6UA4

Human IMPDH2 treated with ATP, IMP, NAD+, and 2 mM GTP. Bent (3/4 compressed, 1/4 extended) segment reconstruction.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003677	molecular_function	DNA binding
A	0003723	molecular_function	RNA binding
A	0003824	molecular_function	catalytic activity
A	0003938	molecular_function	IMP dehydrogenase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005778	cellular_component	peroxisomal membrane
A	0005829	cellular_component	cytosol
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0006177	biological_process	GMP biosynthetic process
A	0006183	biological_process	GTP biosynthetic process
A	0007623	biological_process	circadian rhythm
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0034774	cellular_component	secretory granule lumen
A	0046651	biological_process	lymphocyte proliferation
A	0046872	molecular_function	metal ion binding
A	0070062	cellular_component	extracellular exosome
A	0071353	biological_process	cellular response to interleukin-4
A	0097294	biological_process	'de novo' XMP biosynthetic process
A	1904813	cellular_component	ficolin-1-rich granule lumen
B	0000166	molecular_function	nucleotide binding
B	0003677	molecular_function	DNA binding
B	0003723	molecular_function	RNA binding
B	0003824	molecular_function	catalytic activity
B	0003938	molecular_function	IMP dehydrogenase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005778	cellular_component	peroxisomal membrane
B	0005829	cellular_component	cytosol
B	0006164	biological_process	purine nucleotide biosynthetic process
B	0006177	biological_process	GMP biosynthetic process
B	0006183	biological_process	GTP biosynthetic process
B	0007623	biological_process	circadian rhythm
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0034774	cellular_component	secretory granule lumen
B	0046651	biological_process	lymphocyte proliferation
B	0046872	molecular_function	metal ion binding
B	0070062	cellular_component	extracellular exosome
B	0071353	biological_process	cellular response to interleukin-4
B	0097294	biological_process	'de novo' XMP biosynthetic process
B	1904813	cellular_component	ficolin-1-rich granule lumen
C	0000166	molecular_function	nucleotide binding
C	0003677	molecular_function	DNA binding
C	0003723	molecular_function	RNA binding
C	0003824	molecular_function	catalytic activity
C	0003938	molecular_function	IMP dehydrogenase activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005778	cellular_component	peroxisomal membrane
C	0005829	cellular_component	cytosol
C	0006164	biological_process	purine nucleotide biosynthetic process
C	0006177	biological_process	GMP biosynthetic process
C	0006183	biological_process	GTP biosynthetic process
C	0007623	biological_process	circadian rhythm
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0034774	cellular_component	secretory granule lumen
C	0046651	biological_process	lymphocyte proliferation
C	0046872	molecular_function	metal ion binding
C	0070062	cellular_component	extracellular exosome
C	0071353	biological_process	cellular response to interleukin-4
C	0097294	biological_process	'de novo' XMP biosynthetic process
C	1904813	cellular_component	ficolin-1-rich granule lumen
D	0000166	molecular_function	nucleotide binding
D	0003677	molecular_function	DNA binding
D	0003723	molecular_function	RNA binding
D	0003824	molecular_function	catalytic activity
D	0003938	molecular_function	IMP dehydrogenase activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005778	cellular_component	peroxisomal membrane
D	0005829	cellular_component	cytosol
D	0006164	biological_process	purine nucleotide biosynthetic process
D	0006177	biological_process	GMP biosynthetic process
D	0006183	biological_process	GTP biosynthetic process
D	0007623	biological_process	circadian rhythm
D	0016020	cellular_component	membrane
D	0016491	molecular_function	oxidoreductase activity
D	0034774	cellular_component	secretory granule lumen
D	0046651	biological_process	lymphocyte proliferation
D	0046872	molecular_function	metal ion binding
D	0070062	cellular_component	extracellular exosome
D	0071353	biological_process	cellular response to interleukin-4
D	0097294	biological_process	'de novo' XMP biosynthetic process
D	1904813	cellular_component	ficolin-1-rich granule lumen
E	0000166	molecular_function	nucleotide binding
E	0003677	molecular_function	DNA binding
E	0003723	molecular_function	RNA binding
E	0003824	molecular_function	catalytic activity
E	0003938	molecular_function	IMP dehydrogenase activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005778	cellular_component	peroxisomal membrane
E	0005829	cellular_component	cytosol
E	0006164	biological_process	purine nucleotide biosynthetic process
E	0006177	biological_process	GMP biosynthetic process
E	0006183	biological_process	GTP biosynthetic process
E	0007623	biological_process	circadian rhythm
E	0016020	cellular_component	membrane
E	0016491	molecular_function	oxidoreductase activity
E	0034774	cellular_component	secretory granule lumen
E	0046651	biological_process	lymphocyte proliferation
E	0046872	molecular_function	metal ion binding
E	0070062	cellular_component	extracellular exosome
E	0071353	biological_process	cellular response to interleukin-4
E	0097294	biological_process	'de novo' XMP biosynthetic process
E	1904813	cellular_component	ficolin-1-rich granule lumen
F	0000166	molecular_function	nucleotide binding
F	0003677	molecular_function	DNA binding
F	0003723	molecular_function	RNA binding
F	0003824	molecular_function	catalytic activity
F	0003938	molecular_function	IMP dehydrogenase activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005778	cellular_component	peroxisomal membrane
F	0005829	cellular_component	cytosol
F	0006164	biological_process	purine nucleotide biosynthetic process
F	0006177	biological_process	GMP biosynthetic process
F	0006183	biological_process	GTP biosynthetic process
F	0007623	biological_process	circadian rhythm
F	0016020	cellular_component	membrane
F	0016491	molecular_function	oxidoreductase activity
F	0034774	cellular_component	secretory granule lumen
F	0046651	biological_process	lymphocyte proliferation
F	0046872	molecular_function	metal ion binding
F	0070062	cellular_component	extracellular exosome
F	0071353	biological_process	cellular response to interleukin-4
F	0097294	biological_process	'de novo' XMP biosynthetic process
F	1904813	cellular_component	ficolin-1-rich granule lumen
G	0000166	molecular_function	nucleotide binding
G	0003677	molecular_function	DNA binding
G	0003723	molecular_function	RNA binding
G	0003824	molecular_function	catalytic activity
G	0003938	molecular_function	IMP dehydrogenase activity
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005778	cellular_component	peroxisomal membrane
G	0005829	cellular_component	cytosol
G	0006164	biological_process	purine nucleotide biosynthetic process
G	0006177	biological_process	GMP biosynthetic process
G	0006183	biological_process	GTP biosynthetic process
G	0007623	biological_process	circadian rhythm
G	0016020	cellular_component	membrane
G	0016491	molecular_function	oxidoreductase activity
G	0034774	cellular_component	secretory granule lumen
G	0046651	biological_process	lymphocyte proliferation
G	0046872	molecular_function	metal ion binding
G	0070062	cellular_component	extracellular exosome
G	0071353	biological_process	cellular response to interleukin-4
G	0097294	biological_process	'de novo' XMP biosynthetic process
G	1904813	cellular_component	ficolin-1-rich granule lumen
H	0000166	molecular_function	nucleotide binding
H	0003677	molecular_function	DNA binding
H	0003723	molecular_function	RNA binding
H	0003824	molecular_function	catalytic activity
H	0003938	molecular_function	IMP dehydrogenase activity
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005778	cellular_component	peroxisomal membrane
H	0005829	cellular_component	cytosol
H	0006164	biological_process	purine nucleotide biosynthetic process
H	0006177	biological_process	GMP biosynthetic process
H	0006183	biological_process	GTP biosynthetic process
H	0007623	biological_process	circadian rhythm
H	0016020	cellular_component	membrane
H	0016491	molecular_function	oxidoreductase activity
H	0034774	cellular_component	secretory granule lumen
H	0046651	biological_process	lymphocyte proliferation
H	0046872	molecular_function	metal ion binding
H	0070062	cellular_component	extracellular exosome
H	0071353	biological_process	cellular response to interleukin-4
H	0097294	biological_process	'de novo' XMP biosynthetic process
H	1904813	cellular_component	ficolin-1-rich granule lumen
I	0000166	molecular_function	nucleotide binding
I	0003677	molecular_function	DNA binding
I	0003723	molecular_function	RNA binding
I	0003824	molecular_function	catalytic activity
I	0003938	molecular_function	IMP dehydrogenase activity
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005778	cellular_component	peroxisomal membrane
I	0005829	cellular_component	cytosol
I	0006164	biological_process	purine nucleotide biosynthetic process
I	0006177	biological_process	GMP biosynthetic process
I	0006183	biological_process	GTP biosynthetic process
I	0007623	biological_process	circadian rhythm
I	0016020	cellular_component	membrane
I	0016491	molecular_function	oxidoreductase activity
I	0034774	cellular_component	secretory granule lumen
I	0046651	biological_process	lymphocyte proliferation
I	0046872	molecular_function	metal ion binding
I	0070062	cellular_component	extracellular exosome
I	0071353	biological_process	cellular response to interleukin-4
I	0097294	biological_process	'de novo' XMP biosynthetic process
I	1904813	cellular_component	ficolin-1-rich granule lumen
J	0000166	molecular_function	nucleotide binding
J	0003677	molecular_function	DNA binding
J	0003723	molecular_function	RNA binding
J	0003824	molecular_function	catalytic activity
J	0003938	molecular_function	IMP dehydrogenase activity
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005778	cellular_component	peroxisomal membrane
J	0005829	cellular_component	cytosol
J	0006164	biological_process	purine nucleotide biosynthetic process
J	0006177	biological_process	GMP biosynthetic process
J	0006183	biological_process	GTP biosynthetic process
J	0007623	biological_process	circadian rhythm
J	0016020	cellular_component	membrane
J	0016491	molecular_function	oxidoreductase activity
J	0034774	cellular_component	secretory granule lumen
J	0046651	biological_process	lymphocyte proliferation
J	0046872	molecular_function	metal ion binding
J	0070062	cellular_component	extracellular exosome
J	0071353	biological_process	cellular response to interleukin-4
J	0097294	biological_process	'de novo' XMP biosynthetic process
J	1904813	cellular_component	ficolin-1-rich granule lumen
K	0000166	molecular_function	nucleotide binding
K	0003677	molecular_function	DNA binding
K	0003723	molecular_function	RNA binding
K	0003824	molecular_function	catalytic activity
K	0003938	molecular_function	IMP dehydrogenase activity
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005778	cellular_component	peroxisomal membrane
K	0005829	cellular_component	cytosol
K	0006164	biological_process	purine nucleotide biosynthetic process
K	0006177	biological_process	GMP biosynthetic process
K	0006183	biological_process	GTP biosynthetic process
K	0007623	biological_process	circadian rhythm
K	0016020	cellular_component	membrane
K	0016491	molecular_function	oxidoreductase activity
K	0034774	cellular_component	secretory granule lumen
K	0046651	biological_process	lymphocyte proliferation
K	0046872	molecular_function	metal ion binding
K	0070062	cellular_component	extracellular exosome
K	0071353	biological_process	cellular response to interleukin-4
K	0097294	biological_process	'de novo' XMP biosynthetic process
K	1904813	cellular_component	ficolin-1-rich granule lumen
L	0000166	molecular_function	nucleotide binding
L	0003677	molecular_function	DNA binding
L	0003723	molecular_function	RNA binding
L	0003824	molecular_function	catalytic activity
L	0003938	molecular_function	IMP dehydrogenase activity
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0005778	cellular_component	peroxisomal membrane
L	0005829	cellular_component	cytosol
L	0006164	biological_process	purine nucleotide biosynthetic process
L	0006177	biological_process	GMP biosynthetic process
L	0006183	biological_process	GTP biosynthetic process
L	0007623	biological_process	circadian rhythm
L	0016020	cellular_component	membrane
L	0016491	molecular_function	oxidoreductase activity
L	0034774	cellular_component	secretory granule lumen
L	0046651	biological_process	lymphocyte proliferation
L	0046872	molecular_function	metal ion binding
L	0070062	cellular_component	extracellular exosome
L	0071353	biological_process	cellular response to interleukin-4
L	0097294	biological_process	'de novo' XMP biosynthetic process
L	1904813	cellular_component	ficolin-1-rich granule lumen
M	0000166	molecular_function	nucleotide binding
M	0003677	molecular_function	DNA binding
M	0003723	molecular_function	RNA binding
M	0003824	molecular_function	catalytic activity
M	0003938	molecular_function	IMP dehydrogenase activity
M	0005515	molecular_function	protein binding
M	0005576	cellular_component	extracellular region
M	0005634	cellular_component	nucleus
M	0005737	cellular_component	cytoplasm
M	0005778	cellular_component	peroxisomal membrane
M	0005829	cellular_component	cytosol
M	0006164	biological_process	purine nucleotide biosynthetic process
M	0006177	biological_process	GMP biosynthetic process
M	0006183	biological_process	GTP biosynthetic process
M	0007623	biological_process	circadian rhythm
M	0016020	cellular_component	membrane
M	0016491	molecular_function	oxidoreductase activity
M	0034774	cellular_component	secretory granule lumen
M	0046651	biological_process	lymphocyte proliferation
M	0046872	molecular_function	metal ion binding
M	0070062	cellular_component	extracellular exosome
M	0071353	biological_process	cellular response to interleukin-4
M	0097294	biological_process	'de novo' XMP biosynthetic process
M	1904813	cellular_component	ficolin-1-rich granule lumen
N	0000166	molecular_function	nucleotide binding
N	0003677	molecular_function	DNA binding
N	0003723	molecular_function	RNA binding
N	0003824	molecular_function	catalytic activity
N	0003938	molecular_function	IMP dehydrogenase activity
N	0005515	molecular_function	protein binding
N	0005576	cellular_component	extracellular region
N	0005634	cellular_component	nucleus
N	0005737	cellular_component	cytoplasm
N	0005778	cellular_component	peroxisomal membrane
N	0005829	cellular_component	cytosol
N	0006164	biological_process	purine nucleotide biosynthetic process
N	0006177	biological_process	GMP biosynthetic process
N	0006183	biological_process	GTP biosynthetic process
N	0007623	biological_process	circadian rhythm
N	0016020	cellular_component	membrane
N	0016491	molecular_function	oxidoreductase activity
N	0034774	cellular_component	secretory granule lumen
N	0046651	biological_process	lymphocyte proliferation
N	0046872	molecular_function	metal ion binding
N	0070062	cellular_component	extracellular exosome
N	0071353	biological_process	cellular response to interleukin-4
N	0097294	biological_process	'de novo' XMP biosynthetic process
N	1904813	cellular_component	ficolin-1-rich granule lumen
O	0000166	molecular_function	nucleotide binding
O	0003677	molecular_function	DNA binding
O	0003723	molecular_function	RNA binding
O	0003824	molecular_function	catalytic activity
O	0003938	molecular_function	IMP dehydrogenase activity
O	0005515	molecular_function	protein binding
O	0005576	cellular_component	extracellular region
O	0005634	cellular_component	nucleus
O	0005737	cellular_component	cytoplasm
O	0005778	cellular_component	peroxisomal membrane
O	0005829	cellular_component	cytosol
O	0006164	biological_process	purine nucleotide biosynthetic process
O	0006177	biological_process	GMP biosynthetic process
O	0006183	biological_process	GTP biosynthetic process
O	0007623	biological_process	circadian rhythm
O	0016020	cellular_component	membrane
O	0016491	molecular_function	oxidoreductase activity
O	0034774	cellular_component	secretory granule lumen
O	0046651	biological_process	lymphocyte proliferation
O	0046872	molecular_function	metal ion binding
O	0070062	cellular_component	extracellular exosome
O	0071353	biological_process	cellular response to interleukin-4
O	0097294	biological_process	'de novo' XMP biosynthetic process
O	1904813	cellular_component	ficolin-1-rich granule lumen
P	0000166	molecular_function	nucleotide binding
P	0003677	molecular_function	DNA binding
P	0003723	molecular_function	RNA binding
P	0003824	molecular_function	catalytic activity
P	0003938	molecular_function	IMP dehydrogenase activity
P	0005515	molecular_function	protein binding
P	0005576	cellular_component	extracellular region
P	0005634	cellular_component	nucleus
P	0005737	cellular_component	cytoplasm
P	0005778	cellular_component	peroxisomal membrane
P	0005829	cellular_component	cytosol
P	0006164	biological_process	purine nucleotide biosynthetic process
P	0006177	biological_process	GMP biosynthetic process
P	0006183	biological_process	GTP biosynthetic process
P	0007623	biological_process	circadian rhythm
P	0016020	cellular_component	membrane
P	0016491	molecular_function	oxidoreductase activity
P	0034774	cellular_component	secretory granule lumen
P	0046651	biological_process	lymphocyte proliferation
P	0046872	molecular_function	metal ion binding
P	0070062	cellular_component	extracellular exosome
P	0071353	biological_process	cellular response to interleukin-4
P	0097294	biological_process	'de novo' XMP biosynthetic process
P	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue GTP A 601

Chain	Residue
A	LYS109
A	THR225
A	ATP603
A	GLN112
A	PRO118
A	PHE139
A	CYS140
A	GLY141
A	SER159
A	SER160
A	LYS208

---

site_id	AC2
Number of Residues	7
Details	binding site for residue GTP A 602

Chain	Residue
A	LEU194
A	LYS195
A	ASN198
A	ASP226
A	LEU227
A	ASN230
A	LYS242

---

site_id	AC3
Number of Residues	14
Details	binding site for residue ATP A 603

Chain	Residue
A	SER159
A	SER160
A	ARG161
A	ASP162
A	THR180
A	ASP184
A	LEU185
A	VAL186
A	LYS206
A	GLY207
A	LYS208
A	GTP601
F	ARG224
F	ATP603

---

site_id	AC4
Number of Residues	18
Details	binding site for residue IMP A 604

Chain	Residue
A	SER68
A	MET70
A	ARG322
A	GLY328
A	SER329
A	ILE330
A	CYS331
A	ASP364
A	GLY365
A	GLY366
A	GLY387
A	SER388
A	TYR411
A	GLY413
A	MET414
A	GLY415
A	GLN441
A	NAD605

---

site_id	AC5
Number of Residues	15
Details	binding site for residue NAD A 605

Chain	Residue
A	HIS253
A	GLU254
A	ASP274
A	SER275
A	SER276
A	PHE282
A	ASN303
A	GLY324
A	MET325
A	GLY326
A	MET414
A	GLY415
A	GLN441
A	IMP604
D	GLN469

---

site_id	AC6
Number of Residues	14
Details	binding site for residue GTP B 601

Chain	Residue
B	TYR110
B	GLU111
B	GLN112
B	ILE115
B	PRO118
B	VAL119
B	PHE139
B	CYS140
B	GLY141
B	SER160
B	LYS208
B	THR225
B	ASP226
B	ATP603

---

site_id	AC7
Number of Residues	10
Details	binding site for residue GTP B 602

Chain	Residue
B	GLU111
B	GLN112
B	LEU194
B	LYS195
B	ASN198
B	ASP226
B	LEU227
B	ASN230
B	LYS238
B	LYS242

---

site_id	AC8
Number of Residues	13
Details	binding site for residue ATP B 603

Chain	Residue
B	GTP601
E	ARG161
E	ATP603
B	ILE157
B	SER159
B	SER160
B	ARG161
B	ASP162
B	THR180
B	LEU185
B	VAL186
B	LYS206
B	LYS208

---

site_id	AC9
Number of Residues	18
Details	binding site for residue IMP B 604

Chain	Residue
B	SER68
B	MET70
B	ARG322
B	GLY328
B	SER329
B	ILE330
B	CYS331
B	ASP364
B	GLY365
B	GLY366
B	GLY387
B	SER388
B	TYR411
B	GLY413
B	MET414
B	GLY415
B	GLN441
B	NAD605

---

site_id	AD1
Number of Residues	12
Details	binding site for residue NAD B 605

Chain	Residue
A	GLN469
B	HIS253
B	ASP274
B	SER276
B	PHE282
B	ASN303
B	MET325
B	GLY326
B	CYS331
B	MET414
B	GLN441
B	IMP604

---

site_id	AD2
Number of Residues	13
Details	binding site for residue ATP C 601

Chain	Residue
C	ILE157
C	SER159
C	SER160
C	ARG161
C	ASP162
C	THR180
C	LEU185
C	LYS206
C	GLY207
C	LYS208
C	PRO210
C	ATP602
H	ARG161

---

site_id	AD3
Number of Residues	8
Details	binding site for residue ATP C 602

Chain	Residue
C	ILE115
C	PRO118
C	PHE139
C	CYS140
C	GLY141
C	ALA223
C	THR225
C	ATP601

---

site_id	AD4
Number of Residues	18
Details	binding site for residue IMP C 603

Chain	Residue
C	SER68
C	MET70
C	ARG322
C	GLY328
C	SER329
C	ILE330
C	CYS331
C	ASP364
C	GLY365
C	GLY366
C	GLY387
C	SER388
C	TYR411
C	GLY413
C	MET414
C	GLY415
C	GLN441
C	NAD604

---

site_id	AD5
Number of Residues	14
Details	binding site for residue NAD C 604

Chain	Residue
B	GLN469
C	THR252
C	HIS253
C	ASP274
C	SER275
C	SER276
C	PHE282
C	ASN303
C	MET325
C	GLY326
C	MET414
C	GLY415
C	GLN441
C	IMP603

---

site_id	AD6
Number of Residues	14
Details	binding site for residue GTP D 601

Chain	Residue
D	TYR110
D	GLU111
D	GLN112
D	PRO118
D	PHE139
D	CYS140
D	GLY141
D	SER159
D	SER160
D	ALA223
D	THR225
D	ASP226
D	LYS229
D	ATP603

---

site_id	AD7
Number of Residues	8
Details	binding site for residue GTP D 602

Chain	Residue
D	LEU194
D	LYS195
D	ASN198
D	ASP226
D	LEU227
D	ASN230
D	LYS238
D	LYS242

---

site_id	AD8
Number of Residues	13
Details	binding site for residue ATP D 603

Chain	Residue
D	ILE157
D	SER159
D	SER160
D	ARG161
D	THR180
D	LEU185
D	VAL186
D	LYS206
D	GLY207
D	LYS208
D	GTP601
G	ARG161
G	LYS205

---

site_id	AD9
Number of Residues	19
Details	binding site for residue IMP D 604

Chain	Residue
D	SER68
D	MET70
D	ARG322
D	GLY328
D	SER329
D	CYS331
D	ASP364
D	GLY365
D	GLY366
D	GLY387
D	SER388
D	TYR411
D	GLY413
D	MET414
D	GLY415
D	SER416
D	GLN441
D	GLY442
D	NAD605

---

site_id	AE1
Number of Residues	15
Details	binding site for residue NAD D 605

Chain	Residue
D	THR252
D	HIS253
D	GLU254
D	ASP274
D	SER275
D	SER276
D	PHE282
D	ASN303
D	GLY324
D	MET325
D	GLY326
D	MET414
D	GLY415
D	GLN441
D	IMP604

---

site_id	AE2
Number of Residues	16
Details	binding site for residue GTP E 601

Chain	Residue
E	LYS109
E	TYR110
E	GLU111
E	GLN112
E	PRO118
E	VAL119
E	PHE139
E	CYS140
E	GLY141
E	SER159
E	SER160
E	LYS208
E	ALA223
E	THR225
E	ASP226
E	ATP603

---

site_id	AE3
Number of Residues	9
Details	binding site for residue GTP E 602

Chain	Residue
E	GLN112
E	GLY113
E	LEU194
E	LYS195
E	ASN198
E	ASP226
E	LEU227
E	ASN230
E	LYS242

---

site_id	AE4
Number of Residues	15
Details	binding site for residue ATP E 603

Chain	Residue
B	ARG161
B	LYS205
B	ARG224
B	ATP603
E	SER159
E	SER160
E	ARG161
E	ASP162
E	THR180
E	LEU185
E	VAL186
E	LYS206
E	GLY207
E	LYS208
E	GTP601

---

site_id	AE5
Number of Residues	18
Details	binding site for residue IMP E 604

Chain	Residue
E	SER68
E	MET70
E	GLY328
E	SER329
E	ILE330
E	CYS331
E	ASP364
E	GLY365
E	GLY366
E	MET385
E	GLY387
E	SER388
E	TYR411
E	GLY413
E	MET414
E	GLY415
E	GLN441
E	NAD605

---

site_id	AE6
Number of Residues	18
Details	binding site for residue NAD E 605

Chain	Residue
E	THR252
E	HIS253
E	GLU254
E	ASP274
E	SER275
E	SER276
E	PHE282
E	ASN303
E	GLY324
E	MET325
E	GLY326
E	THR333
E	ASP364
E	MET414
E	GLY415
E	GLN441
E	IMP604
H	GLN469

---

site_id	AE7
Number of Residues	15
Details	binding site for residue GTP F 601

Chain	Residue
F	TYR110
F	GLU111
F	GLN112
F	ILE115
F	PRO118
F	VAL119
F	PHE139
F	CYS140
F	GLY141
F	SER159
F	SER160
F	LYS208
F	THR225
F	ASP226
F	ATP603

---

site_id	AE8
Number of Residues	10
Details	binding site for residue GTP F 602

Chain	Residue
F	GLU111
F	GLN112
F	GLY113
F	LEU194
F	LYS195
F	ASN198
F	ASP226
F	ASN230
F	LYS238
F	LYS242

---

site_id	AE9
Number of Residues	14
Details	binding site for residue ATP F 603

Chain	Residue
A	ARG161
A	ATP603
F	ILE157
F	SER159
F	SER160
F	ARG161
F	ASP162
F	THR180
F	LEU185
F	VAL186
F	LYS206
F	GLY207
F	LYS208
F	GTP601

---

site_id	AF1
Number of Residues	16
Details	binding site for residue IMP F 604

Chain	Residue
F	MET70
F	ARG322
F	GLY328
F	SER329
F	ILE330
F	CYS331
F	ASP364
F	GLY366
F	GLY387
F	SER388
F	TYR411
F	GLY413
F	MET414
F	GLY415
F	GLN441
F	NAD605

---

site_id	AF2
Number of Residues	14
Details	binding site for residue NAD F 605

Chain	Residue
E	GLN469
F	HIS253
F	ASP274
F	SER276
F	PHE282
F	ASN303
F	GLY324
F	MET325
F	GLY326
F	THR333
F	MET414
F	GLY415
F	GLN441
F	IMP604

---

site_id	AF3
Number of Residues	13
Details	binding site for residue ATP G 601

Chain	Residue
D	ARG161
G	ILE157
G	SER159
G	SER160
G	ARG161
G	ASP162
G	THR180
G	LEU185
G	LYS206
G	GLY207
G	LYS208
G	PRO210
G	ATP602

---

site_id	AF4
Number of Residues	12
Details	binding site for residue ATP G 602

Chain	Residue
G	ILE115
G	ASP117
G	PRO118
G	VAL119
G	GLY138
G	PHE139
G	CYS140
G	GLY141
G	SER160
G	ALA223
G	THR225
G	ATP601

---

site_id	AF5
Number of Residues	18
Details	binding site for residue IMP G 603

Chain	Residue
G	SER68
G	MET70
G	ARG322
G	GLY328
G	SER329
G	CYS331
G	ASP364
G	GLY365
G	GLY387
G	SER388
G	TYR411
G	GLY413
G	MET414
G	GLY415
G	SER416
G	GLN441
G	GLY442
G	NAD604

---

site_id	AF6
Number of Residues	14
Details	binding site for residue NAD G 604

Chain	Residue
F	GLN469
G	THR252
G	HIS253
G	GLU254
G	ASP274
G	SER276
G	PHE282
G	ASN303
G	MET325
G	GLY326
G	CYS331
G	MET414
G	GLN441
G	IMP603

---

site_id	AF7
Number of Residues	10
Details	binding site for residue GTP H 601

Chain	Residue
H	TYR110
H	GLU111
H	GLN112
H	PRO118
H	PHE139
H	GLY141
H	SER159
H	SER160
H	THR225
H	ATP603

---

site_id	AF8
Number of Residues	8
Details	binding site for residue GTP H 602

Chain	Residue
H	LEU194
H	LYS195
H	ASN198
H	ASP226
H	LEU227
H	ASN230
H	LYS238
H	LYS242

---

site_id	AF9
Number of Residues	14
Details	binding site for residue ATP H 603

Chain	Residue
C	ARG161
C	LYS205
H	ILE157
H	SER159
H	SER160
H	ARG161
H	THR180
H	ASP184
H	LEU185
H	VAL186
H	LYS206
H	GLY207
H	LYS208
H	GTP601

---

site_id	AG1
Number of Residues	19
Details	binding site for residue IMP H 604

Chain	Residue
H	SER68
H	MET70
H	ARG322
H	GLY328
H	SER329
H	ILE330
H	CYS331
H	ASP364
H	GLY365
H	GLY366
H	MET385
H	GLY387
H	SER388
H	TYR411
H	GLY413
H	MET414
H	GLY415
H	GLN441
H	NAD605

---

site_id	AG2
Number of Residues	14
Details	binding site for residue NAD H 605

Chain	Residue
G	GLN469
H	THR252
H	HIS253
H	ASP274
H	SER275
H	SER276
H	PHE282
H	ASN303
H	GLY324
H	MET325
H	GLY326
H	MET414
H	GLN441
H	IMP604

---

Functional Information from PROSITE/UniProt

site_id	PS00487
Number of Residues	13
Details	IMP_DH_GMP_RED IMP dehydrogenase / GMP reductase signature. LRVGMGsGSICiT

Chain	Residue	Details
A	LEU321-THR333

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	472
Details	Domain: {"description":"CBS 1","evidences":[{"source":"HAMAP-Rule","id":"MF_03156","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	464
Details	Domain: {"description":"CBS 2","evidences":[{"source":"HAMAP-Rule","id":"MF_03156","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Active site: {"description":"Thioimidate intermediate","evidences":[{"source":"HAMAP-Rule","id":"MF_03156","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10097070","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	40
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	88
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03156","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	24
Details	Binding site: {"description":"in other chain","evidences":[{"source":"HAMAP-Rule","id":"MF_03156","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2002","submissionDatabase":"PDB data bank","title":"Crystal structure of human inosine monophosphate dehydrogenase type II complexed with the MPA/NAD analog C2-MAD.","authors":["Risal D.","Strickler M.D.","Goldstein B.M."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	8
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	32
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---