Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6UPV

Alpha-E-catenin ABD-F-actin complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001725	cellular_component	stress fiber
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0005865	cellular_component	striated muscle thin filament
A	0005884	cellular_component	actin filament
A	0016787	molecular_function	hydrolase activity
A	0030240	biological_process	skeletal muscle thin filament assembly
A	0048741	biological_process	skeletal muscle fiber development
B	0001725	cellular_component	stress fiber
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005865	cellular_component	striated muscle thin filament
B	0005884	cellular_component	actin filament
B	0016787	molecular_function	hydrolase activity
B	0030240	biological_process	skeletal muscle thin filament assembly
B	0048741	biological_process	skeletal muscle fiber development
C	0001725	cellular_component	stress fiber
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005856	cellular_component	cytoskeleton
C	0005865	cellular_component	striated muscle thin filament
C	0005884	cellular_component	actin filament
C	0016787	molecular_function	hydrolase activity
C	0030240	biological_process	skeletal muscle thin filament assembly
C	0048741	biological_process	skeletal muscle fiber development
D	0001725	cellular_component	stress fiber
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005856	cellular_component	cytoskeleton
D	0005865	cellular_component	striated muscle thin filament
D	0005884	cellular_component	actin filament
D	0016787	molecular_function	hydrolase activity
D	0030240	biological_process	skeletal muscle thin filament assembly
D	0048741	biological_process	skeletal muscle fiber development
E	0001725	cellular_component	stress fiber
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005856	cellular_component	cytoskeleton
E	0005865	cellular_component	striated muscle thin filament
E	0005884	cellular_component	actin filament
E	0016787	molecular_function	hydrolase activity
E	0030240	biological_process	skeletal muscle thin filament assembly
E	0048741	biological_process	skeletal muscle fiber development
L	0001541	biological_process	ovarian follicle development
L	0001669	cellular_component	acrosomal vesicle
L	0003723	molecular_function	RNA binding
L	0005198	molecular_function	structural molecule activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0005856	cellular_component	cytoskeleton
L	0005886	cellular_component	plasma membrane
L	0005911	cellular_component	cell-cell junction
L	0005912	cellular_component	adherens junction
L	0005915	cellular_component	zonula adherens
L	0005925	cellular_component	focal adhesion
L	0006915	biological_process	apoptotic process
L	0007155	biological_process	cell adhesion
L	0007163	biological_process	establishment or maintenance of cell polarity
L	0007224	biological_process	smoothened signaling pathway
L	0007229	biological_process	integrin-mediated signaling pathway
L	0007405	biological_process	neuroblast proliferation
L	0007406	biological_process	negative regulation of neuroblast proliferation
L	0008013	molecular_function	beta-catenin binding
L	0008104	biological_process	protein localization
L	0008584	biological_process	male gonad development
L	0014070	biological_process	response to organic cyclic compound
L	0014704	cellular_component	intercalated disc
L	0015629	cellular_component	actin cytoskeleton
L	0016264	biological_process	gap junction assembly
L	0016342	cellular_component	catenin complex
L	0016477	biological_process	cell migration
L	0016600	cellular_component	flotillin complex
L	0017166	molecular_function	vinculin binding
L	0030027	cellular_component	lamellipodium
L	0030054	cellular_component	cell junction
L	0031103	biological_process	axon regeneration
L	0042127	biological_process	regulation of cell population proliferation
L	0042475	biological_process	odontogenesis of dentin-containing tooth
L	0042802	molecular_function	identical protein binding
L	0043066	biological_process	negative regulation of apoptotic process
L	0043231	cellular_component	intracellular membrane-bounded organelle
L	0043297	biological_process	apical junction assembly
L	0043627	biological_process	response to estrogen
L	0044877	molecular_function	protein-containing complex binding
L	0045295	molecular_function	gamma-catenin binding
L	0045296	molecular_function	cadherin binding
L	0045880	biological_process	positive regulation of smoothened signaling pathway
L	0048870	biological_process	cell motility
L	0051015	molecular_function	actin filament binding
L	0070161	cellular_component	anchoring junction
L	0071681	biological_process	cellular response to indole-3-methanol
L	0090136	biological_process	epithelial cell-cell adhesion
L	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
L	0098609	biological_process	cell-cell adhesion
L	1900181	biological_process	negative regulation of protein localization to nucleus
L	2000146	biological_process	negative regulation of cell motility
L	2001045	biological_process	negative regulation of integrin-mediated signaling pathway
L	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
L	2001241	biological_process	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
M	0001541	biological_process	ovarian follicle development
M	0001669	cellular_component	acrosomal vesicle
M	0003723	molecular_function	RNA binding
M	0005198	molecular_function	structural molecule activity
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0005856	cellular_component	cytoskeleton
M	0005886	cellular_component	plasma membrane
M	0005911	cellular_component	cell-cell junction
M	0005912	cellular_component	adherens junction
M	0005915	cellular_component	zonula adherens
M	0005925	cellular_component	focal adhesion
M	0006915	biological_process	apoptotic process
M	0007155	biological_process	cell adhesion
M	0007163	biological_process	establishment or maintenance of cell polarity
M	0007224	biological_process	smoothened signaling pathway
M	0007229	biological_process	integrin-mediated signaling pathway
M	0007405	biological_process	neuroblast proliferation
M	0007406	biological_process	negative regulation of neuroblast proliferation
M	0008013	molecular_function	beta-catenin binding
M	0008104	biological_process	protein localization
M	0008584	biological_process	male gonad development
M	0014070	biological_process	response to organic cyclic compound
M	0014704	cellular_component	intercalated disc
M	0015629	cellular_component	actin cytoskeleton
M	0016264	biological_process	gap junction assembly
M	0016342	cellular_component	catenin complex
M	0016477	biological_process	cell migration
M	0016600	cellular_component	flotillin complex
M	0017166	molecular_function	vinculin binding
M	0030027	cellular_component	lamellipodium
M	0030054	cellular_component	cell junction
M	0031103	biological_process	axon regeneration
M	0042127	biological_process	regulation of cell population proliferation
M	0042475	biological_process	odontogenesis of dentin-containing tooth
M	0042802	molecular_function	identical protein binding
M	0043066	biological_process	negative regulation of apoptotic process
M	0043231	cellular_component	intracellular membrane-bounded organelle
M	0043297	biological_process	apical junction assembly
M	0043627	biological_process	response to estrogen
M	0044877	molecular_function	protein-containing complex binding
M	0045295	molecular_function	gamma-catenin binding
M	0045296	molecular_function	cadherin binding
M	0045880	biological_process	positive regulation of smoothened signaling pathway
M	0048870	biological_process	cell motility
M	0051015	molecular_function	actin filament binding
M	0070161	cellular_component	anchoring junction
M	0071681	biological_process	cellular response to indole-3-methanol
M	0090136	biological_process	epithelial cell-cell adhesion
M	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
M	0098609	biological_process	cell-cell adhesion
M	1900181	biological_process	negative regulation of protein localization to nucleus
M	2000146	biological_process	negative regulation of cell motility
M	2001045	biological_process	negative regulation of integrin-mediated signaling pathway
M	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
M	2001241	biological_process	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue ADP A 401

Chain	Residue
A	GLY13
A	TYR306
A	MG402
A	SER14
A	LEU16
A	LYS18
A	ASP157
A	GLY182
A	LYS213
A	GLY302
A	THR303

site_id	AC2
Number of Residues	2
Details	binding site for residue MG A 402

Chain	Residue
A	GLN137
A	ADP401

site_id	AC3
Number of Residues	13
Details	binding site for residue ADP B 401

Chain	Residue
B	GLY13
B	SER14
B	LEU16
B	LYS18
B	GLY156
B	ASP157
B	GLY182
B	LYS213
B	GLU214
B	GLY302
B	TYR306
B	LYS336
B	MG402

site_id	AC4
Number of Residues	2
Details	binding site for residue MG B 402

Chain	Residue
B	GLN137
B	ADP401

site_id	AC5
Number of Residues	13
Details	binding site for residue ADP C 401

Chain	Residue
C	GLY13
C	SER14
C	GLY15
C	LEU16
C	LYS18
C	GLY156
C	ASP157
C	LYS213
C	GLU214
C	GLY302
C	TYR306
C	LYS336
C	MG402

site_id	AC6
Number of Residues	2
Details	binding site for residue MG C 402

Chain	Residue
C	GLN137
C	ADP401

site_id	AC7
Number of Residues	11
Details	binding site for residue ADP D 401

Chain	Residue
D	GLY13
D	SER14
D	LEU16
D	LYS18
D	ASP157
D	LYS213
D	GLY301
D	GLY302
D	TYR306
D	LYS336
D	MG402

site_id	AC8
Number of Residues	2
Details	binding site for residue MG D 402

Chain	Residue
D	GLN137
D	ADP401

site_id	AC9
Number of Residues	12
Details	binding site for residue ADP E 401

Chain	Residue
E	GLY13
E	SER14
E	LEU16
E	LYS18
E	ASP157
E	LYS213
E	GLU214
E	GLY301
E	GLY302
E	TYR306
E	LYS336
E	MG402

site_id	AD1
Number of Residues	2
Details	binding site for residue MG E 402

Chain	Residue
E	GLN137
E	ADP401

Functional Information from PROSITE/UniProt

site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQs.KRG

Chain	Residue	Details
A	TYR53-GLY63

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WITKqEYDE

Chain	Residue	Details
A	TRP356-GLU364

site_id	PS00663
Number of Residues	21
Details	VINCULIN_1 Vinculin family talin-binding region signature. KaLkpeVdkLnimaakRQQEL

Chain	Residue	Details
M	LYS178-LEU198

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR

Chain	Residue	Details
A	LEU104-ARG116

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	MOD_RES: N-acetylaspartate; in Actin, alpha skeletal muscle => ECO:0000269\|PubMed:456601

Chain	Residue	Details
A	ASP1
B	ASP1
C	ASP1
D	ASP1
E	ASP1

site_id	SWS_FT_FI2
Number of Residues	10
Details	MOD_RES: Methionine (R)-sulfoxide => ECO:0000250\|UniProtKB:P68134

Chain	Residue	Details
A	MET44
E	MET47
A	MET47
B	MET44
B	MET47
C	MET44
C	MET47
D	MET44
D	MET47
E	MET44

site_id	SWS_FT_FI3
Number of Residues	5
Details	MOD_RES: Tele-methylhistidine => ECO:0000269\|PubMed:12356759, ECO:0007744\|PDB:1MDU

Chain	Residue	Details
A	HIC73
B	HIC73
C	HIC73
D	HIC73
E	HIC73

site_id	SWS_FT_FI4
Number of Residues	5
Details	MOD_RES: N6-methyllysine => ECO:0000250\|UniProtKB:P68133

Chain	Residue	Details
A	LYS84
B	LYS84
C	LYS84
D	LYS84
E	LYS84

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:18318008

Chain	Residue	Details
M	THR645
L	THR645

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphoserine; by CK1 => ECO:0000269\|PubMed:25653389, ECO:0007744\|PubMed:17487921, ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:21406692

Chain	Residue	Details
M	SER652
L	SER652

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphoserine; by CK1 => ECO:0000269\|PubMed:25653389

Chain	Residue	Details
M	SER655
L	SER655

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by CK1 => ECO:0000269\|PubMed:25653389

Chain	Residue	Details
M	THR658
L	THR658

site_id	SWS_FT_FI9
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
M	LYS57
M	LYS797
L	LYS57
L	LYS797

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)