6UV1
Crystal structure of RNA helicase DDX17 in complex of rU10 RNA
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | binding site for residue ADP A 501 |
| Chain | Residue |
| A | PHE94 |
| A | THR143 |
| A | ASP404 |
| A | ARG432 |
| A | BEF502 |
| A | MG503 |
| A | MG504 |
| A | HOH629 |
| A | HOH632 |
| A | HOH681 |
| A | HOH692 |
| A | PHE112 |
| A | HOH694 |
| A | HOH714 |
| A | HOH719 |
| A | HOH784 |
| A | GLU114 |
| A | PRO115 |
| A | GLN119 |
| A | GLY139 |
| A | SER140 |
| A | GLY141 |
| A | LYS142 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue BEF A 502 |
| Chain | Residue |
| A | THR138 |
| A | GLY139 |
| A | LYS142 |
| A | GLU247 |
| A | GLY402 |
| A | ARG429 |
| A | ARG432 |
| A | ADP501 |
| A | MG503 |
| A | HOH746 |
| A | HOH752 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue MG A 503 |
| Chain | Residue |
| A | GLU247 |
| A | ADP501 |
| A | BEF502 |
| A | HOH614 |
| A | HOH681 |
| A | HOH694 |
| A | HOH746 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue MG A 504 |
| Chain | Residue |
| A | ADP501 |
| A | HOH692 |
| A | HOH719 |
| A | HOH792 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue MG A 505 |
| Chain | Residue |
| A | PRO100 |
| A | ASN155 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue MG A 506 |
| Chain | Residue |
| A | MET319 |
| A | GLU320 |
| site_id | AC7 |
| Number of Residues | 22 |
| Details | binding site for residue ADP B 501 |
| Chain | Residue |
| B | PHE94 |
| B | PHE112 |
| B | GLU114 |
| B | GLN119 |
| B | GLY139 |
| B | SER140 |
| B | GLY141 |
| B | LYS142 |
| B | THR143 |
| B | ASP404 |
| B | ARG432 |
| B | SER433 |
| B | BEF502 |
| B | MG503 |
| B | HOH658 |
| B | HOH663 |
| B | HOH674 |
| B | HOH679 |
| B | HOH688 |
| B | HOH709 |
| B | HOH714 |
| B | HOH744 |
| site_id | AC8 |
| Number of Residues | 12 |
| Details | binding site for residue BEF B 502 |
| Chain | Residue |
| B | THR138 |
| B | GLY139 |
| B | LYS142 |
| B | GLU247 |
| B | GLY402 |
| B | ARG429 |
| B | ARG432 |
| B | ADP501 |
| B | MG503 |
| B | HOH679 |
| B | HOH702 |
| B | HOH744 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 503 |
| Chain | Residue |
| B | ADP501 |
| B | BEF502 |
| B | HOH658 |
| B | HOH667 |
| B | HOH679 |
| B | HOH744 |
| site_id | AD1 |
| Number of Residues | 1 |
| Details | binding site for residue MG B 504 |
| Chain | Residue |
| B | ASN155 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue MG B 505 |
| Chain | Residue |
| B | ARG386 |
| B | GLU406 |
| site_id | AD3 |
| Number of Residues | 2 |
| Details | binding site for residue MG C 101 |
| Chain | Residue |
| A | HOH835 |
| C | U6 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue MG D 101 |
| Chain | Residue |
| D | U6 |
| D | U7 |
| D | HOH216 |
Functional Information from PROSITE/UniProt
| site_id | PS00039 |
| Number of Residues | 9 |
| Details | DEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. VLDEADRmL |
| Chain | Residue | Details |
| A | VAL244-LEU252 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 350 |
| Details | Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 294 |
| Details | Domain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 56 |
| Details | Motif: {"description":"Q motif"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Motif: {"description":"DEAD box"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine; by EP300","evidences":[{"source":"PubMed","id":"20663877","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"16964243","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25772364","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
