6UMS
Crystal structure of MavC in complex with its substrate mimic in C222(1) space group
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| C | 0000151 | cellular_component | ubiquitin ligase complex |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0000209 | biological_process | protein polyubiquitination |
| C | 0000724 | biological_process | double-strand break repair via homologous recombination |
| C | 0000729 | biological_process | DNA double-strand break processing |
| C | 0003723 | molecular_function | RNA binding |
| C | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005654 | cellular_component | nucleoplasm |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006281 | biological_process | DNA repair |
| C | 0006282 | biological_process | regulation of DNA repair |
| C | 0006301 | biological_process | postreplication repair |
| C | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| C | 0006974 | biological_process | DNA damage response |
| C | 0016567 | biological_process | protein ubiquitination |
| C | 0016740 | molecular_function | transferase activity |
| C | 0019787 | molecular_function | ubiquitin-like protein transferase activity |
| C | 0031371 | cellular_component | ubiquitin conjugating enzyme complex |
| C | 0031372 | cellular_component | UBC13-MMS2 complex |
| C | 0031625 | molecular_function | ubiquitin protein ligase binding |
| C | 0032991 | cellular_component | protein-containing complex |
| C | 0033182 | biological_process | obsolete regulation of histone ubiquitination |
| C | 0035370 | cellular_component | UBC13-UEV1A complex |
| C | 0043123 | biological_process | positive regulation of canonical NF-kappaB signal transduction |
| C | 0043130 | molecular_function | ubiquitin binding |
| C | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
| C | 0045739 | biological_process | positive regulation of DNA repair |
| C | 0050852 | biological_process | T cell receptor signaling pathway |
| C | 0051092 | biological_process | positive regulation of NF-kappaB transcription factor activity |
| C | 0061631 | molecular_function | ubiquitin conjugating enzyme activity |
| C | 0070062 | cellular_component | extracellular exosome |
| C | 0070534 | biological_process | protein K63-linked ubiquitination |
| C | 0097027 | molecular_function | ubiquitin-protein transferase activator activity |
| C | 0140374 | biological_process | antiviral innate immune response |
| C | 1902523 | biological_process | positive regulation of protein K63-linked ubiquitination |
| C | 1902533 | biological_process | positive regulation of intracellular signal transduction |
| C | 1904262 | biological_process | negative regulation of TORC1 signaling |
| C | 2000781 | biological_process | positive regulation of double-strand break repair |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | SITE: Interacts with activating enzyme |
| Chain | Residue | Details |
| E | ARG54 | |
| E | ARG72 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | SITE: Essential for function |
| Chain | Residue | Details |
| E | HIS68 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291 |
| Chain | Residue | Details |
| E | SER65 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457 |
| Chain | Residue | Details |
| E | THR66 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: ADP-ribosylglycine => ECO:0000269|PubMed:28525742 |
| Chain | Residue | Details |
| E | CYS76 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603 |
| Chain | Residue | Details |
| E | LYS6 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) |
| Chain | Residue | Details |
| E | CYS76 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 |
| Chain | Residue | Details |
| E | LYS11 | |
| E | LYS48 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860 |
| Chain | Residue | Details |
| E | LYS27 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127 |
| Chain | Residue | Details |
| E | LYS29 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577 |
| Chain | Residue | Details |
| E | LYS33 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106 |
| Chain | Residue | Details |
| E | LYS63 |
