6UD4
GluA2 in complex with its auxiliary subunit CNIH3 in AS map II - (LBD-TMD-C3(AS) II)- with antagonist ZK200775, without NTD
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005216 | molecular_function | monoatomic ion channel activity |
A | 0006811 | biological_process | monoatomic ion transport |
A | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
A | 0016020 | cellular_component | membrane |
A | 0038023 | molecular_function | signaling receptor activity |
B | 0005216 | molecular_function | monoatomic ion channel activity |
B | 0006811 | biological_process | monoatomic ion transport |
B | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
B | 0016020 | cellular_component | membrane |
B | 0038023 | molecular_function | signaling receptor activity |
C | 0005216 | molecular_function | monoatomic ion channel activity |
C | 0006811 | biological_process | monoatomic ion transport |
C | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
C | 0016020 | cellular_component | membrane |
C | 0038023 | molecular_function | signaling receptor activity |
D | 0005216 | molecular_function | monoatomic ion channel activity |
D | 0006811 | biological_process | monoatomic ion transport |
D | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
D | 0016020 | cellular_component | membrane |
D | 0038023 | molecular_function | signaling receptor activity |
E | 0005102 | molecular_function | signaling receptor binding |
E | 0016192 | biological_process | vesicle-mediated transport |
E | 0016247 | molecular_function | channel regulator activity |
E | 0030425 | cellular_component | dendrite |
E | 0032281 | cellular_component | AMPA glutamate receptor complex |
E | 0035249 | biological_process | synaptic transmission, glutamatergic |
E | 0042391 | biological_process | regulation of membrane potential |
E | 0043198 | cellular_component | dendritic shaft |
E | 0045202 | cellular_component | synapse |
E | 0045211 | cellular_component | postsynaptic membrane |
E | 0098978 | cellular_component | glutamatergic synapse |
E | 0099645 | biological_process | neurotransmitter receptor localization to postsynaptic specialization membrane |
E | 2000311 | biological_process | regulation of AMPA receptor activity |
F | 0005102 | molecular_function | signaling receptor binding |
F | 0016192 | biological_process | vesicle-mediated transport |
F | 0016247 | molecular_function | channel regulator activity |
F | 0030425 | cellular_component | dendrite |
F | 0032281 | cellular_component | AMPA glutamate receptor complex |
F | 0035249 | biological_process | synaptic transmission, glutamatergic |
F | 0042391 | biological_process | regulation of membrane potential |
F | 0043198 | cellular_component | dendritic shaft |
F | 0045202 | cellular_component | synapse |
F | 0045211 | cellular_component | postsynaptic membrane |
F | 0098978 | cellular_component | glutamatergic synapse |
F | 0099645 | biological_process | neurotransmitter receptor localization to postsynaptic specialization membrane |
F | 2000311 | biological_process | regulation of AMPA receptor activity |
G | 0005102 | molecular_function | signaling receptor binding |
G | 0016192 | biological_process | vesicle-mediated transport |
G | 0016247 | molecular_function | channel regulator activity |
G | 0030425 | cellular_component | dendrite |
G | 0032281 | cellular_component | AMPA glutamate receptor complex |
G | 0035249 | biological_process | synaptic transmission, glutamatergic |
G | 0042391 | biological_process | regulation of membrane potential |
G | 0043198 | cellular_component | dendritic shaft |
G | 0045202 | cellular_component | synapse |
G | 0045211 | cellular_component | postsynaptic membrane |
G | 0098978 | cellular_component | glutamatergic synapse |
G | 0099645 | biological_process | neurotransmitter receptor localization to postsynaptic specialization membrane |
G | 2000311 | biological_process | regulation of AMPA receptor activity |
H | 0005102 | molecular_function | signaling receptor binding |
H | 0016192 | biological_process | vesicle-mediated transport |
H | 0016247 | molecular_function | channel regulator activity |
H | 0030425 | cellular_component | dendrite |
H | 0032281 | cellular_component | AMPA glutamate receptor complex |
H | 0035249 | biological_process | synaptic transmission, glutamatergic |
H | 0042391 | biological_process | regulation of membrane potential |
H | 0043198 | cellular_component | dendritic shaft |
H | 0045202 | cellular_component | synapse |
H | 0045211 | cellular_component | postsynaptic membrane |
H | 0098978 | cellular_component | glutamatergic synapse |
H | 0099645 | biological_process | neurotransmitter receptor localization to postsynaptic specialization membrane |
H | 2000311 | biological_process | regulation of AMPA receptor activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 9 |
Details | binding site for residue ZK1 A 901 |
Chain | Residue |
A | GLU402 |
A | TYR405 |
A | TYR450 |
A | PRO478 |
A | THR480 |
A | ARG485 |
A | GLY653 |
A | SER654 |
A | TYR732 |
site_id | AC2 |
Number of Residues | 7 |
Details | binding site for residue OLC A 902 |
Chain | Residue |
A | ILE534 |
A | SER537 |
A | VAL538 |
A | PHE541 |
D | SER595 |
D | ARG599 |
D | ILE600 |
site_id | AC3 |
Number of Residues | 4 |
Details | binding site for residue CLR A 903 |
Chain | Residue |
A | TYR797 |
A | GLY801 |
E | MET11 |
E | MET153 |
site_id | AC4 |
Number of Residues | 9 |
Details | binding site for residue ZK1 B 901 |
Chain | Residue |
B | GLU402 |
B | TYR450 |
B | PRO478 |
B | LEU479 |
B | THR480 |
B | ARG485 |
B | GLY653 |
B | SER654 |
B | TYR732 |
site_id | AC5 |
Number of Residues | 3 |
Details | binding site for residue OLC B 902 |
Chain | Residue |
A | ILE600 |
B | TYR533 |
B | SER537 |
site_id | AC6 |
Number of Residues | 5 |
Details | binding site for residue CLR F 201 |
Chain | Residue |
B | TYR797 |
F | LEU14 |
F | ALA18 |
F | MET153 |
F | LEU157 |
site_id | AC7 |
Number of Residues | 4 |
Details | binding site for residue CLR G 201 |
Chain | Residue |
C | GLY804 |
C | LEU808 |
G | MET11 |
G | ALA18 |
site_id | AC8 |
Number of Residues | 7 |
Details | binding site for residue CLR H 201 |
Chain | Residue |
D | TYR797 |
D | VAL800 |
D | GLY804 |
H | MET11 |
H | LEU14 |
H | ALA18 |
H | LEU157 |
site_id | AC9 |
Number of Residues | 9 |
Details | binding site for residue ZK1 C 901 |
Chain | Residue |
C | GLU402 |
C | TYR405 |
C | TYR450 |
C | PRO478 |
C | THR480 |
C | ARG485 |
C | GLY653 |
C | SER654 |
C | TYR732 |
site_id | AD1 |
Number of Residues | 6 |
Details | binding site for residue OLC C 902 |
Chain | Residue |
B | SER595 |
C | ILE534 |
C | VAL538 |
C | PHE541 |
C | ARG545 |
H | LEU69 |
site_id | AD2 |
Number of Residues | 11 |
Details | binding site for residue ZK1 D 901 |
Chain | Residue |
D | GLU402 |
D | TYR405 |
D | TYR450 |
D | PRO478 |
D | LEU479 |
D | THR480 |
D | ARG485 |
D | GLY653 |
D | SER654 |
D | THR686 |
D | TYR732 |
site_id | AD3 |
Number of Residues | 5 |
Details | binding site for residue OLC D 902 |
Chain | Residue |
C | ILE600 |
D | TYR533 |
D | SER537 |
D | PHE541 |
E | LEU69 |
Functional Information from PROSITE/UniProt
site_id | PS01340 |
Number of Residues | 15 |
Details | CORNICHON Cornichon family signature. IafdELrtDFkSPID |
Chain | Residue | Details |
E | ILE29-ASP43 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 160 |
Details | Transmembrane: {"description":"Helical"} |
Chain | Residue | Details |
site_id | SWS_FT_FI2 |
Number of Residues | 80 |
Details | Transmembrane: {"description":"Helical; Name=M4"} |
Chain | Residue | Details |
site_id | SWS_FT_FI3 |
Number of Residues | 24 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI4 |
Number of Residues | 12 |
Details | Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI7 |
Number of Residues | 4 |
Details | Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI8 |
Number of Residues | 4 |
Details | Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000250"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI9 |
Number of Residues | 240 |
Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI10 |
Number of Residues | 2 |
Details | Topological domain: {"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]} |
Chain | Residue | Details |