6UP2

Crystal structure of the murine DHX36 helicase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0005524	molecular_function	ATP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue GOL A 1001

Chain	Residue
A	ARG639
A	LEU640
A	LYS729
A	ARG736
A	TRP774
A	GLU775
A	PHE777
A	CL1002
A	HOH1209

---

site_id	AC2
Number of Residues	3
Details	binding site for residue CL A 1002

Chain	Residue
A	ARG736
A	GLU775
A	GOL1001

---

Functional Information from PROSITE/UniProt

site_id	PS00690
Number of Residues	10
Details	DEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. ShIVLDEIHE

Chain	Residue	Details
A	SER321-GLU330

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	170
Details	Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	170
Details	Domain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	211
Details	Region: {"description":"Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure","evidences":[{"source":"UniProtKB","id":"Q05B79","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	69
Details	Region: {"description":"WH domain","evidences":[{"source":"UniProtKB","id":"Q05B79","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	64
Details	Region: {"description":"OB-fold-like subdomains","evidences":[{"source":"UniProtKB","id":"Q05B79","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	Motif: {"description":"DEAH box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	11
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"source":"UniProtKB","id":"Q9H2U1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	11
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q05B79","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9H2U1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9H2U1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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