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6UIV

Cryo-EM structure of human CALHM2 in an active/open state

Functional Information from GO Data
ChainGOidnamespacecontents
A0005261molecular_functionmonoatomic cation channel activity
A0005886cellular_componentplasma membrane
A0034220biological_processmonoatomic ion transmembrane transport
A0043065biological_processpositive regulation of apoptotic process
A0048167biological_processregulation of synaptic plasticity
A0070509biological_processcalcium ion import
A0098655biological_processmonoatomic cation transmembrane transport
A1903978biological_processregulation of microglial cell activation
A1904669biological_processATP export
B0005261molecular_functionmonoatomic cation channel activity
B0005886cellular_componentplasma membrane
B0034220biological_processmonoatomic ion transmembrane transport
B0043065biological_processpositive regulation of apoptotic process
B0048167biological_processregulation of synaptic plasticity
B0070509biological_processcalcium ion import
B0098655biological_processmonoatomic cation transmembrane transport
B1903978biological_processregulation of microglial cell activation
B1904669biological_processATP export
C0005261molecular_functionmonoatomic cation channel activity
C0005886cellular_componentplasma membrane
C0034220biological_processmonoatomic ion transmembrane transport
C0043065biological_processpositive regulation of apoptotic process
C0048167biological_processregulation of synaptic plasticity
C0070509biological_processcalcium ion import
C0098655biological_processmonoatomic cation transmembrane transport
C1903978biological_processregulation of microglial cell activation
C1904669biological_processATP export
D0005261molecular_functionmonoatomic cation channel activity
D0005886cellular_componentplasma membrane
D0034220biological_processmonoatomic ion transmembrane transport
D0043065biological_processpositive regulation of apoptotic process
D0048167biological_processregulation of synaptic plasticity
D0070509biological_processcalcium ion import
D0098655biological_processmonoatomic cation transmembrane transport
D1903978biological_processregulation of microglial cell activation
D1904669biological_processATP export
E0005261molecular_functionmonoatomic cation channel activity
E0005886cellular_componentplasma membrane
E0034220biological_processmonoatomic ion transmembrane transport
E0043065biological_processpositive regulation of apoptotic process
E0048167biological_processregulation of synaptic plasticity
E0070509biological_processcalcium ion import
E0098655biological_processmonoatomic cation transmembrane transport
E1903978biological_processregulation of microglial cell activation
E1904669biological_processATP export
F0005261molecular_functionmonoatomic cation channel activity
F0005886cellular_componentplasma membrane
F0034220biological_processmonoatomic ion transmembrane transport
F0043065biological_processpositive regulation of apoptotic process
F0048167biological_processregulation of synaptic plasticity
F0070509biological_processcalcium ion import
F0098655biological_processmonoatomic cation transmembrane transport
F1903978biological_processregulation of microglial cell activation
F1904669biological_processATP export
G0005261molecular_functionmonoatomic cation channel activity
G0005886cellular_componentplasma membrane
G0034220biological_processmonoatomic ion transmembrane transport
G0043065biological_processpositive regulation of apoptotic process
G0048167biological_processregulation of synaptic plasticity
G0070509biological_processcalcium ion import
G0098655biological_processmonoatomic cation transmembrane transport
G1903978biological_processregulation of microglial cell activation
G1904669biological_processATP export
H0005261molecular_functionmonoatomic cation channel activity
H0005886cellular_componentplasma membrane
H0034220biological_processmonoatomic ion transmembrane transport
H0043065biological_processpositive regulation of apoptotic process
H0048167biological_processregulation of synaptic plasticity
H0070509biological_processcalcium ion import
H0098655biological_processmonoatomic cation transmembrane transport
H1903978biological_processregulation of microglial cell activation
H1904669biological_processATP export
I0005261molecular_functionmonoatomic cation channel activity
I0005886cellular_componentplasma membrane
I0034220biological_processmonoatomic ion transmembrane transport
I0043065biological_processpositive regulation of apoptotic process
I0048167biological_processregulation of synaptic plasticity
I0070509biological_processcalcium ion import
I0098655biological_processmonoatomic cation transmembrane transport
I1903978biological_processregulation of microglial cell activation
I1904669biological_processATP export
J0005261molecular_functionmonoatomic cation channel activity
J0005886cellular_componentplasma membrane
J0034220biological_processmonoatomic ion transmembrane transport
J0043065biological_processpositive regulation of apoptotic process
J0048167biological_processregulation of synaptic plasticity
J0070509biological_processcalcium ion import
J0098655biological_processmonoatomic cation transmembrane transport
J1903978biological_processregulation of microglial cell activation
J1904669biological_processATP export
K0005261molecular_functionmonoatomic cation channel activity
K0005886cellular_componentplasma membrane
K0034220biological_processmonoatomic ion transmembrane transport
K0043065biological_processpositive regulation of apoptotic process
K0048167biological_processregulation of synaptic plasticity
K0070509biological_processcalcium ion import
K0098655biological_processmonoatomic cation transmembrane transport
K1903978biological_processregulation of microglial cell activation
K1904669biological_processATP export
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1760
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305
ChainResidueDetails
AMET1-VAL21
DMET1-VAL21
DASN77-LEU101
DHIS207-SER323
EMET1-VAL21
EASN77-LEU101
EHIS207-SER323
FMET1-VAL21
FASN77-LEU101
FHIS207-SER323
GMET1-VAL21
AASN77-LEU101
GASN77-LEU101
GHIS207-SER323
HMET1-VAL21
HASN77-LEU101
HHIS207-SER323
IMET1-VAL21
IASN77-LEU101
IHIS207-SER323
JMET1-VAL21
JASN77-LEU101
AHIS207-SER323
JHIS207-SER323
KMET1-VAL21
KASN77-LEU101
KHIS207-SER323
BMET1-VAL21
BASN77-LEU101
BHIS207-SER323
CMET1-VAL21
CASN77-LEU101
CHIS207-SER323

site_idSWS_FT_FI2
Number of Residues231
DetailsTRANSMEM: Helical; Name=S1 => ECO:0000269|PubMed:31776515, ECO:0007744|PDB:6UIV
ChainResidueDetails
AMET22-ALA43
JMET22-ALA43
KMET22-ALA43
BMET22-ALA43
CMET22-ALA43
DMET22-ALA43
EMET22-ALA43
FMET22-ALA43
GMET22-ALA43
HMET22-ALA43
IMET22-ALA43

site_idSWS_FT_FI3
Number of Residues594
DetailsTOPO_DOM: Extracellular => ECO:0000305
ChainResidueDetails
APHE44-ARG52
ESER133-ARG179
FPHE44-ARG52
FSER133-ARG179
GPHE44-ARG52
GSER133-ARG179
HPHE44-ARG52
HSER133-ARG179
IPHE44-ARG52
ISER133-ARG179
JPHE44-ARG52
ASER133-ARG179
JSER133-ARG179
KPHE44-ARG52
KSER133-ARG179
BPHE44-ARG52
BSER133-ARG179
CPHE44-ARG52
CSER133-ARG179
DPHE44-ARG52
DSER133-ARG179
EPHE44-ARG52

site_idSWS_FT_FI4
Number of Residues253
DetailsTRANSMEM: Helical; Name=S2 => ECO:0000269|PubMed:31776515, ECO:0007744|PDB:6UIV
ChainResidueDetails
AASN53-ASN76
JASN53-ASN76
KASN53-ASN76
BASN53-ASN76
CASN53-ASN76
DASN53-ASN76
EASN53-ASN76
FASN53-ASN76
GASN53-ASN76
HASN53-ASN76
IASN53-ASN76

site_idSWS_FT_FI5
Number of Residues330
DetailsTRANSMEM: Helical; Name=S3 => ECO:0000269|PubMed:31776515, ECO:0007744|PDB:6UIV
ChainResidueDetails
ALEU102-LEU132
JLEU102-LEU132
KLEU102-LEU132
BLEU102-LEU132
CLEU102-LEU132
DLEU102-LEU132
ELEU102-LEU132
FLEU102-LEU132
GLEU102-LEU132
HLEU102-LEU132
ILEU102-LEU132

site_idSWS_FT_FI6
Number of Residues286
DetailsTRANSMEM: Helical; Name=S4 => ECO:0000269|PubMed:31776515, ECO:0007744|PDB:6UIV
ChainResidueDetails
ALEU180-LYS206
JLEU180-LYS206
KLEU180-LYS206
BLEU180-LYS206
CLEU180-LYS206
DLEU180-LYS206
ELEU180-LYS206
FLEU180-LYS206
GLEU180-LYS206
HLEU180-LYS206
ILEU180-LYS206

site_idSWS_FT_FI7
Number of Residues11
DetailsSITE: Not N-glycosylated => ECO:0000269|PubMed:31776515
ChainResidueDetails
AASN168
JASN168
KASN168
BASN168
CASN168
DASN168
EASN168
FASN168
GASN168
HASN168
IASN168

222036

PDB entries from 2024-07-03

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