6UZD
Anthrax toxin protective antigen channels bound to edema factor
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005515 | molecular_function | protein binding |
A | 0005576 | cellular_component | extracellular region |
A | 0016020 | cellular_component | membrane |
A | 0020002 | cellular_component | host cell plasma membrane |
A | 0042802 | molecular_function | identical protein binding |
A | 0043409 | biological_process | negative regulation of MAPK cascade |
A | 0044164 | cellular_component | host cell cytosol |
A | 0044174 | cellular_component | host cell endosome |
A | 0044175 | cellular_component | host cell endosome membrane |
A | 0044533 | biological_process | positive regulation of apoptotic process in another organism |
A | 0046872 | molecular_function | metal ion binding |
A | 0051260 | biological_process | protein homooligomerization |
A | 0090729 | molecular_function | toxin activity |
B | 0005515 | molecular_function | protein binding |
B | 0005576 | cellular_component | extracellular region |
B | 0016020 | cellular_component | membrane |
B | 0020002 | cellular_component | host cell plasma membrane |
B | 0042802 | molecular_function | identical protein binding |
B | 0043409 | biological_process | negative regulation of MAPK cascade |
B | 0044164 | cellular_component | host cell cytosol |
B | 0044174 | cellular_component | host cell endosome |
B | 0044175 | cellular_component | host cell endosome membrane |
B | 0044533 | biological_process | positive regulation of apoptotic process in another organism |
B | 0046872 | molecular_function | metal ion binding |
B | 0051260 | biological_process | protein homooligomerization |
B | 0090729 | molecular_function | toxin activity |
C | 0005515 | molecular_function | protein binding |
C | 0005576 | cellular_component | extracellular region |
C | 0016020 | cellular_component | membrane |
C | 0020002 | cellular_component | host cell plasma membrane |
C | 0042802 | molecular_function | identical protein binding |
C | 0043409 | biological_process | negative regulation of MAPK cascade |
C | 0044164 | cellular_component | host cell cytosol |
C | 0044174 | cellular_component | host cell endosome |
C | 0044175 | cellular_component | host cell endosome membrane |
C | 0044533 | biological_process | positive regulation of apoptotic process in another organism |
C | 0046872 | molecular_function | metal ion binding |
C | 0051260 | biological_process | protein homooligomerization |
C | 0090729 | molecular_function | toxin activity |
D | 0005515 | molecular_function | protein binding |
D | 0005576 | cellular_component | extracellular region |
D | 0016020 | cellular_component | membrane |
D | 0020002 | cellular_component | host cell plasma membrane |
D | 0042802 | molecular_function | identical protein binding |
D | 0043409 | biological_process | negative regulation of MAPK cascade |
D | 0044164 | cellular_component | host cell cytosol |
D | 0044174 | cellular_component | host cell endosome |
D | 0044175 | cellular_component | host cell endosome membrane |
D | 0044533 | biological_process | positive regulation of apoptotic process in another organism |
D | 0046872 | molecular_function | metal ion binding |
D | 0051260 | biological_process | protein homooligomerization |
D | 0090729 | molecular_function | toxin activity |
E | 0005515 | molecular_function | protein binding |
E | 0005576 | cellular_component | extracellular region |
E | 0016020 | cellular_component | membrane |
E | 0020002 | cellular_component | host cell plasma membrane |
E | 0042802 | molecular_function | identical protein binding |
E | 0043409 | biological_process | negative regulation of MAPK cascade |
E | 0044164 | cellular_component | host cell cytosol |
E | 0044174 | cellular_component | host cell endosome |
E | 0044175 | cellular_component | host cell endosome membrane |
E | 0044533 | biological_process | positive regulation of apoptotic process in another organism |
E | 0046872 | molecular_function | metal ion binding |
E | 0051260 | biological_process | protein homooligomerization |
E | 0090729 | molecular_function | toxin activity |
F | 0005515 | molecular_function | protein binding |
F | 0005576 | cellular_component | extracellular region |
F | 0016020 | cellular_component | membrane |
F | 0020002 | cellular_component | host cell plasma membrane |
F | 0042802 | molecular_function | identical protein binding |
F | 0043409 | biological_process | negative regulation of MAPK cascade |
F | 0044164 | cellular_component | host cell cytosol |
F | 0044174 | cellular_component | host cell endosome |
F | 0044175 | cellular_component | host cell endosome membrane |
F | 0044533 | biological_process | positive regulation of apoptotic process in another organism |
F | 0046872 | molecular_function | metal ion binding |
F | 0051260 | biological_process | protein homooligomerization |
F | 0090729 | molecular_function | toxin activity |
G | 0005515 | molecular_function | protein binding |
G | 0005576 | cellular_component | extracellular region |
G | 0016020 | cellular_component | membrane |
G | 0020002 | cellular_component | host cell plasma membrane |
G | 0042802 | molecular_function | identical protein binding |
G | 0043409 | biological_process | negative regulation of MAPK cascade |
G | 0044164 | cellular_component | host cell cytosol |
G | 0044174 | cellular_component | host cell endosome |
G | 0044175 | cellular_component | host cell endosome membrane |
G | 0044533 | biological_process | positive regulation of apoptotic process in another organism |
G | 0046872 | molecular_function | metal ion binding |
G | 0051260 | biological_process | protein homooligomerization |
G | 0090729 | molecular_function | toxin activity |
H | 0003824 | molecular_function | catalytic activity |
H | 0004016 | molecular_function | adenylate cyclase activity |
H | 0005515 | molecular_function | protein binding |
H | 0005516 | molecular_function | calmodulin binding |
H | 0005524 | molecular_function | ATP binding |
H | 0005576 | cellular_component | extracellular region |
H | 0006171 | biological_process | cAMP biosynthetic process |
H | 0008237 | molecular_function | metallopeptidase activity |
H | 0008294 | molecular_function | calcium- and calmodulin-responsive adenylate cyclase activity |
H | 0016829 | molecular_function | lyase activity |
H | 0030430 | cellular_component | host cell cytoplasm |
H | 0035821 | biological_process | modulation of process of another organism |
H | 0036094 | molecular_function | small molecule binding |
H | 0044164 | cellular_component | host cell cytosol |
H | 0046872 | molecular_function | metal ion binding |
H | 0090729 | molecular_function | toxin activity |
H | 0099004 | biological_process | calmodulin dependent kinase signaling pathway |
H | 1902494 | cellular_component | catalytic complex |
I | 0003824 | molecular_function | catalytic activity |
I | 0004016 | molecular_function | adenylate cyclase activity |
I | 0005515 | molecular_function | protein binding |
I | 0005516 | molecular_function | calmodulin binding |
I | 0005524 | molecular_function | ATP binding |
I | 0005576 | cellular_component | extracellular region |
I | 0006171 | biological_process | cAMP biosynthetic process |
I | 0008237 | molecular_function | metallopeptidase activity |
I | 0008294 | molecular_function | calcium- and calmodulin-responsive adenylate cyclase activity |
I | 0016829 | molecular_function | lyase activity |
I | 0030430 | cellular_component | host cell cytoplasm |
I | 0035821 | biological_process | modulation of process of another organism |
I | 0036094 | molecular_function | small molecule binding |
I | 0044164 | cellular_component | host cell cytosol |
I | 0046872 | molecular_function | metal ion binding |
I | 0090729 | molecular_function | toxin activity |
I | 0099004 | biological_process | calmodulin dependent kinase signaling pathway |
I | 1902494 | cellular_component | catalytic complex |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | binding site for residue CA A 801 |
Chain | Residue |
A | ASP177 |
A | ASP179 |
A | ASP181 |
A | ILE183 |
A | GLU188 |
site_id | AC2 |
Number of Residues | 6 |
Details | binding site for residue CA A 802 |
Chain | Residue |
A | LYS225 |
A | ASP235 |
A | ASP179 |
A | ASP181 |
A | GLU188 |
A | SER222 |
site_id | AC3 |
Number of Residues | 6 |
Details | binding site for residue CA B 801 |
Chain | Residue |
B | ASP177 |
B | ASP179 |
B | ASP181 |
B | ILE183 |
B | ASP185 |
B | GLU188 |
site_id | AC4 |
Number of Residues | 6 |
Details | binding site for residue CA B 802 |
Chain | Residue |
B | ASP179 |
B | ASP181 |
B | GLU188 |
B | SER222 |
B | LYS225 |
B | ASP235 |
site_id | AC5 |
Number of Residues | 6 |
Details | binding site for residue CA C 801 |
Chain | Residue |
C | ASP177 |
C | ASP179 |
C | ASP181 |
C | ILE183 |
C | ASP185 |
C | GLU188 |
site_id | AC6 |
Number of Residues | 6 |
Details | binding site for residue CA C 802 |
Chain | Residue |
C | ASP179 |
C | ASP181 |
C | GLU188 |
C | SER222 |
C | LYS225 |
C | ASP235 |
site_id | AC7 |
Number of Residues | 6 |
Details | binding site for residue CA D 801 |
Chain | Residue |
D | ASP177 |
D | ASP179 |
D | ASP181 |
D | ILE183 |
D | ASP185 |
D | GLU188 |
site_id | AC8 |
Number of Residues | 6 |
Details | binding site for residue CA D 802 |
Chain | Residue |
D | ASP179 |
D | ASP181 |
D | GLU188 |
D | SER222 |
D | LYS225 |
D | ASP235 |
site_id | AC9 |
Number of Residues | 6 |
Details | binding site for residue CA E 801 |
Chain | Residue |
E | ASP177 |
E | ASP179 |
E | ASP181 |
E | ILE183 |
E | ASP185 |
E | GLU188 |
site_id | AD1 |
Number of Residues | 6 |
Details | binding site for residue CA E 802 |
Chain | Residue |
E | ASP179 |
E | ASP181 |
E | GLU188 |
E | SER222 |
E | LYS225 |
E | ASP235 |
site_id | AD2 |
Number of Residues | 6 |
Details | binding site for residue CA F 801 |
Chain | Residue |
F | ASP177 |
F | ASP179 |
F | ASP181 |
F | ILE183 |
F | ASP185 |
F | GLU188 |
site_id | AD3 |
Number of Residues | 6 |
Details | binding site for residue CA F 802 |
Chain | Residue |
F | ASP179 |
F | ASP181 |
F | GLU188 |
F | SER222 |
F | LYS225 |
F | ASP235 |
site_id | AD4 |
Number of Residues | 6 |
Details | binding site for residue CA G 801 |
Chain | Residue |
G | ASP177 |
G | ASP179 |
G | ASP181 |
G | ILE183 |
G | ASP185 |
G | GLU188 |
site_id | AD5 |
Number of Residues | 6 |
Details | binding site for residue CA G 802 |
Chain | Residue |
G | ASP179 |
G | ASP181 |
G | GLU188 |
G | SER222 |
G | LYS225 |
G | ASP235 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor => ECO:0000269|PubMed:11807546 |
Chain | Residue | Details |
H | HIS318 | |
E | ILE316-SER325 | |
F | GLU302-PHE313 | |
F | ILE316-SER325 | |
G | GLU302-PHE313 | |
G | ILE316-SER325 | |
I | HIS318 | |
B | GLU302-PHE313 | |
B | ILE316-SER325 | |
C | GLU302-PHE313 | |
C | ILE316-SER325 | |
D | GLU302-PHE313 | |
D | ILE316-SER325 | |
E | GLU302-PHE313 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15719022, ECO:0007744|PDB:1XFU, ECO:0007744|PDB:1XFV, ECO:0007744|PDB:1XFW, ECO:0007744|PDB:1XFX, ECO:0007744|PDB:1XFY, ECO:0007744|PDB:1XFZ, ECO:0007744|PDB:1Y0V |
Chain | Residue | Details |
H | ASP458 | |
D | ASP177 | |
D | ASP181 | |
D | ILE183 | |
E | ASP177 | |
E | ASP181 | |
E | ILE183 | |
F | ASP177 | |
F | ASP181 | |
F | ILE183 | |
G | ASP177 | |
H | ASP460 | |
G | ASP181 | |
G | ILE183 | |
H | HIS544 | |
I | ASP458 | |
I | ASP460 | |
I | HIS544 | |
C | ASP177 | |
C | ASP181 | |
C | ILE183 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15719022, ECO:0007744|PDB:1XFW |
Chain | Residue | Details |
H | THR515 | |
I | THR515 | |
C | ASP179 | |
D | ASP179 | |
E | ASP179 | |
F | ASP179 | |
G | ASP179 |
site_id | SWS_FT_FI4 |
Number of Residues | 7 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15326297, ECO:0000269|PubMed:21037566, ECO:0000269|PubMed:25778700, ECO:0000269|PubMed:32047164, ECO:0007744|PDB:1ACC, ECO:0007744|PDB:1TZN, ECO:0007744|PDB:1TZO, ECO:0007744|PDB:3J9C, ECO:0007744|PDB:3KWV, ECO:0007744|PDB:6PSN, ECO:0007744|PDB:6UZB, ECO:0007744|PDB:6UZD, ECO:0007744|PDB:6UZE |
Chain | Residue | Details |
A | GLU188 | |
B | GLU188 | |
C | GLU188 | |
D | GLU188 | |
E | GLU188 | |
F | GLU188 | |
G | GLU188 |
site_id | SWS_FT_FI5 |
Number of Residues | 14 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15243628, ECO:0000269|PubMed:15326297, ECO:0000269|PubMed:21037566, ECO:0000269|PubMed:25778700, ECO:0000269|PubMed:32047164, ECO:0007744|PDB:1ACC, ECO:0007744|PDB:1T6B, ECO:0007744|PDB:1TZN, ECO:0007744|PDB:1TZO, ECO:0007744|PDB:3J9C, ECO:0007744|PDB:3KWV, ECO:0007744|PDB:6PSN, ECO:0007744|PDB:6UZB, ECO:0007744|PDB:6UZD, ECO:0007744|PDB:6UZE |
Chain | Residue | Details |
A | SER222 | |
E | LYS225 | |
F | SER222 | |
F | LYS225 | |
G | SER222 | |
G | LYS225 | |
A | LYS225 | |
B | SER222 | |
B | LYS225 | |
C | SER222 | |
C | LYS225 | |
D | SER222 | |
D | LYS225 | |
E | SER222 |
site_id | SWS_FT_FI6 |
Number of Residues | 7 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15243628, ECO:0000269|PubMed:15326297, ECO:0000269|PubMed:21037566, ECO:0000269|PubMed:32047164, ECO:0007744|PDB:1ACC, ECO:0007744|PDB:1T6B, ECO:0007744|PDB:1TZN, ECO:0007744|PDB:1TZO, ECO:0007744|PDB:3KWV, ECO:0007744|PDB:6PSN, ECO:0007744|PDB:6UZB, ECO:0007744|PDB:6UZD, ECO:0007744|PDB:6UZE |
Chain | Residue | Details |
A | ASP235 | |
B | ASP235 | |
C | ASP235 | |
D | ASP235 | |
E | ASP235 | |
F | ASP235 | |
G | ASP235 |
site_id | SWS_FT_FI7 |
Number of Residues | 7 |
Details | SITE: Cleavage; by FURIN => ECO:0000269|PubMed:11207581, ECO:0000269|PubMed:1438214, ECO:0000269|PubMed:1644824 |
Chain | Residue | Details |
A | ARG167 | |
B | ARG167 | |
C | ARG167 | |
D | ARG167 | |
E | ARG167 | |
F | ARG167 | |
G | ARG167 |
site_id | SWS_FT_FI8 |
Number of Residues | 28 |
Details | SITE: Alpha-clamp => ECO:0000269|PubMed:21037566 |
Chain | Residue | Details |
A | ARG178 | |
C | LEU187 | |
C | PHE236 | |
C | PHE464 | |
D | ARG178 | |
D | LEU187 | |
D | PHE236 | |
D | PHE464 | |
E | ARG178 | |
E | LEU187 | |
E | PHE236 | |
A | LEU187 | |
E | PHE464 | |
F | ARG178 | |
F | LEU187 | |
F | PHE236 | |
F | PHE464 | |
G | ARG178 | |
G | LEU187 | |
G | PHE236 | |
G | PHE464 | |
A | PHE236 | |
A | PHE464 | |
B | ARG178 | |
B | LEU187 | |
B | PHE236 | |
B | PHE464 | |
C | ARG178 |
site_id | SWS_FT_FI9 |
Number of Residues | 7 |
Details | SITE: Cleavage; by chymotrypsin; required for translocation of LF and EF => ECO:0000269|PubMed:7961869 |
Chain | Residue | Details |
A | PHE314 | |
B | PHE314 | |
C | PHE314 | |
D | PHE314 | |
E | PHE314 | |
F | PHE314 | |
G | PHE314 |
site_id | SWS_FT_FI10 |
Number of Residues | 7 |
Details | SITE: Phi-clamp => ECO:0000269|PubMed:16051798, ECO:0000269|PubMed:25778700 |
Chain | Residue | Details |
A | PHE427 | |
B | PHE427 | |
C | PHE427 | |
D | PHE427 | |
E | PHE427 | |
F | PHE427 | |
G | PHE427 |
site_id | SWS_FT_FI11 |
Number of Residues | 7 |
Details | SITE: Essential for binding to cell receptor => ECO:0000269|PubMed:12771151 |
Chain | Residue | Details |
A | ASP683 | |
B | ASP683 | |
C | ASP683 | |
D | ASP683 | |
E | ASP683 | |
F | ASP683 | |
G | ASP683 |