 |
| B | HOH953 |
| site_id | AE2 |
| Number of Residues | 27 |
| Details | binding site for Di-peptide HEC B 601 and CYS B 188 |
| Chain | Residue |
| B | PHE175 |
| B | SER187 |
| B | ALA189 |
| B | SER190 |
| B | CYS191 |
| B | HIS192 |
| B | PRO213 |
| B | GLN214 |
| B | SER222 |
| B | ARG224 |
| B | ASN225 |
| B | ALA226 |
| B | PRO227 |
| B | LEU229 |
| B | PHE256 |
| B | SER257 |
| B | ARG260 |
| B | LEU264 |
| B | GLN267 |
| B | PRO271 |
| B | MET278 |
| B | MET322 |
| B | ARG434 |
| B | HOH743 |
| B | HOH782 |
| B | HOH922 |
| B | HOH953 |
| site_id | AE3 |
| Number of Residues | 27 |
| Details | binding site for Di-peptide HEC B 602 and CYS B 370 |
| Chain | Residue |
| B | GLY365 |
| B | ASN366 |
| B | CYS367 |
| B | MET368 |
| B | SER369 |
| B | HIS371 |
| B | THR372 |
| B | THR386 |
| B | ASP387 |
| B | ASP391 |
| B | ILE393 |
| B | VAL395 |
| B | LEU433 |
| B | THR435 |
| B | PRO436 |
| B | LYS444 |
| B | PHE447 |
| B | MET448 |
| B | HIS449 |
| B | MET463 |
| B | ASN492 |
| B | GOL605 |
| B | HOH768 |
| B | HOH816 |
| B | HOH829 |
| B | HOH885 |
| B | HOH950 |
| site_id | AE4 |
| Number of Residues | 24 |
| Details | binding site for Di-peptide HEC B 602 and CYS B 367 |
| Chain | Residue |
| B | PHE359 |
| B | GLY365 |
| B | ASN366 |
| B | MET368 |
| B | SER369 |
| B | CYS370 |
| B | HIS371 |
| B | ASP391 |
| B | ILE393 |
| B | VAL395 |
| B | LEU433 |
| B | THR435 |
| B | PRO436 |
| B | LYS444 |
| B | PHE447 |
| B | MET448 |
| B | HIS449 |
| B | MET463 |
| B | ASN492 |
| B | HOH768 |
| B | HOH816 |
| B | HOH829 |
| B | HOH885 |
| B | HOH950 |
