6UQD
Co-complex of S. pyogenes 10782 streptopain bound with a SuFEx-based optimized small molecule inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0030430 | cellular_component | host cell cytoplasm |
| A | 0034050 | biological_process | symbiont-induced defense-related programmed cell death |
| A | 0035893 | biological_process | obsolete suppression of platelet aggregation in another organism |
| A | 0042783 | biological_process | symbiont-mediated evasion of host immune response |
| A | 0043655 | cellular_component | host extracellular space |
| A | 0044164 | cellular_component | host cell cytosol |
| A | 0052035 | biological_process | obsolete positive regulation by symbiont of host inflammatory response |
| A | 0090729 | molecular_function | toxin activity |
| A | 0140321 | biological_process | symbiont-mediated suppression of host autophagy |
| B | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0006508 | biological_process | proteolysis |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0008234 | molecular_function | cysteine-type peptidase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0030430 | cellular_component | host cell cytoplasm |
| B | 0034050 | biological_process | symbiont-induced defense-related programmed cell death |
| B | 0035893 | biological_process | obsolete suppression of platelet aggregation in another organism |
| B | 0042783 | biological_process | symbiont-mediated evasion of host immune response |
| B | 0043655 | cellular_component | host extracellular space |
| B | 0044164 | cellular_component | host cell cytosol |
| B | 0052035 | biological_process | obsolete positive regulation by symbiont of host inflammatory response |
| B | 0090729 | molecular_function | toxin activity |
| B | 0140321 | biological_process | symbiont-mediated suppression of host autophagy |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue QF4 A 501 |
| Chain | Residue |
| A | GLN162 |
| A | VAL334 |
| A | GLY338 |
| A | GLY339 |
| A | HIS340 |
| A | HOH663 |
| A | CYS192 |
| A | SER279 |
| A | SER280 |
| A | GLY281 |
| A | SER282 |
| A | ALA283 |
| A | GLN332 |
| A | GLY333 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | binding site for residue QF4 B 501 |
| Chain | Residue |
| B | GLN162 |
| B | CYS192 |
| B | SER279 |
| B | SER280 |
| B | GLY281 |
| B | SER282 |
| B | ALA283 |
| B | GLN332 |
| B | GLY333 |
| B | VAL334 |
| B | GLY338 |
| B | GLY339 |
| B | HIS340 |
| B | HOH664 |
| B | HOH678 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"19712682","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22645124","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8675287","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"19712682","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22645124","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4D8E","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"covalent","evidences":[{"source":"PubMed","id":"19712682","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22645124","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2UZJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4D8E","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22645124","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4D8I","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Cysteine methyl disulfide; in zymogen form","evidences":[{"source":"PubMed","id":"6381494","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 22 |
| Details | Region: {"description":"C-terminal active site loop","evidences":[{"source":"PubMed","id":"22645124","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
