6UZ0
Cardiac sodium channel with flecainide
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0001518 | cellular_component | voltage-gated sodium channel complex |
A | 0003674 | molecular_function | molecular_function |
A | 0005216 | molecular_function | monoatomic ion channel activity |
A | 0005248 | molecular_function | voltage-gated sodium channel activity |
A | 0005261 | molecular_function | monoatomic cation channel activity |
A | 0005575 | cellular_component | cellular_component |
A | 0005886 | cellular_component | plasma membrane |
A | 0006091 | biological_process | generation of precursor metabolites and energy |
A | 0006811 | biological_process | monoatomic ion transport |
A | 0006814 | biological_process | sodium ion transport |
A | 0008218 | biological_process | bioluminescence |
A | 0016020 | cellular_component | membrane |
A | 0055085 | biological_process | transmembrane transport |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 882 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
Chain | Residue | Details |
A | MET1-SER132 | |
A | PRO1787-ARG1849 | |
A | LEU1898-VAL1909 | |
A | THR1958-VAL1976 | |
A | ARG180-PRO193 | |
A | SER235-ASP253 | |
A | VAL412-GLN915 | |
A | LEU1087-THR1100 | |
A | GLU1141-LYS1156 | |
A | TRP1260-ILE1526 | |
A | CYS1577-THR1590 | |
A | ARG1637-MET1653 |
site_id | SWS_FT_FI2 |
Number of Residues | 18 |
Details | TRANSMEM: Helical; Name=S1 of repeat I => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | LEU133-GLN151 |
site_id | SWS_FT_FI3 |
Number of Residues | 309 |
Details | TOPO_DOM: Extracellular => ECO:0000305 |
Chain | Residue | Details |
A | HIS152-THR158 | |
A | LEU1610-TYR1617 | |
A | SER1674-THR1725 | |
A | ALA1748-ILE1764 | |
A | GLY1868-GLU1878 | |
A | GLY1928-GLU1940 | |
A | ALA1995-THR2016 | |
A | GLU2040-GLY2068 | |
A | ASP212-SER217 | |
A | MET274-SER358 | |
A | ARG384-TYR390 | |
A | ASN935-PHE945 | |
A | THR1121-HIS1122 | |
A | ALA1176-VAL1204 | |
A | PHE1226-LYS1238 | |
A | VAL1545-GLU1557 |
site_id | SWS_FT_FI4 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=S2 of repeat I => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | LYS159-ALA179 |
site_id | SWS_FT_FI5 |
Number of Residues | 17 |
Details | TRANSMEM: Helical; Name=S3 of repeat I => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | TRP194-VAL211 |
site_id | SWS_FT_FI6 |
Number of Residues | 16 |
Details | TRANSMEM: Helical; Name=S4 of repeat I => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | ALA218-ILE234 |
site_id | SWS_FT_FI7 |
Number of Residues | 19 |
Details | TRANSMEM: Helical; Name=S5 of repeat I => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | VAL254-PHE273 |
site_id | SWS_FT_FI8 |
Number of Residues | 87 |
Details | INTRAMEM: Pore-forming => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | PHE359-LEU383 | |
A | GLU1205-ALA1225 | |
A | GLY1726-PRO1747 | |
A | ARG2017-LYS2039 |
site_id | SWS_FT_FI9 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=S6 of repeat I => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | MET391-ALA411 |
site_id | SWS_FT_FI10 |
Number of Residues | 18 |
Details | TRANSMEM: Helical; Name=S1 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | SER916-LEU934 |
site_id | SWS_FT_FI11 |
Number of Residues | 19 |
Details | TRANSMEM: Helical; Name=S2 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | SER1067-ALA1086 |
site_id | SWS_FT_FI12 |
Number of Residues | 19 |
Details | TRANSMEM: Helical; Name=S3 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | THR1101-ALA1120 |
site_id | SWS_FT_FI13 |
Number of Residues | 17 |
Details | TRANSMEM: Helical; Name=S4 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | SER1123-VAL1140 |
site_id | SWS_FT_FI14 |
Number of Residues | 18 |
Details | TRANSMEM: Helical; Name=S5 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | ARG1157-VAL1175 |
site_id | SWS_FT_FI15 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=S6 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | VAL1239-LYS1259 |
site_id | SWS_FT_FI16 |
Number of Residues | 17 |
Details | TRANSMEM: Helical; Name=S1 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | VAL1527-MET1544 |
site_id | SWS_FT_FI17 |
Number of Residues | 18 |
Details | TRANSMEM: Helical; Name=S2 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | LYS1558-GLU1576 |
site_id | SWS_FT_FI18 |
Number of Residues | 18 |
Details | TRANSMEM: Helical; Name=S3 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | ASN1591-VAL1609 |
site_id | SWS_FT_FI19 |
Number of Residues | 18 |
Details | TRANSMEM: Helical; Name=S4 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | PHE1618-LEU1636 |
site_id | SWS_FT_FI20 |
Number of Residues | 19 |
Details | TRANSMEM: Helical; Name=S5 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | MET1654-TYR1673 |
site_id | SWS_FT_FI21 |
Number of Residues | 21 |
Details | TRANSMEM: Helical; Name=S6 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | VAL1765-GLU1786 |
site_id | SWS_FT_FI22 |
Number of Residues | 17 |
Details | TRANSMEM: Helical; Name=S1 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | ILE1850-SER1867 |
site_id | SWS_FT_FI23 |
Number of Residues | 18 |
Details | TRANSMEM: Helical; Name=S2 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | GLU1879-THR1897 |
site_id | SWS_FT_FI24 |
Number of Residues | 17 |
Details | TRANSMEM: Helical; Name=S3 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | SER1910-ASP1927 |
site_id | SWS_FT_FI25 |
Number of Residues | 16 |
Details | TRANSMEM: Helical; Name=S4 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | GLY1941-THR1957 |
site_id | SWS_FT_FI26 |
Number of Residues | 17 |
Details | TRANSMEM: Helical; Name=S5 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | GLN1977-SER1994 |
site_id | SWS_FT_FI27 |
Number of Residues | 22 |
Details | TRANSMEM: Helical; Name=S6 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | ILE2069-GLN2091 |
site_id | SWS_FT_FI28 |
Number of Residues | 1 |
Details | SITE: Cys residue near the selectivity filter, which has a free thiol that is susceptible to reaction with methanethiosulfonate (MTSET); Sodium current is irreversibly blocked by MTSET => ECO:0000250|UniProtKB:P04775, ECO:0000269|PubMed:26039939 |
Chain | Residue | Details |
A | CYS374 |
site_id | SWS_FT_FI29 |
Number of Residues | 8 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q14524 |
Chain | Residue | Details |
A | SER37 | |
A | SER655 | |
A | SER658 | |
A | TYR695 | |
A | LYS708 | |
A | ILE769 | |
A | PHE862 | |
A | ASN865 |
site_id | SWS_FT_FI30 |
Number of Residues | 1 |
Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q14524 |
Chain | Residue | Details |
A | THR39 |
site_id | SWS_FT_FI31 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903 |
Chain | Residue | Details |
A | HIS681 | |
A | ARG682 |
site_id | SWS_FT_FI32 |
Number of Residues | 1 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:22673903 |
Chain | Residue | Details |
A | CYS684 |
site_id | SWS_FT_FI33 |
Number of Residues | 1 |
Details | MOD_RES: Omega-N-methylarginine; alternate => ECO:0000250|UniProtKB:Q14524 |
Chain | Residue | Details |
A | ILE724 |
site_id | SWS_FT_FI34 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9JJV9 |
Chain | Residue | Details |
A | LEU737 |
site_id | SWS_FT_FI35 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine; by PKC => ECO:0000250|UniProtKB:Q14524 |
Chain | Residue | Details |
A | LEU1823 |
site_id | SWS_FT_FI36 |
Number of Residues | 13 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
A | ASN215 | |
A | LYS1685 | |
A | PHE1694 | |
A | ALA1700 | |
A | GLN1708 | |
A | ASN284 | |
A | ASN289 | |
A | ASN292 | |
A | ASN319 | |
A | ASN329 | |
A | LEU938 | |
A | HIS1122 | |
A | GLN1183 |
site_id | SWS_FT_FI37 |
Number of Residues | 1 |
Details | MOD_RES: (Z)-2,3-didehydrotyrosine => ECO:0000269|PubMed:8448132 |
Chain | Residue | Details |
A | TYR1974 |
site_id | SWS_FT_FI38 |
Number of Residues | 2 |
Details | CROSSLNK: 5-imidazolinone (Ser-Gly) => ECO:0000269|PubMed:8448132 |
Chain | Residue | Details |
A | THR1973 | |
A | GLY1975 |