6UCB
GluA2 in complex with its auxiliary subunit CNIH3 - with antagonist ZK200775, LBD, TMD, CNIH3, and lipids
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005216 | molecular_function | monoatomic ion channel activity |
A | 0006811 | biological_process | monoatomic ion transport |
A | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
A | 0016020 | cellular_component | membrane |
A | 0038023 | molecular_function | signaling receptor activity |
B | 0005216 | molecular_function | monoatomic ion channel activity |
B | 0006811 | biological_process | monoatomic ion transport |
B | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
B | 0016020 | cellular_component | membrane |
B | 0038023 | molecular_function | signaling receptor activity |
C | 0005216 | molecular_function | monoatomic ion channel activity |
C | 0006811 | biological_process | monoatomic ion transport |
C | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
C | 0016020 | cellular_component | membrane |
C | 0038023 | molecular_function | signaling receptor activity |
D | 0005216 | molecular_function | monoatomic ion channel activity |
D | 0006811 | biological_process | monoatomic ion transport |
D | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
D | 0016020 | cellular_component | membrane |
D | 0038023 | molecular_function | signaling receptor activity |
E | 0005886 | cellular_component | plasma membrane |
E | 0016192 | biological_process | vesicle-mediated transport |
E | 0016247 | molecular_function | channel regulator activity |
E | 0032281 | cellular_component | AMPA glutamate receptor complex |
E | 0035249 | biological_process | synaptic transmission, glutamatergic |
E | 0042391 | biological_process | regulation of membrane potential |
E | 0043198 | cellular_component | dendritic shaft |
E | 0045202 | cellular_component | synapse |
E | 0045211 | cellular_component | postsynaptic membrane |
E | 0051668 | biological_process | localization within membrane |
E | 0098978 | cellular_component | glutamatergic synapse |
E | 0099645 | biological_process | neurotransmitter receptor localization to postsynaptic specialization membrane |
E | 2000311 | biological_process | regulation of AMPA receptor activity |
F | 0005886 | cellular_component | plasma membrane |
F | 0016192 | biological_process | vesicle-mediated transport |
F | 0016247 | molecular_function | channel regulator activity |
F | 0032281 | cellular_component | AMPA glutamate receptor complex |
F | 0035249 | biological_process | synaptic transmission, glutamatergic |
F | 0042391 | biological_process | regulation of membrane potential |
F | 0043198 | cellular_component | dendritic shaft |
F | 0045202 | cellular_component | synapse |
F | 0045211 | cellular_component | postsynaptic membrane |
F | 0051668 | biological_process | localization within membrane |
F | 0098978 | cellular_component | glutamatergic synapse |
F | 0099645 | biological_process | neurotransmitter receptor localization to postsynaptic specialization membrane |
F | 2000311 | biological_process | regulation of AMPA receptor activity |
G | 0005886 | cellular_component | plasma membrane |
G | 0016192 | biological_process | vesicle-mediated transport |
G | 0016247 | molecular_function | channel regulator activity |
G | 0032281 | cellular_component | AMPA glutamate receptor complex |
G | 0035249 | biological_process | synaptic transmission, glutamatergic |
G | 0042391 | biological_process | regulation of membrane potential |
G | 0043198 | cellular_component | dendritic shaft |
G | 0045202 | cellular_component | synapse |
G | 0045211 | cellular_component | postsynaptic membrane |
G | 0051668 | biological_process | localization within membrane |
G | 0098978 | cellular_component | glutamatergic synapse |
G | 0099645 | biological_process | neurotransmitter receptor localization to postsynaptic specialization membrane |
G | 2000311 | biological_process | regulation of AMPA receptor activity |
H | 0005886 | cellular_component | plasma membrane |
H | 0016192 | biological_process | vesicle-mediated transport |
H | 0016247 | molecular_function | channel regulator activity |
H | 0032281 | cellular_component | AMPA glutamate receptor complex |
H | 0035249 | biological_process | synaptic transmission, glutamatergic |
H | 0042391 | biological_process | regulation of membrane potential |
H | 0043198 | cellular_component | dendritic shaft |
H | 0045202 | cellular_component | synapse |
H | 0045211 | cellular_component | postsynaptic membrane |
H | 0051668 | biological_process | localization within membrane |
H | 0098978 | cellular_component | glutamatergic synapse |
H | 0099645 | biological_process | neurotransmitter receptor localization to postsynaptic specialization membrane |
H | 2000311 | biological_process | regulation of AMPA receptor activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 8 |
Details | binding site for residue ZK1 A 901 |
Chain | Residue |
A | TYR450 |
A | PRO478 |
A | THR480 |
A | ARG485 |
A | GLY653 |
A | SER654 |
A | THR686 |
A | TYR732 |
site_id | AC2 |
Number of Residues | 4 |
Details | binding site for residue OLC A 902 |
Chain | Residue |
A | MET527 |
A | PAM903 |
F | PAM202 |
A | TYR523 |
site_id | AC3 |
Number of Residues | 3 |
Details | binding site for residue PAM A 903 |
Chain | Residue |
A | OLC902 |
A | PAM904 |
F | PAM202 |
site_id | AC4 |
Number of Residues | 5 |
Details | binding site for residue PAM A 904 |
Chain | Residue |
A | GLY513 |
A | VAL514 |
A | PHE515 |
A | PAM903 |
E | CLR202 |
site_id | AC5 |
Number of Residues | 10 |
Details | binding site for residue ZK1 B 901 |
Chain | Residue |
B | TYR450 |
B | PRO478 |
B | LEU479 |
B | THR480 |
B | ARG485 |
B | GLY653 |
B | SER654 |
B | THR686 |
B | MET708 |
B | TYR732 |
site_id | AC6 |
Number of Residues | 4 |
Details | binding site for residue OLC B 902 |
Chain | Residue |
B | SER595 |
C | ILE534 |
C | ARG545 |
H | PAM202 |
site_id | AC7 |
Number of Residues | 3 |
Details | binding site for residue OLC B 903 |
Chain | Residue |
A | ILE600 |
B | ARG545 |
G | PAM201 |
site_id | AC8 |
Number of Residues | 4 |
Details | binding site for residue OLC B 904 |
Chain | Residue |
B | TYR523 |
B | MET527 |
B | PAM905 |
G | PAM201 |
site_id | AC9 |
Number of Residues | 4 |
Details | binding site for residue PAM B 905 |
Chain | Residue |
B | ILE798 |
B | OLC904 |
B | PAM906 |
G | PAM201 |
site_id | AD1 |
Number of Residues | 3 |
Details | binding site for residue PAM B 906 |
Chain | Residue |
B | GLY801 |
B | PAM905 |
B | CLR907 |
site_id | AD2 |
Number of Residues | 7 |
Details | binding site for residue CLR B 907 |
Chain | Residue |
B | GLY804 |
B | LEU808 |
B | PAM906 |
F | LEU14 |
F | ALA18 |
F | MET153 |
F | LEU157 |
site_id | AD3 |
Number of Residues | 8 |
Details | binding site for residue ZK1 C 901 |
Chain | Residue |
C | TYR450 |
C | PRO478 |
C | THR480 |
C | ARG485 |
C | GLY653 |
C | SER654 |
C | THR686 |
C | TYR732 |
site_id | AD4 |
Number of Residues | 5 |
Details | binding site for residue OLC C 902 |
Chain | Residue |
C | TYR523 |
C | MET527 |
C | PAM903 |
H | PAM201 |
H | PAM202 |
site_id | AD5 |
Number of Residues | 3 |
Details | binding site for residue PAM C 903 |
Chain | Residue |
C | OLC902 |
C | PAM904 |
H | PAM202 |
site_id | AD6 |
Number of Residues | 5 |
Details | binding site for residue PAM C 904 |
Chain | Residue |
C | GLY513 |
C | VAL514 |
C | PHE515 |
C | PAM903 |
G | CLR202 |
site_id | AD7 |
Number of Residues | 7 |
Details | binding site for residue PAM E 201 |
Chain | Residue |
D | TYR523 |
D | MET527 |
D | VAL530 |
D | OLC903 |
D | OLC904 |
D | PAM905 |
E | CYS84 |
site_id | AD8 |
Number of Residues | 7 |
Details | binding site for residue CLR E 202 |
Chain | Residue |
A | GLY804 |
A | PAM904 |
E | LEU14 |
E | VAL15 |
E | ALA18 |
E | MET153 |
E | LEU157 |
site_id | AD9 |
Number of Residues | 1 |
Details | binding site for residue PAM F 201 |
Chain | Residue |
F | GLN86 |
site_id | AE1 |
Number of Residues | 8 |
Details | binding site for residue PAM F 202 |
Chain | Residue |
A | TYR523 |
A | MET527 |
A | VAL530 |
A | OLC902 |
A | PAM903 |
D | OLC902 |
F | CYS84 |
F | GLN86 |
site_id | AE2 |
Number of Residues | 8 |
Details | binding site for residue PAM G 201 |
Chain | Residue |
B | TYR523 |
B | MET527 |
B | OLC903 |
B | OLC904 |
B | PAM905 |
G | CYS84 |
G | ALA85 |
G | GLN86 |
site_id | AE3 |
Number of Residues | 6 |
Details | binding site for residue CLR G 202 |
Chain | Residue |
C | GLY804 |
C | PAM904 |
G | LEU14 |
G | ALA18 |
G | MET153 |
G | LEU157 |
site_id | AE4 |
Number of Residues | 2 |
Details | binding site for residue PAM H 201 |
Chain | Residue |
C | OLC902 |
H | GLN86 |
site_id | AE5 |
Number of Residues | 9 |
Details | binding site for residue PAM H 202 |
Chain | Residue |
B | PHE607 |
B | OLC902 |
C | TYR523 |
C | MET527 |
C | VAL530 |
C | OLC902 |
C | PAM903 |
H | CYS84 |
H | GLN86 |
site_id | AE6 |
Number of Residues | 7 |
Details | binding site for residue CLR H 203 |
Chain | Residue |
D | GLY804 |
D | LEU808 |
D | PAM906 |
H | LEU14 |
H | ALA18 |
H | MET153 |
H | LEU157 |
site_id | AE7 |
Number of Residues | 10 |
Details | binding site for residue ZK1 D 901 |
Chain | Residue |
D | TYR450 |
D | PRO478 |
D | LEU479 |
D | THR480 |
D | ARG485 |
D | GLY653 |
D | SER654 |
D | THR686 |
D | MET708 |
D | TYR732 |
site_id | AE8 |
Number of Residues | 5 |
Details | binding site for residue OLC D 902 |
Chain | Residue |
A | SER537 |
A | VAL538 |
A | PHE541 |
D | ARG599 |
F | PAM202 |
site_id | AE9 |
Number of Residues | 4 |
Details | binding site for residue OLC D 903 |
Chain | Residue |
D | TYR533 |
D | SER537 |
E | LEU69 |
E | PAM201 |
site_id | AF1 |
Number of Residues | 4 |
Details | binding site for residue OLC D 904 |
Chain | Residue |
D | TYR523 |
D | MET527 |
D | PAM905 |
E | PAM201 |
site_id | AF2 |
Number of Residues | 4 |
Details | binding site for residue PAM D 905 |
Chain | Residue |
D | ILE798 |
D | OLC904 |
D | PAM906 |
E | PAM201 |
site_id | AF3 |
Number of Residues | 3 |
Details | binding site for residue PAM D 906 |
Chain | Residue |
D | GLY801 |
D | PAM905 |
H | CLR203 |
Functional Information from PROSITE/UniProt
site_id | PS01340 |
Number of Residues | 15 |
Details | CORNICHON Cornichon family signature. IafdELrtDFkSPID |
Chain | Residue | Details |
E | ILE29-ASP43 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 212 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
Chain | Residue | Details |
E | MET1-TYR10 | |
E | ASN94-LYS138 | |
F | MET1-TYR10 | |
F | ASN94-LYS138 | |
G | MET1-TYR10 | |
G | ASN94-LYS138 | |
H | MET1-TYR10 | |
H | ASN94-LYS138 |
site_id | SWS_FT_FI2 |
Number of Residues | 240 |
Details | TRANSMEM: Helical => ECO:0000255 |
Chain | Residue | Details |
E | MET11-PHE31 | |
H | MET11-PHE31 | |
H | SER73-LEU93 | |
H | LEU139-SER159 | |
E | SER73-LEU93 | |
E | LEU139-SER159 | |
F | MET11-PHE31 | |
F | SER73-LEU93 | |
F | LEU139-SER159 | |
G | MET11-PHE31 | |
G | SER73-LEU93 | |
G | LEU139-SER159 |
site_id | SWS_FT_FI3 |
Number of Residues | 164 |
Details | TOPO_DOM: Lumenal => ECO:0000255 |
Chain | Residue | Details |
E | ASP32-TYR72 | |
E | SER160 | |
F | ASP32-TYR72 | |
F | SER160 | |
G | ASP32-TYR72 | |
G | SER160 | |
H | ASP32-TYR72 | |
H | SER160 |
site_id | SWS_FT_FI4 |
Number of Residues | 60 |
Details | INTRAMEM: Helical; Pore-forming |
Chain | Residue | Details |
A | PHE571-ARG586 | |
B | PHE571-ARG586 | |
C | PHE571-ARG586 | |
D | PHE571-ARG586 |
site_id | SWS_FT_FI5 |
Number of Residues | 8 |
Details | INTRAMEM: |
Chain | Residue | Details |
A | GLN587-CYS589 | |
B | GLN587-CYS589 | |
C | GLN587-CYS589 | |
D | GLN587-CYS589 |
site_id | SWS_FT_FI6 |
Number of Residues | 80 |
Details | TRANSMEM: Helical; Name=M4 |
Chain | Residue | Details |
A | VAL792-ILE812 | |
B | VAL792-ILE812 | |
C | VAL792-ILE812 | |
D | VAL792-ILE812 |
site_id | SWS_FT_FI7 |
Number of Residues | 24 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO |
Chain | Residue | Details |
A | PRO478 | |
B | SER654 | |
B | THR655 | |
B | GLU705 | |
C | PRO478 | |
C | THR480 | |
C | ARG485 | |
C | SER654 | |
C | THR655 | |
C | GLU705 | |
D | PRO478 | |
A | THR480 | |
D | THR480 | |
D | ARG485 | |
D | SER654 | |
D | THR655 | |
D | GLU705 | |
A | ARG485 | |
A | SER654 | |
A | THR655 | |
A | GLU705 | |
B | PRO478 | |
B | THR480 | |
B | ARG485 |
site_id | SWS_FT_FI8 |
Number of Residues | 12 |
Details | SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 |
Chain | Residue | Details |
A | ARG453 | |
D | ARG453 | |
D | ARG660 | |
D | LYS752 | |
A | ARG660 | |
A | LYS752 | |
B | ARG453 | |
B | ARG660 | |
B | LYS752 | |
C | ARG453 | |
C | ARG660 | |
C | LYS752 |
site_id | SWS_FT_FI9 |
Number of Residues | 4 |
Details | SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405 |
Chain | Residue | Details |
A | ILE633 | |
B | ILE633 | |
C | ILE633 | |
D | ILE633 |
site_id | SWS_FT_FI10 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293 |
Chain | Residue | Details |
A | SER662 | |
B | SER662 | |
C | SER662 | |
D | SER662 |
site_id | SWS_FT_FI11 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293 |
Chain | Residue | Details |
A | SER696 | |
B | SER696 | |
C | SER696 | |
D | SER696 |
site_id | SWS_FT_FI12 |
Number of Residues | 8 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P23819 |
Chain | Residue | Details |
A | SER839 | |
A | SER842 | |
B | SER839 | |
B | SER842 | |
C | SER839 | |
C | SER842 | |
D | SER839 | |
D | SER842 |
site_id | SWS_FT_FI13 |
Number of Residues | 8 |
Details | LIPID: S-palmitoyl cysteine => ECO:0000250 |
Chain | Residue | Details |
A | CYS589 | |
A | CYS815 | |
B | CYS589 | |
B | CYS815 | |
C | CYS589 | |
C | CYS815 | |
D | CYS589 | |
D | CYS815 |
site_id | SWS_FT_FI14 |
Number of Residues | 4 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21317873 |
Chain | Residue | Details |
A | ASN235 | |
B | ASN235 | |
C | ASN235 | |
D | ASN235 |
site_id | SWS_FT_FI15 |
Number of Residues | 4 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19946266, ECO:0000269|PubMed:21317873, ECO:0000269|PubMed:25103405 |
Chain | Residue | Details |
A | ASN349 | |
B | ASN349 | |
C | ASN349 | |
D | ASN349 |
site_id | SWS_FT_FI16 |
Number of Residues | 8 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
A | ASN385 | |
A | ASN392 | |
B | ASN385 | |
B | ASN392 | |
C | ASN385 | |
C | ASN392 | |
D | ASN385 | |
D | ASN392 |