6U9H

Arabidopsis thaliana acetohydroxyacid synthase complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0003824	molecular_function	catalytic activity
A	0003984	molecular_function	acetolactate synthase activity
A	0009082	biological_process	branched-chain amino acid biosynthetic process
A	0030976	molecular_function	thiamine pyrophosphate binding
A	0050660	molecular_function	flavin adenine dinucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0003824	molecular_function	catalytic activity
B	0003984	molecular_function	acetolactate synthase activity
B	0009082	biological_process	branched-chain amino acid biosynthetic process
B	0030976	molecular_function	thiamine pyrophosphate binding
B	0050660	molecular_function	flavin adenine dinucleotide binding
F	0001666	biological_process	response to hypoxia
F	0003984	molecular_function	acetolactate synthase activity
F	0005515	molecular_function	protein binding
F	0005777	cellular_component	peroxisome
F	0005829	cellular_component	cytosol
F	0008652	biological_process	amino acid biosynthetic process
F	0009082	biological_process	branched-chain amino acid biosynthetic process
F	0009097	biological_process	isoleucine biosynthetic process
F	0009099	biological_process	L-valine biosynthetic process
F	0009507	cellular_component	chloroplast
F	1990610	molecular_function	acetolactate synthase regulator activity
G	0001666	biological_process	response to hypoxia
G	0003984	molecular_function	acetolactate synthase activity
G	0005515	molecular_function	protein binding
G	0005777	cellular_component	peroxisome
G	0005829	cellular_component	cytosol
G	0008652	biological_process	amino acid biosynthetic process
G	0009082	biological_process	branched-chain amino acid biosynthetic process
G	0009097	biological_process	isoleucine biosynthetic process
G	0009099	biological_process	L-valine biosynthetic process
G	0009507	cellular_component	chloroplast
G	1990610	molecular_function	acetolactate synthase regulator activity
H	0000287	molecular_function	magnesium ion binding
H	0003824	molecular_function	catalytic activity
H	0003984	molecular_function	acetolactate synthase activity
H	0009082	biological_process	branched-chain amino acid biosynthetic process
H	0030976	molecular_function	thiamine pyrophosphate binding
H	0050660	molecular_function	flavin adenine dinucleotide binding
I	0000287	molecular_function	magnesium ion binding
I	0003824	molecular_function	catalytic activity
I	0003984	molecular_function	acetolactate synthase activity
I	0009082	biological_process	branched-chain amino acid biosynthetic process
I	0030976	molecular_function	thiamine pyrophosphate binding
I	0050660	molecular_function	flavin adenine dinucleotide binding
J	0001666	biological_process	response to hypoxia
J	0003984	molecular_function	acetolactate synthase activity
J	0005515	molecular_function	protein binding
J	0005777	cellular_component	peroxisome
J	0005829	cellular_component	cytosol
J	0008652	biological_process	amino acid biosynthetic process
J	0009082	biological_process	branched-chain amino acid biosynthetic process
J	0009097	biological_process	isoleucine biosynthetic process
J	0009099	biological_process	L-valine biosynthetic process
J	0009507	cellular_component	chloroplast
J	1990610	molecular_function	acetolactate synthase regulator activity
K	0001666	biological_process	response to hypoxia
K	0003984	molecular_function	acetolactate synthase activity
K	0005515	molecular_function	protein binding
K	0005777	cellular_component	peroxisome
K	0005829	cellular_component	cytosol
K	0008652	biological_process	amino acid biosynthetic process
K	0009082	biological_process	branched-chain amino acid biosynthetic process
K	0009097	biological_process	isoleucine biosynthetic process
K	0009099	biological_process	L-valine biosynthetic process
K	0009507	cellular_component	chloroplast
K	1990610	molecular_function	acetolactate synthase regulator activity
L	0000287	molecular_function	magnesium ion binding
L	0003824	molecular_function	catalytic activity
L	0003984	molecular_function	acetolactate synthase activity
L	0009082	biological_process	branched-chain amino acid biosynthetic process
L	0030976	molecular_function	thiamine pyrophosphate binding
L	0050660	molecular_function	flavin adenine dinucleotide binding
M	0000287	molecular_function	magnesium ion binding
M	0003824	molecular_function	catalytic activity
M	0003984	molecular_function	acetolactate synthase activity
M	0009082	biological_process	branched-chain amino acid biosynthetic process
M	0030976	molecular_function	thiamine pyrophosphate binding
M	0050660	molecular_function	flavin adenine dinucleotide binding
N	0001666	biological_process	response to hypoxia
N	0003984	molecular_function	acetolactate synthase activity
N	0005515	molecular_function	protein binding
N	0005777	cellular_component	peroxisome
N	0005829	cellular_component	cytosol
N	0008652	biological_process	amino acid biosynthetic process
N	0009082	biological_process	branched-chain amino acid biosynthetic process
N	0009097	biological_process	isoleucine biosynthetic process
N	0009099	biological_process	L-valine biosynthetic process
N	0009507	cellular_component	chloroplast
N	1990610	molecular_function	acetolactate synthase regulator activity
O	0001666	biological_process	response to hypoxia
O	0003984	molecular_function	acetolactate synthase activity
O	0005515	molecular_function	protein binding
O	0005777	cellular_component	peroxisome
O	0005829	cellular_component	cytosol
O	0008652	biological_process	amino acid biosynthetic process
O	0009082	biological_process	branched-chain amino acid biosynthetic process
O	0009097	biological_process	isoleucine biosynthetic process
O	0009099	biological_process	L-valine biosynthetic process
O	0009507	cellular_component	chloroplast
O	1990610	molecular_function	acetolactate synthase regulator activity
P	0000287	molecular_function	magnesium ion binding
P	0003824	molecular_function	catalytic activity
P	0003984	molecular_function	acetolactate synthase activity
P	0009082	biological_process	branched-chain amino acid biosynthetic process
P	0030976	molecular_function	thiamine pyrophosphate binding
P	0050660	molecular_function	flavin adenine dinucleotide binding
Q	0000287	molecular_function	magnesium ion binding
Q	0003824	molecular_function	catalytic activity
Q	0003984	molecular_function	acetolactate synthase activity
Q	0009082	biological_process	branched-chain amino acid biosynthetic process
Q	0030976	molecular_function	thiamine pyrophosphate binding
Q	0050660	molecular_function	flavin adenine dinucleotide binding
R	0001666	biological_process	response to hypoxia
R	0003984	molecular_function	acetolactate synthase activity
R	0005515	molecular_function	protein binding
R	0005777	cellular_component	peroxisome
R	0005829	cellular_component	cytosol
R	0008652	biological_process	amino acid biosynthetic process
R	0009082	biological_process	branched-chain amino acid biosynthetic process
R	0009097	biological_process	isoleucine biosynthetic process
R	0009099	biological_process	L-valine biosynthetic process
R	0009507	cellular_component	chloroplast
R	1990610	molecular_function	acetolactate synthase regulator activity
S	0001666	biological_process	response to hypoxia
S	0003984	molecular_function	acetolactate synthase activity
S	0005515	molecular_function	protein binding
S	0005777	cellular_component	peroxisome
S	0005829	cellular_component	cytosol
S	0008652	biological_process	amino acid biosynthetic process
S	0009082	biological_process	branched-chain amino acid biosynthetic process
S	0009097	biological_process	isoleucine biosynthetic process
S	0009099	biological_process	L-valine biosynthetic process
S	0009507	cellular_component	chloroplast
S	1990610	molecular_function	acetolactate synthase regulator activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue MG A 701

Chain	Residue
A	GLY537
A	ASP538
A	GLY539
A	TPP703

---

site_id	AC2
Number of Residues	33
Details	binding site for residue FAD A 702

Chain	Residue
A	GLY308
A	GLY309
A	LEU311
A	ASN312
A	THR331
A	LEU332
A	MET333
A	MET348
A	LEU349
A	GLY350
A	MET351
A	HIS352
A	GLY353
A	GLY371
A	VAL372
A	ARG373
A	ASP375
A	ARG377
A	VAL378
A	ASP395
A	ILE396
A	ASP397
A	GLU400
A	VAL415
A	VAL485
A	MET490
A	GLY508
B	GLN207
A	ASP185
A	SER186
A	ARG246
A	PRO247
A	GLY307

---

site_id	AC3
Number of Residues	23
Details	binding site for residue TPP A 703

Chain	Residue
A	VAL485
A	GLY486
A	GLN487
A	HIS488
A	GLY511
A	MET513
A	GLY537
A	ASP538
A	GLY539
A	SER540
A	MET543
A	LEU563
A	ASN565
A	HIS567
A	LEU568
A	GLY569
A	MET570
A	MG701
B	TYR118
B	PRO119
B	GLY120
B	GLU144
B	PRO170

---

site_id	AC4
Number of Residues	6
Details	binding site for residue MG B 701

Chain	Residue
B	ASP538
B	ASN565
B	HIS567
B	LEU568
B	GLY569
B	TPP703

---

site_id	AC5
Number of Residues	32
Details	binding site for residue FAD B 702

Chain	Residue
A	PHE206
B	ASP185
B	SER186
B	ARG246
B	PRO247
B	GLY308
B	GLY309
B	ASN312
B	THR331
B	LEU332
B	MET333
B	LEU349
B	GLY350
B	MET351
B	HIS352
B	GLY353
B	GLY371
B	VAL372
B	ARG373
B	ASP375
B	ARG377
B	VAL378
B	ASP395
B	ILE396
B	GLU400
B	ASP414
B	VAL415
B	VAL485
B	GLN489
B	MET490
B	GLY508
B	GLY509

---

site_id	AC6
Number of Residues	24
Details	binding site for residue TPP B 703

Chain	Residue
A	PRO119
A	GLU144
A	THR167
A	PRO170
A	GLY171
A	ASN174
A	GLN207
B	VAL485
B	GLY486
B	GLN487
B	HIS488
B	GLY511
B	MET513
B	GLY537
B	ASP538
B	GLY539
B	SER540
B	ASN565
B	HIS567
B	LEU568
B	GLY569
B	MET570
B	MG701
A	TYR118

---

site_id	AC7
Number of Residues	4
Details	binding site for residue MG H 701

Chain	Residue
H	GLY537
H	ASP538
H	GLY539
H	TPP703

---

site_id	AC8
Number of Residues	33
Details	binding site for residue FAD H 702

Chain	Residue
H	ASP185
H	SER186
H	ARG246
H	PRO247
H	GLY307
H	GLY308
H	GLY309
H	LEU311
H	ASN312
H	THR331
H	LEU332
H	MET333
H	MET348
H	LEU349
H	GLY350
H	MET351
H	HIS352
H	GLY353
H	GLY371
H	VAL372
H	ARG373
H	ASP375
H	ARG377
H	VAL378
H	ASP395
H	ILE396
H	ASP397
H	GLU400
H	VAL415
H	VAL485
H	MET490
H	SER507
H	GLY508

---

site_id	AC9
Number of Residues	23
Details	binding site for residue TPP H 703

Chain	Residue
H	VAL485
H	GLY486
H	GLN487
H	HIS488
H	GLY511
H	MET513
H	GLY537
H	ASP538
H	GLY539
H	SER540
H	MET543
H	LEU563
H	ASN565
H	HIS567
H	LEU568
H	GLY569
H	MET570
H	MG701
I	TYR118
I	PRO119
I	GLY120
I	GLU144
I	PRO170

---

site_id	AD1
Number of Residues	6
Details	binding site for residue MG I 701

Chain	Residue
I	ASP538
I	ASN565
I	HIS567
I	LEU568
I	GLY569
I	TPP703

---

site_id	AD2
Number of Residues	32
Details	binding site for residue FAD I 702

Chain	Residue
H	PHE206
I	ASP185
I	SER186
I	ARG246
I	PRO247
I	GLY308
I	GLY309
I	ASN312
I	THR331
I	LEU332
I	MET333
I	LEU349
I	GLY350
I	MET351
I	HIS352
I	GLY353
I	GLY371
I	VAL372
I	ARG373
I	ASP375
I	ARG377
I	VAL378
I	ASP395
I	ILE396
I	GLU400
I	ASP414
I	VAL415
I	VAL485
I	GLN489
I	MET490
I	GLY508
I	GLY509

---

site_id	AD3
Number of Residues	23
Details	binding site for residue TPP I 703

Chain	Residue
H	TYR118
H	PRO119
H	GLU144
H	THR167
H	PRO170
H	GLY171
H	GLN207
I	VAL485
I	GLY486
I	GLN487
I	HIS488
I	GLY511
I	MET513
I	GLY537
I	ASP538
I	GLY539
I	SER540
I	ASN565
I	HIS567
I	LEU568
I	GLY569
I	MET570
I	MG701

---

site_id	AD4
Number of Residues	4
Details	binding site for residue MG L 701

Chain	Residue
L	GLY537
L	ASP538
L	GLY539
L	TPP703

---

site_id	AD5
Number of Residues	33
Details	binding site for residue FAD L 702

Chain	Residue
L	ASP185
L	SER186
L	ARG246
L	PRO247
L	GLY307
L	GLY308
L	GLY309
L	LEU311
L	ASN312
L	THR331
L	LEU332
L	MET333
L	MET348
L	LEU349
L	GLY350
L	MET351
L	HIS352
L	GLY353
L	GLY371
L	VAL372
L	ARG373
L	ASP375
L	ARG377
L	VAL378
L	ASP395
L	ILE396
L	ASP397
L	GLU400
L	VAL415
L	VAL485
L	MET490
L	GLY508
M	PHE206

---

site_id	AD6
Number of Residues	23
Details	binding site for residue TPP L 703

Chain	Residue
L	VAL485
L	GLY486
L	GLN487
L	HIS488
L	GLY511
L	MET513
L	GLY537
L	ASP538
L	GLY539
L	SER540
L	MET543
L	LEU563
L	ASN565
L	HIS567
L	LEU568
L	GLY569
L	MET570
L	MG701
M	TYR118
M	PRO119
M	GLY120
M	GLU144
M	PRO170

---

site_id	AD7
Number of Residues	6
Details	binding site for residue MG M 701

Chain	Residue
M	ASP538
M	ASN565
M	HIS567
M	LEU568
M	GLY569
M	TPP703

---

site_id	AD8
Number of Residues	32
Details	binding site for residue FAD M 702

Chain	Residue
L	PHE206
M	ASP185
M	SER186
M	ARG246
M	PRO247
M	GLY308
M	GLY309
M	ASN312
M	THR331
M	LEU332
M	MET333
M	LEU349
M	GLY350
M	MET351
M	HIS352
M	GLY353
M	GLY371
M	VAL372
M	ARG373
M	ASP375
M	ARG377
M	VAL378
M	ASP395
M	ILE396
M	GLU400
M	ASP414
M	VAL415
M	VAL485
M	GLN489
M	MET490
M	GLY508
M	GLY509

---

site_id	AD9
Number of Residues	23
Details	binding site for residue TPP M 703

Chain	Residue
L	PRO119
L	GLU144
L	THR167
L	PRO170
L	GLY171
L	ASN174
L	GLN207
M	VAL485
M	GLY486
M	GLN487
M	HIS488
M	GLY511
M	MET513
M	GLY537
M	ASP538
M	GLY539
M	SER540
M	ASN565
M	HIS567
M	LEU568
M	GLY569
M	MET570
M	MG701

---

site_id	AE1
Number of Residues	4
Details	binding site for residue MG P 701

Chain	Residue
P	GLY537
P	ASP538
P	GLY539
P	TPP703

---

site_id	AE2
Number of Residues	33
Details	binding site for residue FAD P 702

Chain	Residue
P	ASP185
P	SER186
P	ARG246
P	PRO247
P	GLY307
P	GLY308
P	GLY309
P	LEU311
P	ASN312
P	THR331
P	LEU332
P	MET333
P	MET348
P	LEU349
P	GLY350
P	MET351
P	HIS352
P	GLY353
P	GLY371
P	VAL372
P	ARG373
P	ASP375
P	ARG377
P	VAL378
P	ASP395
P	ILE396
P	ASP397
P	GLU400
P	VAL415
P	VAL485
P	MET490
P	GLY508
Q	PHE206

---

site_id	AE3
Number of Residues	23
Details	binding site for residue TPP P 703

Chain	Residue
P	VAL485
P	GLY486
P	GLN487
P	HIS488
P	GLY511
P	MET513
P	GLY537
P	ASP538
P	GLY539
P	SER540
P	MET543
P	LEU563
P	ASN565
P	HIS567
P	LEU568
P	GLY569
P	MET570
P	MG701
Q	TYR118
Q	PRO119
Q	GLY120
Q	GLU144
Q	PRO170

---

site_id	AE4
Number of Residues	6
Details	binding site for residue MG Q 701

Chain	Residue
Q	ASP538
Q	ASN565
Q	HIS567
Q	LEU568
Q	GLY569
Q	TPP703

---

site_id	AE5
Number of Residues	32
Details	binding site for residue FAD Q 702

Chain	Residue
P	PHE206
Q	ASP185
Q	SER186
Q	ARG246
Q	PRO247
Q	GLY308
Q	GLY309
Q	ASN312
Q	THR331
Q	LEU332
Q	MET333
Q	LEU349
Q	GLY350
Q	MET351
Q	HIS352
Q	GLY353
Q	GLY371
Q	VAL372
Q	ARG373
Q	ASP375
Q	ARG377
Q	VAL378
Q	ASP395
Q	ILE396
Q	GLU400
Q	ASP414
Q	VAL415
Q	VAL485
Q	GLN489
Q	MET490
Q	GLY508
Q	GLY509

---

site_id	AE6
Number of Residues	22
Details	binding site for residue TPP Q 703

Chain	Residue
P	PRO119
P	GLU144
P	THR167
P	PRO170
P	GLY171
P	GLN207
Q	VAL485
Q	GLY486
Q	GLN487
Q	HIS488
Q	GLY511
Q	MET513
Q	GLY537
Q	ASP538
Q	GLY539
Q	SER540
Q	ASN565
Q	HIS567
Q	LEU568
Q	GLY569
Q	MET570
Q	MG701

---

Functional Information from PROSITE/UniProt

site_id	PS00187
Number of Residues	20
Details	TPP_ENZYMES Thiamine pyrophosphate enzymes signature. IGasvanPdaivVdIdGDGS

Chain	Residue	Details
A	ILE521-SER540

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	256
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16407096","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	72
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32640464","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U9H","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16407096","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Z8N","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16407096","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1YBH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	88
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16407096","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32640464","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U9H","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	56
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32640464","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VZ8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16407096","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19187232","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32640464","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U9H","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16407096","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19187232","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16407096","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19187232","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32640464","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VZ8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	8
Details	Modified residue: {"description":"Cysteine sulfinic acid (-SO2H)","evidences":[{"source":"PubMed","id":"16407096","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19187232","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	288
Details	Domain: {"description":"ACT 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01007","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	296
Details	Domain: {"description":"ACT 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01007","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---