6UAJ
Human IMPDH2 treated with ATP, IMP, NAD+, and 2 mM GTP. Free canonical octamer reconstruction.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0003938 | molecular_function | IMP dehydrogenase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005778 | cellular_component | peroxisomal membrane |
| A | 0005829 | cellular_component | cytosol |
| A | 0006164 | biological_process | purine nucleotide biosynthetic process |
| A | 0006177 | biological_process | GMP biosynthetic process |
| A | 0006183 | biological_process | GTP biosynthetic process |
| A | 0007623 | biological_process | circadian rhythm |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0034774 | cellular_component | secretory granule lumen |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0097294 | biological_process | 'de novo' XMP biosynthetic process |
| A | 1904813 | cellular_component | ficolin-1-rich granule lumen |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0003938 | molecular_function | IMP dehydrogenase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005778 | cellular_component | peroxisomal membrane |
| B | 0005829 | cellular_component | cytosol |
| B | 0006164 | biological_process | purine nucleotide biosynthetic process |
| B | 0006177 | biological_process | GMP biosynthetic process |
| B | 0006183 | biological_process | GTP biosynthetic process |
| B | 0007623 | biological_process | circadian rhythm |
| B | 0016020 | cellular_component | membrane |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0034774 | cellular_component | secretory granule lumen |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0097294 | biological_process | 'de novo' XMP biosynthetic process |
| B | 1904813 | cellular_component | ficolin-1-rich granule lumen |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003723 | molecular_function | RNA binding |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0003938 | molecular_function | IMP dehydrogenase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005634 | cellular_component | nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005778 | cellular_component | peroxisomal membrane |
| C | 0005829 | cellular_component | cytosol |
| C | 0006164 | biological_process | purine nucleotide biosynthetic process |
| C | 0006177 | biological_process | GMP biosynthetic process |
| C | 0006183 | biological_process | GTP biosynthetic process |
| C | 0007623 | biological_process | circadian rhythm |
| C | 0016020 | cellular_component | membrane |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0034774 | cellular_component | secretory granule lumen |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0070062 | cellular_component | extracellular exosome |
| C | 0097294 | biological_process | 'de novo' XMP biosynthetic process |
| C | 1904813 | cellular_component | ficolin-1-rich granule lumen |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003723 | molecular_function | RNA binding |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0003938 | molecular_function | IMP dehydrogenase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005576 | cellular_component | extracellular region |
| D | 0005634 | cellular_component | nucleus |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005778 | cellular_component | peroxisomal membrane |
| D | 0005829 | cellular_component | cytosol |
| D | 0006164 | biological_process | purine nucleotide biosynthetic process |
| D | 0006177 | biological_process | GMP biosynthetic process |
| D | 0006183 | biological_process | GTP biosynthetic process |
| D | 0007623 | biological_process | circadian rhythm |
| D | 0016020 | cellular_component | membrane |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0034774 | cellular_component | secretory granule lumen |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0070062 | cellular_component | extracellular exosome |
| D | 0097294 | biological_process | 'de novo' XMP biosynthetic process |
| D | 1904813 | cellular_component | ficolin-1-rich granule lumen |
| E | 0000166 | molecular_function | nucleotide binding |
| E | 0003677 | molecular_function | DNA binding |
| E | 0003723 | molecular_function | RNA binding |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0003938 | molecular_function | IMP dehydrogenase activity |
| E | 0005515 | molecular_function | protein binding |
| E | 0005576 | cellular_component | extracellular region |
| E | 0005634 | cellular_component | nucleus |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005778 | cellular_component | peroxisomal membrane |
| E | 0005829 | cellular_component | cytosol |
| E | 0006164 | biological_process | purine nucleotide biosynthetic process |
| E | 0006177 | biological_process | GMP biosynthetic process |
| E | 0006183 | biological_process | GTP biosynthetic process |
| E | 0007623 | biological_process | circadian rhythm |
| E | 0016020 | cellular_component | membrane |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0034774 | cellular_component | secretory granule lumen |
| E | 0046872 | molecular_function | metal ion binding |
| E | 0070062 | cellular_component | extracellular exosome |
| E | 0097294 | biological_process | 'de novo' XMP biosynthetic process |
| E | 1904813 | cellular_component | ficolin-1-rich granule lumen |
| F | 0000166 | molecular_function | nucleotide binding |
| F | 0003677 | molecular_function | DNA binding |
| F | 0003723 | molecular_function | RNA binding |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0003938 | molecular_function | IMP dehydrogenase activity |
| F | 0005515 | molecular_function | protein binding |
| F | 0005576 | cellular_component | extracellular region |
| F | 0005634 | cellular_component | nucleus |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005778 | cellular_component | peroxisomal membrane |
| F | 0005829 | cellular_component | cytosol |
| F | 0006164 | biological_process | purine nucleotide biosynthetic process |
| F | 0006177 | biological_process | GMP biosynthetic process |
| F | 0006183 | biological_process | GTP biosynthetic process |
| F | 0007623 | biological_process | circadian rhythm |
| F | 0016020 | cellular_component | membrane |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0034774 | cellular_component | secretory granule lumen |
| F | 0046872 | molecular_function | metal ion binding |
| F | 0070062 | cellular_component | extracellular exosome |
| F | 0097294 | biological_process | 'de novo' XMP biosynthetic process |
| F | 1904813 | cellular_component | ficolin-1-rich granule lumen |
| G | 0000166 | molecular_function | nucleotide binding |
| G | 0003677 | molecular_function | DNA binding |
| G | 0003723 | molecular_function | RNA binding |
| G | 0003824 | molecular_function | catalytic activity |
| G | 0003938 | molecular_function | IMP dehydrogenase activity |
| G | 0005515 | molecular_function | protein binding |
| G | 0005576 | cellular_component | extracellular region |
| G | 0005634 | cellular_component | nucleus |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0005778 | cellular_component | peroxisomal membrane |
| G | 0005829 | cellular_component | cytosol |
| G | 0006164 | biological_process | purine nucleotide biosynthetic process |
| G | 0006177 | biological_process | GMP biosynthetic process |
| G | 0006183 | biological_process | GTP biosynthetic process |
| G | 0007623 | biological_process | circadian rhythm |
| G | 0016020 | cellular_component | membrane |
| G | 0016491 | molecular_function | oxidoreductase activity |
| G | 0034774 | cellular_component | secretory granule lumen |
| G | 0046872 | molecular_function | metal ion binding |
| G | 0070062 | cellular_component | extracellular exosome |
| G | 0097294 | biological_process | 'de novo' XMP biosynthetic process |
| G | 1904813 | cellular_component | ficolin-1-rich granule lumen |
| H | 0000166 | molecular_function | nucleotide binding |
| H | 0003677 | molecular_function | DNA binding |
| H | 0003723 | molecular_function | RNA binding |
| H | 0003824 | molecular_function | catalytic activity |
| H | 0003938 | molecular_function | IMP dehydrogenase activity |
| H | 0005515 | molecular_function | protein binding |
| H | 0005576 | cellular_component | extracellular region |
| H | 0005634 | cellular_component | nucleus |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0005778 | cellular_component | peroxisomal membrane |
| H | 0005829 | cellular_component | cytosol |
| H | 0006164 | biological_process | purine nucleotide biosynthetic process |
| H | 0006177 | biological_process | GMP biosynthetic process |
| H | 0006183 | biological_process | GTP biosynthetic process |
| H | 0007623 | biological_process | circadian rhythm |
| H | 0016020 | cellular_component | membrane |
| H | 0016491 | molecular_function | oxidoreductase activity |
| H | 0034774 | cellular_component | secretory granule lumen |
| H | 0046872 | molecular_function | metal ion binding |
| H | 0070062 | cellular_component | extracellular exosome |
| H | 0097294 | biological_process | 'de novo' XMP biosynthetic process |
| H | 1904813 | cellular_component | ficolin-1-rich granule lumen |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue GTP A 601 |
| Chain | Residue |
| A | TYR110 |
| A | ATP603 |
| A | GLN112 |
| A | ILE115 |
| A | PRO118 |
| A | PHE139 |
| A | CYS140 |
| A | GLY141 |
| A | SER160 |
| A | THR225 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue GTP A 602 |
| Chain | Residue |
| A | LEU194 |
| A | LYS195 |
| A | ASN198 |
| A | ASP226 |
| A | LEU227 |
| A | ASN230 |
| A | PRO234 |
| A | LYS238 |
| A | LYS242 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | binding site for residue ATP A 603 |
| Chain | Residue |
| A | SER159 |
| A | SER160 |
| A | ARG161 |
| A | THR180 |
| A | ASP184 |
| A | LEU185 |
| A | VAL186 |
| A | LYS206 |
| A | GLY207 |
| A | LYS208 |
| A | GTP601 |
| F | ARG224 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details | binding site for residue IMP A 604 |
| Chain | Residue |
| A | SER68 |
| A | MET70 |
| A | ARG322 |
| A | ILE330 |
| A | CYS331 |
| A | ASP364 |
| A | GLY365 |
| A | ILE367 |
| A | GLY387 |
| A | SER388 |
| A | TYR411 |
| A | GLY413 |
| A | MET414 |
| A | GLY415 |
| A | NAD605 |
| site_id | AC5 |
| Number of Residues | 13 |
| Details | binding site for residue NAD A 605 |
| Chain | Residue |
| A | THR252 |
| A | HIS253 |
| A | ASP274 |
| A | SER275 |
| A | SER276 |
| A | PHE282 |
| A | ASN303 |
| A | ASP364 |
| A | MET414 |
| A | GLN441 |
| A | IMP604 |
| D | ILE42 |
| D | GLN469 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | binding site for residue GTP B 601 |
| Chain | Residue |
| B | TYR110 |
| B | GLN112 |
| B | ILE115 |
| B | PRO118 |
| B | PHE139 |
| B | CYS140 |
| B | GLY141 |
| B | SER160 |
| B | THR225 |
| B | ATP603 |
| site_id | AC7 |
| Number of Residues | 15 |
| Details | binding site for residue IMP B 604 |
| Chain | Residue |
| B | SER68 |
| B | MET70 |
| B | ARG322 |
| B | ILE330 |
| B | CYS331 |
| B | ASP364 |
| B | GLY365 |
| B | ILE367 |
| B | GLY387 |
| B | SER388 |
| B | TYR411 |
| B | GLY413 |
| B | MET414 |
| B | GLY415 |
| B | NAD605 |
| site_id | AC8 |
| Number of Residues | 13 |
| Details | binding site for residue NAD B 605 |
| Chain | Residue |
| A | ILE42 |
| A | GLN469 |
| B | THR252 |
| B | HIS253 |
| B | ASP274 |
| B | SER275 |
| B | SER276 |
| B | PHE282 |
| B | ASN303 |
| B | ASP364 |
| B | MET414 |
| B | GLN441 |
| B | IMP604 |
| site_id | AC9 |
| Number of Residues | 10 |
| Details | binding site for residue GTP C 601 |
| Chain | Residue |
| C | ILE115 |
| C | PRO118 |
| C | PHE139 |
| C | CYS140 |
| C | GLY141 |
| C | SER160 |
| C | THR225 |
| C | ATP603 |
| C | TYR110 |
| C | GLN112 |
| site_id | AD1 |
| Number of Residues | 15 |
| Details | binding site for residue IMP C 604 |
| Chain | Residue |
| C | SER68 |
| C | MET70 |
| C | ARG322 |
| C | ILE330 |
| C | CYS331 |
| C | ASP364 |
| C | GLY365 |
| C | ILE367 |
| C | GLY387 |
| C | SER388 |
| C | TYR411 |
| C | GLY413 |
| C | MET414 |
| C | GLY415 |
| C | NAD605 |
| site_id | AD2 |
| Number of Residues | 13 |
| Details | binding site for residue NAD C 605 |
| Chain | Residue |
| B | ILE42 |
| B | GLN469 |
| C | THR252 |
| C | HIS253 |
| C | ASP274 |
| C | SER275 |
| C | SER276 |
| C | PHE282 |
| C | ASN303 |
| C | ASP364 |
| C | MET414 |
| C | GLN441 |
| C | IMP604 |
| site_id | AD3 |
| Number of Residues | 10 |
| Details | binding site for residue GTP D 601 |
| Chain | Residue |
| D | TYR110 |
| D | GLN112 |
| D | ILE115 |
| D | PRO118 |
| D | PHE139 |
| D | CYS140 |
| D | GLY141 |
| D | SER160 |
| D | THR225 |
| D | ATP603 |
| site_id | AD4 |
| Number of Residues | 15 |
| Details | binding site for residue IMP D 604 |
| Chain | Residue |
| D | SER68 |
| D | MET70 |
| D | ARG322 |
| D | ILE330 |
| D | CYS331 |
| D | ASP364 |
| D | GLY365 |
| D | ILE367 |
| D | GLY387 |
| D | SER388 |
| D | TYR411 |
| D | GLY413 |
| D | MET414 |
| D | GLY415 |
| D | NAD605 |
| site_id | AD5 |
| Number of Residues | 13 |
| Details | binding site for residue NAD D 605 |
| Chain | Residue |
| C | ILE42 |
| C | GLN469 |
| D | THR252 |
| D | HIS253 |
| D | ASP274 |
| D | SER275 |
| D | SER276 |
| D | PHE282 |
| D | ASN303 |
| D | ASP364 |
| D | MET414 |
| D | GLN441 |
| D | IMP604 |
| site_id | AD6 |
| Number of Residues | 10 |
| Details | binding site for residue GTP E 601 |
| Chain | Residue |
| E | TYR110 |
| E | GLN112 |
| E | ILE115 |
| E | PRO118 |
| E | PHE139 |
| E | CYS140 |
| E | GLY141 |
| E | SER160 |
| E | THR225 |
| E | ATP603 |
| site_id | AD7 |
| Number of Residues | 15 |
| Details | binding site for residue IMP E 604 |
| Chain | Residue |
| E | SER68 |
| E | MET70 |
| E | ARG322 |
| E | ILE330 |
| E | CYS331 |
| E | ASP364 |
| E | GLY365 |
| E | ILE367 |
| E | GLY387 |
| E | SER388 |
| E | TYR411 |
| E | GLY413 |
| E | MET414 |
| E | GLY415 |
| E | NAD605 |
| site_id | AD8 |
| Number of Residues | 13 |
| Details | binding site for residue NAD E 605 |
| Chain | Residue |
| E | THR252 |
| E | HIS253 |
| E | ASP274 |
| E | SER275 |
| E | SER276 |
| E | PHE282 |
| E | ASN303 |
| E | ASP364 |
| E | MET414 |
| E | GLN441 |
| E | IMP604 |
| H | ILE42 |
| H | GLN469 |
| site_id | AD9 |
| Number of Residues | 10 |
| Details | binding site for residue GTP F 601 |
| Chain | Residue |
| F | TYR110 |
| F | GLN112 |
| F | ILE115 |
| F | PRO118 |
| F | PHE139 |
| F | CYS140 |
| F | GLY141 |
| F | SER160 |
| F | THR225 |
| F | ATP603 |
| site_id | AE1 |
| Number of Residues | 15 |
| Details | binding site for residue IMP F 604 |
| Chain | Residue |
| F | SER68 |
| F | MET70 |
| F | ARG322 |
| F | ILE330 |
| F | CYS331 |
| F | ASP364 |
| F | GLY365 |
| F | ILE367 |
| F | GLY387 |
| F | SER388 |
| F | TYR411 |
| F | GLY413 |
| F | MET414 |
| F | GLY415 |
| F | NAD605 |
| site_id | AE2 |
| Number of Residues | 13 |
| Details | binding site for residue NAD F 605 |
| Chain | Residue |
| E | ILE42 |
| E | GLN469 |
| F | THR252 |
| F | HIS253 |
| F | ASP274 |
| F | SER275 |
| F | SER276 |
| F | PHE282 |
| F | ASN303 |
| F | ASP364 |
| F | MET414 |
| F | GLN441 |
| F | IMP604 |
| site_id | AE3 |
| Number of Residues | 10 |
| Details | binding site for residue GTP G 601 |
| Chain | Residue |
| G | TYR110 |
| G | GLN112 |
| G | ILE115 |
| G | PRO118 |
| G | PHE139 |
| G | CYS140 |
| G | GLY141 |
| G | SER160 |
| G | THR225 |
| G | ATP603 |
| site_id | AE4 |
| Number of Residues | 15 |
| Details | binding site for residue IMP G 604 |
| Chain | Residue |
| G | SER68 |
| G | MET70 |
| G | ARG322 |
| G | ILE330 |
| G | CYS331 |
| G | ASP364 |
| G | GLY365 |
| G | ILE367 |
| G | GLY387 |
| G | SER388 |
| G | TYR411 |
| G | GLY413 |
| G | MET414 |
| G | GLY415 |
| G | NAD605 |
| site_id | AE5 |
| Number of Residues | 13 |
| Details | binding site for residue NAD G 605 |
| Chain | Residue |
| F | ILE42 |
| F | GLN469 |
| G | THR252 |
| G | HIS253 |
| G | ASP274 |
| G | SER275 |
| G | SER276 |
| G | PHE282 |
| G | ASN303 |
| G | ASP364 |
| G | MET414 |
| G | GLN441 |
| G | IMP604 |
| site_id | AE6 |
| Number of Residues | 10 |
| Details | binding site for residue GTP H 601 |
| Chain | Residue |
| H | TYR110 |
| H | GLN112 |
| H | ILE115 |
| H | PRO118 |
| H | PHE139 |
| H | CYS140 |
| H | GLY141 |
| H | SER160 |
| H | THR225 |
| H | ATP603 |
| site_id | AE7 |
| Number of Residues | 15 |
| Details | binding site for residue IMP H 604 |
| Chain | Residue |
| H | SER68 |
| H | MET70 |
| H | ARG322 |
| H | ILE330 |
| H | CYS331 |
| H | ASP364 |
| H | GLY365 |
| H | ILE367 |
| H | GLY387 |
| H | SER388 |
| H | TYR411 |
| H | GLY413 |
| H | MET414 |
| H | GLY415 |
| H | NAD605 |
| site_id | AE8 |
| Number of Residues | 13 |
| Details | binding site for residue NAD H 605 |
| Chain | Residue |
| G | ILE42 |
| G | GLN469 |
| H | THR252 |
| H | HIS253 |
| H | ASP274 |
| H | SER275 |
| H | SER276 |
| H | PHE282 |
| H | ASN303 |
| H | ASP364 |
| H | MET414 |
| H | GLN441 |
| H | IMP604 |
| site_id | AE9 |
| Number of Residues | 13 |
| Details | binding site for Di-peptide GTP B 602 and ASP B 226 |
| Chain | Residue |
| B | GLN112 |
| B | LEU194 |
| B | LYS195 |
| B | ASN198 |
| B | ARG224 |
| B | THR225 |
| B | LEU227 |
| B | LYS228 |
| B | LYS229 |
| B | ASN230 |
| B | PRO234 |
| B | LYS238 |
| B | LYS242 |
| site_id | AF1 |
| Number of Residues | 15 |
| Details | binding site for Di-peptide ATP B 603 and ARG B 161 |
| Chain | Residue |
| B | SER159 |
| B | SER160 |
| B | ASP162 |
| B | ILE163 |
| B | ASP164 |
| B | PHE165 |
| B | THR180 |
| B | ASP184 |
| B | LEU185 |
| B | VAL186 |
| B | LYS206 |
| B | GLY207 |
| B | LYS208 |
| B | GTP601 |
| E | ARG224 |
| site_id | AF2 |
| Number of Residues | 13 |
| Details | binding site for Di-peptide GTP C 602 and ASP C 226 |
| Chain | Residue |
| C | GLN112 |
| C | LEU194 |
| C | LYS195 |
| C | ASN198 |
| C | ARG224 |
| C | THR225 |
| C | LEU227 |
| C | LYS228 |
| C | LYS229 |
| C | ASN230 |
| C | PRO234 |
| C | LYS238 |
| C | LYS242 |
| site_id | AF3 |
| Number of Residues | 15 |
| Details | binding site for Di-peptide ATP C 603 and ARG C 161 |
| Chain | Residue |
| C | SER159 |
| C | SER160 |
| C | ASP162 |
| C | ILE163 |
| C | ASP164 |
| C | PHE165 |
| C | THR180 |
| C | ASP184 |
| C | LEU185 |
| C | VAL186 |
| C | LYS206 |
| C | GLY207 |
| C | LYS208 |
| C | GTP601 |
| H | ARG224 |
| site_id | AF4 |
| Number of Residues | 13 |
| Details | binding site for Di-peptide GTP D 602 and ASP D 226 |
| Chain | Residue |
| D | GLN112 |
| D | LEU194 |
| D | LYS195 |
| D | ASN198 |
| D | ARG224 |
| D | THR225 |
| D | LEU227 |
| D | LYS228 |
| D | LYS229 |
| D | ASN230 |
| D | PRO234 |
| D | LYS238 |
| D | LYS242 |
| site_id | AF5 |
| Number of Residues | 15 |
| Details | binding site for Di-peptide ATP D 603 and ARG D 161 |
| Chain | Residue |
| D | SER159 |
| D | SER160 |
| D | ASP162 |
| D | ILE163 |
| D | ASP164 |
| D | PHE165 |
| D | THR180 |
| D | ASP184 |
| D | LEU185 |
| D | VAL186 |
| D | LYS206 |
| D | GLY207 |
| D | LYS208 |
| D | GTP601 |
| G | ARG224 |
| site_id | AF6 |
| Number of Residues | 13 |
| Details | binding site for Di-peptide GTP E 602 and ASP E 226 |
| Chain | Residue |
| E | GLN112 |
| E | LEU194 |
| E | LYS195 |
| E | ASN198 |
| E | ARG224 |
| E | THR225 |
| E | LEU227 |
| E | LYS228 |
| E | LYS229 |
| E | ASN230 |
| E | PRO234 |
| E | LYS238 |
| E | LYS242 |
| site_id | AF7 |
| Number of Residues | 15 |
| Details | binding site for Di-peptide ATP E 603 and ARG E 161 |
| Chain | Residue |
| B | ARG224 |
| E | SER159 |
| E | SER160 |
| E | ASP162 |
| E | ILE163 |
| E | ASP164 |
| E | PHE165 |
| E | THR180 |
| E | ASP184 |
| E | LEU185 |
| E | VAL186 |
| E | LYS206 |
| E | GLY207 |
| E | LYS208 |
| E | GTP601 |
| site_id | AF8 |
| Number of Residues | 13 |
| Details | binding site for Di-peptide GTP F 602 and ASP F 226 |
| Chain | Residue |
| F | GLN112 |
| F | LEU194 |
| F | LYS195 |
| F | ASN198 |
| F | ARG224 |
| F | THR225 |
| F | LEU227 |
| F | LYS228 |
| F | LYS229 |
| F | ASN230 |
| F | PRO234 |
| F | LYS238 |
| F | LYS242 |
| site_id | AF9 |
| Number of Residues | 15 |
| Details | binding site for Di-peptide ATP F 603 and ARG F 161 |
| Chain | Residue |
| A | ARG224 |
| F | SER159 |
| F | SER160 |
| F | ASP162 |
| F | ILE163 |
| F | ASP164 |
| F | PHE165 |
| F | THR180 |
| F | ASP184 |
| F | LEU185 |
| F | VAL186 |
| F | LYS206 |
| F | GLY207 |
| F | LYS208 |
| F | GTP601 |
| site_id | AG1 |
| Number of Residues | 13 |
| Details | binding site for Di-peptide GTP G 602 and ASP G 226 |
| Chain | Residue |
| G | GLN112 |
| G | LEU194 |
| G | LYS195 |
| G | ASN198 |
| G | ARG224 |
| G | THR225 |
| G | LEU227 |
| G | LYS228 |
| G | LYS229 |
| G | ASN230 |
| G | PRO234 |
| G | LYS238 |
| G | LYS242 |
| site_id | AG2 |
| Number of Residues | 15 |
| Details | binding site for Di-peptide ATP G 603 and ARG G 161 |
| Chain | Residue |
| D | ARG224 |
| G | SER159 |
| G | SER160 |
| G | ASP162 |
| G | ILE163 |
| G | ASP164 |
| G | PHE165 |
| G | THR180 |
| G | ASP184 |
| G | LEU185 |
| G | VAL186 |
| G | LYS206 |
| G | GLY207 |
| G | LYS208 |
| G | GTP601 |
| site_id | AG3 |
| Number of Residues | 13 |
| Details | binding site for Di-peptide GTP H 602 and ASP H 226 |
| Chain | Residue |
| H | GLN112 |
| H | LEU194 |
| H | LYS195 |
| H | ASN198 |
| H | ARG224 |
| H | THR225 |
| H | LEU227 |
| H | LYS228 |
| H | LYS229 |
| H | ASN230 |
| H | PRO234 |
| H | LYS238 |
| H | LYS242 |
| site_id | AG4 |
| Number of Residues | 15 |
| Details | binding site for Di-peptide ATP H 603 and ARG H 161 |
| Chain | Residue |
| C | ARG224 |
| H | SER159 |
| H | SER160 |
| H | ASP162 |
| H | ILE163 |
| H | ASP164 |
| H | PHE165 |
| H | THR180 |
| H | ASP184 |
| H | LEU185 |
| H | VAL186 |
| H | LYS206 |
| H | GLY207 |
| H | LYS208 |
| H | GTP601 |
Functional Information from PROSITE/UniProt
| site_id | PS00487 |
| Number of Residues | 13 |
| Details | IMP_DH_GMP_RED IMP dehydrogenase / GMP reductase signature. LRVGMGsGSICiT |
| Chain | Residue | Details |
| A | LEU321-THR333 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 472 |
| Details | Domain: {"description":"CBS 1","evidences":[{"source":"HAMAP-Rule","id":"MF_03156","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 464 |
| Details | Domain: {"description":"CBS 2","evidences":[{"source":"HAMAP-Rule","id":"MF_03156","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Active site: {"description":"Thioimidate intermediate","evidences":[{"source":"HAMAP-Rule","id":"MF_03156","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10097070","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 40 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 88 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03156","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 24 |
| Details | Binding site: {"description":"in other chain","evidences":[{"source":"HAMAP-Rule","id":"MF_03156","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2002","submissionDatabase":"PDB data bank","title":"Crystal structure of human inosine monophosphate dehydrogenase type II complexed with the MPA/NAD analog C2-MAD.","authors":["Risal D.","Strickler M.D.","Goldstein B.M."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 32 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
