Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6UC4

Barbed end side of a cofilactin cluster

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0001725	cellular_component	stress fiber
A	0003785	molecular_function	actin monomer binding
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005523	molecular_function	tropomyosin binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0005865	cellular_component	striated muscle thin filament
A	0005884	cellular_component	actin filament
A	0010628	biological_process	positive regulation of gene expression
A	0016787	molecular_function	hydrolase activity
A	0019904	molecular_function	protein domain specific binding
A	0030027	cellular_component	lamellipodium
A	0030041	biological_process	actin filament polymerization
A	0030175	cellular_component	filopodium
A	0030240	biological_process	skeletal muscle thin filament assembly
A	0031013	molecular_function	troponin I binding
A	0031432	molecular_function	titin binding
A	0031941	cellular_component	filamentous actin
A	0032036	molecular_function	myosin heavy chain binding
A	0032432	cellular_component	actin filament bundle
A	0042802	molecular_function	identical protein binding
A	0044297	cellular_component	cell body
A	0048306	molecular_function	calcium-dependent protein binding
A	0048741	biological_process	skeletal muscle fiber development
A	0051017	biological_process	actin filament bundle assembly
A	0090131	biological_process	mesenchyme migration
A	0098723	cellular_component	skeletal muscle myofibril
A	0140660	molecular_function	cytoskeletal motor activator activity
B	0000287	molecular_function	magnesium ion binding
B	0001725	cellular_component	stress fiber
B	0003785	molecular_function	actin monomer binding
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005523	molecular_function	tropomyosin binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005865	cellular_component	striated muscle thin filament
B	0005884	cellular_component	actin filament
B	0010628	biological_process	positive regulation of gene expression
B	0016787	molecular_function	hydrolase activity
B	0019904	molecular_function	protein domain specific binding
B	0030027	cellular_component	lamellipodium
B	0030041	biological_process	actin filament polymerization
B	0030175	cellular_component	filopodium
B	0030240	biological_process	skeletal muscle thin filament assembly
B	0031013	molecular_function	troponin I binding
B	0031432	molecular_function	titin binding
B	0031941	cellular_component	filamentous actin
B	0032036	molecular_function	myosin heavy chain binding
B	0032432	cellular_component	actin filament bundle
B	0042802	molecular_function	identical protein binding
B	0044297	cellular_component	cell body
B	0048306	molecular_function	calcium-dependent protein binding
B	0048741	biological_process	skeletal muscle fiber development
B	0051017	biological_process	actin filament bundle assembly
B	0090131	biological_process	mesenchyme migration
B	0098723	cellular_component	skeletal muscle myofibril
B	0140660	molecular_function	cytoskeletal motor activator activity
C	0000287	molecular_function	magnesium ion binding
C	0001725	cellular_component	stress fiber
C	0003785	molecular_function	actin monomer binding
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005523	molecular_function	tropomyosin binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005856	cellular_component	cytoskeleton
C	0005865	cellular_component	striated muscle thin filament
C	0005884	cellular_component	actin filament
C	0010628	biological_process	positive regulation of gene expression
C	0016787	molecular_function	hydrolase activity
C	0019904	molecular_function	protein domain specific binding
C	0030027	cellular_component	lamellipodium
C	0030041	biological_process	actin filament polymerization
C	0030175	cellular_component	filopodium
C	0030240	biological_process	skeletal muscle thin filament assembly
C	0031013	molecular_function	troponin I binding
C	0031432	molecular_function	titin binding
C	0031941	cellular_component	filamentous actin
C	0032036	molecular_function	myosin heavy chain binding
C	0032432	cellular_component	actin filament bundle
C	0042802	molecular_function	identical protein binding
C	0044297	cellular_component	cell body
C	0048306	molecular_function	calcium-dependent protein binding
C	0048741	biological_process	skeletal muscle fiber development
C	0051017	biological_process	actin filament bundle assembly
C	0090131	biological_process	mesenchyme migration
C	0098723	cellular_component	skeletal muscle myofibril
C	0140660	molecular_function	cytoskeletal motor activator activity
D	0000287	molecular_function	magnesium ion binding
D	0001725	cellular_component	stress fiber
D	0003785	molecular_function	actin monomer binding
D	0005509	molecular_function	calcium ion binding
D	0005515	molecular_function	protein binding
D	0005523	molecular_function	tropomyosin binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005856	cellular_component	cytoskeleton
D	0005865	cellular_component	striated muscle thin filament
D	0005884	cellular_component	actin filament
D	0010628	biological_process	positive regulation of gene expression
D	0016787	molecular_function	hydrolase activity
D	0019904	molecular_function	protein domain specific binding
D	0030027	cellular_component	lamellipodium
D	0030041	biological_process	actin filament polymerization
D	0030175	cellular_component	filopodium
D	0030240	biological_process	skeletal muscle thin filament assembly
D	0031013	molecular_function	troponin I binding
D	0031432	molecular_function	titin binding
D	0031941	cellular_component	filamentous actin
D	0032036	molecular_function	myosin heavy chain binding
D	0032432	cellular_component	actin filament bundle
D	0042802	molecular_function	identical protein binding
D	0044297	cellular_component	cell body
D	0048306	molecular_function	calcium-dependent protein binding
D	0048741	biological_process	skeletal muscle fiber development
D	0051017	biological_process	actin filament bundle assembly
D	0090131	biological_process	mesenchyme migration
D	0098723	cellular_component	skeletal muscle myofibril
D	0140660	molecular_function	cytoskeletal motor activator activity
E	0000287	molecular_function	magnesium ion binding
E	0001725	cellular_component	stress fiber
E	0003785	molecular_function	actin monomer binding
E	0005509	molecular_function	calcium ion binding
E	0005515	molecular_function	protein binding
E	0005523	molecular_function	tropomyosin binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005856	cellular_component	cytoskeleton
E	0005865	cellular_component	striated muscle thin filament
E	0005884	cellular_component	actin filament
E	0010628	biological_process	positive regulation of gene expression
E	0016787	molecular_function	hydrolase activity
E	0019904	molecular_function	protein domain specific binding
E	0030027	cellular_component	lamellipodium
E	0030041	biological_process	actin filament polymerization
E	0030175	cellular_component	filopodium
E	0030240	biological_process	skeletal muscle thin filament assembly
E	0031013	molecular_function	troponin I binding
E	0031432	molecular_function	titin binding
E	0031941	cellular_component	filamentous actin
E	0032036	molecular_function	myosin heavy chain binding
E	0032432	cellular_component	actin filament bundle
E	0042802	molecular_function	identical protein binding
E	0044297	cellular_component	cell body
E	0048306	molecular_function	calcium-dependent protein binding
E	0048741	biological_process	skeletal muscle fiber development
E	0051017	biological_process	actin filament bundle assembly
E	0090131	biological_process	mesenchyme migration
E	0098723	cellular_component	skeletal muscle myofibril
E	0140660	molecular_function	cytoskeletal motor activator activity
F	0000287	molecular_function	magnesium ion binding
F	0001725	cellular_component	stress fiber
F	0003785	molecular_function	actin monomer binding
F	0005509	molecular_function	calcium ion binding
F	0005515	molecular_function	protein binding
F	0005523	molecular_function	tropomyosin binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005856	cellular_component	cytoskeleton
F	0005865	cellular_component	striated muscle thin filament
F	0005884	cellular_component	actin filament
F	0010628	biological_process	positive regulation of gene expression
F	0016787	molecular_function	hydrolase activity
F	0019904	molecular_function	protein domain specific binding
F	0030027	cellular_component	lamellipodium
F	0030041	biological_process	actin filament polymerization
F	0030175	cellular_component	filopodium
F	0030240	biological_process	skeletal muscle thin filament assembly
F	0031013	molecular_function	troponin I binding
F	0031432	molecular_function	titin binding
F	0031941	cellular_component	filamentous actin
F	0032036	molecular_function	myosin heavy chain binding
F	0032432	cellular_component	actin filament bundle
F	0042802	molecular_function	identical protein binding
F	0044297	cellular_component	cell body
F	0048306	molecular_function	calcium-dependent protein binding
F	0048741	biological_process	skeletal muscle fiber development
F	0051017	biological_process	actin filament bundle assembly
F	0090131	biological_process	mesenchyme migration
F	0098723	cellular_component	skeletal muscle myofibril
F	0140660	molecular_function	cytoskeletal motor activator activity
G	0000287	molecular_function	magnesium ion binding
G	0001725	cellular_component	stress fiber
G	0003785	molecular_function	actin monomer binding
G	0005509	molecular_function	calcium ion binding
G	0005515	molecular_function	protein binding
G	0005523	molecular_function	tropomyosin binding
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005856	cellular_component	cytoskeleton
G	0005865	cellular_component	striated muscle thin filament
G	0005884	cellular_component	actin filament
G	0010628	biological_process	positive regulation of gene expression
G	0016787	molecular_function	hydrolase activity
G	0019904	molecular_function	protein domain specific binding
G	0030027	cellular_component	lamellipodium
G	0030041	biological_process	actin filament polymerization
G	0030175	cellular_component	filopodium
G	0030240	biological_process	skeletal muscle thin filament assembly
G	0031013	molecular_function	troponin I binding
G	0031432	molecular_function	titin binding
G	0031941	cellular_component	filamentous actin
G	0032036	molecular_function	myosin heavy chain binding
G	0032432	cellular_component	actin filament bundle
G	0042802	molecular_function	identical protein binding
G	0044297	cellular_component	cell body
G	0048306	molecular_function	calcium-dependent protein binding
G	0048741	biological_process	skeletal muscle fiber development
G	0051017	biological_process	actin filament bundle assembly
G	0090131	biological_process	mesenchyme migration
G	0098723	cellular_component	skeletal muscle myofibril
G	0140660	molecular_function	cytoskeletal motor activator activity
H	0000287	molecular_function	magnesium ion binding
H	0001725	cellular_component	stress fiber
H	0003785	molecular_function	actin monomer binding
H	0005509	molecular_function	calcium ion binding
H	0005515	molecular_function	protein binding
H	0005523	molecular_function	tropomyosin binding
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0005856	cellular_component	cytoskeleton
H	0005865	cellular_component	striated muscle thin filament
H	0005884	cellular_component	actin filament
H	0010628	biological_process	positive regulation of gene expression
H	0016787	molecular_function	hydrolase activity
H	0019904	molecular_function	protein domain specific binding
H	0030027	cellular_component	lamellipodium
H	0030041	biological_process	actin filament polymerization
H	0030175	cellular_component	filopodium
H	0030240	biological_process	skeletal muscle thin filament assembly
H	0031013	molecular_function	troponin I binding
H	0031432	molecular_function	titin binding
H	0031941	cellular_component	filamentous actin
H	0032036	molecular_function	myosin heavy chain binding
H	0032432	cellular_component	actin filament bundle
H	0042802	molecular_function	identical protein binding
H	0044297	cellular_component	cell body
H	0048306	molecular_function	calcium-dependent protein binding
H	0048741	biological_process	skeletal muscle fiber development
H	0051017	biological_process	actin filament bundle assembly
H	0090131	biological_process	mesenchyme migration
H	0098723	cellular_component	skeletal muscle myofibril
H	0140660	molecular_function	cytoskeletal motor activator activity
I	0000281	biological_process	mitotic cytokinesis
I	0003779	molecular_function	actin binding
I	0005515	molecular_function	protein binding
I	0005615	cellular_component	extracellular space
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005856	cellular_component	cytoskeleton
I	0005886	cellular_component	plasma membrane
I	0005925	cellular_component	focal adhesion
I	0007010	biological_process	cytoskeleton organization
I	0007266	biological_process	Rho protein signal transduction
I	0009615	biological_process	response to virus
I	0015629	cellular_component	actin cytoskeleton
I	0016020	cellular_component	membrane
I	0016363	cellular_component	nuclear matrix
I	0022604	biological_process	regulation of cell morphogenesis
I	0030027	cellular_component	lamellipodium
I	0030036	biological_process	actin cytoskeleton organization
I	0030042	biological_process	actin filament depolymerization
I	0030043	biological_process	actin filament fragmentation
I	0030424	cellular_component	axon
I	0030426	cellular_component	growth cone
I	0031258	cellular_component	lamellipodium membrane
I	0031982	cellular_component	vesicle
I	0032587	cellular_component	ruffle membrane
I	0040019	biological_process	positive regulation of embryonic development
I	0042995	cellular_component	cell projection
I	0043066	biological_process	negative regulation of apoptotic process
I	0044794	biological_process	positive regulation by host of viral process
I	0051014	biological_process	actin filament severing
I	0051015	molecular_function	actin filament binding
I	0051293	biological_process	establishment of spindle localization
I	0061001	biological_process	regulation of dendritic spine morphogenesis
I	0070062	cellular_component	extracellular exosome
J	0000287	molecular_function	magnesium ion binding
J	0001725	cellular_component	stress fiber
J	0003785	molecular_function	actin monomer binding
J	0005509	molecular_function	calcium ion binding
J	0005515	molecular_function	protein binding
J	0005523	molecular_function	tropomyosin binding
J	0005524	molecular_function	ATP binding
J	0005737	cellular_component	cytoplasm
J	0005856	cellular_component	cytoskeleton
J	0005865	cellular_component	striated muscle thin filament
J	0005884	cellular_component	actin filament
J	0010628	biological_process	positive regulation of gene expression
J	0016787	molecular_function	hydrolase activity
J	0019904	molecular_function	protein domain specific binding
J	0030027	cellular_component	lamellipodium
J	0030041	biological_process	actin filament polymerization
J	0030175	cellular_component	filopodium
J	0030240	biological_process	skeletal muscle thin filament assembly
J	0031013	molecular_function	troponin I binding
J	0031432	molecular_function	titin binding
J	0031941	cellular_component	filamentous actin
J	0032036	molecular_function	myosin heavy chain binding
J	0032432	cellular_component	actin filament bundle
J	0042802	molecular_function	identical protein binding
J	0044297	cellular_component	cell body
J	0048306	molecular_function	calcium-dependent protein binding
J	0048741	biological_process	skeletal muscle fiber development
J	0051017	biological_process	actin filament bundle assembly
J	0090131	biological_process	mesenchyme migration
J	0098723	cellular_component	skeletal muscle myofibril
J	0140660	molecular_function	cytoskeletal motor activator activity
K	0000287	molecular_function	magnesium ion binding
K	0001725	cellular_component	stress fiber
K	0003785	molecular_function	actin monomer binding
K	0005509	molecular_function	calcium ion binding
K	0005515	molecular_function	protein binding
K	0005523	molecular_function	tropomyosin binding
K	0005524	molecular_function	ATP binding
K	0005737	cellular_component	cytoplasm
K	0005856	cellular_component	cytoskeleton
K	0005865	cellular_component	striated muscle thin filament
K	0005884	cellular_component	actin filament
K	0010628	biological_process	positive regulation of gene expression
K	0016787	molecular_function	hydrolase activity
K	0019904	molecular_function	protein domain specific binding
K	0030027	cellular_component	lamellipodium
K	0030041	biological_process	actin filament polymerization
K	0030175	cellular_component	filopodium
K	0030240	biological_process	skeletal muscle thin filament assembly
K	0031013	molecular_function	troponin I binding
K	0031432	molecular_function	titin binding
K	0031941	cellular_component	filamentous actin
K	0032036	molecular_function	myosin heavy chain binding
K	0032432	cellular_component	actin filament bundle
K	0042802	molecular_function	identical protein binding
K	0044297	cellular_component	cell body
K	0048306	molecular_function	calcium-dependent protein binding
K	0048741	biological_process	skeletal muscle fiber development
K	0051017	biological_process	actin filament bundle assembly
K	0090131	biological_process	mesenchyme migration
K	0098723	cellular_component	skeletal muscle myofibril
K	0140660	molecular_function	cytoskeletal motor activator activity
L	0000287	molecular_function	magnesium ion binding
L	0001725	cellular_component	stress fiber
L	0003785	molecular_function	actin monomer binding
L	0005509	molecular_function	calcium ion binding
L	0005515	molecular_function	protein binding
L	0005523	molecular_function	tropomyosin binding
L	0005524	molecular_function	ATP binding
L	0005737	cellular_component	cytoplasm
L	0005856	cellular_component	cytoskeleton
L	0005865	cellular_component	striated muscle thin filament
L	0005884	cellular_component	actin filament
L	0010628	biological_process	positive regulation of gene expression
L	0016787	molecular_function	hydrolase activity
L	0019904	molecular_function	protein domain specific binding
L	0030027	cellular_component	lamellipodium
L	0030041	biological_process	actin filament polymerization
L	0030175	cellular_component	filopodium
L	0030240	biological_process	skeletal muscle thin filament assembly
L	0031013	molecular_function	troponin I binding
L	0031432	molecular_function	titin binding
L	0031941	cellular_component	filamentous actin
L	0032036	molecular_function	myosin heavy chain binding
L	0032432	cellular_component	actin filament bundle
L	0042802	molecular_function	identical protein binding
L	0044297	cellular_component	cell body
L	0048306	molecular_function	calcium-dependent protein binding
L	0048741	biological_process	skeletal muscle fiber development
L	0051017	biological_process	actin filament bundle assembly
L	0090131	biological_process	mesenchyme migration
L	0098723	cellular_component	skeletal muscle myofibril
L	0140660	molecular_function	cytoskeletal motor activator activity
M	0000281	biological_process	mitotic cytokinesis
M	0003779	molecular_function	actin binding
M	0005515	molecular_function	protein binding
M	0005615	cellular_component	extracellular space
M	0005634	cellular_component	nucleus
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0005856	cellular_component	cytoskeleton
M	0005886	cellular_component	plasma membrane
M	0005925	cellular_component	focal adhesion
M	0007010	biological_process	cytoskeleton organization
M	0007266	biological_process	Rho protein signal transduction
M	0009615	biological_process	response to virus
M	0015629	cellular_component	actin cytoskeleton
M	0016020	cellular_component	membrane
M	0016363	cellular_component	nuclear matrix
M	0022604	biological_process	regulation of cell morphogenesis
M	0030027	cellular_component	lamellipodium
M	0030036	biological_process	actin cytoskeleton organization
M	0030042	biological_process	actin filament depolymerization
M	0030043	biological_process	actin filament fragmentation
M	0030424	cellular_component	axon
M	0030426	cellular_component	growth cone
M	0031258	cellular_component	lamellipodium membrane
M	0031982	cellular_component	vesicle
M	0032587	cellular_component	ruffle membrane
M	0040019	biological_process	positive regulation of embryonic development
M	0042995	cellular_component	cell projection
M	0043066	biological_process	negative regulation of apoptotic process
M	0044794	biological_process	positive regulation by host of viral process
M	0051014	biological_process	actin filament severing
M	0051015	molecular_function	actin filament binding
M	0051293	biological_process	establishment of spindle localization
M	0061001	biological_process	regulation of dendritic spine morphogenesis
M	0070062	cellular_component	extracellular exosome
N	0000281	biological_process	mitotic cytokinesis
N	0003779	molecular_function	actin binding
N	0005515	molecular_function	protein binding
N	0005615	cellular_component	extracellular space
N	0005634	cellular_component	nucleus
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0005856	cellular_component	cytoskeleton
N	0005886	cellular_component	plasma membrane
N	0005925	cellular_component	focal adhesion
N	0007010	biological_process	cytoskeleton organization
N	0007266	biological_process	Rho protein signal transduction
N	0009615	biological_process	response to virus
N	0015629	cellular_component	actin cytoskeleton
N	0016020	cellular_component	membrane
N	0016363	cellular_component	nuclear matrix
N	0022604	biological_process	regulation of cell morphogenesis
N	0030027	cellular_component	lamellipodium
N	0030036	biological_process	actin cytoskeleton organization
N	0030042	biological_process	actin filament depolymerization
N	0030043	biological_process	actin filament fragmentation
N	0030424	cellular_component	axon
N	0030426	cellular_component	growth cone
N	0031258	cellular_component	lamellipodium membrane
N	0031982	cellular_component	vesicle
N	0032587	cellular_component	ruffle membrane
N	0040019	biological_process	positive regulation of embryonic development
N	0042995	cellular_component	cell projection
N	0043066	biological_process	negative regulation of apoptotic process
N	0044794	biological_process	positive regulation by host of viral process
N	0051014	biological_process	actin filament severing
N	0051015	molecular_function	actin filament binding
N	0051293	biological_process	establishment of spindle localization
N	0061001	biological_process	regulation of dendritic spine morphogenesis
N	0070062	cellular_component	extracellular exosome
O	0000281	biological_process	mitotic cytokinesis
O	0003779	molecular_function	actin binding
O	0005515	molecular_function	protein binding
O	0005615	cellular_component	extracellular space
O	0005634	cellular_component	nucleus
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0005856	cellular_component	cytoskeleton
O	0005886	cellular_component	plasma membrane
O	0005925	cellular_component	focal adhesion
O	0007010	biological_process	cytoskeleton organization
O	0007266	biological_process	Rho protein signal transduction
O	0009615	biological_process	response to virus
O	0015629	cellular_component	actin cytoskeleton
O	0016020	cellular_component	membrane
O	0016363	cellular_component	nuclear matrix
O	0022604	biological_process	regulation of cell morphogenesis
O	0030027	cellular_component	lamellipodium
O	0030036	biological_process	actin cytoskeleton organization
O	0030042	biological_process	actin filament depolymerization
O	0030043	biological_process	actin filament fragmentation
O	0030424	cellular_component	axon
O	0030426	cellular_component	growth cone
O	0031258	cellular_component	lamellipodium membrane
O	0031982	cellular_component	vesicle
O	0032587	cellular_component	ruffle membrane
O	0040019	biological_process	positive regulation of embryonic development
O	0042995	cellular_component	cell projection
O	0043066	biological_process	negative regulation of apoptotic process
O	0044794	biological_process	positive regulation by host of viral process
O	0051014	biological_process	actin filament severing
O	0051015	molecular_function	actin filament binding
O	0051293	biological_process	establishment of spindle localization
O	0061001	biological_process	regulation of dendritic spine morphogenesis
O	0070062	cellular_component	extracellular exosome
P	0000281	biological_process	mitotic cytokinesis
P	0003779	molecular_function	actin binding
P	0005515	molecular_function	protein binding
P	0005615	cellular_component	extracellular space
P	0005634	cellular_component	nucleus
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0005856	cellular_component	cytoskeleton
P	0005886	cellular_component	plasma membrane
P	0005925	cellular_component	focal adhesion
P	0007010	biological_process	cytoskeleton organization
P	0007266	biological_process	Rho protein signal transduction
P	0009615	biological_process	response to virus
P	0015629	cellular_component	actin cytoskeleton
P	0016020	cellular_component	membrane
P	0016363	cellular_component	nuclear matrix
P	0022604	biological_process	regulation of cell morphogenesis
P	0030027	cellular_component	lamellipodium
P	0030036	biological_process	actin cytoskeleton organization
P	0030042	biological_process	actin filament depolymerization
P	0030043	biological_process	actin filament fragmentation
P	0030424	cellular_component	axon
P	0030426	cellular_component	growth cone
P	0031258	cellular_component	lamellipodium membrane
P	0031982	cellular_component	vesicle
P	0032587	cellular_component	ruffle membrane
P	0040019	biological_process	positive regulation of embryonic development
P	0042995	cellular_component	cell projection
P	0043066	biological_process	negative regulation of apoptotic process
P	0044794	biological_process	positive regulation by host of viral process
P	0051014	biological_process	actin filament severing
P	0051015	molecular_function	actin filament binding
P	0051293	biological_process	establishment of spindle localization
P	0061001	biological_process	regulation of dendritic spine morphogenesis
P	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue MG A 801

Chain	Residue
A	GLN137
A	ADP802

site_id	AC2
Number of Residues	14
Details	binding site for residue ADP A 802

Chain	Residue
A	GLU214
A	GLY301
A	GLY302
A	THR303
A	TYR306
A	LYS336
A	MG801
A	GLY13
A	SER14
A	LEU16
A	LYS18
A	GLY156
A	ASP157
A	LYS213

site_id	AC3
Number of Residues	2
Details	binding site for residue MG B 801

Chain	Residue
B	GLN137
B	ADP802

site_id	AC4
Number of Residues	14
Details	binding site for residue ADP B 802

Chain	Residue
B	GLY13
B	SER14
B	LEU16
B	LYS18
B	GLY156
B	ASP157
B	LYS213
B	GLU214
B	GLY301
B	GLY302
B	THR303
B	TYR306
B	LYS336
B	MG801

site_id	AC5
Number of Residues	2
Details	binding site for residue MG C 801

Chain	Residue
C	GLN137
C	ADP802

site_id	AC6
Number of Residues	14
Details	binding site for residue ADP C 802

Chain	Residue
C	GLY13
C	SER14
C	LEU16
C	LYS18
C	GLY156
C	ASP157
C	LYS213
C	GLU214
C	GLY301
C	GLY302
C	THR303
C	TYR306
C	LYS336
C	MG801

site_id	AC7
Number of Residues	3
Details	binding site for residue MG D 401

Chain	Residue
D	GLN137
D	ASP154
D	ADP402

site_id	AC8
Number of Residues	15
Details	binding site for residue ADP D 402

Chain	Residue
D	GLY13
D	SER14
D	GLY15
D	LEU16
D	LYS18
D	GLY156
D	ASP157
D	LYS213
D	GLU214
D	GLY302
D	THR303
D	MET305
D	TYR306
D	LYS336
D	MG401

site_id	AC9
Number of Residues	1
Details	binding site for residue MG E 801

Chain	Residue
E	ADP802

site_id	AD1
Number of Residues	12
Details	binding site for residue ADP E 802

Chain	Residue
E	GLY156
E	ASP157
E	LYS213
E	GLU214
E	GLY301
E	GLY302
E	THR303
E	TYR306
E	LYS336
E	MG801
H	LEU16
H	LYS18

site_id	AD2
Number of Residues	1
Details	binding site for residue MG F 801

Chain	Residue
F	ADP802

site_id	AD3
Number of Residues	12
Details	binding site for residue ADP F 802

Chain	Residue
F	GLY156
F	ASP157
F	LYS213
F	GLU214
F	GLY301
F	GLY302
F	THR303
F	TYR306
F	LYS336
F	MG801
G	LEU16
G	LYS18

site_id	AD4
Number of Residues	3
Details	binding site for residue MG J 401

Chain	Residue
J	GLN137
J	ASP154
J	ADP402

site_id	AD5
Number of Residues	15
Details	binding site for residue ADP J 402

Chain	Residue
J	LYS18
J	GLY156
J	ASP157
J	LYS213
J	GLU214
J	GLY302
J	THR303
J	MET305
J	TYR306
J	LYS336
J	MG401
J	GLY13
J	SER14
J	GLY15
J	LEU16

site_id	AD6
Number of Residues	3
Details	binding site for residue MG K 401

Chain	Residue
K	GLN137
K	ASP154
K	ADP402

site_id	AD7
Number of Residues	15
Details	binding site for residue ADP K 402

Chain	Residue
K	GLY13
K	SER14
K	GLY15
K	LEU16
K	LYS18
K	GLY156
K	ASP157
K	LYS213
K	GLU214
K	GLY302
K	THR303
K	MET305
K	TYR306
K	LYS336
K	MG401

site_id	AD8
Number of Residues	3
Details	binding site for residue MG L 401

Chain	Residue
L	GLN137
L	ASP154
L	ADP402

site_id	AD9
Number of Residues	15
Details	binding site for residue ADP L 402

Chain	Residue
L	GLY13
L	SER14
L	GLY15
L	LEU16
L	LYS18
L	GLY156
L	ASP157
L	LYS213
L	GLU214
L	GLY302
L	THR303
L	MET305
L	TYR306
L	LYS336
L	MG401

Functional Information from PROSITE/UniProt

site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQs.KRG

Chain	Residue	Details
A	TYR53-GLY63

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WITKqEYDE

Chain	Residue	Details
A	TRP356-GLU364

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR

Chain	Residue	Details
A	LEU104-ARG116

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	MOD_RES: N-acetylalanine => ECO:0000269\|PubMed:30550596, ECO:0000269\|Ref.9, ECO:0007744\|PubMed:19369195, ECO:0007744\|PubMed:19413330, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:21406692, ECO:0007744\|PubMed:22223895, ECO:0007744\|PubMed:22814378, ECO:0007744\|PubMed:25944712

Chain	Residue	Details
I	ALA2
K	CYS0
L	CYS0
M	ALA2
N	ALA2
O	ALA2
P	ALA2
F	CYS0
G	CYS0
H	CYS0
J	CYS0

site_id	SWS_FT_FI2
Number of Residues	5
Details	MOD_RES: Phosphoserine; by NRK => ECO:0000269\|PubMed:12837278, ECO:0000269\|PubMed:30550596, ECO:0007744\|PubMed:17081983, ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:19369195, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:21406692, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
I	SER3
K	ASP1
L	ASP1
M	SER3
N	SER3
O	SER3
P	SER3
F	ASP1
G	ASP1
H	ASP1
J	ASP1

site_id	SWS_FT_FI3
Number of Residues	5
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P18760

Chain	Residue	Details
I	SER8
E	MET47
F	MET44
F	MET47
G	MET44
G	MET47
H	MET44
H	MET47
J	MET44
J	MET47
K	MET44
M	SER8
K	MET47
L	MET44
L	MET47
N	SER8
O	SER8
P	SER8
C	MET47
D	MET44
D	MET47
E	MET44

site_id	SWS_FT_FI4
Number of Residues	15
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
I	LYS13
O	LYS13
O	LYS73
O	LYS144
P	LYS13
P	LYS73
P	LYS144
I	LYS73
I	LYS144
M	LYS13
M	LYS73
M	LYS144
N	LYS13
N	LYS73
N	LYS144

site_id	SWS_FT_FI5
Number of Residues	5
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:20068231

Chain	Residue	Details
I	THR25
K	HIS73
L	HIS73
M	THR25
N	THR25
O	THR25
P	THR25
F	HIS73
G	HIS73
H	HIS73
J	HIS73

site_id	SWS_FT_FI6
Number of Residues	5
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
I	SER41
K	LYS84
L	LYS84
M	SER41
N	SER41
O	SER41
P	SER41
F	LYS84
G	LYS84
H	LYS84
J	LYS84

site_id	SWS_FT_FI7
Number of Residues	5
Details	MOD_RES: Phosphothreonine => ECO:0000269\|PubMed:30550596

Chain	Residue	Details
I	THR63
K	ARG177
L	ARG177
M	THR63
N	THR63
O	THR63
P	THR63
F	ARG177
G	ARG177
H	ARG177
J	ARG177

site_id	SWS_FT_FI8
Number of Residues	5
Details	MOD_RES: Phosphotyrosine => ECO:0007744\|PubMed:19690332

Chain	Residue	Details
I	TYR68
M	TYR68
N	TYR68
O	TYR68
P	TYR68

site_id	SWS_FT_FI9
Number of Residues	5
Details	MOD_RES: Phosphotyrosine => ECO:0000269\|PubMed:30550596

Chain	Residue	Details
I	TYR82
M	TYR82
N	TYR82
O	TYR82
P	TYR82

site_id	SWS_FT_FI10
Number of Residues	5
Details	MOD_RES: Phosphoserine => ECO:0000269\|PubMed:30550596

Chain	Residue	Details
I	SER108
M	SER108
N	SER108
O	SER108
P	SER108

site_id	SWS_FT_FI11
Number of Residues	5
Details	MOD_RES: Phosphotyrosine => ECO:0007744\|PubMed:15592455

Chain	Residue	Details
I	TYR140
M	TYR140
N	TYR140
O	TYR140
P	TYR140

site_id	SWS_FT_FI12
Number of Residues	5
Details	MOD_RES: Phosphoserine => ECO:0000269\|PubMed:30550596, ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:19690332, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
I	SER156
M	SER156
N	SER156
O	SER156
P	SER156

site_id	SWS_FT_FI13
Number of Residues	10
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
I	LYS132
M	LYS132
N	LYS132
O	LYS132
P	LYS132

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)