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6UAN

B-Raf:14-3-3 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0005737cellular_componentcytoplasm
B0000165biological_processMAPK cascade
B0002318biological_processmyeloid progenitor cell differentiation
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0004676molecular_function3-phosphoinositide-dependent protein kinase activity
B0004677molecular_functionDNA-dependent protein kinase activity
B0004679molecular_functionAMP-activated protein kinase activity
B0004694molecular_functioneukaryotic translation initiation factor 2alpha kinase activity
B0004708molecular_functionMAP kinase kinase activity
B0004709molecular_functionMAP kinase kinase kinase activity
B0004711molecular_functionribosomal protein S6 kinase activity
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006338biological_processchromatin remodeling
B0006468biological_processprotein phosphorylation
B0007165biological_processsignal transduction
B0007173biological_processepidermal growth factor receptor signaling pathway
B0008542biological_processvisual learning
B0009887biological_processanimal organ morphogenesis
B0010628biological_processpositive regulation of gene expression
B0010764biological_processnegative regulation of fibroblast migration
B0010828biological_processpositive regulation of D-glucose transmembrane transport
B0016079biological_processsynaptic vesicle exocytosis
B0030154biological_processcell differentiation
B0030878biological_processthyroid gland development
B0031267molecular_functionsmall GTPase binding
B0031434molecular_functionmitogen-activated protein kinase kinase binding
B0033077biological_processT cell differentiation in thymus
B0033138biological_processpositive regulation of peptidyl-serine phosphorylation
B0034446biological_processsubstrate adhesion-dependent cell spreading
B0035019biological_processsomatic stem cell population maintenance
B0035175molecular_functionhistone H3S10 kinase activity
B0035402molecular_functionhistone H3T11 kinase activity
B0035403molecular_functionhistone H3T6 kinase activity
B0035979molecular_functionhistone H2AXS139 kinase activity
B0036211biological_processprotein modification process
B0042127biological_processregulation of cell population proliferation
B0042802molecular_functionidentical protein binding
B0043005cellular_componentneuron projection
B0043066biological_processnegative regulation of apoptotic process
B0043149biological_processstress fiber assembly
B0043231cellular_componentintracellular membrane-bounded organelle
B0043367biological_processCD4-positive, alpha-beta T cell differentiation
B0043368biological_processpositive T cell selection
B0043369biological_processCD4-positive or CD8-positive, alpha-beta T cell lineage commitment
B0043434biological_processresponse to peptide hormone
B0043524biological_processnegative regulation of neuron apoptotic process
B0044022molecular_functionhistone H3S28 kinase activity
B0044023molecular_functionhistone H4S1 kinase activity
B0044024molecular_functionhistone H2AS1 kinase activity
B0044025molecular_functionhistone H2BS14 kinase activity
B0044297cellular_componentcell body
B0044877molecular_functionprotein-containing complex binding
B0045580biological_processregulation of T cell differentiation
B0046632biological_processalpha-beta T cell differentiation
B0046872molecular_functionmetal ion binding
B0048538biological_processthymus development
B0048679biological_processregulation of axon regeneration
B0048680biological_processpositive regulation of axon regeneration
B0050772biological_processpositive regulation of axonogenesis
B0050852biological_processT cell receptor signaling pathway
B0051496biological_processpositive regulation of stress fiber assembly
B0051591biological_processresponse to cAMP
B0060291biological_processlong-term synaptic potentiation
B0060323biological_processhead morphogenesis
B0060324biological_processface development
B0070371biological_processERK1 and ERK2 cascade
B0070374biological_processpositive regulation of ERK1 and ERK2 cascade
B0071277biological_processcellular response to calcium ion
B0071466biological_processcellular response to xenobiotic stimulus
B0072354molecular_functionhistone H3T3 kinase activity
B0072371molecular_functionhistone H2AS121 kinase activity
B0072518molecular_functionRho-dependent protein serine/threonine kinase activity
B0072577biological_processendothelial cell apoptotic process
B0090150biological_processestablishment of protein localization to membrane
B0097110molecular_functionscaffold protein binding
B0098793cellular_componentpresynapse
B0098794cellular_componentpostsynapse
B0098978cellular_componentglutamatergic synapse
B0099170biological_processpostsynaptic modulation of chemical synaptic transmission
B0106310molecular_functionprotein serine kinase activity
B0140823molecular_functionhistone H2BS36 kinase activity
B0140855molecular_functionhistone H3S57 kinase activity
B0140857molecular_functionhistone H3T45 kinase activity
B1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
B1990090biological_processcellular response to nerve growth factor stimulus
B1990244molecular_functionhistone H2AT120 kinase activity
B2000301biological_processnegative regulation of synaptic vesicle exocytosis
B2000352biological_processnegative regulation of endothelial cell apoptotic process
C0000165biological_processMAPK cascade
C0002318biological_processmyeloid progenitor cell differentiation
C0004672molecular_functionprotein kinase activity
C0004674molecular_functionprotein serine/threonine kinase activity
C0004676molecular_function3-phosphoinositide-dependent protein kinase activity
C0004677molecular_functionDNA-dependent protein kinase activity
C0004679molecular_functionAMP-activated protein kinase activity
C0004694molecular_functioneukaryotic translation initiation factor 2alpha kinase activity
C0004708molecular_functionMAP kinase kinase activity
C0004709molecular_functionMAP kinase kinase kinase activity
C0004711molecular_functionribosomal protein S6 kinase activity
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006338biological_processchromatin remodeling
C0006468biological_processprotein phosphorylation
C0007165biological_processsignal transduction
C0007173biological_processepidermal growth factor receptor signaling pathway
C0008542biological_processvisual learning
C0009887biological_processanimal organ morphogenesis
C0010628biological_processpositive regulation of gene expression
C0010764biological_processnegative regulation of fibroblast migration
C0010828biological_processpositive regulation of D-glucose transmembrane transport
C0016079biological_processsynaptic vesicle exocytosis
C0030154biological_processcell differentiation
C0030878biological_processthyroid gland development
C0031267molecular_functionsmall GTPase binding
C0031434molecular_functionmitogen-activated protein kinase kinase binding
C0033077biological_processT cell differentiation in thymus
C0033138biological_processpositive regulation of peptidyl-serine phosphorylation
C0034446biological_processsubstrate adhesion-dependent cell spreading
C0035019biological_processsomatic stem cell population maintenance
C0035175molecular_functionhistone H3S10 kinase activity
C0035402molecular_functionhistone H3T11 kinase activity
C0035403molecular_functionhistone H3T6 kinase activity
C0035979molecular_functionhistone H2AXS139 kinase activity
C0036211biological_processprotein modification process
C0042127biological_processregulation of cell population proliferation
C0042802molecular_functionidentical protein binding
C0043005cellular_componentneuron projection
C0043066biological_processnegative regulation of apoptotic process
C0043149biological_processstress fiber assembly
C0043231cellular_componentintracellular membrane-bounded organelle
C0043367biological_processCD4-positive, alpha-beta T cell differentiation
C0043368biological_processpositive T cell selection
C0043369biological_processCD4-positive or CD8-positive, alpha-beta T cell lineage commitment
C0043434biological_processresponse to peptide hormone
C0043524biological_processnegative regulation of neuron apoptotic process
C0044022molecular_functionhistone H3S28 kinase activity
C0044023molecular_functionhistone H4S1 kinase activity
C0044024molecular_functionhistone H2AS1 kinase activity
C0044025molecular_functionhistone H2BS14 kinase activity
C0044297cellular_componentcell body
C0044877molecular_functionprotein-containing complex binding
C0045580biological_processregulation of T cell differentiation
C0046632biological_processalpha-beta T cell differentiation
C0046872molecular_functionmetal ion binding
C0048538biological_processthymus development
C0048679biological_processregulation of axon regeneration
C0048680biological_processpositive regulation of axon regeneration
C0050772biological_processpositive regulation of axonogenesis
C0050852biological_processT cell receptor signaling pathway
C0051496biological_processpositive regulation of stress fiber assembly
C0051591biological_processresponse to cAMP
C0060291biological_processlong-term synaptic potentiation
C0060323biological_processhead morphogenesis
C0060324biological_processface development
C0070371biological_processERK1 and ERK2 cascade
C0070374biological_processpositive regulation of ERK1 and ERK2 cascade
C0071277biological_processcellular response to calcium ion
C0071466biological_processcellular response to xenobiotic stimulus
C0072354molecular_functionhistone H3T3 kinase activity
C0072371molecular_functionhistone H2AS121 kinase activity
C0072518molecular_functionRho-dependent protein serine/threonine kinase activity
C0072577biological_processendothelial cell apoptotic process
C0090150biological_processestablishment of protein localization to membrane
C0097110molecular_functionscaffold protein binding
C0098793cellular_componentpresynapse
C0098794cellular_componentpostsynapse
C0098978cellular_componentglutamatergic synapse
C0099170biological_processpostsynaptic modulation of chemical synaptic transmission
C0106310molecular_functionprotein serine kinase activity
C0140823molecular_functionhistone H2BS36 kinase activity
C0140855molecular_functionhistone H3S57 kinase activity
C0140857molecular_functionhistone H3T45 kinase activity
C1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
C1990090biological_processcellular response to nerve growth factor stimulus
C1990244molecular_functionhistone H2AT120 kinase activity
C2000301biological_processnegative regulation of synaptic vesicle exocytosis
C2000352biological_processnegative regulation of endothelial cell apoptotic process
Z0005737cellular_componentcytoplasm
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues21
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGSGSFGTVYkGkwhgd.............VAVK
ChainResidueDetails
BILE463-LYS483

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKsnNIFL
ChainResidueDetails
BILE572-LEU584

site_idPS00479
Number of Residues46
DetailsZF_DAG_PE_1 Zinc finger phorbol-ester/DAG-type signature. HnFvrktfftlaf.CdfCrklLfqgfr.....CqtCgykfHqrCstevplm..C
ChainResidueDetails
BHIS235-CYS280

site_idPS00796
Number of Residues11
Details1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV
ChainResidueDetails
AARG42-VAL52

site_idPS00797
Number of Residues20
Details1433_2 14-3-3 proteins signature 2. YKDSTLIMQLLRDNLTLWTS
ChainResidueDetails
ATYR212-SER231

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues92
DetailsZN_FING: Phorbol-ester/DAG-type => ECO:0000255|PROSITE-ProRule:PRU00226
ChainResidueDetails
BTHR234-CYS280
CTHR234-CYS280

site_idSWS_FT_FI2
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
ChainResidueDetails
BASP576
CASP576

site_idSWS_FT_FI3
Number of Residues16
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
BHIS235
CCYS248
CCYS251
CCYS261
CCYS264
CHIS269
CCYS272
CCYS280
BCYS248
BCYS251
BCYS261
BCYS264
BHIS269
BCYS272
BCYS280
CHIS235

site_idSWS_FT_FI4
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
BILE463
BLYS483
CILE463
CLYS483

site_idSWS_FT_FI5
Number of Residues4
DetailsSITE: Breakpoint for translocation to form KIAA1549-BRAF fusion protein
ChainResidueDetails
BASP380
BMET438
CASP380
CMET438

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: N-acetylalanine => ECO:0000269|Ref.8
ChainResidueDetails
BALA2
CALA2

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
BSER151
CSER151

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P28028
ChainResidueDetails
BSER333
BSER750
CSER333
CSER750

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: Phosphoserine; by SGK1 => ECO:0000269|PubMed:11410590, ECO:0000269|Ref.8, ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER365
CSER365

site_idSWS_FT_FI10
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:1508179
ChainResidueDetails
BCYS373
CCYS373

site_idSWS_FT_FI11
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000269|Ref.8
ChainResidueDetails
BTHR396
CTHR396

site_idSWS_FT_FI12
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|Ref.8
ChainResidueDetails
BSER399
CSER399

site_idSWS_FT_FI13
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000269|Ref.8, ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
BTHR401
CTHR401

site_idSWS_FT_FI14
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER446
CSER446

site_idSWS_FT_FI15
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
BSER447
CSER447

site_idSWS_FT_FI16
Number of Residues2
DetailsMOD_RES: Omega-N-methylarginine; by PRMT5 => ECO:0000269|PubMed:21917714
ChainResidueDetails
BARG671
CARG671

site_idSWS_FT_FI17
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|Ref.8, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
BSEP729
CSEP729

site_idSWS_FT_FI18
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by MAPK1 => ECO:0000269|PubMed:19710016
ChainResidueDetails
BTHR753
CTHR753

site_idSWS_FT_FI19
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23907581
ChainResidueDetails
BLYS578
CLYS578

227561

PDB entries from 2024-11-20

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