6UZB

Anthrax toxin protective antigen channels bound to edema factor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0020002	cellular_component	host cell plasma membrane
A	0042802	molecular_function	identical protein binding
A	0044164	cellular_component	host cell cytosol
A	0044175	cellular_component	host cell endosome membrane
A	0046872	molecular_function	metal ion binding
A	0051260	biological_process	protein homooligomerization
A	0090729	molecular_function	toxin activity
A	0141070	biological_process	symbiont-mediated suppression of host MAPK cascade
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0020002	cellular_component	host cell plasma membrane
B	0042802	molecular_function	identical protein binding
B	0044164	cellular_component	host cell cytosol
B	0044175	cellular_component	host cell endosome membrane
B	0046872	molecular_function	metal ion binding
B	0051260	biological_process	protein homooligomerization
B	0090729	molecular_function	toxin activity
B	0141070	biological_process	symbiont-mediated suppression of host MAPK cascade
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0020002	cellular_component	host cell plasma membrane
C	0042802	molecular_function	identical protein binding
C	0044164	cellular_component	host cell cytosol
C	0044175	cellular_component	host cell endosome membrane
C	0046872	molecular_function	metal ion binding
C	0051260	biological_process	protein homooligomerization
C	0090729	molecular_function	toxin activity
C	0141070	biological_process	symbiont-mediated suppression of host MAPK cascade
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0020002	cellular_component	host cell plasma membrane
D	0042802	molecular_function	identical protein binding
D	0044164	cellular_component	host cell cytosol
D	0044175	cellular_component	host cell endosome membrane
D	0046872	molecular_function	metal ion binding
D	0051260	biological_process	protein homooligomerization
D	0090729	molecular_function	toxin activity
D	0141070	biological_process	symbiont-mediated suppression of host MAPK cascade
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0020002	cellular_component	host cell plasma membrane
E	0042802	molecular_function	identical protein binding
E	0044164	cellular_component	host cell cytosol
E	0044175	cellular_component	host cell endosome membrane
E	0046872	molecular_function	metal ion binding
E	0051260	biological_process	protein homooligomerization
E	0090729	molecular_function	toxin activity
E	0141070	biological_process	symbiont-mediated suppression of host MAPK cascade
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0020002	cellular_component	host cell plasma membrane
F	0042802	molecular_function	identical protein binding
F	0044164	cellular_component	host cell cytosol
F	0044175	cellular_component	host cell endosome membrane
F	0046872	molecular_function	metal ion binding
F	0051260	biological_process	protein homooligomerization
F	0090729	molecular_function	toxin activity
F	0141070	biological_process	symbiont-mediated suppression of host MAPK cascade
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0020002	cellular_component	host cell plasma membrane
G	0042802	molecular_function	identical protein binding
G	0044164	cellular_component	host cell cytosol
G	0044175	cellular_component	host cell endosome membrane
G	0046872	molecular_function	metal ion binding
G	0051260	biological_process	protein homooligomerization
G	0090729	molecular_function	toxin activity
G	0141070	biological_process	symbiont-mediated suppression of host MAPK cascade
H	0000166	molecular_function	nucleotide binding
H	0003824	molecular_function	catalytic activity
H	0004016	molecular_function	adenylate cyclase activity
H	0005516	molecular_function	calmodulin binding
H	0005524	molecular_function	ATP binding
H	0005576	cellular_component	extracellular region
H	0006171	biological_process	cAMP biosynthetic process
H	0008237	molecular_function	metallopeptidase activity
H	0008294	molecular_function	calcium- and calmodulin-responsive adenylate cyclase activity
H	0010856	molecular_function	adenylate cyclase activator activity
H	0016829	molecular_function	lyase activity
H	0032564	molecular_function	dATP binding
H	0044164	cellular_component	host cell cytosol
H	0046872	molecular_function	metal ion binding
H	0052027	biological_process	symbiont-mediated perturbation of host signal transduction pathway
H	0090729	molecular_function	toxin activity
H	0141042	biological_process	symbiont-mediated cAMP intoxication of host cell
H	1902494	cellular_component	catalytic complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue CA A 801

Chain	Residue
A	ASP177
A	ASP179
A	ASP181
A	ILE183
A	ASP185
A	GLU188

---

site_id	AC2
Number of Residues	6
Details	binding site for residue CA A 802

Chain	Residue
A	SER222
A	LYS225
A	ASP235
A	ASP179
A	ASP181
A	GLU188

---

site_id	AC3
Number of Residues	5
Details	binding site for residue CA B 801

Chain	Residue
B	ASP177
B	ASP179
B	ASP181
B	ILE183
B	GLU188

---

site_id	AC4
Number of Residues	6
Details	binding site for residue CA B 802

Chain	Residue
B	ASP179
B	ASP181
B	GLU188
B	SER222
B	LYS225
B	ASP235

---

site_id	AC5
Number of Residues	5
Details	binding site for residue CA C 801

Chain	Residue
C	ASP177
C	ASP179
C	ASP181
C	ILE183
C	GLU188

---

site_id	AC6
Number of Residues	6
Details	binding site for residue CA C 802

Chain	Residue
C	ASP179
C	ASP181
C	GLU188
C	SER222
C	LYS225
C	ASP235

---

site_id	AC7
Number of Residues	6
Details	binding site for residue CA D 801

Chain	Residue
D	ASP177
D	ASP179
D	ASP181
D	ILE183
D	ASP185
D	GLU188

---

site_id	AC8
Number of Residues	6
Details	binding site for residue CA D 802

Chain	Residue
D	ASP179
D	ASP181
D	GLU188
D	SER222
D	LYS225
D	ASP235

---

site_id	AC9
Number of Residues	6
Details	binding site for residue CA E 801

Chain	Residue
E	ASP177
E	ASP179
E	ASP181
E	ILE183
E	ASP185
E	GLU188

---

site_id	AD1
Number of Residues	6
Details	binding site for residue CA E 802

Chain	Residue
E	ASP179
E	ASP181
E	GLU188
E	SER222
E	LYS225
E	ASP235

---

site_id	AD2
Number of Residues	5
Details	binding site for residue CA F 801

Chain	Residue
F	ASP177
F	ASP179
F	ASP181
F	ILE183
F	GLU188

---

site_id	AD3
Number of Residues	6
Details	binding site for residue CA F 802

Chain	Residue
F	ASP179
F	ASP181
F	GLU188
F	SER222
F	LYS225
F	ASP235

---

site_id	AD4
Number of Residues	6
Details	binding site for residue CA G 801

Chain	Residue
G	ASP177
G	ASP179
G	ASP181
G	ILE183
G	ASP185
G	GLU188

---

site_id	AD5
Number of Residues	6
Details	binding site for residue CA G 802

Chain	Residue
G	ASP179
G	ASP181
G	GLU188
G	SER222
G	LYS225
G	ASP235

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	140
Details	Transmembrane: {"description":"Beta stranded","evidences":[{"source":"PubMed","id":"25778700","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32047164","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6PSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	56
Details	Region: {"description":"Alpha-clamp","evidences":[{"source":"PubMed","id":"21037566","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1596
Details	Region: {"description":"Domain 2, membrane insertion and heptamerization","evidences":[{"source":"PubMed","id":"9039918","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	217
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	749
Details	Region: {"description":"Domain 3, heptamerization","evidences":[{"source":"PubMed","id":"9039918","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	973
Details	Region: {"description":"Domain 4, binding to the receptor","evidences":[{"source":"PubMed","id":"9039918","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	147
Details	Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	21
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15243628","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15326297","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21037566","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25778700","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32047164","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9039918","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ACC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3J9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6PSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15243628","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15326297","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21037566","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25778700","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32047164","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9039918","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ACC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3J9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6PSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15326297","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21037566","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25778700","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32047164","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ACC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3J9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6PSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15243628","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15326297","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21037566","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25778700","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32047164","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ACC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3J9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6PSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15243628","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15326297","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21037566","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32047164","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ACC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6PSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	28
Details	Site: {"description":"Alpha-clamp","evidences":[{"source":"PubMed","id":"21037566","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	7
Details	Site: {"description":"Cleavage; by chymotrypsin; required for translocation of LF and EF","evidences":[{"source":"PubMed","id":"7961869","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	7
Details	Site: {"description":"Phi-clamp","evidences":[{"source":"PubMed","id":"16051798","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25778700","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	7
Details	Site: {"description":"Essential for binding to cell receptor","evidences":[{"source":"PubMed","id":"12771151","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	213
Details	Domain: {"description":"ATLF-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU01339","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	139
Details	Region: {"description":"Catalytic CB","evidences":[{"source":"PubMed","id":"11807546","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	132
Details	Region: {"description":"Catalytic CA2","evidences":[{"source":"PubMed","id":"11807546","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"11807546","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15719022","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1XFU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XFV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XFW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XFX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XFY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XFZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Y0V","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15719022","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1XFW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---