6UCU
Cryo-EM structure of the mitochondrial TOM complex from yeast (dimer)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005741 | cellular_component | mitochondrial outer membrane |
| A | 0005742 | cellular_component | mitochondrial outer membrane translocase complex |
| A | 0005758 | cellular_component | mitochondrial intermembrane space |
| A | 0005829 | cellular_component | cytosol |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0008320 | molecular_function | protein transmembrane transporter activity |
| A | 0015031 | biological_process | protein transport |
| A | 0015288 | molecular_function | porin activity |
| A | 0030150 | biological_process | protein import into mitochondrial matrix |
| A | 0045040 | biological_process | protein insertion into mitochondrial outer membrane |
| A | 0046930 | cellular_component | pore complex |
| A | 0055085 | biological_process | transmembrane transport |
| B | 0005515 | molecular_function | protein binding |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005741 | cellular_component | mitochondrial outer membrane |
| B | 0005742 | cellular_component | mitochondrial outer membrane translocase complex |
| B | 0006886 | biological_process | intracellular protein transport |
| B | 0008320 | molecular_function | protein transmembrane transporter activity |
| B | 0015031 | biological_process | protein transport |
| B | 0030150 | biological_process | protein import into mitochondrial matrix |
| B | 0045040 | biological_process | protein insertion into mitochondrial outer membrane |
| C | 0005515 | molecular_function | protein binding |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005741 | cellular_component | mitochondrial outer membrane |
| C | 0005742 | cellular_component | mitochondrial outer membrane translocase complex |
| C | 0006626 | biological_process | protein targeting to mitochondrion |
| C | 0008320 | molecular_function | protein transmembrane transporter activity |
| C | 0015031 | biological_process | protein transport |
| C | 0045040 | biological_process | protein insertion into mitochondrial outer membrane |
| C | 0070096 | biological_process | mitochondrial outer membrane translocase complex assembly |
| C | 0071806 | biological_process | protein transmembrane transport |
| D | 0005739 | cellular_component | mitochondrion |
| D | 0005741 | cellular_component | mitochondrial outer membrane |
| D | 0005742 | cellular_component | mitochondrial outer membrane translocase complex |
| D | 0008320 | molecular_function | protein transmembrane transporter activity |
| D | 0015031 | biological_process | protein transport |
| D | 0030150 | biological_process | protein import into mitochondrial matrix |
| D | 0045040 | biological_process | protein insertion into mitochondrial outer membrane |
| D | 0070096 | biological_process | mitochondrial outer membrane translocase complex assembly |
| E | 0005739 | cellular_component | mitochondrion |
| E | 0005741 | cellular_component | mitochondrial outer membrane |
| E | 0005742 | cellular_component | mitochondrial outer membrane translocase complex |
| E | 0008320 | molecular_function | protein transmembrane transporter activity |
| E | 0015031 | biological_process | protein transport |
| E | 0030150 | biological_process | protein import into mitochondrial matrix |
| E | 0045040 | biological_process | protein insertion into mitochondrial outer membrane |
| I | 0005515 | molecular_function | protein binding |
| I | 0005739 | cellular_component | mitochondrion |
| I | 0005741 | cellular_component | mitochondrial outer membrane |
| I | 0005742 | cellular_component | mitochondrial outer membrane translocase complex |
| I | 0005758 | cellular_component | mitochondrial intermembrane space |
| I | 0005829 | cellular_component | cytosol |
| I | 0006811 | biological_process | monoatomic ion transport |
| I | 0008320 | molecular_function | protein transmembrane transporter activity |
| I | 0015031 | biological_process | protein transport |
| I | 0015288 | molecular_function | porin activity |
| I | 0030150 | biological_process | protein import into mitochondrial matrix |
| I | 0045040 | biological_process | protein insertion into mitochondrial outer membrane |
| I | 0046930 | cellular_component | pore complex |
| I | 0055085 | biological_process | transmembrane transport |
| J | 0005515 | molecular_function | protein binding |
| J | 0005739 | cellular_component | mitochondrion |
| J | 0005741 | cellular_component | mitochondrial outer membrane |
| J | 0005742 | cellular_component | mitochondrial outer membrane translocase complex |
| J | 0006886 | biological_process | intracellular protein transport |
| J | 0008320 | molecular_function | protein transmembrane transporter activity |
| J | 0015031 | biological_process | protein transport |
| J | 0030150 | biological_process | protein import into mitochondrial matrix |
| J | 0045040 | biological_process | protein insertion into mitochondrial outer membrane |
| K | 0005515 | molecular_function | protein binding |
| K | 0005739 | cellular_component | mitochondrion |
| K | 0005741 | cellular_component | mitochondrial outer membrane |
| K | 0005742 | cellular_component | mitochondrial outer membrane translocase complex |
| K | 0006626 | biological_process | protein targeting to mitochondrion |
| K | 0008320 | molecular_function | protein transmembrane transporter activity |
| K | 0015031 | biological_process | protein transport |
| K | 0045040 | biological_process | protein insertion into mitochondrial outer membrane |
| K | 0070096 | biological_process | mitochondrial outer membrane translocase complex assembly |
| K | 0071806 | biological_process | protein transmembrane transport |
| L | 0005739 | cellular_component | mitochondrion |
| L | 0005741 | cellular_component | mitochondrial outer membrane |
| L | 0005742 | cellular_component | mitochondrial outer membrane translocase complex |
| L | 0008320 | molecular_function | protein transmembrane transporter activity |
| L | 0015031 | biological_process | protein transport |
| L | 0030150 | biological_process | protein import into mitochondrial matrix |
| L | 0045040 | biological_process | protein insertion into mitochondrial outer membrane |
| L | 0070096 | biological_process | mitochondrial outer membrane translocase complex assembly |
| M | 0005739 | cellular_component | mitochondrion |
| M | 0005741 | cellular_component | mitochondrial outer membrane |
| M | 0005742 | cellular_component | mitochondrial outer membrane translocase complex |
| M | 0008320 | molecular_function | protein transmembrane transporter activity |
| M | 0015031 | biological_process | protein transport |
| M | 0030150 | biological_process | protein import into mitochondrial matrix |
| M | 0045040 | biological_process | protein insertion into mitochondrial outer membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | binding site for residue LMT A 401 |
| Chain | Residue |
| B | LMT201 |
| D | LEU57 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | binding site for residue LMT A 402 |
| Chain | Residue |
| A | SER320 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | binding site for residue LMT A 403 |
| Chain | Residue |
| A | PHE347 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue LMT A 404 |
| Chain | Residue |
| A | TYR232 |
| A | THR234 |
| A | GLY247 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue LMT A 408 |
| Chain | Residue |
| A | ASN149 |
| A | GLN169 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | binding site for residue LMT A 409 |
| Chain | Residue |
| E | LMT101 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue LMT A 414 |
| Chain | Residue |
| A | ARG330 |
| B | THR104 |
| B | LEU115 |
| B | GLN122 |
| I | ARG330 |
| I | VAL332 |
| I | LMT401 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | binding site for residue LMT A 415 |
| Chain | Residue |
| J | LMT204 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue LMT A 416 |
| Chain | Residue |
| A | LYS113 |
| E | PRO56 |
| J | GLY96 |
| site_id | AD1 |
| Number of Residues | 1 |
| Details | binding site for residue LMT A 417 |
| Chain | Residue |
| J | LMT203 |
| site_id | AD2 |
| Number of Residues | 1 |
| Details | binding site for residue LMT B 201 |
| Chain | Residue |
| A | LMT401 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue LMT B 203 |
| Chain | Residue |
| B | PHE92 |
| I | LMT404 |
| M | LMT101 |
| site_id | AD4 |
| Number of Residues | 1 |
| Details | binding site for residue LMT B 204 |
| Chain | Residue |
| I | LMT402 |
| site_id | AD5 |
| Number of Residues | 1 |
| Details | binding site for residue LMT C 101 |
| Chain | Residue |
| C | GLU22 |
| site_id | AD6 |
| Number of Residues | 2 |
| Details | binding site for residue LMT C 102 |
| Chain | Residue |
| A | LEU213 |
| C | ALA32 |
| site_id | AD7 |
| Number of Residues | 1 |
| Details | binding site for residue LMT D 101 |
| Chain | Residue |
| D | PHE42 |
| site_id | AD8 |
| Number of Residues | 2 |
| Details | binding site for residue LMT D 102 |
| Chain | Residue |
| D | GLN50 |
| D | LMT103 |
| site_id | AD9 |
| Number of Residues | 1 |
| Details | binding site for residue LMT D 103 |
| Chain | Residue |
| D | LMT102 |
| site_id | AE1 |
| Number of Residues | 2 |
| Details | binding site for residue LMT E 101 |
| Chain | Residue |
| A | LMT409 |
| E | HIS43 |
| site_id | AE2 |
| Number of Residues | 2 |
| Details | binding site for residue LMT E 103 |
| Chain | Residue |
| E | LMT104 |
| J | LMT203 |
| site_id | AE3 |
| Number of Residues | 3 |
| Details | binding site for residue LMT E 104 |
| Chain | Residue |
| E | HIS29 |
| E | TYR30 |
| E | LMT103 |
| site_id | AE4 |
| Number of Residues | 7 |
| Details | binding site for residue LMT I 401 |
| Chain | Residue |
| A | ARG330 |
| A | VAL332 |
| A | LMT414 |
| I | ARG330 |
| J | THR104 |
| J | LEU115 |
| J | GLN122 |
| site_id | AE5 |
| Number of Residues | 1 |
| Details | binding site for residue LMT I 402 |
| Chain | Residue |
| B | LMT204 |
| site_id | AE6 |
| Number of Residues | 3 |
| Details | binding site for residue LMT I 403 |
| Chain | Residue |
| B | GLY96 |
| I | LYS113 |
| M | PRO56 |
| site_id | AE7 |
| Number of Residues | 1 |
| Details | binding site for residue LMT I 404 |
| Chain | Residue |
| B | LMT203 |
| site_id | AE8 |
| Number of Residues | 2 |
| Details | binding site for residue LMT I 405 |
| Chain | Residue |
| J | LMT201 |
| L | LEU57 |
| site_id | AE9 |
| Number of Residues | 1 |
| Details | binding site for residue LMT I 406 |
| Chain | Residue |
| I | SER320 |
| site_id | AF1 |
| Number of Residues | 1 |
| Details | binding site for residue LMT I 407 |
| Chain | Residue |
| I | PHE347 |
| site_id | AF2 |
| Number of Residues | 3 |
| Details | binding site for residue LMT I 408 |
| Chain | Residue |
| I | TYR232 |
| I | THR234 |
| I | GLY247 |
| site_id | AF3 |
| Number of Residues | 2 |
| Details | binding site for residue LMT I 412 |
| Chain | Residue |
| I | ASN149 |
| I | GLN169 |
| site_id | AF4 |
| Number of Residues | 1 |
| Details | binding site for residue LMT I 413 |
| Chain | Residue |
| M | LMT103 |
| site_id | AF5 |
| Number of Residues | 1 |
| Details | binding site for residue LMT J 201 |
| Chain | Residue |
| I | LMT405 |
| site_id | AF6 |
| Number of Residues | 3 |
| Details | binding site for residue LMT J 203 |
| Chain | Residue |
| A | LMT417 |
| E | LMT103 |
| J | PHE92 |
| site_id | AF7 |
| Number of Residues | 1 |
| Details | binding site for residue LMT J 204 |
| Chain | Residue |
| A | LMT415 |
| site_id | AF8 |
| Number of Residues | 1 |
| Details | binding site for residue LMT K 101 |
| Chain | Residue |
| K | GLU22 |
| site_id | AF9 |
| Number of Residues | 2 |
| Details | binding site for residue LMT K 102 |
| Chain | Residue |
| I | LEU213 |
| K | ALA32 |
| site_id | AG1 |
| Number of Residues | 1 |
| Details | binding site for residue LMT L 101 |
| Chain | Residue |
| L | PHE42 |
| site_id | AG2 |
| Number of Residues | 2 |
| Details | binding site for residue LMT L 102 |
| Chain | Residue |
| L | GLN50 |
| L | LMT103 |
| site_id | AG3 |
| Number of Residues | 1 |
| Details | binding site for residue LMT L 103 |
| Chain | Residue |
| L | LMT102 |
| site_id | AG4 |
| Number of Residues | 2 |
| Details | binding site for residue LMT M 101 |
| Chain | Residue |
| B | LMT203 |
| M | LMT102 |
| site_id | AG5 |
| Number of Residues | 3 |
| Details | binding site for residue LMT M 102 |
| Chain | Residue |
| M | HIS29 |
| M | TYR30 |
| M | LMT101 |
| site_id | AG6 |
| Number of Residues | 2 |
| Details | binding site for residue LMT M 103 |
| Chain | Residue |
| I | LMT413 |
| M | HIS43 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 34 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000250 |
| Chain | Residue | Details |
| E | SER2-LYS19 | |
| M | SER2-LYS19 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 42 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| E | ILE20-TRP41 | |
| M | ILE20-TRP41 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 36 |
| Details | TOPO_DOM: Mitochondrial intermembrane => ECO:0000250 |
| Chain | Residue | Details |
| E | ALA42-VAL60 | |
| M | ALA42-VAL60 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| D | MET1 | |
| L | MET1 | |
| J | SER44 | |
| J | SER46 |
