Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6UGF

Katanin hexamer in the ring conformation with resolved protomer one in complex with substrate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000212	biological_process	meiotic spindle organization
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000785	cellular_component	chromatin
A	0000922	cellular_component	spindle pole
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005694	cellular_component	chromosome
A	0005737	cellular_component	cytoplasm
A	0005813	cellular_component	centrosome
A	0005819	cellular_component	spindle
A	0005874	cellular_component	microtubule
A	0007019	biological_process	microtubule depolymerization
A	0007143	biological_process	female meiotic nuclear division
A	0008017	molecular_function	microtubule binding
A	0008352	cellular_component	katanin complex
A	0008568	molecular_function	microtubule severing ATPase activity
A	0009792	biological_process	embryo development ending in birth or egg hatching
A	0016853	molecular_function	isomerase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0019903	molecular_function	protein phosphatase binding
A	0042802	molecular_function	identical protein binding
A	0051013	biological_process	microtubule severing
A	0051229	biological_process	meiotic spindle disassembly
A	0051301	biological_process	cell division
A	0051321	biological_process	meiotic cell cycle
A	0060090	molecular_function	molecular adaptor activity
A	0071688	biological_process	striated muscle myosin thick filament assembly
A	0072687	cellular_component	meiotic spindle
A	0090619	cellular_component	meiotic spindle pole
A	0090736	molecular_function	MATH domain binding
A	1902120	biological_process	negative regulation of meiotic spindle elongation
B	0000166	molecular_function	nucleotide binding
B	0000212	biological_process	meiotic spindle organization
B	0000226	biological_process	microtubule cytoskeleton organization
B	0000785	cellular_component	chromatin
B	0000922	cellular_component	spindle pole
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005694	cellular_component	chromosome
B	0005737	cellular_component	cytoplasm
B	0005813	cellular_component	centrosome
B	0005819	cellular_component	spindle
B	0005874	cellular_component	microtubule
B	0007019	biological_process	microtubule depolymerization
B	0007143	biological_process	female meiotic nuclear division
B	0008017	molecular_function	microtubule binding
B	0008352	cellular_component	katanin complex
B	0008568	molecular_function	microtubule severing ATPase activity
B	0009792	biological_process	embryo development ending in birth or egg hatching
B	0016853	molecular_function	isomerase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0019903	molecular_function	protein phosphatase binding
B	0042802	molecular_function	identical protein binding
B	0051013	biological_process	microtubule severing
B	0051229	biological_process	meiotic spindle disassembly
B	0051301	biological_process	cell division
B	0051321	biological_process	meiotic cell cycle
B	0060090	molecular_function	molecular adaptor activity
B	0071688	biological_process	striated muscle myosin thick filament assembly
B	0072687	cellular_component	meiotic spindle
B	0090619	cellular_component	meiotic spindle pole
B	0090736	molecular_function	MATH domain binding
B	1902120	biological_process	negative regulation of meiotic spindle elongation
C	0000166	molecular_function	nucleotide binding
C	0000212	biological_process	meiotic spindle organization
C	0000226	biological_process	microtubule cytoskeleton organization
C	0000785	cellular_component	chromatin
C	0000922	cellular_component	spindle pole
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0005737	cellular_component	cytoplasm
C	0005813	cellular_component	centrosome
C	0005819	cellular_component	spindle
C	0005874	cellular_component	microtubule
C	0007019	biological_process	microtubule depolymerization
C	0007143	biological_process	female meiotic nuclear division
C	0008017	molecular_function	microtubule binding
C	0008352	cellular_component	katanin complex
C	0008568	molecular_function	microtubule severing ATPase activity
C	0009792	biological_process	embryo development ending in birth or egg hatching
C	0016853	molecular_function	isomerase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0019903	molecular_function	protein phosphatase binding
C	0042802	molecular_function	identical protein binding
C	0051013	biological_process	microtubule severing
C	0051229	biological_process	meiotic spindle disassembly
C	0051301	biological_process	cell division
C	0051321	biological_process	meiotic cell cycle
C	0060090	molecular_function	molecular adaptor activity
C	0071688	biological_process	striated muscle myosin thick filament assembly
C	0072687	cellular_component	meiotic spindle
C	0090619	cellular_component	meiotic spindle pole
C	0090736	molecular_function	MATH domain binding
C	1902120	biological_process	negative regulation of meiotic spindle elongation
D	0000166	molecular_function	nucleotide binding
D	0000212	biological_process	meiotic spindle organization
D	0000226	biological_process	microtubule cytoskeleton organization
D	0000785	cellular_component	chromatin
D	0000922	cellular_component	spindle pole
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005694	cellular_component	chromosome
D	0005737	cellular_component	cytoplasm
D	0005813	cellular_component	centrosome
D	0005819	cellular_component	spindle
D	0005874	cellular_component	microtubule
D	0007019	biological_process	microtubule depolymerization
D	0007143	biological_process	female meiotic nuclear division
D	0008017	molecular_function	microtubule binding
D	0008352	cellular_component	katanin complex
D	0008568	molecular_function	microtubule severing ATPase activity
D	0009792	biological_process	embryo development ending in birth or egg hatching
D	0016853	molecular_function	isomerase activity
D	0016887	molecular_function	ATP hydrolysis activity
D	0019903	molecular_function	protein phosphatase binding
D	0042802	molecular_function	identical protein binding
D	0051013	biological_process	microtubule severing
D	0051229	biological_process	meiotic spindle disassembly
D	0051301	biological_process	cell division
D	0051321	biological_process	meiotic cell cycle
D	0060090	molecular_function	molecular adaptor activity
D	0071688	biological_process	striated muscle myosin thick filament assembly
D	0072687	cellular_component	meiotic spindle
D	0090619	cellular_component	meiotic spindle pole
D	0090736	molecular_function	MATH domain binding
D	1902120	biological_process	negative regulation of meiotic spindle elongation
E	0000166	molecular_function	nucleotide binding
E	0000212	biological_process	meiotic spindle organization
E	0000226	biological_process	microtubule cytoskeleton organization
E	0000785	cellular_component	chromatin
E	0000922	cellular_component	spindle pole
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005694	cellular_component	chromosome
E	0005737	cellular_component	cytoplasm
E	0005813	cellular_component	centrosome
E	0005819	cellular_component	spindle
E	0005874	cellular_component	microtubule
E	0007019	biological_process	microtubule depolymerization
E	0007143	biological_process	female meiotic nuclear division
E	0008017	molecular_function	microtubule binding
E	0008352	cellular_component	katanin complex
E	0008568	molecular_function	microtubule severing ATPase activity
E	0009792	biological_process	embryo development ending in birth or egg hatching
E	0016853	molecular_function	isomerase activity
E	0016887	molecular_function	ATP hydrolysis activity
E	0019903	molecular_function	protein phosphatase binding
E	0042802	molecular_function	identical protein binding
E	0051013	biological_process	microtubule severing
E	0051229	biological_process	meiotic spindle disassembly
E	0051301	biological_process	cell division
E	0051321	biological_process	meiotic cell cycle
E	0060090	molecular_function	molecular adaptor activity
E	0071688	biological_process	striated muscle myosin thick filament assembly
E	0072687	cellular_component	meiotic spindle
E	0090619	cellular_component	meiotic spindle pole
E	0090736	molecular_function	MATH domain binding
E	1902120	biological_process	negative regulation of meiotic spindle elongation
F	0000166	molecular_function	nucleotide binding
F	0000212	biological_process	meiotic spindle organization
F	0000226	biological_process	microtubule cytoskeleton organization
F	0000785	cellular_component	chromatin
F	0000922	cellular_component	spindle pole
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0005694	cellular_component	chromosome
F	0005737	cellular_component	cytoplasm
F	0005813	cellular_component	centrosome
F	0005819	cellular_component	spindle
F	0005874	cellular_component	microtubule
F	0007019	biological_process	microtubule depolymerization
F	0007143	biological_process	female meiotic nuclear division
F	0008017	molecular_function	microtubule binding
F	0008352	cellular_component	katanin complex
F	0008568	molecular_function	microtubule severing ATPase activity
F	0009792	biological_process	embryo development ending in birth or egg hatching
F	0016853	molecular_function	isomerase activity
F	0016887	molecular_function	ATP hydrolysis activity
F	0019903	molecular_function	protein phosphatase binding
F	0042802	molecular_function	identical protein binding
F	0051013	biological_process	microtubule severing
F	0051229	biological_process	meiotic spindle disassembly
F	0051301	biological_process	cell division
F	0051321	biological_process	meiotic cell cycle
F	0060090	molecular_function	molecular adaptor activity
F	0071688	biological_process	striated muscle myosin thick filament assembly
F	0072687	cellular_component	meiotic spindle
F	0090619	cellular_component	meiotic spindle pole
F	0090736	molecular_function	MATH domain binding
F	1902120	biological_process	negative regulation of meiotic spindle elongation

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue ATP B 501

Chain	Residue
B	ILE196
B	LEU370
B	ALA399
B	MG502
C	ARG352
B	PRO235
B	GLY236
B	THR237
B	GLY238
B	LYS239
B	THR240
B	LEU241
B	ASN340

site_id	AC2
Number of Residues	3
Details	binding site for residue MG B 502

Chain	Residue
B	THR240
B	ATP501
C	ARG352

site_id	AC3
Number of Residues	12
Details	binding site for residue ATP C 501

Chain	Residue
C	PRO235
C	GLY236
C	THR237
C	GLY238
C	LYS239
C	THR240
C	LEU241
C	GLN293
C	GLY398
C	ALA399
C	MG502
D	ARG352

site_id	AC4
Number of Residues	3
Details	binding site for residue MG C 502

Chain	Residue
C	THR240
C	ATP501
D	ARG352

site_id	AC5
Number of Residues	12
Details	binding site for residue ATP D 501

Chain	Residue
D	ILE196
D	PRO235
D	GLY236
D	THR237
D	GLY238
D	LYS239
D	THR240
D	GLN293
D	GLY398
D	MG502
E	ARG351
E	ARG352

site_id	AC6
Number of Residues	2
Details	binding site for residue MG D 502

Chain	Residue
D	THR240
D	ATP501

site_id	AC7
Number of Residues	15
Details	binding site for residue ATP E 501

Chain	Residue
E	ASP194
E	ILE195
E	ILE196
E	PRO235
E	THR237
E	GLY238
E	LYS239
E	THR240
E	LEU241
E	ASN340
E	GLY398
E	ALA399
E	MG502
F	ARG351
F	ARG352

site_id	AC8
Number of Residues	3
Details	binding site for residue MG E 502

Chain	Residue
E	THR240
E	ATP501
F	ARG352

site_id	AC9
Number of Residues	10
Details	binding site for residue ATP F 501

Chain	Residue
F	PRO235
F	GLY236
F	THR237
F	GLY238
F	LYS239
F	THR240
F	LEU241
F	LEU370
F	GLY398
F	ALA399

Functional Information from PROSITE/UniProt

site_id	PS00674
Number of Residues	20
Details	AAA AAA-protein family signature. VfVLaATNipweLDeALrrR

Chain	Residue	Details
A	VAL333-ARG352

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	42
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03023","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"28783150","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5WC0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WCB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28783150","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5WC0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WCB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)