6UQU

Serendipitous Discovery of Aryl Boronic Acids as beta-Lactamase Inhibitors

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008800	molecular_function	beta-lactamase activity
A	0016787	molecular_function	hydrolase activity
A	0017001	biological_process	antibiotic catabolic process
A	0030288	cellular_component	outer membrane-bounded periplasmic space
A	0033252	biological_process	regulation of beta-lactamase activity
A	0042597	cellular_component	periplasmic space
A	0046677	biological_process	response to antibiotic

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue PBC A 401

Chain	Residue
A	SER90
A	LEU145
A	TYR177
A	ASN179
A	TYR249
A	GLY344
A	SER345
A	HOH660
A	HOH808

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site_id	AC2
Number of Residues	3
Details	binding site for residue CL A 402

Chain	Residue
A	GLN146
A	PHE147
A	ASN179

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Functional Information from PROSITE/UniProt

site_id	PS00336
Number of Residues	8
Details	BETA_LACTAMASE_C Beta-lactamase class-C active site. FEIGSVSK

Chain	Residue	Details
A	PHE86-LYS93

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Acyl-ester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU10102","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P00811","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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