6UW8

Cryo-EM structure of the human TRPV3 K169A mutant briefly exposed to 2-APB for 3 minutes, determined in lipid nanodisc

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005261	molecular_function	monoatomic cation channel activity
A	0005262	molecular_function	calcium channel activity
A	0005272	molecular_function	sodium channel activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005886	cellular_component	plasma membrane
A	0005929	cellular_component	cilium
A	0006811	biological_process	monoatomic ion transport
A	0006816	biological_process	calcium ion transport
A	0007015	biological_process	actin filament organization
A	0007231	biological_process	osmosensory signaling pathway
A	0009266	biological_process	response to temperature stimulus
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0035725	biological_process	sodium ion transmembrane transport
A	0042636	biological_process	negative regulation of hair cycle
A	0042802	molecular_function	identical protein binding
A	0043235	cellular_component	receptor complex
A	0046872	molecular_function	metal ion binding
A	0055085	biological_process	transmembrane transport
A	0070588	biological_process	calcium ion transmembrane transport
A	0090280	biological_process	positive regulation of calcium ion import
A	0098703	biological_process	calcium ion import across plasma membrane
B	0005216	molecular_function	monoatomic ion channel activity
B	0005261	molecular_function	monoatomic cation channel activity
B	0005262	molecular_function	calcium channel activity
B	0005272	molecular_function	sodium channel activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005764	cellular_component	lysosome
B	0005886	cellular_component	plasma membrane
B	0005929	cellular_component	cilium
B	0006811	biological_process	monoatomic ion transport
B	0006816	biological_process	calcium ion transport
B	0007015	biological_process	actin filament organization
B	0007231	biological_process	osmosensory signaling pathway
B	0009266	biological_process	response to temperature stimulus
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0035725	biological_process	sodium ion transmembrane transport
B	0042636	biological_process	negative regulation of hair cycle
B	0042802	molecular_function	identical protein binding
B	0043235	cellular_component	receptor complex
B	0046872	molecular_function	metal ion binding
B	0055085	biological_process	transmembrane transport
B	0070588	biological_process	calcium ion transmembrane transport
B	0090280	biological_process	positive regulation of calcium ion import
B	0098703	biological_process	calcium ion import across plasma membrane
C	0005216	molecular_function	monoatomic ion channel activity
C	0005261	molecular_function	monoatomic cation channel activity
C	0005262	molecular_function	calcium channel activity
C	0005272	molecular_function	sodium channel activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005764	cellular_component	lysosome
C	0005886	cellular_component	plasma membrane
C	0005929	cellular_component	cilium
C	0006811	biological_process	monoatomic ion transport
C	0006816	biological_process	calcium ion transport
C	0007015	biological_process	actin filament organization
C	0007231	biological_process	osmosensory signaling pathway
C	0009266	biological_process	response to temperature stimulus
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0035725	biological_process	sodium ion transmembrane transport
C	0042636	biological_process	negative regulation of hair cycle
C	0042802	molecular_function	identical protein binding
C	0043235	cellular_component	receptor complex
C	0046872	molecular_function	metal ion binding
C	0055085	biological_process	transmembrane transport
C	0070588	biological_process	calcium ion transmembrane transport
C	0090280	biological_process	positive regulation of calcium ion import
C	0098703	biological_process	calcium ion import across plasma membrane
D	0005216	molecular_function	monoatomic ion channel activity
D	0005261	molecular_function	monoatomic cation channel activity
D	0005262	molecular_function	calcium channel activity
D	0005272	molecular_function	sodium channel activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005764	cellular_component	lysosome
D	0005886	cellular_component	plasma membrane
D	0005929	cellular_component	cilium
D	0006811	biological_process	monoatomic ion transport
D	0006816	biological_process	calcium ion transport
D	0007015	biological_process	actin filament organization
D	0007231	biological_process	osmosensory signaling pathway
D	0009266	biological_process	response to temperature stimulus
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0035725	biological_process	sodium ion transmembrane transport
D	0042636	biological_process	negative regulation of hair cycle
D	0042802	molecular_function	identical protein binding
D	0043235	cellular_component	receptor complex
D	0046872	molecular_function	metal ion binding
D	0055085	biological_process	transmembrane transport
D	0070588	biological_process	calcium ion transmembrane transport
D	0090280	biological_process	positive regulation of calcium ion import
D	0098703	biological_process	calcium ion import across plasma membrane

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	116
Details	Transmembrane: {"description":"Helical; Name=S1","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	112
Details	Transmembrane: {"description":"Helical; Name=S2","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	48
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=S3","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	24
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=S4","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	152
Details	Transmembrane: {"description":"Helical; Name=S5","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	100
Details	Intramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	144
Details	Transmembrane: {"description":"Helical; Name=S6","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	124
Details	Repeat: {"description":"ANK 1","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	112
Details	Repeat: {"description":"ANK 2","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	116
Details	Repeat: {"description":"ANK 3","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	120
Details	Repeat: {"description":"ANK 4","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	128
Details	Repeat: {"description":"ANK 5","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	88
Details	Repeat: {"description":"ANK 6","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	88
Details	Repeat: {"description":"ANK 7","evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37648856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38691614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V6M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---