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6UC4

Barbed end side of a cofilactin cluster

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000287molecular_functionmagnesium ion binding
A0001725cellular_componentstress fiber
A0003785molecular_functionactin monomer binding
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005523molecular_functiontropomyosin binding
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005856cellular_componentcytoskeleton
A0005865cellular_componentstriated muscle thin filament
A0005884cellular_componentactin filament
A0010628biological_processpositive regulation of gene expression
A0016787molecular_functionhydrolase activity
A0019904molecular_functionprotein domain specific binding
A0030027cellular_componentlamellipodium
A0030041biological_processactin filament polymerization
A0030175cellular_componentfilopodium
A0030240biological_processskeletal muscle thin filament assembly
A0031013molecular_functiontroponin I binding
A0031432molecular_functiontitin binding
A0031941cellular_componentfilamentous actin
A0032036molecular_functionmyosin heavy chain binding
A0032432cellular_componentactin filament bundle
A0042802molecular_functionidentical protein binding
A0044297cellular_componentcell body
A0048306molecular_functioncalcium-dependent protein binding
A0048741biological_processskeletal muscle fiber development
A0051017biological_processactin filament bundle assembly
A0090131biological_processmesenchyme migration
A0098723cellular_componentskeletal muscle myofibril
A0140660molecular_functioncytoskeletal motor activator activity
B0000166molecular_functionnucleotide binding
B0000287molecular_functionmagnesium ion binding
B0001725cellular_componentstress fiber
B0003785molecular_functionactin monomer binding
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005523molecular_functiontropomyosin binding
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005856cellular_componentcytoskeleton
B0005865cellular_componentstriated muscle thin filament
B0005884cellular_componentactin filament
B0010628biological_processpositive regulation of gene expression
B0016787molecular_functionhydrolase activity
B0019904molecular_functionprotein domain specific binding
B0030027cellular_componentlamellipodium
B0030041biological_processactin filament polymerization
B0030175cellular_componentfilopodium
B0030240biological_processskeletal muscle thin filament assembly
B0031013molecular_functiontroponin I binding
B0031432molecular_functiontitin binding
B0031941cellular_componentfilamentous actin
B0032036molecular_functionmyosin heavy chain binding
B0032432cellular_componentactin filament bundle
B0042802molecular_functionidentical protein binding
B0044297cellular_componentcell body
B0048306molecular_functioncalcium-dependent protein binding
B0048741biological_processskeletal muscle fiber development
B0051017biological_processactin filament bundle assembly
B0090131biological_processmesenchyme migration
B0098723cellular_componentskeletal muscle myofibril
B0140660molecular_functioncytoskeletal motor activator activity
C0000166molecular_functionnucleotide binding
C0000287molecular_functionmagnesium ion binding
C0001725cellular_componentstress fiber
C0003785molecular_functionactin monomer binding
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005523molecular_functiontropomyosin binding
C0005524molecular_functionATP binding
C0005737cellular_componentcytoplasm
C0005856cellular_componentcytoskeleton
C0005865cellular_componentstriated muscle thin filament
C0005884cellular_componentactin filament
C0010628biological_processpositive regulation of gene expression
C0016787molecular_functionhydrolase activity
C0019904molecular_functionprotein domain specific binding
C0030027cellular_componentlamellipodium
C0030041biological_processactin filament polymerization
C0030175cellular_componentfilopodium
C0030240biological_processskeletal muscle thin filament assembly
C0031013molecular_functiontroponin I binding
C0031432molecular_functiontitin binding
C0031941cellular_componentfilamentous actin
C0032036molecular_functionmyosin heavy chain binding
C0032432cellular_componentactin filament bundle
C0042802molecular_functionidentical protein binding
C0044297cellular_componentcell body
C0048306molecular_functioncalcium-dependent protein binding
C0048741biological_processskeletal muscle fiber development
C0051017biological_processactin filament bundle assembly
C0090131biological_processmesenchyme migration
C0098723cellular_componentskeletal muscle myofibril
C0140660molecular_functioncytoskeletal motor activator activity
D0000166molecular_functionnucleotide binding
D0000287molecular_functionmagnesium ion binding
D0001725cellular_componentstress fiber
D0003785molecular_functionactin monomer binding
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005523molecular_functiontropomyosin binding
D0005524molecular_functionATP binding
D0005737cellular_componentcytoplasm
D0005856cellular_componentcytoskeleton
D0005865cellular_componentstriated muscle thin filament
D0005884cellular_componentactin filament
D0010628biological_processpositive regulation of gene expression
D0016787molecular_functionhydrolase activity
D0019904molecular_functionprotein domain specific binding
D0030027cellular_componentlamellipodium
D0030041biological_processactin filament polymerization
D0030175cellular_componentfilopodium
D0030240biological_processskeletal muscle thin filament assembly
D0031013molecular_functiontroponin I binding
D0031432molecular_functiontitin binding
D0031941cellular_componentfilamentous actin
D0032036molecular_functionmyosin heavy chain binding
D0032432cellular_componentactin filament bundle
D0042802molecular_functionidentical protein binding
D0044297cellular_componentcell body
D0048306molecular_functioncalcium-dependent protein binding
D0048741biological_processskeletal muscle fiber development
D0051017biological_processactin filament bundle assembly
D0090131biological_processmesenchyme migration
D0098723cellular_componentskeletal muscle myofibril
D0140660molecular_functioncytoskeletal motor activator activity
E0000166molecular_functionnucleotide binding
E0000287molecular_functionmagnesium ion binding
E0001725cellular_componentstress fiber
E0003785molecular_functionactin monomer binding
E0005509molecular_functioncalcium ion binding
E0005515molecular_functionprotein binding
E0005523molecular_functiontropomyosin binding
E0005524molecular_functionATP binding
E0005737cellular_componentcytoplasm
E0005856cellular_componentcytoskeleton
E0005865cellular_componentstriated muscle thin filament
E0005884cellular_componentactin filament
E0010628biological_processpositive regulation of gene expression
E0016787molecular_functionhydrolase activity
E0019904molecular_functionprotein domain specific binding
E0030027cellular_componentlamellipodium
E0030041biological_processactin filament polymerization
E0030175cellular_componentfilopodium
E0030240biological_processskeletal muscle thin filament assembly
E0031013molecular_functiontroponin I binding
E0031432molecular_functiontitin binding
E0031941cellular_componentfilamentous actin
E0032036molecular_functionmyosin heavy chain binding
E0032432cellular_componentactin filament bundle
E0042802molecular_functionidentical protein binding
E0044297cellular_componentcell body
E0048306molecular_functioncalcium-dependent protein binding
E0048741biological_processskeletal muscle fiber development
E0051017biological_processactin filament bundle assembly
E0090131biological_processmesenchyme migration
E0098723cellular_componentskeletal muscle myofibril
E0140660molecular_functioncytoskeletal motor activator activity
F0000166molecular_functionnucleotide binding
F0000287molecular_functionmagnesium ion binding
F0001725cellular_componentstress fiber
F0003785molecular_functionactin monomer binding
F0005509molecular_functioncalcium ion binding
F0005515molecular_functionprotein binding
F0005523molecular_functiontropomyosin binding
F0005524molecular_functionATP binding
F0005737cellular_componentcytoplasm
F0005856cellular_componentcytoskeleton
F0005865cellular_componentstriated muscle thin filament
F0005884cellular_componentactin filament
F0010628biological_processpositive regulation of gene expression
F0016787molecular_functionhydrolase activity
F0019904molecular_functionprotein domain specific binding
F0030027cellular_componentlamellipodium
F0030041biological_processactin filament polymerization
F0030175cellular_componentfilopodium
F0030240biological_processskeletal muscle thin filament assembly
F0031013molecular_functiontroponin I binding
F0031432molecular_functiontitin binding
F0031941cellular_componentfilamentous actin
F0032036molecular_functionmyosin heavy chain binding
F0032432cellular_componentactin filament bundle
F0042802molecular_functionidentical protein binding
F0044297cellular_componentcell body
F0048306molecular_functioncalcium-dependent protein binding
F0048741biological_processskeletal muscle fiber development
F0051017biological_processactin filament bundle assembly
F0090131biological_processmesenchyme migration
F0098723cellular_componentskeletal muscle myofibril
F0140660molecular_functioncytoskeletal motor activator activity
G0000166molecular_functionnucleotide binding
G0000287molecular_functionmagnesium ion binding
G0001725cellular_componentstress fiber
G0003785molecular_functionactin monomer binding
G0005509molecular_functioncalcium ion binding
G0005515molecular_functionprotein binding
G0005523molecular_functiontropomyosin binding
G0005524molecular_functionATP binding
G0005737cellular_componentcytoplasm
G0005856cellular_componentcytoskeleton
G0005865cellular_componentstriated muscle thin filament
G0005884cellular_componentactin filament
G0010628biological_processpositive regulation of gene expression
G0016787molecular_functionhydrolase activity
G0019904molecular_functionprotein domain specific binding
G0030027cellular_componentlamellipodium
G0030041biological_processactin filament polymerization
G0030175cellular_componentfilopodium
G0030240biological_processskeletal muscle thin filament assembly
G0031013molecular_functiontroponin I binding
G0031432molecular_functiontitin binding
G0031941cellular_componentfilamentous actin
G0032036molecular_functionmyosin heavy chain binding
G0032432cellular_componentactin filament bundle
G0042802molecular_functionidentical protein binding
G0044297cellular_componentcell body
G0048306molecular_functioncalcium-dependent protein binding
G0048741biological_processskeletal muscle fiber development
G0051017biological_processactin filament bundle assembly
G0090131biological_processmesenchyme migration
G0098723cellular_componentskeletal muscle myofibril
G0140660molecular_functioncytoskeletal motor activator activity
H0000166molecular_functionnucleotide binding
H0000287molecular_functionmagnesium ion binding
H0001725cellular_componentstress fiber
H0003785molecular_functionactin monomer binding
H0005509molecular_functioncalcium ion binding
H0005515molecular_functionprotein binding
H0005523molecular_functiontropomyosin binding
H0005524molecular_functionATP binding
H0005737cellular_componentcytoplasm
H0005856cellular_componentcytoskeleton
H0005865cellular_componentstriated muscle thin filament
H0005884cellular_componentactin filament
H0010628biological_processpositive regulation of gene expression
H0016787molecular_functionhydrolase activity
H0019904molecular_functionprotein domain specific binding
H0030027cellular_componentlamellipodium
H0030041biological_processactin filament polymerization
H0030175cellular_componentfilopodium
H0030240biological_processskeletal muscle thin filament assembly
H0031013molecular_functiontroponin I binding
H0031432molecular_functiontitin binding
H0031941cellular_componentfilamentous actin
H0032036molecular_functionmyosin heavy chain binding
H0032432cellular_componentactin filament bundle
H0042802molecular_functionidentical protein binding
H0044297cellular_componentcell body
H0048306molecular_functioncalcium-dependent protein binding
H0048741biological_processskeletal muscle fiber development
H0051017biological_processactin filament bundle assembly
H0090131biological_processmesenchyme migration
H0098723cellular_componentskeletal muscle myofibril
H0140660molecular_functioncytoskeletal motor activator activity
I0000281biological_processmitotic cytokinesis
I0001755biological_processneural crest cell migration
I0001842biological_processneural fold formation
I0003779molecular_functionactin binding
I0005102molecular_functionsignaling receptor binding
I0005515molecular_functionprotein binding
I0005615cellular_componentextracellular space
I0005634cellular_componentnucleus
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0005856cellular_componentcytoskeleton
I0005886cellular_componentplasma membrane
I0005911cellular_componentcell-cell junction
I0005925cellular_componentfocal adhesion
I0006606biological_processprotein import into nucleus
I0007010biological_processcytoskeleton organization
I0007015biological_processactin filament organization
I0007162biological_processnegative regulation of cell adhesion
I0007266biological_processRho protein signal transduction
I0008154biological_processactin polymerization or depolymerization
I0009615biological_processresponse to virus
I0010592biological_processpositive regulation of lamellipodium assembly
I0010593biological_processnegative regulation of lamellipodium assembly
I0014823biological_processresponse to activity
I0015629cellular_componentactin cytoskeleton
I0016020cellular_componentmembrane
I0016363cellular_componentnuclear matrix
I0019903molecular_functionprotein phosphatase binding
I0021766biological_processhippocampus development
I0022604biological_processregulation of cell morphogenesis
I0030010biological_processestablishment of cell polarity
I0030027cellular_componentlamellipodium
I0030030biological_processcell projection organization
I0030036biological_processactin cytoskeleton organization
I0030042biological_processactin filament depolymerization
I0030043biological_processactin filament fragmentation
I0030175cellular_componentfilopodium
I0030307biological_processpositive regulation of cell growth
I0030424cellular_componentaxon
I0030426cellular_componentgrowth cone
I0030835biological_processnegative regulation of actin filament depolymerization
I0030836biological_processpositive regulation of actin filament depolymerization
I0030864cellular_componentcortical actin cytoskeleton
I0031252cellular_componentcell leading edge
I0031258cellular_componentlamellipodium membrane
I0031915biological_processpositive regulation of synaptic plasticity
I0031966cellular_componentmitochondrial membrane
I0031982cellular_componentvesicle
I0032232biological_processnegative regulation of actin filament bundle assembly
I0032587cellular_componentruffle membrane
I0040019biological_processpositive regulation of embryonic development
I0042995cellular_componentcell projection
I0043025cellular_componentneuronal cell body
I0043066biological_processnegative regulation of apoptotic process
I0043197cellular_componentdendritic spine
I0043200biological_processresponse to amino acid
I0044794biological_processpositive regulation by host of viral process
I0045792biological_processnegative regulation of cell size
I0045862biological_processpositive regulation of proteolysis
I0048870biological_processcell motility
I0050804biological_processmodulation of chemical synaptic transmission
I0051014biological_processactin filament severing
I0051015molecular_functionactin filament binding
I0051293biological_processestablishment of spindle localization
I0051511biological_processnegative regulation of unidimensional cell growth
I0051894biological_processpositive regulation of focal adhesion assembly
I0060999biological_processpositive regulation of dendritic spine development
I0061001biological_processregulation of dendritic spine morphogenesis
I0070062cellular_componentextracellular exosome
I0070301biological_processcellular response to hydrogen peroxide
I0071347biological_processcellular response to interleukin-1
I0071354biological_processcellular response to interleukin-6
I0071356biological_processcellular response to tumor necrosis factor
I0071362biological_processcellular response to ether
I0071364biological_processcellular response to epidermal growth factor stimulus
I0090732cellular_componentcofilin-actin rod
I0097060cellular_componentsynaptic membrane
I0098885biological_processmodification of postsynaptic actin cytoskeleton
I0098978cellular_componentglutamatergic synapse
I0099092cellular_componentpostsynaptic density, intracellular component
I1902936molecular_functionphosphatidylinositol bisphosphate binding
I1902951biological_processnegative regulation of dendritic spine maintenance
I1905873biological_processpositive regulation of protein localization to cell leading edge
I1905875biological_processnegative regulation of postsynaptic density organization
I1990314biological_processcellular response to insulin-like growth factor stimulus
I2000146biological_processnegative regulation of cell motility
I2000147biological_processpositive regulation of cell motility
I2000784biological_processpositive regulation of establishment of cell polarity regulating cell shape
I2000814biological_processpositive regulation of barbed-end actin filament capping
J0000166molecular_functionnucleotide binding
J0000287molecular_functionmagnesium ion binding
J0001725cellular_componentstress fiber
J0003785molecular_functionactin monomer binding
J0005509molecular_functioncalcium ion binding
J0005515molecular_functionprotein binding
J0005523molecular_functiontropomyosin binding
J0005524molecular_functionATP binding
J0005737cellular_componentcytoplasm
J0005856cellular_componentcytoskeleton
J0005865cellular_componentstriated muscle thin filament
J0005884cellular_componentactin filament
J0010628biological_processpositive regulation of gene expression
J0016787molecular_functionhydrolase activity
J0019904molecular_functionprotein domain specific binding
J0030027cellular_componentlamellipodium
J0030041biological_processactin filament polymerization
J0030175cellular_componentfilopodium
J0030240biological_processskeletal muscle thin filament assembly
J0031013molecular_functiontroponin I binding
J0031432molecular_functiontitin binding
J0031941cellular_componentfilamentous actin
J0032036molecular_functionmyosin heavy chain binding
J0032432cellular_componentactin filament bundle
J0042802molecular_functionidentical protein binding
J0044297cellular_componentcell body
J0048306molecular_functioncalcium-dependent protein binding
J0048741biological_processskeletal muscle fiber development
J0051017biological_processactin filament bundle assembly
J0090131biological_processmesenchyme migration
J0098723cellular_componentskeletal muscle myofibril
J0140660molecular_functioncytoskeletal motor activator activity
K0000166molecular_functionnucleotide binding
K0000287molecular_functionmagnesium ion binding
K0001725cellular_componentstress fiber
K0003785molecular_functionactin monomer binding
K0005509molecular_functioncalcium ion binding
K0005515molecular_functionprotein binding
K0005523molecular_functiontropomyosin binding
K0005524molecular_functionATP binding
K0005737cellular_componentcytoplasm
K0005856cellular_componentcytoskeleton
K0005865cellular_componentstriated muscle thin filament
K0005884cellular_componentactin filament
K0010628biological_processpositive regulation of gene expression
K0016787molecular_functionhydrolase activity
K0019904molecular_functionprotein domain specific binding
K0030027cellular_componentlamellipodium
K0030041biological_processactin filament polymerization
K0030175cellular_componentfilopodium
K0030240biological_processskeletal muscle thin filament assembly
K0031013molecular_functiontroponin I binding
K0031432molecular_functiontitin binding
K0031941cellular_componentfilamentous actin
K0032036molecular_functionmyosin heavy chain binding
K0032432cellular_componentactin filament bundle
K0042802molecular_functionidentical protein binding
K0044297cellular_componentcell body
K0048306molecular_functioncalcium-dependent protein binding
K0048741biological_processskeletal muscle fiber development
K0051017biological_processactin filament bundle assembly
K0090131biological_processmesenchyme migration
K0098723cellular_componentskeletal muscle myofibril
K0140660molecular_functioncytoskeletal motor activator activity
L0000166molecular_functionnucleotide binding
L0000287molecular_functionmagnesium ion binding
L0001725cellular_componentstress fiber
L0003785molecular_functionactin monomer binding
L0005509molecular_functioncalcium ion binding
L0005515molecular_functionprotein binding
L0005523molecular_functiontropomyosin binding
L0005524molecular_functionATP binding
L0005737cellular_componentcytoplasm
L0005856cellular_componentcytoskeleton
L0005865cellular_componentstriated muscle thin filament
L0005884cellular_componentactin filament
L0010628biological_processpositive regulation of gene expression
L0016787molecular_functionhydrolase activity
L0019904molecular_functionprotein domain specific binding
L0030027cellular_componentlamellipodium
L0030041biological_processactin filament polymerization
L0030175cellular_componentfilopodium
L0030240biological_processskeletal muscle thin filament assembly
L0031013molecular_functiontroponin I binding
L0031432molecular_functiontitin binding
L0031941cellular_componentfilamentous actin
L0032036molecular_functionmyosin heavy chain binding
L0032432cellular_componentactin filament bundle
L0042802molecular_functionidentical protein binding
L0044297cellular_componentcell body
L0048306molecular_functioncalcium-dependent protein binding
L0048741biological_processskeletal muscle fiber development
L0051017biological_processactin filament bundle assembly
L0090131biological_processmesenchyme migration
L0098723cellular_componentskeletal muscle myofibril
L0140660molecular_functioncytoskeletal motor activator activity
M0000281biological_processmitotic cytokinesis
M0001755biological_processneural crest cell migration
M0001842biological_processneural fold formation
M0003779molecular_functionactin binding
M0005102molecular_functionsignaling receptor binding
M0005515molecular_functionprotein binding
M0005615cellular_componentextracellular space
M0005634cellular_componentnucleus
M0005737cellular_componentcytoplasm
M0005829cellular_componentcytosol
M0005856cellular_componentcytoskeleton
M0005886cellular_componentplasma membrane
M0005911cellular_componentcell-cell junction
M0005925cellular_componentfocal adhesion
M0006606biological_processprotein import into nucleus
M0007010biological_processcytoskeleton organization
M0007015biological_processactin filament organization
M0007162biological_processnegative regulation of cell adhesion
M0007266biological_processRho protein signal transduction
M0008154biological_processactin polymerization or depolymerization
M0009615biological_processresponse to virus
M0010592biological_processpositive regulation of lamellipodium assembly
M0010593biological_processnegative regulation of lamellipodium assembly
M0014823biological_processresponse to activity
M0015629cellular_componentactin cytoskeleton
M0016020cellular_componentmembrane
M0016363cellular_componentnuclear matrix
M0019903molecular_functionprotein phosphatase binding
M0021766biological_processhippocampus development
M0022604biological_processregulation of cell morphogenesis
M0030010biological_processestablishment of cell polarity
M0030027cellular_componentlamellipodium
M0030030biological_processcell projection organization
M0030036biological_processactin cytoskeleton organization
M0030042biological_processactin filament depolymerization
M0030043biological_processactin filament fragmentation
M0030175cellular_componentfilopodium
M0030307biological_processpositive regulation of cell growth
M0030424cellular_componentaxon
M0030426cellular_componentgrowth cone
M0030835biological_processnegative regulation of actin filament depolymerization
M0030836biological_processpositive regulation of actin filament depolymerization
M0030864cellular_componentcortical actin cytoskeleton
M0031252cellular_componentcell leading edge
M0031258cellular_componentlamellipodium membrane
M0031915biological_processpositive regulation of synaptic plasticity
M0031966cellular_componentmitochondrial membrane
M0031982cellular_componentvesicle
M0032232biological_processnegative regulation of actin filament bundle assembly
M0032587cellular_componentruffle membrane
M0040019biological_processpositive regulation of embryonic development
M0042995cellular_componentcell projection
M0043025cellular_componentneuronal cell body
M0043066biological_processnegative regulation of apoptotic process
M0043197cellular_componentdendritic spine
M0043200biological_processresponse to amino acid
M0044794biological_processpositive regulation by host of viral process
M0045792biological_processnegative regulation of cell size
M0045862biological_processpositive regulation of proteolysis
M0048870biological_processcell motility
M0050804biological_processmodulation of chemical synaptic transmission
M0051014biological_processactin filament severing
M0051015molecular_functionactin filament binding
M0051293biological_processestablishment of spindle localization
M0051511biological_processnegative regulation of unidimensional cell growth
M0051894biological_processpositive regulation of focal adhesion assembly
M0060999biological_processpositive regulation of dendritic spine development
M0061001biological_processregulation of dendritic spine morphogenesis
M0070062cellular_componentextracellular exosome
M0070301biological_processcellular response to hydrogen peroxide
M0071347biological_processcellular response to interleukin-1
M0071354biological_processcellular response to interleukin-6
M0071356biological_processcellular response to tumor necrosis factor
M0071362biological_processcellular response to ether
M0071364biological_processcellular response to epidermal growth factor stimulus
M0090732cellular_componentcofilin-actin rod
M0097060cellular_componentsynaptic membrane
M0098885biological_processmodification of postsynaptic actin cytoskeleton
M0098978cellular_componentglutamatergic synapse
M0099092cellular_componentpostsynaptic density, intracellular component
M1902936molecular_functionphosphatidylinositol bisphosphate binding
M1902951biological_processnegative regulation of dendritic spine maintenance
M1905873biological_processpositive regulation of protein localization to cell leading edge
M1905875biological_processnegative regulation of postsynaptic density organization
M1990314biological_processcellular response to insulin-like growth factor stimulus
M2000146biological_processnegative regulation of cell motility
M2000147biological_processpositive regulation of cell motility
M2000784biological_processpositive regulation of establishment of cell polarity regulating cell shape
M2000814biological_processpositive regulation of barbed-end actin filament capping
N0000281biological_processmitotic cytokinesis
N0001755biological_processneural crest cell migration
N0001842biological_processneural fold formation
N0003779molecular_functionactin binding
N0005102molecular_functionsignaling receptor binding
N0005515molecular_functionprotein binding
N0005615cellular_componentextracellular space
N0005634cellular_componentnucleus
N0005737cellular_componentcytoplasm
N0005829cellular_componentcytosol
N0005856cellular_componentcytoskeleton
N0005886cellular_componentplasma membrane
N0005911cellular_componentcell-cell junction
N0005925cellular_componentfocal adhesion
N0006606biological_processprotein import into nucleus
N0007010biological_processcytoskeleton organization
N0007015biological_processactin filament organization
N0007162biological_processnegative regulation of cell adhesion
N0007266biological_processRho protein signal transduction
N0008154biological_processactin polymerization or depolymerization
N0009615biological_processresponse to virus
N0010592biological_processpositive regulation of lamellipodium assembly
N0010593biological_processnegative regulation of lamellipodium assembly
N0014823biological_processresponse to activity
N0015629cellular_componentactin cytoskeleton
N0016020cellular_componentmembrane
N0016363cellular_componentnuclear matrix
N0019903molecular_functionprotein phosphatase binding
N0021766biological_processhippocampus development
N0022604biological_processregulation of cell morphogenesis
N0030010biological_processestablishment of cell polarity
N0030027cellular_componentlamellipodium
N0030030biological_processcell projection organization
N0030036biological_processactin cytoskeleton organization
N0030042biological_processactin filament depolymerization
N0030043biological_processactin filament fragmentation
N0030175cellular_componentfilopodium
N0030307biological_processpositive regulation of cell growth
N0030424cellular_componentaxon
N0030426cellular_componentgrowth cone
N0030835biological_processnegative regulation of actin filament depolymerization
N0030836biological_processpositive regulation of actin filament depolymerization
N0030864cellular_componentcortical actin cytoskeleton
N0031252cellular_componentcell leading edge
N0031258cellular_componentlamellipodium membrane
N0031915biological_processpositive regulation of synaptic plasticity
N0031966cellular_componentmitochondrial membrane
N0031982cellular_componentvesicle
N0032232biological_processnegative regulation of actin filament bundle assembly
N0032587cellular_componentruffle membrane
N0040019biological_processpositive regulation of embryonic development
N0042995cellular_componentcell projection
N0043025cellular_componentneuronal cell body
N0043066biological_processnegative regulation of apoptotic process
N0043197cellular_componentdendritic spine
N0043200biological_processresponse to amino acid
N0044794biological_processpositive regulation by host of viral process
N0045792biological_processnegative regulation of cell size
N0045862biological_processpositive regulation of proteolysis
N0048870biological_processcell motility
N0050804biological_processmodulation of chemical synaptic transmission
N0051014biological_processactin filament severing
N0051015molecular_functionactin filament binding
N0051293biological_processestablishment of spindle localization
N0051511biological_processnegative regulation of unidimensional cell growth
N0051894biological_processpositive regulation of focal adhesion assembly
N0060999biological_processpositive regulation of dendritic spine development
N0061001biological_processregulation of dendritic spine morphogenesis
N0070062cellular_componentextracellular exosome
N0070301biological_processcellular response to hydrogen peroxide
N0071347biological_processcellular response to interleukin-1
N0071354biological_processcellular response to interleukin-6
N0071356biological_processcellular response to tumor necrosis factor
N0071362biological_processcellular response to ether
N0071364biological_processcellular response to epidermal growth factor stimulus
N0090732cellular_componentcofilin-actin rod
N0097060cellular_componentsynaptic membrane
N0098885biological_processmodification of postsynaptic actin cytoskeleton
N0098978cellular_componentglutamatergic synapse
N0099092cellular_componentpostsynaptic density, intracellular component
N1902936molecular_functionphosphatidylinositol bisphosphate binding
N1902951biological_processnegative regulation of dendritic spine maintenance
N1905873biological_processpositive regulation of protein localization to cell leading edge
N1905875biological_processnegative regulation of postsynaptic density organization
N1990314biological_processcellular response to insulin-like growth factor stimulus
N2000146biological_processnegative regulation of cell motility
N2000147biological_processpositive regulation of cell motility
N2000784biological_processpositive regulation of establishment of cell polarity regulating cell shape
N2000814biological_processpositive regulation of barbed-end actin filament capping
O0000281biological_processmitotic cytokinesis
O0001755biological_processneural crest cell migration
O0001842biological_processneural fold formation
O0003779molecular_functionactin binding
O0005102molecular_functionsignaling receptor binding
O0005515molecular_functionprotein binding
O0005615cellular_componentextracellular space
O0005634cellular_componentnucleus
O0005737cellular_componentcytoplasm
O0005829cellular_componentcytosol
O0005856cellular_componentcytoskeleton
O0005886cellular_componentplasma membrane
O0005911cellular_componentcell-cell junction
O0005925cellular_componentfocal adhesion
O0006606biological_processprotein import into nucleus
O0007010biological_processcytoskeleton organization
O0007015biological_processactin filament organization
O0007162biological_processnegative regulation of cell adhesion
O0007266biological_processRho protein signal transduction
O0008154biological_processactin polymerization or depolymerization
O0009615biological_processresponse to virus
O0010592biological_processpositive regulation of lamellipodium assembly
O0010593biological_processnegative regulation of lamellipodium assembly
O0014823biological_processresponse to activity
O0015629cellular_componentactin cytoskeleton
O0016020cellular_componentmembrane
O0016363cellular_componentnuclear matrix
O0019903molecular_functionprotein phosphatase binding
O0021766biological_processhippocampus development
O0022604biological_processregulation of cell morphogenesis
O0030010biological_processestablishment of cell polarity
O0030027cellular_componentlamellipodium
O0030030biological_processcell projection organization
O0030036biological_processactin cytoskeleton organization
O0030042biological_processactin filament depolymerization
O0030043biological_processactin filament fragmentation
O0030175cellular_componentfilopodium
O0030307biological_processpositive regulation of cell growth
O0030424cellular_componentaxon
O0030426cellular_componentgrowth cone
O0030835biological_processnegative regulation of actin filament depolymerization
O0030836biological_processpositive regulation of actin filament depolymerization
O0030864cellular_componentcortical actin cytoskeleton
O0031252cellular_componentcell leading edge
O0031258cellular_componentlamellipodium membrane
O0031915biological_processpositive regulation of synaptic plasticity
O0031966cellular_componentmitochondrial membrane
O0031982cellular_componentvesicle
O0032232biological_processnegative regulation of actin filament bundle assembly
O0032587cellular_componentruffle membrane
O0040019biological_processpositive regulation of embryonic development
O0042995cellular_componentcell projection
O0043025cellular_componentneuronal cell body
O0043066biological_processnegative regulation of apoptotic process
O0043197cellular_componentdendritic spine
O0043200biological_processresponse to amino acid
O0044794biological_processpositive regulation by host of viral process
O0045792biological_processnegative regulation of cell size
O0045862biological_processpositive regulation of proteolysis
O0048870biological_processcell motility
O0050804biological_processmodulation of chemical synaptic transmission
O0051014biological_processactin filament severing
O0051015molecular_functionactin filament binding
O0051293biological_processestablishment of spindle localization
O0051511biological_processnegative regulation of unidimensional cell growth
O0051894biological_processpositive regulation of focal adhesion assembly
O0060999biological_processpositive regulation of dendritic spine development
O0061001biological_processregulation of dendritic spine morphogenesis
O0070062cellular_componentextracellular exosome
O0070301biological_processcellular response to hydrogen peroxide
O0071347biological_processcellular response to interleukin-1
O0071354biological_processcellular response to interleukin-6
O0071356biological_processcellular response to tumor necrosis factor
O0071362biological_processcellular response to ether
O0071364biological_processcellular response to epidermal growth factor stimulus
O0090732cellular_componentcofilin-actin rod
O0097060cellular_componentsynaptic membrane
O0098885biological_processmodification of postsynaptic actin cytoskeleton
O0098978cellular_componentglutamatergic synapse
O0099092cellular_componentpostsynaptic density, intracellular component
O1902936molecular_functionphosphatidylinositol bisphosphate binding
O1902951biological_processnegative regulation of dendritic spine maintenance
O1905873biological_processpositive regulation of protein localization to cell leading edge
O1905875biological_processnegative regulation of postsynaptic density organization
O1990314biological_processcellular response to insulin-like growth factor stimulus
O2000146biological_processnegative regulation of cell motility
O2000147biological_processpositive regulation of cell motility
O2000784biological_processpositive regulation of establishment of cell polarity regulating cell shape
O2000814biological_processpositive regulation of barbed-end actin filament capping
P0000281biological_processmitotic cytokinesis
P0001755biological_processneural crest cell migration
P0001842biological_processneural fold formation
P0003779molecular_functionactin binding
P0005102molecular_functionsignaling receptor binding
P0005515molecular_functionprotein binding
P0005615cellular_componentextracellular space
P0005634cellular_componentnucleus
P0005737cellular_componentcytoplasm
P0005829cellular_componentcytosol
P0005856cellular_componentcytoskeleton
P0005886cellular_componentplasma membrane
P0005911cellular_componentcell-cell junction
P0005925cellular_componentfocal adhesion
P0006606biological_processprotein import into nucleus
P0007010biological_processcytoskeleton organization
P0007015biological_processactin filament organization
P0007162biological_processnegative regulation of cell adhesion
P0007266biological_processRho protein signal transduction
P0008154biological_processactin polymerization or depolymerization
P0009615biological_processresponse to virus
P0010592biological_processpositive regulation of lamellipodium assembly
P0010593biological_processnegative regulation of lamellipodium assembly
P0014823biological_processresponse to activity
P0015629cellular_componentactin cytoskeleton
P0016020cellular_componentmembrane
P0016363cellular_componentnuclear matrix
P0019903molecular_functionprotein phosphatase binding
P0021766biological_processhippocampus development
P0022604biological_processregulation of cell morphogenesis
P0030010biological_processestablishment of cell polarity
P0030027cellular_componentlamellipodium
P0030030biological_processcell projection organization
P0030036biological_processactin cytoskeleton organization
P0030042biological_processactin filament depolymerization
P0030043biological_processactin filament fragmentation
P0030175cellular_componentfilopodium
P0030307biological_processpositive regulation of cell growth
P0030424cellular_componentaxon
P0030426cellular_componentgrowth cone
P0030835biological_processnegative regulation of actin filament depolymerization
P0030836biological_processpositive regulation of actin filament depolymerization
P0030864cellular_componentcortical actin cytoskeleton
P0031252cellular_componentcell leading edge
P0031258cellular_componentlamellipodium membrane
P0031915biological_processpositive regulation of synaptic plasticity
P0031966cellular_componentmitochondrial membrane
P0031982cellular_componentvesicle
P0032232biological_processnegative regulation of actin filament bundle assembly
P0032587cellular_componentruffle membrane
P0040019biological_processpositive regulation of embryonic development
P0042995cellular_componentcell projection
P0043025cellular_componentneuronal cell body
P0043066biological_processnegative regulation of apoptotic process
P0043197cellular_componentdendritic spine
P0043200biological_processresponse to amino acid
P0044794biological_processpositive regulation by host of viral process
P0045792biological_processnegative regulation of cell size
P0045862biological_processpositive regulation of proteolysis
P0048870biological_processcell motility
P0050804biological_processmodulation of chemical synaptic transmission
P0051014biological_processactin filament severing
P0051015molecular_functionactin filament binding
P0051293biological_processestablishment of spindle localization
P0051511biological_processnegative regulation of unidimensional cell growth
P0051894biological_processpositive regulation of focal adhesion assembly
P0060999biological_processpositive regulation of dendritic spine development
P0061001biological_processregulation of dendritic spine morphogenesis
P0070062cellular_componentextracellular exosome
P0070301biological_processcellular response to hydrogen peroxide
P0071347biological_processcellular response to interleukin-1
P0071354biological_processcellular response to interleukin-6
P0071356biological_processcellular response to tumor necrosis factor
P0071362biological_processcellular response to ether
P0071364biological_processcellular response to epidermal growth factor stimulus
P0090732cellular_componentcofilin-actin rod
P0097060cellular_componentsynaptic membrane
P0098885biological_processmodification of postsynaptic actin cytoskeleton
P0098978cellular_componentglutamatergic synapse
P0099092cellular_componentpostsynaptic density, intracellular component
P1902936molecular_functionphosphatidylinositol bisphosphate binding
P1902951biological_processnegative regulation of dendritic spine maintenance
P1905873biological_processpositive regulation of protein localization to cell leading edge
P1905875biological_processnegative regulation of postsynaptic density organization
P1990314biological_processcellular response to insulin-like growth factor stimulus
P2000146biological_processnegative regulation of cell motility
P2000147biological_processpositive regulation of cell motility
P2000784biological_processpositive regulation of establishment of cell polarity regulating cell shape
P2000814biological_processpositive regulation of barbed-end actin filament capping
Functional Information from PDB Data
site_idAC1
Number of Residues2
Detailsbinding site for residue MG A 801
ChainResidue
AGLN137
AADP802

site_idAC2
Number of Residues14
Detailsbinding site for residue ADP A 802
ChainResidue
AGLU214
AGLY301
AGLY302
ATHR303
ATYR306
ALYS336
AMG801
AGLY13
ASER14
ALEU16
ALYS18
AGLY156
AASP157
ALYS213

site_idAC3
Number of Residues2
Detailsbinding site for residue MG B 801
ChainResidue
BGLN137
BADP802

site_idAC4
Number of Residues14
Detailsbinding site for residue ADP B 802
ChainResidue
BGLY13
BSER14
BLEU16
BLYS18
BGLY156
BASP157
BLYS213
BGLU214
BGLY301
BGLY302
BTHR303
BTYR306
BLYS336
BMG801

site_idAC5
Number of Residues2
Detailsbinding site for residue MG C 801
ChainResidue
CGLN137
CADP802

site_idAC6
Number of Residues14
Detailsbinding site for residue ADP C 802
ChainResidue
CGLY13
CSER14
CLEU16
CLYS18
CGLY156
CASP157
CLYS213
CGLU214
CGLY301
CGLY302
CTHR303
CTYR306
CLYS336
CMG801

site_idAC7
Number of Residues3
Detailsbinding site for residue MG D 401
ChainResidue
DGLN137
DASP154
DADP402

site_idAC8
Number of Residues15
Detailsbinding site for residue ADP D 402
ChainResidue
DGLY13
DSER14
DGLY15
DLEU16
DLYS18
DGLY156
DASP157
DLYS213
DGLU214
DGLY302
DTHR303
DMET305
DTYR306
DLYS336
DMG401

site_idAC9
Number of Residues1
Detailsbinding site for residue MG E 801
ChainResidue
EADP802

site_idAD1
Number of Residues12
Detailsbinding site for residue ADP E 802
ChainResidue
EGLY156
EASP157
ELYS213
EGLU214
EGLY301
EGLY302
ETHR303
ETYR306
ELYS336
EMG801
HLEU16
HLYS18

site_idAD2
Number of Residues1
Detailsbinding site for residue MG F 801
ChainResidue
FADP802

site_idAD3
Number of Residues12
Detailsbinding site for residue ADP F 802
ChainResidue
FGLY156
FASP157
FLYS213
FGLU214
FGLY301
FGLY302
FTHR303
FTYR306
FLYS336
FMG801
GLEU16
GLYS18

site_idAD4
Number of Residues3
Detailsbinding site for residue MG J 401
ChainResidue
JGLN137
JASP154
JADP402

site_idAD5
Number of Residues15
Detailsbinding site for residue ADP J 402
ChainResidue
JLYS18
JGLY156
JASP157
JLYS213
JGLU214
JGLY302
JTHR303
JMET305
JTYR306
JLYS336
JMG401
JGLY13
JSER14
JGLY15
JLEU16

site_idAD6
Number of Residues3
Detailsbinding site for residue MG K 401
ChainResidue
KGLN137
KASP154
KADP402

site_idAD7
Number of Residues15
Detailsbinding site for residue ADP K 402
ChainResidue
KGLY13
KSER14
KGLY15
KLEU16
KLYS18
KGLY156
KASP157
KLYS213
KGLU214
KGLY302
KTHR303
KMET305
KTYR306
KLYS336
KMG401

site_idAD8
Number of Residues3
Detailsbinding site for residue MG L 401
ChainResidue
LGLN137
LASP154
LADP402

site_idAD9
Number of Residues15
Detailsbinding site for residue ADP L 402
ChainResidue
LGLY13
LSER14
LGLY15
LLEU16
LLYS18
LGLY156
LASP157
LLYS213
LGLU214
LGLY302
LTHR303
LMET305
LTYR306
LLYS336
LMG401

Functional Information from PROSITE/UniProt
site_idPS00406
Number of Residues11
DetailsACTINS_1 Actins signature 1. YVGDEAQs.KRG
ChainResidueDetails
ATYR53-GLY63

site_idPS00432
Number of Residues9
DetailsACTINS_2 Actins signature 2. WITKqEYDE
ChainResidueDetails
ATRP356-GLU364

site_idPS01132
Number of Residues13
DetailsACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR
ChainResidueDetails
ALEU104-ARG116

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues5
DetailsMOD_RES: N-acetylalanine => ECO:0000269|PubMed:30550596, ECO:0000269|Ref.9, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712
ChainResidueDetails
IALA2
KCYS0
LCYS0
MALA2
NALA2
OALA2
PALA2
FCYS0
GCYS0
HCYS0
JCYS0

site_idSWS_FT_FI2
Number of Residues5
DetailsMOD_RES: Phosphoserine; by NRK => ECO:0000269|PubMed:12837278, ECO:0000269|PubMed:30550596, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
ISER3
KASP1
LASP1
MSER3
NSER3
OSER3
PSER3
FASP1
GASP1
HASP1
JASP1

site_idSWS_FT_FI3
Number of Residues5
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P18760
ChainResidueDetails
ISER8
EMET47
FMET44
FMET47
GMET44
GMET47
HMET44
HMET47
JMET44
JMET47
KMET44
MSER8
KMET47
LMET44
LMET47
NSER8
OSER8
PSER8
CMET47
DMET44
DMET47
EMET44

site_idSWS_FT_FI4
Number of Residues15
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ILYS13
OLYS13
OLYS73
OLYS144
PLYS13
PLYS73
PLYS144
ILYS73
ILYS144
MLYS13
MLYS73
MLYS144
NLYS13
NLYS73
NLYS144

site_idSWS_FT_FI5
Number of Residues5
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231
ChainResidueDetails
ITHR25
KHIS73
LHIS73
MTHR25
NTHR25
OTHR25
PTHR25
FHIS73
GHIS73
HHIS73
JHIS73

site_idSWS_FT_FI6
Number of Residues5
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ISER41
KLYS84
LLYS84
MSER41
NSER41
OSER41
PSER41
FLYS84
GLYS84
HLYS84
JLYS84

site_idSWS_FT_FI7
Number of Residues5
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:30550596
ChainResidueDetails
ITHR63
KARG177
LARG177
MTHR63
NTHR63
OTHR63
PTHR63
FARG177
GARG177
HARG177
JARG177

site_idSWS_FT_FI8
Number of Residues5
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332
ChainResidueDetails
ITYR68
MTYR68
NTYR68
OTYR68
PTYR68

site_idSWS_FT_FI9
Number of Residues5
DetailsMOD_RES: Phosphotyrosine => ECO:0000269|PubMed:30550596
ChainResidueDetails
ITYR82
MTYR82
NTYR82
OTYR82
PTYR82

site_idSWS_FT_FI10
Number of Residues5
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:30550596
ChainResidueDetails
ISER108
MSER108
NSER108
OSER108
PSER108

site_idSWS_FT_FI11
Number of Residues5
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455
ChainResidueDetails
ITYR140
MTYR140
NTYR140
OTYR140
PTYR140

site_idSWS_FT_FI12
Number of Residues5
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:30550596, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
ISER156
MSER156
NSER156
OSER156
PSER156

site_idSWS_FT_FI13
Number of Residues10
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ILYS132
MLYS132
NLYS132
OLYS132
PLYS132

237423

PDB entries from 2025-06-11

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