Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help
SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6UU6

E. coli sigma-S transcription initiation complex with a 4-nt RNA and a UTP ("Old" crystal soaked with UTP, ddCTP, and dinucleotide ApG for 30 minutes)

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
AAA0003677molecular_functionDNA binding
AAA0003899molecular_functionDNA-directed RNA polymerase activity
AAA0006351biological_processDNA-templated transcription
AAA0046983molecular_functionprotein dimerization activity
BBB0003677molecular_functionDNA binding
BBB0003899molecular_functionDNA-directed RNA polymerase activity
BBB0006351biological_processDNA-templated transcription
BBB0046983molecular_functionprotein dimerization activity
CCC0000345cellular_componentcytosolic DNA-directed RNA polymerase complex
CCC0000428cellular_componentDNA-directed RNA polymerase complex
CCC0003677molecular_functionDNA binding
CCC0003899molecular_functionDNA-directed RNA polymerase activity
CCC0005515molecular_functionprotein binding
CCC0005737cellular_componentcytoplasm
CCC0005829cellular_componentcytosol
CCC0006351biological_processDNA-templated transcription
CCC0006352biological_processDNA-templated transcription initiation
CCC0006879biological_processintracellular iron ion homeostasis
CCC0008023cellular_componenttranscription elongation factor complex
CCC0009408biological_processresponse to heat
CCC0016020cellular_componentmembrane
CCC0016740molecular_functiontransferase activity
CCC0016779molecular_functionnucleotidyltransferase activity
CCC0031564biological_processtranscription antitermination
CCC0032549molecular_functionribonucleoside binding
CCC0032784biological_processregulation of DNA-templated transcription elongation
CCC0034062molecular_function5'-3' RNA polymerase activity
CCC0036460biological_processcellular response to cell envelope stress
CCC0042128biological_processnitrate assimilation
CCC0044780biological_processbacterial-type flagellum assembly
CCC0046677biological_processresponse to antibiotic
CCC0048870biological_processcell motility
CCC0071973biological_processbacterial-type flagellum-dependent cell motility
CCC0090605biological_processsubmerged biofilm formation
CCC2000142biological_processregulation of DNA-templated transcription initiation
DDD0000287molecular_functionmagnesium ion binding
DDD0000345cellular_componentcytosolic DNA-directed RNA polymerase complex
DDD0000428cellular_componentDNA-directed RNA polymerase complex
DDD0003677molecular_functionDNA binding
DDD0003899molecular_functionDNA-directed RNA polymerase activity
DDD0005515molecular_functionprotein binding
DDD0005737cellular_componentcytoplasm
DDD0005829cellular_componentcytosol
DDD0006351biological_processDNA-templated transcription
DDD0006352biological_processDNA-templated transcription initiation
DDD0006879biological_processintracellular iron ion homeostasis
DDD0008023cellular_componenttranscription elongation factor complex
DDD0008270molecular_functionzinc ion binding
DDD0009408biological_processresponse to heat
DDD0016020cellular_componentmembrane
DDD0016740molecular_functiontransferase activity
DDD0016779molecular_functionnucleotidyltransferase activity
DDD0031564biological_processtranscription antitermination
DDD0032784biological_processregulation of DNA-templated transcription elongation
DDD0034062molecular_function5'-3' RNA polymerase activity
DDD0036460biological_processcellular response to cell envelope stress
DDD0042128biological_processnitrate assimilation
DDD0044780biological_processbacterial-type flagellum assembly
DDD0046677biological_processresponse to antibiotic
DDD0046872molecular_functionmetal ion binding
DDD0048870biological_processcell motility
DDD0071973biological_processbacterial-type flagellum-dependent cell motility
DDD0090605biological_processsubmerged biofilm formation
DDD2000142biological_processregulation of DNA-templated transcription initiation
EEE0000345cellular_componentcytosolic DNA-directed RNA polymerase complex
EEE0000428cellular_componentDNA-directed RNA polymerase complex
EEE0001000molecular_functionbacterial-type RNA polymerase core enzyme binding
EEE0003677molecular_functionDNA binding
EEE0003899molecular_functionDNA-directed RNA polymerase activity
EEE0005829cellular_componentcytosol
EEE0006351biological_processDNA-templated transcription
EEE0006352biological_processDNA-templated transcription initiation
EEE0006879biological_processintracellular iron ion homeostasis
EEE0008023cellular_componenttranscription elongation factor complex
EEE0009408biological_processresponse to heat
EEE0016740molecular_functiontransferase activity
EEE0016779molecular_functionnucleotidyltransferase activity
EEE0030880cellular_componentRNA polymerase complex
EEE0031564biological_processtranscription antitermination
EEE0032784biological_processregulation of DNA-templated transcription elongation
EEE0034062molecular_function5'-3' RNA polymerase activity
EEE0036460biological_processcellular response to cell envelope stress
EEE0042128biological_processnitrate assimilation
EEE0044780biological_processbacterial-type flagellum assembly
EEE0048870biological_processcell motility
EEE0065003biological_processprotein-containing complex assembly
EEE0071973biological_processbacterial-type flagellum-dependent cell motility
EEE0090605biological_processsubmerged biofilm formation
EEE2000142biological_processregulation of DNA-templated transcription initiation
FFF0000345cellular_componentcytosolic DNA-directed RNA polymerase complex
FFF0000976molecular_functiontranscription cis-regulatory region binding
FFF0001000molecular_functionbacterial-type RNA polymerase core enzyme binding
FFF0003677molecular_functionDNA binding
FFF0003700molecular_functionDNA-binding transcription factor activity
FFF0003899molecular_functionDNA-directed RNA polymerase activity
FFF0005515molecular_functionprotein binding
FFF0005737cellular_componentcytoplasm
FFF0006351biological_processDNA-templated transcription
FFF0006352biological_processDNA-templated transcription initiation
FFF0006355biological_processregulation of DNA-templated transcription
FFF0006950biological_processresponse to stress
FFF0010468biological_processregulation of gene expression
FFF0016987molecular_functionsigma factor activity
FFF0045892biological_processnegative regulation of DNA-templated transcription
FFF1903865cellular_componentsigma factor antagonist complex
FFF2000142biological_processregulation of DNA-templated transcription initiation
Functional Information from PROSITE/UniProt
site_idPS00715
Number of Residues14
DetailsSIGMA70_1 Sigma-70 factors family signature 1. DLIEeGnLGLIrAV
ChainResidueDetails
FFFASP118-VAL131
site_idPS00716
Number of Residues27
DetailsSIGMA70_2 Sigma-70 factors family signature 2. TleDVGreigLTrerVrQIQvegLrrL
ChainResidueDetails
FFFTHR287-LEU313
site_idPS01166
Number of Residues13
DetailsRNA_POL_BETA RNA polymerases beta chain signature. GdKMAGrHGNKGV
ChainResidueDetails
CCCGLY1063-VAL1075
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsRegion: {"description":"Required for interaction with Crp at class II promoters"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"HAMAP-Rule","id":"MF_01321","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues11
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"32871103","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MEX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MEY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"HAMAP-Rule","id":"MF_01322","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18723842","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues19
DetailsDNA binding: {"description":"H-T-H motif","evidences":[{"source":"HAMAP-Rule","id":"MF_00959","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues33
DetailsRegion: {"description":"Sigma-70 factor domain-1"}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues70
DetailsRegion: {"description":"Sigma-70 factor domain-2"}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues75
DetailsRegion: {"description":"Sigma-70 factor domain-3"}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues53
DetailsRegion: {"description":"Sigma-70 factor domain-4"}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues3
DetailsMotif: {"description":"Interaction with polymerase core subunit RpoC"}
ChainResidueDetails

243531

PDB entries from 2025-10-22

PDB statisticsPDBj update infoContact PDBjnumon