6V1X
Cryo-EM Structure of the Hyperpolarization-Activated Potassium Channel KAT1: Tetramer
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005249 | molecular_function | voltage-gated potassium channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006813 | biological_process | potassium ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0055085 | biological_process | transmembrane transport |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005249 | molecular_function | voltage-gated potassium channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006813 | biological_process | potassium ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0055085 | biological_process | transmembrane transport |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005249 | molecular_function | voltage-gated potassium channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0006813 | biological_process | potassium ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0055085 | biological_process | transmembrane transport |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005249 | molecular_function | voltage-gated potassium channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0006813 | biological_process | potassium ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0055085 | biological_process | transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue QNP A 601 |
| Chain | Residue |
| A | TRP75 |
| A | SER179 |
| A | ARG197 |
| A | LYS200 |
| A | VAL204 |
| A | TYR290 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue QNJ A 602 |
| Chain | Residue |
| A | SER179 |
| A | PHE283 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue QNP B 601 |
| Chain | Residue |
| B | SER179 |
| B | ARG197 |
| B | LYS200 |
| B | SER203 |
| B | VAL204 |
| B | TYR290 |
| B | TRP75 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue QNJ B 602 |
| Chain | Residue |
| B | SER179 |
| B | PHE283 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue QNJ C 601 |
| Chain | Residue |
| C | SER179 |
| C | PHE283 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue QNP C 602 |
| Chain | Residue |
| C | TRP75 |
| C | SER179 |
| C | ARG197 |
| C | LYS200 |
| C | VAL204 |
| C | TYR290 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue QNJ D 601 |
| Chain | Residue |
| D | SER179 |
| D | PHE283 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue QNP D 602 |
| Chain | Residue |
| D | TRP75 |
| D | SER179 |
| D | ARG197 |
| D | LYS200 |
| D | VAL204 |
| D | TYR290 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 388 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | MET1-GLU63 | |
| D | MET1-GLU63 | |
| D | VAL112-LEU134 | |
| D | LYS187-LYS200 | |
| A | VAL112-LEU134 | |
| A | LYS187-LYS200 | |
| B | MET1-GLU63 | |
| B | VAL112-LEU134 | |
| B | LYS187-LYS200 | |
| C | MET1-GLU63 | |
| C | VAL112-LEU134 | |
| C | LYS187-LYS200 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Name=Segment S1 => ECO:0000255 |
| Chain | Residue | Details |
| A | MET64-ILE84 | |
| B | MET64-ILE84 | |
| C | MET64-ILE84 | |
| D | MET64-ILE84 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 172 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | THR85-ALA90 | |
| C | ASN156-ARG165 | |
| C | ARG222-VAL248 | |
| C | GLU269-ARG272 | |
| D | THR85-ALA90 | |
| D | ASN156-ARG165 | |
| D | ARG222-VAL248 | |
| D | GLU269-ARG272 | |
| A | ASN156-ARG165 | |
| A | ARG222-VAL248 | |
| A | GLU269-ARG272 | |
| B | THR85-ALA90 | |
| B | ASN156-ARG165 | |
| B | ARG222-VAL248 | |
| B | GLU269-ARG272 | |
| C | THR85-ALA90 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Name=Segment S2 => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE91-PHE111 | |
| B | ILE91-PHE111 | |
| C | ILE91-PHE111 | |
| D | ILE91-PHE111 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Name=Segment S3 => ECO:0000255 |
| Chain | Residue | Details |
| A | SER135-PHE155 | |
| B | SER135-PHE155 | |
| C | SER135-PHE155 | |
| D | SER135-PHE155 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Voltage-sensor; Name=Segment S4 => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE166-GLU186 | |
| B | ILE166-GLU186 | |
| C | ILE166-GLU186 | |
| D | ILE166-GLU186 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Name=Segment S5 => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU201-ASP221 | |
| B | LEU201-ASP221 | |
| C | LEU201-ASP221 | |
| D | LEU201-ASP221 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 76 |
| Details | INTRAMEM: Pore-forming; Name=Segment H5 => ECO:0000255 |
| Chain | Residue | Details |
| A | THR249-ALA268 | |
| B | THR249-ALA268 | |
| C | THR249-ALA268 | |
| D | THR249-ALA268 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Name=Segment S6 => ECO:0000255 |
| Chain | Residue | Details |
| A | GLU273-GLY293 | |
| B | GLU273-GLY293 | |
| C | GLU273-GLY293 | |
| D | GLU273-GLY293 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | LEU377 | |
| B | LEU377 | |
| C | LEU377 | |
| D | LEU377 |
