Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
| A | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
| A | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
| B | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
| B | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue QAG A 601 |
| Chain | Residue |
| A | LEU100 |
| A | PRO236 |
| A | TYR318 |
| B | GLU138 |
| B | HOH647 |
| A | LYS101 |
| A | LYS103 |
| A | TYR181 |
| A | TYR188 |
| A | PHE227 |
| A | TRP229 |
| A | LEU234 |
| A | HIS235 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 602 |
| Chain | Residue |
| A | LYS73 |
| A | TYR146 |
| A | PRO150 |
| A | GLN151 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 603 |
| Chain | Residue |
| A | LYS476 |
| A | SER515 |
| A | GLU516 |
| A | LEU517 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 604 |
| Chain | Residue |
| A | LYS331 |
| A | GLY333 |
| A | GLN334 |
| A | LYS512 |
| A | HOH728 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 605 |
| Chain | Residue |
| A | ARG277 |
| A | GLN278 |
| A | LYS281 |
| A | HOH714 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 606 |
| Chain | Residue |
| A | THR473 |
| A | ASN474 |
| A | GLN475 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 607 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 608 |
| Chain | Residue |
| A | LEU425 |
| A | TRP426 |
| A | TYR427 |
| A | GLN509 |
| A | HOH805 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 609 |
| Chain | Residue |
| A | GLN161 |
| A | ILE180 |
| A | TYR181 |
| A | GLN182 |
| B | GLU138 |
| B | THR139 |
| B | PRO140 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 610 |
| Chain | Residue |
| A | GLU6 |
| A | VAL8 |
| A | SER163 |
| A | HOH830 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue MG A 611 |
| Chain | Residue |
| A | ASP443 |
| A | ASP498 |
| A | ASP549 |
| A | HOH743 |
| A | HOH760 |
| A | HOH827 |
| A | HOH831 |
| site_id | AD3 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 B 501 |
| Chain | Residue |
| B | HIS235 |
| B | TRP239 |
| site_id | AD4 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 B 502 |
| Chain | Residue |
| A | THR403 |
| A | GLU404 |
| A | TYR405 |
| B | LYS331 |
| B | GLN332 |
| B | GLY333 |
| B | LYS424 |
| B | HOH682 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 503 |
| Chain | Residue |
| A | LYS104 |
| B | PRO97 |
| B | ALA98 |
| B | GLY99 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 504 |
| Chain | Residue |
| B | TRP24 |
| B | GLU399 |
| B | TRP402 |
| B | THR403 |
| B | HOH601 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | BINDING: |
| Chain | Residue | Details |
| B | ASP110 | |
| B | ASP185 | |
| B | ASP186 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | SITE: Essential for RT p66/p51 heterodimerization |
| Chain | Residue | Details |
| B | TRP401 | |
| B | TRP414 | |
| A | ASP498 | |
| A | ASP549 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | SITE: Essential for RT p66/p51 heterodimerization |
| Chain | Residue | Details |
| A | TRP401 | |
| A | TRP414 | |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by viral protease; partial |
| Chain | Residue | Details |
| A | PHE440 | |
