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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6UAN

B-Raf:14-3-3 complex

Functional Information from GO Data
ChainGOidnamespacecontents
B0000165biological_processMAPK cascade
B0000166molecular_functionnucleotide binding
B0003824molecular_functioncatalytic activity
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0004708molecular_functionMAP kinase kinase activity
B0004709molecular_functionMAP kinase kinase kinase activity
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006468biological_processprotein phosphorylation
B0007165biological_processsignal transduction
B0007173biological_processepidermal growth factor receptor signaling pathway
B0008270molecular_functionzinc ion binding
B0009887biological_processanimal organ morphogenesis
B0010628biological_processpositive regulation of gene expression
B0010828biological_processpositive regulation of D-glucose transmembrane transport
B0016301molecular_functionkinase activity
B0016740molecular_functiontransferase activity
B0031267molecular_functionsmall GTPase binding
B0033138biological_processpositive regulation of peptidyl-serine phosphorylation
B0042802molecular_functionidentical protein binding
B0043005cellular_componentneuron projection
B0043066biological_processnegative regulation of apoptotic process
B0044297cellular_componentcell body
B0046872molecular_functionmetal ion binding
B0070374biological_processpositive regulation of ERK1 and ERK2 cascade
B0071277biological_processcellular response to calcium ion
B0090150biological_processestablishment of protein localization to membrane
B0097110molecular_functionscaffold protein binding
B0098794cellular_componentpostsynapse
B0098978cellular_componentglutamatergic synapse
B0099170biological_processpostsynaptic modulation of chemical synaptic transmission
B0106310molecular_functionprotein serine kinase activity
C0000165biological_processMAPK cascade
C0000166molecular_functionnucleotide binding
C0003824molecular_functioncatalytic activity
C0004672molecular_functionprotein kinase activity
C0004674molecular_functionprotein serine/threonine kinase activity
C0004708molecular_functionMAP kinase kinase activity
C0004709molecular_functionMAP kinase kinase kinase activity
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006468biological_processprotein phosphorylation
C0007165biological_processsignal transduction
C0007173biological_processepidermal growth factor receptor signaling pathway
C0008270molecular_functionzinc ion binding
C0009887biological_processanimal organ morphogenesis
C0010628biological_processpositive regulation of gene expression
C0010828biological_processpositive regulation of D-glucose transmembrane transport
C0016301molecular_functionkinase activity
C0016740molecular_functiontransferase activity
C0031267molecular_functionsmall GTPase binding
C0033138biological_processpositive regulation of peptidyl-serine phosphorylation
C0042802molecular_functionidentical protein binding
C0043005cellular_componentneuron projection
C0043066biological_processnegative regulation of apoptotic process
C0044297cellular_componentcell body
C0046872molecular_functionmetal ion binding
C0070374biological_processpositive regulation of ERK1 and ERK2 cascade
C0071277biological_processcellular response to calcium ion
C0090150biological_processestablishment of protein localization to membrane
C0097110molecular_functionscaffold protein binding
C0098794cellular_componentpostsynapse
C0098978cellular_componentglutamatergic synapse
C0099170biological_processpostsynaptic modulation of chemical synaptic transmission
C0106310molecular_functionprotein serine kinase activity
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues21
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGSGSFGTVYkGkwhgd.............VAVK
ChainResidueDetails
BILE463-LYS483
site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKsnNIFL
ChainResidueDetails
BILE572-LEU584
site_idPS00479
Number of Residues46
DetailsZF_DAG_PE_1 Zinc finger phorbol-ester/DAG-type signature. HnFvrktfftlaf.CdfCrklLfqgfr.....CqtCgykfHqrCstevplm..C
ChainResidueDetails
BHIS235-CYS280
site_idPS00796
Number of Residues11
Details1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV
ChainResidueDetails
AARG42-VAL52
site_idPS00797
Number of Residues20
Details1433_2 14-3-3 proteins signature 2. YKDSTLIMQLLRDNLTLWTS
ChainResidueDetails
ATYR212-SER231
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI2
Number of Residues2
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues18
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Boldt K.","von Kriegsheim A.F.","Zebisch A.","Kolch W."]}},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23907581","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues260
DetailsDomain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues1
DetailsModified residue: {"description":"Omega-N-methylarginine; by PRMT5","evidences":[{"source":"PubMed","id":"21917714","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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