6U9Q

Crystal Structure Analysis of DNA-BCL11A Znf domain complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1001

Chain	Residue
A	CYS744
A	CYS747
A	HIS760
A	HIS764

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 1002

Chain	Residue
A	CYS772
A	CYS775
A	HIS788
A	HIS792

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 1003

Chain	Residue
A	CYS805
A	HIS818
A	HIS823
A	CYS802

---

site_id	AC4
Number of Residues	6
Details	binding site for residue PO4 A 1004

Chain	Residue
A	PHE751
A	LYS752
A	ASN753
A	ASN756
A	HOH1102
A	HOH1109

---

site_id	AC5
Number of Residues	5
Details	binding site for residue PO4 A 1005

Chain	Residue
A	ARG740
A	ASN776
A	LYS821
A	TRP822
A	HOH1148

---

site_id	AC6
Number of Residues	5
Details	binding site for residue MG C 1201

Chain	Residue
A	SER783
A	HOH1120
A	HOH1125
C	DT4
C	DG5

---

Functional Information from PROSITE/UniProt

site_id	PS00028
Number of Residues	21
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cey..CgkvFkncsnltvHrrs..H

Chain	Residue	Details
A	CYS744-HIS764
A	CYS772-HIS792
A	CYS802-HIS823

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	22
Details	ZN_FING: C2H2-type 4 => ECO:0000255|PROSITE-ProRule:PRU00042

Chain	Residue	Details
A	ASP742-HIS764

---

site_id	SWS_FT_FI2
Number of Residues	22
Details	ZN_FING: C2H2-type 5 => ECO:0000255|PROSITE-ProRule:PRU00042

Chain	Residue	Details
A	TYR770-HIS792

---

site_id	SWS_FT_FI3
Number of Residues	23
Details	ZN_FING: C2H2-type 6 => ECO:0000255|PROSITE-ProRule:PRU00042

Chain	Residue	Details
A	TYR800-HIS823

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS833

---