6URW

Crystal structure of ricin A chain in complex with inhibitor 4-(2-thienylmethyl)benzoic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0017148	biological_process	negative regulation of translation
A	0030598	molecular_function	rRNA N-glycosylase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue EDO A 301

Chain	Residue
A	ALA118
A	PHE119
A	GLN160
A	EDO321

---

site_id	AC2
Number of Residues	3
Details	binding site for residue EDO A 302

Chain	Residue
A	GLN128
A	DMS323
A	HOH467

---

site_id	AC3
Number of Residues	6
Details	binding site for residue EDO A 303

Chain	Residue
A	VAL38
A	HIS40
A	ILE42
A	PRO43
A	GLN19
A	THR22

---

site_id	AC4
Number of Residues	7
Details	binding site for residue EDO A 304

Chain	Residue
A	GLU61
A	GLU67
A	SER69
A	VAL70
A	THR71
A	ALA86
A	GLY87

---

site_id	AC5
Number of Residues	6
Details	binding site for residue EDO A 305

Chain	Residue
A	ARG134
A	ILE205
A	ASN209
A	HOH402
A	HOH416
A	HOH483

---

site_id	AC6
Number of Residues	4
Details	binding site for residue EDO A 306

Chain	Residue
A	GLN5
A	THR71
A	ARG85
A	PHE108

---

site_id	AC7
Number of Residues	2
Details	binding site for residue EDO A 307

Chain	Residue
A	ARG29
A	HOH455

---

site_id	AC8
Number of Residues	7
Details	binding site for residue EDO A 308

Chain	Residue
A	ASN141
A	GLY142
A	PRO143
A	ASN195
A	ARG196
A	ARG197
A	HOH433

---

site_id	AC9
Number of Residues	3
Details	binding site for residue EDO A 309

Chain	Residue
A	ARG26
A	ARG189
A	HOH403

---

site_id	AD1
Number of Residues	1
Details	binding site for residue EDO A 310

Chain	Residue
A	ARG258

---

site_id	AD2
Number of Residues	5
Details	binding site for residue EDO A 311

Chain	Residue
A	ALA118
A	GLN160
A	PRO162
A	THR163
A	EDO318

---

site_id	AD3
Number of Residues	7
Details	binding site for residue EDO A 312

Chain	Residue
A	ALA118
A	PHE119
A	ARG125
A	PRO162
A	EDO316
A	EDO318
A	HOH408

---

site_id	AD4
Number of Residues	1
Details	binding site for residue EDO A 313

Chain	Residue
A	ASN23

---

site_id	AD5
Number of Residues	4
Details	binding site for residue EDO A 314

Chain	Residue
A	PHE92
A	ARG114
A	THR116
A	HOH409

---

site_id	AD6
Number of Residues	4
Details	binding site for residue EDO A 315

Chain	Residue
A	ARG234
A	ARG234
A	PHE240
A	ILE247

---

site_id	AD7
Number of Residues	3
Details	binding site for residue EDO A 316

Chain	Residue
A	GLY131
A	ASN132
A	EDO312

---

site_id	AD8
Number of Residues	1
Details	binding site for residue EDO A 317

Chain	Residue
A	THR156

---

site_id	AD9
Number of Residues	4
Details	binding site for residue EDO A 318

Chain	Residue
A	ALA118
A	ARG166
A	EDO311
A	EDO312

---

site_id	AE1
Number of Residues	3
Details	binding site for residue EDO A 319

Chain	Residue
A	ASN136
A	GLU138
A	ARG166

---

site_id	AE2
Number of Residues	3
Details	binding site for residue EDO A 320

Chain	Residue
A	PRO3
A	LYS4
A	GLN5

---

site_id	AE3
Number of Residues	4
Details	binding site for residue EDO A 321

Chain	Residue
A	TYR115
A	TYR154
A	GLN160
A	EDO301

---

site_id	AE4
Number of Residues	4
Details	binding site for residue EDO A 322

Chain	Residue
A	GLY212
A	THR216
A	ARG258
A	PRO262

---

site_id	AE5
Number of Residues	5
Details	binding site for residue DMS A 323

Chain	Residue
A	GLN128
A	GLY131
A	ASN132
A	EDO302
A	HOH418

---

site_id	AE6
Number of Residues	7
Details	binding site for residue R7T A 324

Chain	Residue
A	TYR183
A	SER203
A	ARG234
A	ARG235
A	ILE247
A	ILE251
A	HOH421

---

Functional Information from PROSITE/UniProt

site_id	PS00275
Number of Residues	17
Details	SHIGA_RICIN Shiga/ricin ribosomal inactivating toxins active site signature. IqMIsEAARFQyIEgeM

Chain	Residue	Details
A	ILE172-MET188

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"evidences":[{"source":"UniProtKB","id":"P84531","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"8780513","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1OBT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","featureId":"CAR_000080","evidences":[{"source":"PubMed","id":"1368517","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; partial","featureId":"CAR_000081","evidences":[{"source":"PubMed","id":"1368517","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---