Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004146 | molecular_function | dihydrofolate reductase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0044281 | biological_process | small molecule metabolic process |
| A | 0046452 | biological_process | dihydrofolate metabolic process |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046655 | biological_process | folic acid metabolic process |
| A | 0050661 | molecular_function | NADP binding |
| A | 0070401 | molecular_function | NADP+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue MMV A 301 |
| Chain | Residue |
| A | ILE15 |
| A | LEU67 |
| A | ARG70 |
| A | ILE108 |
| A | TYR114 |
| A | NAP304 |
| A | HOH536 |
| A | HOH544 |
| A | TRP16 |
| A | ILE30 |
| A | ASP37 |
| A | LEU38 |
| A | PHE41 |
| A | LYS42 |
| A | PRO61 |
| A | HIS64 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 302 |
| Chain | Residue |
| A | TRP32 |
| A | ARG33 |
| A | LEU34 |
| A | HOH403 |
| A | HOH501 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 303 |
| Chain | Residue |
| A | HIS168 |
| A | TYR170 |
| A | HOH402 |
| site_id | AC4 |
| Number of Residues | 36 |
| Details | binding site for residue NAP A 304 |
| Chain | Residue |
| A | TRP16 |
| A | ALA17 |
| A | ILE24 |
| A | GLY25 |
| A | ARG26 |
| A | GLY29 |
| A | GLY53 |
| A | ARG54 |
| A | ARG55 |
| A | THR56 |
| A | SER59 |
| A | VAL75 |
| A | THR76 |
| A | ARG77 |
| A | GLN78 |
| A | GLY90 |
| A | ILE108 |
| A | GLY110 |
| A | ALA111 |
| A | GLN112 |
| A | ILE113 |
| A | TYR114 |
| A | MMV301 |
| A | HOH407 |
| A | HOH438 |
| A | HOH460 |
| A | HOH482 |
| A | HOH498 |
| A | HOH510 |
| A | HOH512 |
| A | HOH518 |
| A | HOH520 |
| A | HOH523 |
| A | HOH533 |
| A | HOH559 |
| A | HOH579 |
Functional Information from PROSITE/UniProt
| site_id | PS00075 |
| Number of Residues | 23 |
| Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGrdggIPWrlpe.DlahFkrlT |
| Chain | Residue | Details |
| A | VAL23-THR45 | |
