6UJI

Low resolution crystal structure (5.5 A) of the anthrax toxin protective antigen heptamer prepore D425A mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0051260	biological_process	protein homooligomerization
B	0005576	cellular_component	extracellular region
B	0051260	biological_process	protein homooligomerization
C	0005576	cellular_component	extracellular region
C	0051260	biological_process	protein homooligomerization
D	0005576	cellular_component	extracellular region
D	0051260	biological_process	protein homooligomerization
E	0005576	cellular_component	extracellular region
E	0051260	biological_process	protein homooligomerization
F	0005576	cellular_component	extracellular region
F	0051260	biological_process	protein homooligomerization
G	0005576	cellular_component	extracellular region
G	0051260	biological_process	protein homooligomerization
H	0005576	cellular_component	extracellular region
H	0051260	biological_process	protein homooligomerization
I	0005576	cellular_component	extracellular region
I	0051260	biological_process	protein homooligomerization
J	0005576	cellular_component	extracellular region
J	0051260	biological_process	protein homooligomerization
K	0005576	cellular_component	extracellular region
K	0051260	biological_process	protein homooligomerization
L	0005576	cellular_component	extracellular region
L	0051260	biological_process	protein homooligomerization
M	0005576	cellular_component	extracellular region
M	0051260	biological_process	protein homooligomerization
N	0005576	cellular_component	extracellular region
N	0051260	biological_process	protein homooligomerization

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	73
Details	Transmembrane: {"description":"Beta stranded","evidences":[{"source":"PubMed","id":"25778700","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32047164","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6PSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	112
Details	Region: {"description":"Alpha-clamp","evidences":[{"source":"PubMed","id":"21037566","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1498
Details	Region: {"description":"Domain 3, heptamerization","evidences":[{"source":"PubMed","id":"9039918","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	42
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15243628","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15326297","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21037566","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25778700","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32047164","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9039918","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ACC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3J9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6PSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15243628","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15326297","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21037566","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25778700","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32047164","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9039918","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ACC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3J9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6PSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15326297","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21037566","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25778700","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32047164","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ACC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3J9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6PSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	28
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15243628","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15326297","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21037566","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25778700","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32047164","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ACC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3J9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6PSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15243628","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15326297","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21037566","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32047164","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ACC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6PSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	56
Details	Site: {"description":"Alpha-clamp","evidences":[{"source":"PubMed","id":"21037566","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	5
Details	Site: {"description":"Cleavage; by chymotrypsin; required for translocation of LF and EF","evidences":[{"source":"PubMed","id":"7961869","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	695
Details	Region: {"description":"Domain 4, binding to the receptor","evidences":[{"source":"PubMed","id":"9039918","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	11
Details	Site: {"description":"Essential for binding to cell receptor","evidences":[{"source":"PubMed","id":"12771151","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---