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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6UIX

Cryo-EM structure of human CALHM2 gap junction

Functional Information from GO Data
ChainGOidnamespacecontents
A0005261molecular_functionmonoatomic cation channel activity
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0034220biological_processmonoatomic ion transmembrane transport
A0043065biological_processpositive regulation of apoptotic process
A0048167biological_processregulation of synaptic plasticity
A0070509biological_processcalcium ion import
A0098655biological_processmonoatomic cation transmembrane transport
A1903978biological_processregulation of microglial cell activation
A1904669biological_processATP export
B0005261molecular_functionmonoatomic cation channel activity
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0034220biological_processmonoatomic ion transmembrane transport
B0043065biological_processpositive regulation of apoptotic process
B0048167biological_processregulation of synaptic plasticity
B0070509biological_processcalcium ion import
B0098655biological_processmonoatomic cation transmembrane transport
B1903978biological_processregulation of microglial cell activation
B1904669biological_processATP export
C0005261molecular_functionmonoatomic cation channel activity
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0034220biological_processmonoatomic ion transmembrane transport
C0043065biological_processpositive regulation of apoptotic process
C0048167biological_processregulation of synaptic plasticity
C0070509biological_processcalcium ion import
C0098655biological_processmonoatomic cation transmembrane transport
C1903978biological_processregulation of microglial cell activation
C1904669biological_processATP export
D0005261molecular_functionmonoatomic cation channel activity
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0034220biological_processmonoatomic ion transmembrane transport
D0043065biological_processpositive regulation of apoptotic process
D0048167biological_processregulation of synaptic plasticity
D0070509biological_processcalcium ion import
D0098655biological_processmonoatomic cation transmembrane transport
D1903978biological_processregulation of microglial cell activation
D1904669biological_processATP export
E0005261molecular_functionmonoatomic cation channel activity
E0005886cellular_componentplasma membrane
E0006811biological_processmonoatomic ion transport
E0034220biological_processmonoatomic ion transmembrane transport
E0043065biological_processpositive regulation of apoptotic process
E0048167biological_processregulation of synaptic plasticity
E0070509biological_processcalcium ion import
E0098655biological_processmonoatomic cation transmembrane transport
E1903978biological_processregulation of microglial cell activation
E1904669biological_processATP export
F0005261molecular_functionmonoatomic cation channel activity
F0005886cellular_componentplasma membrane
F0006811biological_processmonoatomic ion transport
F0034220biological_processmonoatomic ion transmembrane transport
F0043065biological_processpositive regulation of apoptotic process
F0048167biological_processregulation of synaptic plasticity
F0070509biological_processcalcium ion import
F0098655biological_processmonoatomic cation transmembrane transport
F1903978biological_processregulation of microglial cell activation
F1904669biological_processATP export
G0005261molecular_functionmonoatomic cation channel activity
G0005886cellular_componentplasma membrane
G0006811biological_processmonoatomic ion transport
G0034220biological_processmonoatomic ion transmembrane transport
G0043065biological_processpositive regulation of apoptotic process
G0048167biological_processregulation of synaptic plasticity
G0070509biological_processcalcium ion import
G0098655biological_processmonoatomic cation transmembrane transport
G1903978biological_processregulation of microglial cell activation
G1904669biological_processATP export
H0005261molecular_functionmonoatomic cation channel activity
H0005886cellular_componentplasma membrane
H0006811biological_processmonoatomic ion transport
H0034220biological_processmonoatomic ion transmembrane transport
H0043065biological_processpositive regulation of apoptotic process
H0048167biological_processregulation of synaptic plasticity
H0070509biological_processcalcium ion import
H0098655biological_processmonoatomic cation transmembrane transport
H1903978biological_processregulation of microglial cell activation
H1904669biological_processATP export
I0005261molecular_functionmonoatomic cation channel activity
I0005886cellular_componentplasma membrane
I0006811biological_processmonoatomic ion transport
I0034220biological_processmonoatomic ion transmembrane transport
I0043065biological_processpositive regulation of apoptotic process
I0048167biological_processregulation of synaptic plasticity
I0070509biological_processcalcium ion import
I0098655biological_processmonoatomic cation transmembrane transport
I1903978biological_processregulation of microglial cell activation
I1904669biological_processATP export
J0005261molecular_functionmonoatomic cation channel activity
J0005886cellular_componentplasma membrane
J0006811biological_processmonoatomic ion transport
J0034220biological_processmonoatomic ion transmembrane transport
J0043065biological_processpositive regulation of apoptotic process
J0048167biological_processregulation of synaptic plasticity
J0070509biological_processcalcium ion import
J0098655biological_processmonoatomic cation transmembrane transport
J1903978biological_processregulation of microglial cell activation
J1904669biological_processATP export
K0005261molecular_functionmonoatomic cation channel activity
K0005886cellular_componentplasma membrane
K0006811biological_processmonoatomic ion transport
K0034220biological_processmonoatomic ion transmembrane transport
K0043065biological_processpositive regulation of apoptotic process
K0048167biological_processregulation of synaptic plasticity
K0070509biological_processcalcium ion import
K0098655biological_processmonoatomic cation transmembrane transport
K1903978biological_processregulation of microglial cell activation
K1904669biological_processATP export
L0005261molecular_functionmonoatomic cation channel activity
L0005886cellular_componentplasma membrane
L0006811biological_processmonoatomic ion transport
L0034220biological_processmonoatomic ion transmembrane transport
L0043065biological_processpositive regulation of apoptotic process
L0048167biological_processregulation of synaptic plasticity
L0070509biological_processcalcium ion import
L0098655biological_processmonoatomic cation transmembrane transport
L1903978biological_processregulation of microglial cell activation
L1904669biological_processATP export
M0005261molecular_functionmonoatomic cation channel activity
M0005886cellular_componentplasma membrane
M0006811biological_processmonoatomic ion transport
M0034220biological_processmonoatomic ion transmembrane transport
M0043065biological_processpositive regulation of apoptotic process
M0048167biological_processregulation of synaptic plasticity
M0070509biological_processcalcium ion import
M0098655biological_processmonoatomic cation transmembrane transport
M1903978biological_processregulation of microglial cell activation
M1904669biological_processATP export
N0005261molecular_functionmonoatomic cation channel activity
N0005886cellular_componentplasma membrane
N0006811biological_processmonoatomic ion transport
N0034220biological_processmonoatomic ion transmembrane transport
N0043065biological_processpositive regulation of apoptotic process
N0048167biological_processregulation of synaptic plasticity
N0070509biological_processcalcium ion import
N0098655biological_processmonoatomic cation transmembrane transport
N1903978biological_processregulation of microglial cell activation
N1904669biological_processATP export
O0005261molecular_functionmonoatomic cation channel activity
O0005886cellular_componentplasma membrane
O0006811biological_processmonoatomic ion transport
O0034220biological_processmonoatomic ion transmembrane transport
O0043065biological_processpositive regulation of apoptotic process
O0048167biological_processregulation of synaptic plasticity
O0070509biological_processcalcium ion import
O0098655biological_processmonoatomic cation transmembrane transport
O1903978biological_processregulation of microglial cell activation
O1904669biological_processATP export
P0005261molecular_functionmonoatomic cation channel activity
P0005886cellular_componentplasma membrane
P0006811biological_processmonoatomic ion transport
P0034220biological_processmonoatomic ion transmembrane transport
P0043065biological_processpositive regulation of apoptotic process
P0048167biological_processregulation of synaptic plasticity
P0070509biological_processcalcium ion import
P0098655biological_processmonoatomic cation transmembrane transport
P1903978biological_processregulation of microglial cell activation
P1904669biological_processATP export
Q0005261molecular_functionmonoatomic cation channel activity
Q0005886cellular_componentplasma membrane
Q0006811biological_processmonoatomic ion transport
Q0034220biological_processmonoatomic ion transmembrane transport
Q0043065biological_processpositive regulation of apoptotic process
Q0048167biological_processregulation of synaptic plasticity
Q0070509biological_processcalcium ion import
Q0098655biological_processmonoatomic cation transmembrane transport
Q1903978biological_processregulation of microglial cell activation
Q1904669biological_processATP export
R0005261molecular_functionmonoatomic cation channel activity
R0005886cellular_componentplasma membrane
R0006811biological_processmonoatomic ion transport
R0034220biological_processmonoatomic ion transmembrane transport
R0043065biological_processpositive regulation of apoptotic process
R0048167biological_processregulation of synaptic plasticity
R0070509biological_processcalcium ion import
R0098655biological_processmonoatomic cation transmembrane transport
R1903978biological_processregulation of microglial cell activation
R1904669biological_processATP export
S0005261molecular_functionmonoatomic cation channel activity
S0005886cellular_componentplasma membrane
S0006811biological_processmonoatomic ion transport
S0034220biological_processmonoatomic ion transmembrane transport
S0043065biological_processpositive regulation of apoptotic process
S0048167biological_processregulation of synaptic plasticity
S0070509biological_processcalcium ion import
S0098655biological_processmonoatomic cation transmembrane transport
S1903978biological_processregulation of microglial cell activation
S1904669biological_processATP export
T0005261molecular_functionmonoatomic cation channel activity
T0005886cellular_componentplasma membrane
T0006811biological_processmonoatomic ion transport
T0034220biological_processmonoatomic ion transmembrane transport
T0043065biological_processpositive regulation of apoptotic process
T0048167biological_processregulation of synaptic plasticity
T0070509biological_processcalcium ion import
T0098655biological_processmonoatomic cation transmembrane transport
T1903978biological_processregulation of microglial cell activation
T1904669biological_processATP export
U0005261molecular_functionmonoatomic cation channel activity
U0005886cellular_componentplasma membrane
U0006811biological_processmonoatomic ion transport
U0034220biological_processmonoatomic ion transmembrane transport
U0043065biological_processpositive regulation of apoptotic process
U0048167biological_processregulation of synaptic plasticity
U0070509biological_processcalcium ion import
U0098655biological_processmonoatomic cation transmembrane transport
U1903978biological_processregulation of microglial cell activation
U1904669biological_processATP export
V0005261molecular_functionmonoatomic cation channel activity
V0005886cellular_componentplasma membrane
V0006811biological_processmonoatomic ion transport
V0034220biological_processmonoatomic ion transmembrane transport
V0043065biological_processpositive regulation of apoptotic process
V0048167biological_processregulation of synaptic plasticity
V0070509biological_processcalcium ion import
V0098655biological_processmonoatomic cation transmembrane transport
V1903978biological_processregulation of microglial cell activation
V1904669biological_processATP export
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1188
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues506
DetailsTransmembrane: {"description":"Helical; Name=S2","evidences":[{"source":"PubMed","id":"31776515","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6UIV","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues528
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues660
DetailsTransmembrane: {"description":"Helical; Name=S3","evidences":[{"source":"PubMed","id":"31776515","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6UIV","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues572
DetailsTransmembrane: {"description":"Helical; Name=S4","evidences":[{"source":"PubMed","id":"31776515","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6UIV","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues154
DetailsRegion: {"description":"Hemichannel docking","evidences":[{"source":"PubMed","id":"31776515","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31988524","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6UIV","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues814
DetailsRegion: {"description":"Intersubunit interaction","evidences":[{"source":"PubMed","id":"31776515","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6UIV","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues22
DetailsSite: {"description":"Not N-glycosylated","evidences":[{"source":"PubMed","id":"31776515","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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