6UEN
Cryo-EM structure of the respiratory syncytial virus RNA polymerase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003968 | molecular_function | RNA-directed RNA polymerase activity |
| A | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006370 | biological_process | 7-methylguanosine mRNA capping |
| B | 0001172 | biological_process | RNA-templated transcription |
| B | 0003968 | molecular_function | RNA-directed RNA polymerase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0019058 | biological_process | viral life cycle |
| B | 0030430 | cellular_component | host cell cytoplasm |
| B | 0044423 | cellular_component | virion component |
| B | 0085034 | biological_process | symbiont-mediated suppression of host NF-kappaB cascade |
| C | 0001172 | biological_process | RNA-templated transcription |
| C | 0003968 | molecular_function | RNA-directed RNA polymerase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0019058 | biological_process | viral life cycle |
| C | 0030430 | cellular_component | host cell cytoplasm |
| C | 0044423 | cellular_component | virion component |
| C | 0085034 | biological_process | symbiont-mediated suppression of host NF-kappaB cascade |
| D | 0001172 | biological_process | RNA-templated transcription |
| D | 0003968 | molecular_function | RNA-directed RNA polymerase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0019058 | biological_process | viral life cycle |
| D | 0030430 | cellular_component | host cell cytoplasm |
| D | 0044423 | cellular_component | virion component |
| D | 0085034 | biological_process | symbiont-mediated suppression of host NF-kappaB cascade |
| E | 0001172 | biological_process | RNA-templated transcription |
| E | 0003968 | molecular_function | RNA-directed RNA polymerase activity |
| E | 0005515 | molecular_function | protein binding |
| E | 0019058 | biological_process | viral life cycle |
| E | 0030430 | cellular_component | host cell cytoplasm |
| E | 0044423 | cellular_component | virion component |
| E | 0085034 | biological_process | symbiont-mediated suppression of host NF-kappaB cascade |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YGCIVYH |
| Chain | Residue | Details |
| A | TYR249-HIS255 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 184 |
| Details | Domain: {"description":"RdRp catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00539","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 492 |
| Details | Region: {"description":"GDP polyribonucleotidyltransferase","evidences":[{"source":"PubMed","id":"31495574","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile; for GDP polyribonucleotidyltransferase activity","evidences":[{"source":"UniProtKB","id":"P03523","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31495574","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31953395","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 40 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 10 |
| Details | Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 10 |
| Details | Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 11 |
| Details | Compositional bias: {"description":"Acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 16 |
| Details | Region: {"description":"Binding to RNA-directed RNA polymerase L","evidences":[{"source":"PubMed","id":"25653447","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26474524","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 9 |
| Details | Region: {"description":"Binding to the N-RNA complex","evidences":[{"source":"PubMed","id":"17170452","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25407889","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26474524","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by host","evidences":[{"source":"PubMed","id":"12368320","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26474524","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
