6UCB
GluA2 in complex with its auxiliary subunit CNIH3 - with antagonist ZK200775, LBD, TMD, CNIH3, and lipids
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0038023 | molecular_function | signaling receptor activity |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| B | 0016020 | cellular_component | membrane |
| B | 0038023 | molecular_function | signaling receptor activity |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| C | 0016020 | cellular_component | membrane |
| C | 0038023 | molecular_function | signaling receptor activity |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| D | 0016020 | cellular_component | membrane |
| D | 0038023 | molecular_function | signaling receptor activity |
| E | 0005102 | molecular_function | signaling receptor binding |
| E | 0016192 | biological_process | vesicle-mediated transport |
| E | 0016247 | molecular_function | channel regulator activity |
| E | 0030425 | cellular_component | dendrite |
| E | 0032281 | cellular_component | AMPA glutamate receptor complex |
| E | 0035249 | biological_process | synaptic transmission, glutamatergic |
| E | 0042391 | biological_process | regulation of membrane potential |
| E | 0043198 | cellular_component | dendritic shaft |
| E | 0045202 | cellular_component | synapse |
| E | 0045211 | cellular_component | postsynaptic membrane |
| E | 0098978 | cellular_component | glutamatergic synapse |
| E | 0099645 | biological_process | neurotransmitter receptor localization to postsynaptic specialization membrane |
| E | 2000311 | biological_process | regulation of AMPA receptor activity |
| F | 0005102 | molecular_function | signaling receptor binding |
| F | 0016192 | biological_process | vesicle-mediated transport |
| F | 0016247 | molecular_function | channel regulator activity |
| F | 0030425 | cellular_component | dendrite |
| F | 0032281 | cellular_component | AMPA glutamate receptor complex |
| F | 0035249 | biological_process | synaptic transmission, glutamatergic |
| F | 0042391 | biological_process | regulation of membrane potential |
| F | 0043198 | cellular_component | dendritic shaft |
| F | 0045202 | cellular_component | synapse |
| F | 0045211 | cellular_component | postsynaptic membrane |
| F | 0098978 | cellular_component | glutamatergic synapse |
| F | 0099645 | biological_process | neurotransmitter receptor localization to postsynaptic specialization membrane |
| F | 2000311 | biological_process | regulation of AMPA receptor activity |
| G | 0005102 | molecular_function | signaling receptor binding |
| G | 0016192 | biological_process | vesicle-mediated transport |
| G | 0016247 | molecular_function | channel regulator activity |
| G | 0030425 | cellular_component | dendrite |
| G | 0032281 | cellular_component | AMPA glutamate receptor complex |
| G | 0035249 | biological_process | synaptic transmission, glutamatergic |
| G | 0042391 | biological_process | regulation of membrane potential |
| G | 0043198 | cellular_component | dendritic shaft |
| G | 0045202 | cellular_component | synapse |
| G | 0045211 | cellular_component | postsynaptic membrane |
| G | 0098978 | cellular_component | glutamatergic synapse |
| G | 0099645 | biological_process | neurotransmitter receptor localization to postsynaptic specialization membrane |
| G | 2000311 | biological_process | regulation of AMPA receptor activity |
| H | 0005102 | molecular_function | signaling receptor binding |
| H | 0016192 | biological_process | vesicle-mediated transport |
| H | 0016247 | molecular_function | channel regulator activity |
| H | 0030425 | cellular_component | dendrite |
| H | 0032281 | cellular_component | AMPA glutamate receptor complex |
| H | 0035249 | biological_process | synaptic transmission, glutamatergic |
| H | 0042391 | biological_process | regulation of membrane potential |
| H | 0043198 | cellular_component | dendritic shaft |
| H | 0045202 | cellular_component | synapse |
| H | 0045211 | cellular_component | postsynaptic membrane |
| H | 0098978 | cellular_component | glutamatergic synapse |
| H | 0099645 | biological_process | neurotransmitter receptor localization to postsynaptic specialization membrane |
| H | 2000311 | biological_process | regulation of AMPA receptor activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue ZK1 A 901 |
| Chain | Residue |
| A | TYR450 |
| A | PRO478 |
| A | THR480 |
| A | ARG485 |
| A | GLY653 |
| A | SER654 |
| A | THR686 |
| A | TYR732 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue OLC A 902 |
| Chain | Residue |
| A | MET527 |
| A | PAM903 |
| F | PAM202 |
| A | TYR523 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue PAM A 903 |
| Chain | Residue |
| A | OLC902 |
| A | PAM904 |
| F | PAM202 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue PAM A 904 |
| Chain | Residue |
| A | GLY513 |
| A | VAL514 |
| A | PHE515 |
| A | PAM903 |
| E | CLR202 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | binding site for residue ZK1 B 901 |
| Chain | Residue |
| B | TYR450 |
| B | PRO478 |
| B | LEU479 |
| B | THR480 |
| B | ARG485 |
| B | GLY653 |
| B | SER654 |
| B | THR686 |
| B | MET708 |
| B | TYR732 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue OLC B 902 |
| Chain | Residue |
| B | SER595 |
| C | ILE534 |
| C | ARG545 |
| H | PAM202 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue OLC B 903 |
| Chain | Residue |
| A | ILE600 |
| B | ARG545 |
| G | PAM201 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue OLC B 904 |
| Chain | Residue |
| B | TYR523 |
| B | MET527 |
| B | PAM905 |
| G | PAM201 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue PAM B 905 |
| Chain | Residue |
| B | ILE798 |
| B | OLC904 |
| B | PAM906 |
| G | PAM201 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue PAM B 906 |
| Chain | Residue |
| B | GLY801 |
| B | PAM905 |
| B | CLR907 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue CLR B 907 |
| Chain | Residue |
| B | GLY804 |
| B | LEU808 |
| B | PAM906 |
| F | LEU14 |
| F | ALA18 |
| F | MET153 |
| F | LEU157 |
| site_id | AD3 |
| Number of Residues | 8 |
| Details | binding site for residue ZK1 C 901 |
| Chain | Residue |
| C | TYR450 |
| C | PRO478 |
| C | THR480 |
| C | ARG485 |
| C | GLY653 |
| C | SER654 |
| C | THR686 |
| C | TYR732 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue OLC C 902 |
| Chain | Residue |
| C | TYR523 |
| C | MET527 |
| C | PAM903 |
| H | PAM201 |
| H | PAM202 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue PAM C 903 |
| Chain | Residue |
| C | OLC902 |
| C | PAM904 |
| H | PAM202 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue PAM C 904 |
| Chain | Residue |
| C | GLY513 |
| C | VAL514 |
| C | PHE515 |
| C | PAM903 |
| G | CLR202 |
| site_id | AD7 |
| Number of Residues | 7 |
| Details | binding site for residue PAM E 201 |
| Chain | Residue |
| D | TYR523 |
| D | MET527 |
| D | VAL530 |
| D | OLC903 |
| D | OLC904 |
| D | PAM905 |
| E | CYS84 |
| site_id | AD8 |
| Number of Residues | 7 |
| Details | binding site for residue CLR E 202 |
| Chain | Residue |
| A | GLY804 |
| A | PAM904 |
| E | LEU14 |
| E | VAL15 |
| E | ALA18 |
| E | MET153 |
| E | LEU157 |
| site_id | AD9 |
| Number of Residues | 1 |
| Details | binding site for residue PAM F 201 |
| Chain | Residue |
| F | GLN86 |
| site_id | AE1 |
| Number of Residues | 8 |
| Details | binding site for residue PAM F 202 |
| Chain | Residue |
| A | TYR523 |
| A | MET527 |
| A | VAL530 |
| A | OLC902 |
| A | PAM903 |
| D | OLC902 |
| F | CYS84 |
| F | GLN86 |
| site_id | AE2 |
| Number of Residues | 8 |
| Details | binding site for residue PAM G 201 |
| Chain | Residue |
| B | TYR523 |
| B | MET527 |
| B | OLC903 |
| B | OLC904 |
| B | PAM905 |
| G | CYS84 |
| G | ALA85 |
| G | GLN86 |
| site_id | AE3 |
| Number of Residues | 6 |
| Details | binding site for residue CLR G 202 |
| Chain | Residue |
| C | GLY804 |
| C | PAM904 |
| G | LEU14 |
| G | ALA18 |
| G | MET153 |
| G | LEU157 |
| site_id | AE4 |
| Number of Residues | 2 |
| Details | binding site for residue PAM H 201 |
| Chain | Residue |
| C | OLC902 |
| H | GLN86 |
| site_id | AE5 |
| Number of Residues | 9 |
| Details | binding site for residue PAM H 202 |
| Chain | Residue |
| B | PHE607 |
| B | OLC902 |
| C | TYR523 |
| C | MET527 |
| C | VAL530 |
| C | OLC902 |
| C | PAM903 |
| H | CYS84 |
| H | GLN86 |
| site_id | AE6 |
| Number of Residues | 7 |
| Details | binding site for residue CLR H 203 |
| Chain | Residue |
| D | GLY804 |
| D | LEU808 |
| D | PAM906 |
| H | LEU14 |
| H | ALA18 |
| H | MET153 |
| H | LEU157 |
| site_id | AE7 |
| Number of Residues | 10 |
| Details | binding site for residue ZK1 D 901 |
| Chain | Residue |
| D | TYR450 |
| D | PRO478 |
| D | LEU479 |
| D | THR480 |
| D | ARG485 |
| D | GLY653 |
| D | SER654 |
| D | THR686 |
| D | MET708 |
| D | TYR732 |
| site_id | AE8 |
| Number of Residues | 5 |
| Details | binding site for residue OLC D 902 |
| Chain | Residue |
| A | SER537 |
| A | VAL538 |
| A | PHE541 |
| D | ARG599 |
| F | PAM202 |
| site_id | AE9 |
| Number of Residues | 4 |
| Details | binding site for residue OLC D 903 |
| Chain | Residue |
| D | TYR533 |
| D | SER537 |
| E | LEU69 |
| E | PAM201 |
| site_id | AF1 |
| Number of Residues | 4 |
| Details | binding site for residue OLC D 904 |
| Chain | Residue |
| D | TYR523 |
| D | MET527 |
| D | PAM905 |
| E | PAM201 |
| site_id | AF2 |
| Number of Residues | 4 |
| Details | binding site for residue PAM D 905 |
| Chain | Residue |
| D | ILE798 |
| D | OLC904 |
| D | PAM906 |
| E | PAM201 |
| site_id | AF3 |
| Number of Residues | 3 |
| Details | binding site for residue PAM D 906 |
| Chain | Residue |
| D | GLY801 |
| D | PAM905 |
| H | CLR203 |
Functional Information from PROSITE/UniProt
| site_id | PS01340 |
| Number of Residues | 15 |
| Details | CORNICHON Cornichon family signature. IafdELrtDFkSPID |
| Chain | Residue | Details |
| E | ILE29-ASP43 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 160 |
| Details | Transmembrane: {"description":"Helical"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 80 |
| Details | Transmembrane: {"description":"Helical; Name=M4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 240 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Topological domain: {"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
