6UJZ

HIV-1 wild-type reverse transcriptase-DNA complex with (+)-FTC-TP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003964	molecular_function	RNA-directed DNA polymerase activity
A	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
A	0006278	biological_process	RNA-templated DNA biosynthetic process
B	0003964	molecular_function	RNA-directed DNA polymerase activity
B	0006278	biological_process	RNA-templated DNA biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue SO4 A 601

Chain	Residue
A	ARG206
A	GLY436
A	ASN460
A	ARG461
A	HOH701
B	ALA288

---

site_id	AC2
Number of Residues	2
Details	binding site for residue SO4 A 602

Chain	Residue
A	GLN340
B	THR200

---

site_id	AC3
Number of Residues	4
Details	binding site for residue MG A 603

Chain	Residue
A	VAL111
A	ASP185
A	N8G604
A	ASP110

---

site_id	AC4
Number of Residues	16
Details	binding site for residue N8G A 604

Chain	Residue
A	LYS65
A	LYS70
A	ARG72
A	ASP110
A	VAL111
A	GLY112
A	ASP113
A	ALA114
A	TYR115
A	GLN151
A	ASP185
A	LYS220
A	MG603
P	DOC822
T	DG705
T	DG706

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	123
Details	Domain: {"description":"RNase H type-1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00408","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Region: {"description":"RT 'primer grip'","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	32
Details	Motif: {"description":"Tryptophan repeat motif","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12206668","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Site: {"description":"Essential for RT p66/p51 heterodimerization","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Site: {"description":"Cleavage; by viral protease; partial","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues
Details	M-CSA 175

Chain

Residue

Details

---