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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6UXN

Crystal structure of BAK core domain BH3-groove-dimer in complex with phosphatidylserine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0042981	biological_process	regulation of apoptotic process
B	0042981	biological_process	regulation of apoptotic process
C	0042981	biological_process	regulation of apoptotic process
D	0042981	biological_process	regulation of apoptotic process
E	0042981	biological_process	regulation of apoptotic process
F	0042981	biological_process	regulation of apoptotic process
G	0042981	biological_process	regulation of apoptotic process
H	0042981	biological_process	regulation of apoptotic process
I	0042981	biological_process	regulation of apoptotic process
J	0042981	biological_process	regulation of apoptotic process
K	0042981	biological_process	regulation of apoptotic process
L	0042981	biological_process	regulation of apoptotic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue 8SP A 201

Chain	Residue
A	ILE123
A	ASN124
A	TRP125
A	LEU132
B	LEU132
B	TYR136

site_id	AC2
Number of Residues	9
Details	binding site for residue 8SP A 202

Chain	Residue
C	LEU132
C	TYR136
D	TYR108
D	ASN124
D	TRP125
D	VAL128
A	THR95
A	HIS99
A	HOH302

site_id	AC3
Number of Residues	2
Details	binding site for residue SO4 A 203

Chain	Residue
A	GLN73
A	ARG76

site_id	AC4
Number of Residues	8
Details	binding site for residue 8SP B 201

Chain	Residue
A	LEU132
A	TYR136
B	ILE123
B	ASN124
B	TRP125
B	VAL128
E	HIS99
F	TYR108

site_id	AC5
Number of Residues	11
Details	binding site for residue 8SP B 202

Chain	Residue
B	ALA104
B	GLU105
B	ASN106
B	ALA107
B	TYR108
B	GLU109
B	GLY135
B	HOH301
E	LEU140
E	TYR143
E	GLN144

site_id	AC6
Number of Residues	6
Details	binding site for residue SO4 B 203

Chain	Residue
B	ARG88
B	HOH302
B	HOH304
C	HOH301
D	ARG88
F	ARG88

site_id	AC7
Number of Residues	3
Details	binding site for residue SO4 B 204

Chain	Residue
B	THR70
B	GLY72
B	ARG76

site_id	AC8
Number of Residues	4
Details	binding site for residue GOL C 201

Chain	Residue
C	MET96
D	GLN73
D	GLN77
F	ASN124

site_id	AC9
Number of Residues	2
Details	binding site for residue SO4 C 202

Chain	Residue
C	GLN73
C	ARG76

site_id	AD1
Number of Residues	8
Details	binding site for residue 8SP D 201

Chain	Residue
C	ILE123
C	ASN124
C	TRP125
C	VAL128
C	VAL129
C	LEU132
D	LEU132
D	TYR136

site_id	AD2
Number of Residues	5
Details	binding site for residue 8SP D 202

Chain	Residue
C	LEU140
C	GLN144
D	PHE111
D	LEU132
D	GLY135

site_id	AD3
Number of Residues	5
Details	binding site for residue SO4 D 203

Chain	Residue
D	THR70
D	GLY72
D	ARG76
D	HOH301
D	HOH303

site_id	AD4
Number of Residues	5
Details	binding site for residue 8SP E 201

Chain	Residue
E	ILE123
E	ASN124
E	TRP125
E	VAL128
F	TYR136

site_id	AD5
Number of Residues	3
Details	binding site for residue SO4 E 202

Chain	Residue
D	ARG87
E	GLN73
E	ARG76

site_id	AD6
Number of Residues	3
Details	binding site for residue SO4 E 203

Chain	Residue
E	ARG137
E	HIS141
E	GLN144

site_id	AD7
Number of Residues	4
Details	binding site for residue SO4 E 204

Chain	Residue
E	THR70
E	GLY72
E	GLN73
E	ARG76

site_id	AD8
Number of Residues	8
Details	binding site for residue 8SP F 201

Chain	Residue
B	TYR108
B	PHE111
E	LEU132
E	TYR136
F	ILE123
F	ASN124
F	TRP125
F	VAL128

site_id	AD9
Number of Residues	11
Details	binding site for residue 8SP F 202

Chain	Residue
F	GLU109
F	PHE111
F	GLY135
F	HOH305
A	TYR143
A	GLN144
F	ALA104
F	GLU105
F	ASN106
F	ALA107
F	TYR108

site_id	AE1
Number of Residues	3
Details	binding site for residue SO4 F 203

Chain	Residue
F	THR70
F	GLY72
F	ARG76

site_id	AE2
Number of Residues	10
Details	binding site for residue 8SP G 201

Chain	Residue
G	TYR108
G	ILE123
G	ASN124
G	TRP125
G	VAL128
G	VAL129
H	LEU132
H	GLY133
H	TYR136
H	8SP202

site_id	AE3
Number of Residues	2
Details	binding site for residue SO4 G 202

Chain	Residue
G	GLN73
G	ARG76

site_id	AE4
Number of Residues	9
Details	binding site for residue 8SP H 201

Chain	Residue
G	LEU132
G	TYR136
H	TYR108
H	ASN124
H	TRP125
H	VAL128
H	8SP202
K	THR95
K	HIS99

site_id	AE5
Number of Residues	11
Details	binding site for residue 8SP H 202

Chain	Residue
G	GLN144
G	8SP201
H	ALA104
H	GLU105
H	ASN106
H	ALA107
H	TYR108
H	GLU109
H	PHE111
H	GLY135
H	8SP201

site_id	AE6
Number of Residues	3
Details	binding site for residue SO4 H 203

Chain	Residue
G	HOH303
H	ARG88
H	HOH303

site_id	AE7
Number of Residues	3
Details	binding site for residue SO4 H 204

Chain	Residue
H	THR70
H	GLY72
H	ARG76

site_id	AE8
Number of Residues	1
Details	binding site for residue SO4 H 205

Chain	Residue
H	ASN124

site_id	AE9
Number of Residues	6
Details	binding site for residue 8SP I 201

Chain	Residue
I	ILE123
I	ASN124
I	TRP125
I	VAL128
J	LEU132
J	TYR136

site_id	AF1
Number of Residues	2
Details	binding site for residue SO4 I 202

Chain	Residue
I	GLN73
I	ARG76

site_id	AF2
Number of Residues	11
Details	binding site for residue 8SP J 200

Chain	Residue
G	THR95
G	HIS99
I	LEU132
I	TYR136
J	ILE123
J	ASN124
J	TRP125
J	VAL128
J	HOH307
L	TYR108
L	8SP202

site_id	AF3
Number of Residues	11
Details	binding site for residue 8SP J 201

Chain	Residue
J	ALA104
J	GLU105
J	ASN106
J	ALA107
J	TYR108
J	GLU109
J	PHE111
J	TYR136
J	LEU138
K	TYR143
K	GLN144

site_id	AF4
Number of Residues	8
Details	binding site for residue 8SP K 201

Chain	Residue
I	TYR108
K	ILE123
K	ASN124
K	TRP125
K	VAL128
L	LEU132
L	TYR136
L	8SP202

site_id	AF5
Number of Residues	2
Details	binding site for residue SO4 K 202

Chain	Residue
K	GLN73
K	ARG76

site_id	AF6
Number of Residues	3
Details	binding site for residue SO4 K 203

Chain	Residue
K	HIS141
K	GLN144
K	HIS145

site_id	AF7
Number of Residues	7
Details	binding site for residue 8SP L 201

Chain	Residue
J	TYR108
K	ASN86
K	LEU132
K	TYR136
L	ASN124
L	TRP125
L	SO4205

site_id	AF8
Number of Residues	13
Details	binding site for residue 8SP L 202

Chain	Residue
I	LEU140
J	8SP200
K	8SP201
L	ALA104
L	GLU105
L	ASN106
L	ALA107
L	TYR108
L	GLU109
L	PHE111
L	GLY135
L	LEU138
L	HOH301

site_id	AF9
Number of Residues	3
Details	binding site for residue SO4 L 203

Chain	Residue
L	THR70
L	GLY72
L	ARG76

site_id	AG1
Number of Residues	4
Details	binding site for residue SO4 L 204

Chain	Residue
L	ARG137
L	HIS141
L	GLN144
L	HIS145

site_id	AG2
Number of Residues	2
Details	binding site for residue SO4 L 205

Chain	Residue
L	ASN124
L	8SP201

Functional Information from PROSITE/UniProt

site_id	PS01080
Number of Residues	19
Details	BH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. LFeSGi.NWGRVVALLgFGY

Chain	Residue	Details
A	LEU118-TYR136

site_id	PS01259
Number of Residues	15
Details	BH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. VgrqLAiIGDDINRR

Chain	Residue	Details
A	VAL74-ARG88

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	168
Details	Motif: {"description":"BH3"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	228
Details	Motif: {"description":"BH1"}

Chain

Residue

Details

247947

PDB entries from 2026-01-21

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