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6UV2

Crystal structure of the core domain of RNA helicase DDX17 with RNA pri-125a-oligo1

Functional Information from GO Data
ChainGOidnamespacecontents
A0003676molecular_functionnucleic acid binding
A0003724molecular_functionRNA helicase activity
A0005524molecular_functionATP binding
Functional Information from PDB Data
site_idAC1
Number of Residues23
Detailsbinding site for residue ADP A 501
ChainResidue
APHE94
ATHR143
AASP404
AARG432
ASER433
ABEF502
AMG503
AHOH655
AHOH675
AHOH697
AHOH726
APHE112
AHOH741
AHOH743
AHOH790
AHOH800
AGLU114
AGLN119
AGLN137
AGLY139
ASER140
AGLY141
ALYS142

site_idAC2
Number of Residues13
Detailsbinding site for residue BEF A 502
ChainResidue
ATHR138
AGLY139
ALYS142
AGLU247
AGLY402
AARG429
AARG432
AADP501
AMG503
AHOH726
AHOH735
AHOH736
AHOH787

site_idAC3
Number of Residues6
Detailsbinding site for residue MG A 503
ChainResidue
AADP501
ABEF502
AHOH697
AHOH726
AHOH735
AHOH736

site_idAC4
Number of Residues7
Detailsbinding site for residue MG A 504
ChainResidue
AARG130
AASP131
AARG293
AASP294
AMG505
AHOH786
AHOH892

site_idAC5
Number of Residues6
Detailsbinding site for residue MG A 505
ChainResidue
ALYS53
AGLY129
AASP131
AGLN272
AMG504
AHOH786

site_idAC6
Number of Residues5
Detailsbinding site for residue MG A 506
ChainResidue
AASN302
AGLU304
ASER306
AHOH775
AHOH776

Functional Information from PROSITE/UniProt
site_idPS00039
Number of Residues9
DetailsDEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. VLDEADRmL
ChainResidueDetails
AVAL244-LEU252

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00541
ChainResidueDetails
AALA136

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N6-acetyllysine; by EP300 => ECO:0000269|PubMed:20663877
ChainResidueDetails
ALYS42

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:16964243
ChainResidueDetails
ATHR444

site_idSWS_FT_FI4
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS50

site_idSWS_FT_FI5
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS449

226707

PDB entries from 2024-10-30

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